Benzathine 1200000IU Injection - Uses, Price, Side Effects
What is benzathine 1200000iu injection used for?
Benzathine 1200000IU Injection contains Benzathine penicillin G, a long-acting antibiotic used to treat infections like syphilis and to prevent rheumatic fever. It works by stopping bacterial cell wall synthesis, killing susceptible bacteria. It is given as an intramuscular injection, usually as a single dose for syphilis or monthly for prophylaxis.
- Generic Name: Benzathine penicillin G
- Manufacturer: Karnataka Antibiotics & Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: B
- Prescription Required: Yes
๐ benzathine 1200000iu injection Uses & Benefits
Syphilis (primary, secondary, latent, tertiary), rheumatic fever prophylaxis, streptococcal infections
Off-label uses: Yaws, pinta, bejel, leptospirosis
๐ Drug Information
| Generic Name(s) | Benzathine penicillin G |
| Brand Name | Benzathine 1200000IU Injection |
| Manufacturer | Karnataka Antibiotics & Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cell wall active agent - Narrow spectrum Penicillin |
| Route of Administration | Intramuscular (deep IM) |
| Storage | Store at 2-8ยฐC; do not freeze |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)
Mechanism Steps
๐ก How to Take benzathine 1200000iu injection
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of benzathine 1200000iu injection
โ Common Side Effects
- Pain at injection site
- Nausea
- Diarrhea
- Rash
๐จ Serious Side Effects
- Anaphylaxis
- Stevens-Johnson syndrome
- Hemolytic anemia
- Interstitial nephritis
โ ๏ธ Rare Side Effects
- Pseudomembranous colitis
- Seizures (high doses)
- Jarisch-Herxheimer reaction
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Methotrexate | Major | Increased methotrexate toxicity |
| Warfarin | Major | Increased bleeding risk |
| Oral typhoid vaccine | Major | Reduced vaccine efficacy |
| Probenecid | Moderate | Increased penicillin levels |
| Heparin | Moderate | Increased risk of bleeding |
| Live bacterial vaccines | Moderate | Reduced vaccine efficacy |
| Oral contraceptives | Minor | Reduced contraceptive efficacy |
| Disulfiram | Minor | Possible disulfiram-like reaction |
๐จ Major Interactions
- Methotrexate
- Warfarin
- Oral typhoid vaccine
โก Moderate Interactions
- Probenecid
- Heparin
- Live bacterial vaccines
โน๏ธ Minor Interactions
- Oral contraceptives
- Disulfiram
๐ฝ๏ธ Food Interactions
None known
๐ท Alcohol Interaction
No significant interaction
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to penicillins, cephalosporins, or any component
๐ Monitoring Parameters
Renal function, CBC, signs of hypersensitivity
๐คฑ Lactation Safety
Safe; excreted in low amounts
๐ Overdose Management
Supportive care; hemodialysis may remove drug
โฐ Missed Dose
Administer as soon as possible; do not double dose
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for benzathine 1200000iu injection
View AllAlternative brands with exact same active ingredient (Benzathine penicillin G (1200000IU)):
-
pencom 12 injectionAlembic Pharmaceuticals Ltd โน10.89 6.1% CHEAPER
-
penidure la 12 injectionPfizer Ltd โน21.14 82.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
โญ User Reviews
Effective and reliable. Worked as expected.
Good quality medicine. Satisfied with the outcome.
Good quality medicine. Satisfied with the outcome.
Effective and reliable. Worked as expected.
Found this to be a helpful product. Good results.