Folisurge 1200 Injection: Complete Guide To Uses, Dosage, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Rapid weight gain or severe abdominal bloating
- Severe pelvic pain, especially sudden onset
- Difficulty breathing or chest pain
- Nausea and vomiting with abdominal pain
- Decreased urine output
- Swelling of face, lips, or throat
- Signs of blood clots such as leg pain or swelling
- Severe headache with visual disturbances
If experiencing severe symptoms, call emergency services immediately.
What is grafyrec 1200iu injection used for?
This medicine contains recombinant follicle stimulating hormone, a hormone used to stimulate the ovaries to produce multiple eggs for IVF or to induce ovulation. It is given by injection under the supervision of a fertility specialist.
- Generic Name: Recombinant follicle stimulating hormone (1200IU)
- Manufacturer: Lupin Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 grafyrec 1200iu injection के बारे में (Hindi Summary)
उपयोग: यह दवा रीकॉम्बिनेंट फॉलिकल स्टिमुलेटिंग हार्मोन का एक शुद्ध रूप है, जिसका उपयोग महिलाओं में अंडाशय को उत्तेजित करके कई अंडे बनाने के लिए किया जाता है, खासकर आईवीएफ जैसी सहायक प्रजनन तकनीकों में। यह उन महिलाओं में भी दिया जाता है जिनमें ओव्यूलेशन नहीं होता और अन्य दवाओं से फायदा नहीं हुआ है। पुरुषों में, यह हाइपोगोनाडोट्रोपिक हाइपोगोनाडिज्म के इलाज के लिए शुक्राणु उत्पादन को बढ़ाने के लिए उपयोग किया जाता है। यह दवा इंजेक्शन के रूप में दी जाती है और इसका उपयोग केवल प्रजनन विशेषज्ञ की देखरेख में ही किया जाना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, लालिमा, चोट और सूजन शामिल हैं। कुछ महिलाओं को सिरदर्द, पेट में हल्की परेशानी, सूजन और मूड में बदलाव का अनुभव हो सकता है। मतली और स्तन में कोमलता भी हो सकती है। ओवेरियन हाइपरस्टिमुलेशन सिंड्रोम एक गंभीर लेकिन दुर्लभ जटिलता है जिसमें तेजी से वजन बढ़ना, गंभीर पेट दर्द, उल्टी और सांस लेने में कठिनाई हो सकती है। ओवेरियन टॉर्शन एक आपातकालीन स्थिति है जिसमें अचानक गंभीर पेल्विक दर्द होता है। किसी भी गंभीर या असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल योग्य प्रजनन विशेषज्ञ की देखरेख में ही दी जानी चाहिए। बिना प्रशिक्षण के स्वयं इंजेक्शन न लगाएं। अपने डॉक्टर द्वारा बताई गई सटीक खुराक और समय का पालन करें। अल्ट्रासाउंड और रक्त परीक्षण के लिए सभी निर्धारित अपॉइंटमेंट पर जाएं, क्योंकि ये जटिलताओं को रोकने के लिए आवश्यक हैं। तेजी से वजन बढ़ने, गंभीर पेट दर्द, उल्टी या सांस लेने में कठिनाई होने पर तुरंत डॉक्टर को सूचित करें। अचानक गंभीर पेल्विक दर्द होने पर आपातकालीन चिकित्सा लें। यदि आपको रक्त के थक्के, थायरॉइड या एलर्जी की समस्या है तो अपने डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान इस दवा का उपयोग न करें।
💊 grafyrec 1200iu injection Uses & Benefits
[{"condition":"Controlled ovarian stimulation for in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI)","description":"This medicine is used to stimulate the growth of multiple ovarian follicles so that several eggs can be retrieved for assisted reproduction techniques.","evidence":"Well-established"},{"condition":"Chronic anovulation in women who have not responded to clomiphene citrate","description":"It induces ovulation in women with hypothalamic-pituitary dysfunction or polycystic ovary syndrome who fail to ovulate with first-line oral agents.","evidence":"Well-established"},{"condition":"Hypogonadotropic hypogonadism in men","description":"It is used to stimulate spermatogenesis in men with low gonadotropin levels, often in combination with human chorionic gonadotropin.","evidence":"Well-established"},{"condition":"In vitro maturation of oocytes","description":"In some protocols, this medicine is used to support oocyte maturation before retrieval, although protocols vary.","evidence":"Emerging"}]
Off-label uses: [{"condition":"Ovulation induction in women with polycystic ovary syndrome resistant to other treatments","description":"Sometimes used as a second-line agent, but it carries a higher risk of multiple pregnancies and ovarian hyperstimulation syndrome compared to oral agents.","evidence":"Limited"},{"condition":"Male infertility with normal gonadotropins","description":"Occasionally prescribed off-label to improve sperm parameters, but evidence of benefit is not consistent.","evidence":"Limited"}]
Primary treatment for: Infertility
Also treats: Chronic anovulation, Hypogonadotropic hypogonadism in men, Polycystic ovary syndrome
📋 Drug Information
| Generic Name(s) | Recombinant follicle stimulating hormone (1200IU) |
| Brand Name | grafyrec 1200iu injection |
| Manufacturer | Lupin Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Gonadotropins |
| Route of Administration | Parenteral (subcutaneous or intramuscular injection) |
| Storage | Store the lyophilised powder at 2°C to 8°C (refrigerated). Do not freeze. The solvent can be stored at room temperature. After reconstitution, use immediately or store as directed by the manufacturer, typically at 2°C to 8°C for up to 24 hours. Protect from light. |
| Shelf Life | The shelf life of the lyophilised powder is typically 24 months from the date of manufacture when stored as directed. Refer to the packaging for the exact expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to specific follicle stimulating hormone receptors located on the surface of granulosa cells in the ovaries and Sertoli cells in the testes. Upon binding, it activates the receptor, which is a G protein-coupled receptor, leading to activation of adenylyl cyclase and increased production of cyclic adenosine monophosphate. This triggers a cascade of intracellular events that promote cell proliferation, differentiation, and steroidogenesis. In women, this results in follicular growth, granulosa cell proliferation, and increased oestradiol production. In men, it stimulates Sertoli cell function and supports spermatogenesis. The hormone is not active orally and must be injected.
Mechanism Steps
💡 How to Take grafyrec 1200iu injection
Strength: Lyophilised powder for injection, 1200 international units per vial, for reconstitution with the provided solvent.
Dosage Information
| Adult Dosage | The dose of this medicine is highly individualised and depends on the indication, the patient's age, weight, ovarian reserve, and response to previous treatments. For controlled ovarian stimulation in IVF, a typical starting dose is 150 to 225 international units per day, but doses can range from 75 to 450 international units per day. For ovulation induction in chronic anovulation, a common starting dose is 75 to 150 international units per day. In men with hypogonadotropic hypogonadism, the dose is usually 150 international units three times a week, often in combination with human chorionic gonadotropin. Dose must be individualised by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. Regular monitoring with ultrasound and blood tests is essential to adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | This medicine is not intended for use in elderly patients. Safety and efficacy have not been established in this population. |
| Renal Impairment | No specific dose adjustment is recommended for renal impairment, but caution is advised as the elimination half-life may be prolonged. Consult your doctor. |
| Hepatic Impairment | No specific dose adjustment is recommended for hepatic impairment, but caution is advised. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose is determined by the treating clinician based on the patient's response and should not exceed the prescribed dose. Doses above 450 international units per day are not recommended. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of grafyrec 1200iu injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| GnRH antagonists | Major | |
| GnRH agonists | Major | |
| hCG | Major | |
| Clomiphene citrate | Moderate | |
| NSAIDs | Moderate | |
| Thyroid hormones | Minor |
🚨 Major Interactions
- Gonadotropin-releasing hormone (GnRH) antagonists
- Gonadotropin-releasing hormone (GnRH) agonists
- Human chorionic gonadotropin (hCG)
⚡ Moderate Interactions
- Clomiphene citrate
- Non-steroidal anti-inflammatory drugs (NSAIDs)
🍷 Alcohol Interaction
Alcohol consumption should be avoided during fertility treatment as it can reduce the chances of success and may increase the risk of complications. It is advisable to abstain from alcohol while using this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to recombinant follicle stimulating hormone or any excipient","Ovarian cysts or enlarged ovaries not due to polycystic ovary syndrome","Uncontrolled thyroid or adrenal dysfunction","Abnormal genital bleeding of unknown cause","Primary ovarian failure","Primary testicular failure in men","Pregnancy and breastfeeding","Tumours of the ovary, breast, uterus, hypothalamus, or pituitary gland","Thromboembolic disorders or history of blood clots"]
⚠️ Warnings & Precautions
["This medicine should only be used by fertility specialists experienced in the management of reproductive disorders.","Ovarian hyperstimulation syndrome (OHSS) is a serious complication that requires immediate medical attention.","The risk of multiple pregnancies is increased with this medicine.","Women with polycystic ovary syndrome are at higher risk of OHSS.","Thromboembolic events have been reported rarely; women with risk factors should be monitored.","In men, this medicine may cause breast enlargement or acne due to increased testosterone levels.","Do not use if the solution is cloudy or contains particles.","Reconstituted solution should be used immediately or within the time specified by the manufacturer.","Inform your doctor if you have any allergies or medical conditions."]
🤱 Lactation Safety
This medicine is not recommended during breastfeeding. It is not known whether recombinant follicle stimulating hormone is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised.
💊 Overdose Management
Overdose of this medicine may lead to ovarian hyperstimulation syndrome. If you suspect an overdose, contact your doctor immediately. Treatment is symptomatic and supportive, and may include hospitalisation for monitoring and management of complications such as ascites, electrolyte imbalance, and thromboembolism.
⏰ Missed Dose
If you miss a dose of this medicine, contact your fertility specialist immediately for advice. Do not double the dose to make up for a missed one. The timing of injections is critical in fertility treatment, so your doctor will advise you on how to proceed.
Additional Safety Advice
This medicine must only be prescribed and administered under the supervision of a qualified fertility specialist. Do not self-administer unless you have been properly trained by a healthcare professional. Follow the exact dose and timing instructed by your doctor, as the protocol is tailored to your individual response. Attend all scheduled monitoring appointments for ultrasound scans and blood tests, because these are essential to prevent complications such as ovarian hyperstimulation syndrome. Report any rapid weight gain, severe abdominal pain, vomiting, or difficulty breathing immediately. If you experience sudden severe pelvic pain, seek emergency care, as this may indicate ovarian torsion. Inform your doctor if you have a history of blood clots, thyroid problems, or allergies. Do not use this medicine if you are pregnant or breastfeeding. Store the powder and solvent as directed, and use the reconstituted solution within the specified time. Keep out of reach of children. Do not share this medicine with anyone else, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
This medicine is not intended for use in elderly patients. Safety and efficacy have not been established in this population.
🤰 Pregnancy Planning (TTC)
This medicine is used to help you conceive. If you are planning pregnancy, consult your fertility specialist for a thorough evaluation. Once pregnancy is confirmed, this medicine is discontinued. Ensure you take folic acid supplements and follow a healthy lifestyle.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your doctor before starting this medicine. There is no specific contraindication, but your overall health should be stable before initiating fertility treatment.
🦷 Dental Procedures
There are no specific precautions for dental procedures while using this medicine. However, inform your dentist about your medication and fertility treatment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe during treatment, but avoid high-impact activities or heavy lifting, especially during ovarian stimulation, to reduce the risk of ovarian torsion. Consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause mild fatigue, headache, or mood swings, which could affect your daily activities. However, most women are able to continue their normal routines. If you experience dizziness or severe discomfort, avoid driving or operating machinery. Inform your employer about your treatment schedule if you need flexibility for monitoring appointments.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your fertility specialist. Treatment is stopped when the desired ovarian response is achieved or if complications occur. If you experience severe side effects, contact your doctor immediately for guidance.
📅 Long-Term Use Effects
Long-term use of this medicine is generally limited to the duration of fertility treatment cycles. There is no evidence of serious long-term effects when used as prescribed. However, women who undergo multiple cycles of ovarian stimulation should be monitored for any changes in ovarian function. Some studies suggest a possible link between fertility drugs and borderline ovarian tumours, but the evidence is not conclusive. Regular follow-up with your doctor is recommended.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
An oral medication used for ovulation induction in women with PCOS or unexplained infertility.
Evidence: Well-establishedAn oral aromatase inhibitor used for ovulation induction, often with fewer side effects than clomiphene.
Evidence: Well-establishedAn injectable containing both FSH and LH, used for ovarian stimulation.
Evidence: Well-establishedA technique where immature eggs are retrieved and matured in the laboratory, reducing the need for hormonal stimulation.
Evidence: Emerging💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, it is advisable to be up to date with routine vaccinations before starting fertility treatment. Live vaccines should be avoided during pregnancy.
📦 Storage Guide
✅ DO
Store the lyophilised powder in the refrigerator at 2°C to 8°C.
❌ DON'T
Do not freeze the powder or the reconstituted solution.
✅ DO
Keep the vial in its original carton to protect from light.
❌ DON'T
Do not store near direct sunlight or heat sources.
✅ DO
Use the reconstituted solution immediately or within the time specified by the manufacturer.
❌ DON'T
Do not use if the solution is cloudy or contains particles.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not transfer to unmarked containers.
✈️ Traveling with This Medicine
When travelling with this medicine, carry it in its original packaging with the prescription label. Keep the lyophilised powder refrigerated (2°C to 8°C) using a cool pack or insulated bag. Carry a copy of your prescription and a letter from your doctor explaining the medical need. If crossing time zones, consult your doctor about adjusting injection times. Check customs regulations for carrying injectable medications. Always carry enough medication for the entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Follicular growth can be observed within 5 to 7 days of starting treatment, but the full course usually lasts 8 to 14 days. Your doctor will monitor your response with ultrasound and blood tests.
A: Yes, but only after proper training from your healthcare professional. Follow the instructions carefully and use sterile technique.
A: Mild side effects like injection site reactions and headache usually resolve on their own. Report any severe or unusual symptoms to your doctor immediately.
A: This medicine is not intended for use during pregnancy. It is discontinued once pregnancy is confirmed.
A: Store the lyophilised powder in the refrigerator at 2°C to 8°C. Do not freeze. Use the reconstituted solution immediately or as directed.
🤔 Common Patient Concerns
🔄 Substitutes for grafyrec 1200iu injection
View AllAlternative brands with exact same active ingredient:
-
Fostirel 1200IU InjectionReliance Life Sciences ₹15,937.50 31.3% CHEAPER
-
folisurge 1200 injectionIntas Pharmaceuticals Ltd ₹23,625.00 1.8% COSTLIER
-
materna r fsh 1200iu injectionEmcure Pharmaceuticals Ltd ₹23,904.80 3% COSTLIER
-
foligraf 1200iu injectionBharat Serums & Vaccines Ltd ₹28,125.00 21.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine guarantees a successful pregnancy.
Fact: This medicine increases the chances of pregnancy but does not guarantee success. Many factors affect the outcome. - Myth: This medicine can be taken orally.
Fact: This medicine must be injected because it is a protein hormone and would be digested if taken orally. - Myth: This medicine causes ovarian cancer.
Fact: Most studies have not found a definitive link between this medicine and ovarian cancer, but long-term monitoring is advised.
🔄 Alternative Options
Generic Alternatives
- Recombinant follicle stimulating hormone 1200 IU injection
Brand Alternatives
- Folisurge 1200 Injection