Aptin M 500mg/20mg Tablet SR: Complete Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Muscle pain, difficulty breathing, or extreme tiredness (possible lactic acidosis)
- Severe abdominal pain radiating to the back (possible pancreatitis)
- Swelling of face, lips, or throat, or difficulty breathing (severe allergic reaction)
- Yellowing of skin or eyes, dark urine (liver problems)
- Decreased urine output or swelling in legs (kidney problems)
- Persistent nausea, vomiting, or severe diarrhea
- Symptoms of hypoglycemia: shakiness, sweating, confusion, rapid heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is genericart metformin hydrochloride+teneligliptin 500mg/20mg tablet er used for?
This medicine is a combination of Metformin and Teneligliptin used to treat type 2 diabetes. It lowers blood sugar by improving insulin sensitivity and increasing insulin release when needed. It is taken once daily with a meal.
- Generic Name: Metformin (500mg) + Teneligliptin (20mg)
- Manufacturer: Swast Aushadhi Seva Generic Medicine Store
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 genericart metformin hydrochloride+teneligliptin 500mg/20mg tablet er के बारे में (Hindi Summary)
उपयोग: यह दवा मेटफॉर्मिन और टेनेलिग्लिप्टिन का संयोजन है, जिसका उपयोग टाइप 2 मधुमेह (डायबिटीज) के इलाज में किया जाता है। यह रक्त शर्करा को नियंत्रित करने में मदद करती है। यह इंसुलिन की संवेदनशीलता को बढ़ाती है और जब आवश्यक हो तब इंसुलिन के स्राव को बढ़ावा देती है। इसे आमतौर पर दिन में एक बार भोजन के साथ लिया जाता है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, दस्त, पेट में असुविधा, भूख में कमी और मुँह में धातु जैसा स्वाद शामिल हैं। ये आमतौर पर हल्के होते हैं और समय के साथ ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन लैक्टिक एसिडोसिस, अग्नाशयशोथ (पैन्क्रियाटाइटिस) और गंभीर एलर्जी प्रतिक्रियाएँ हो सकती हैं। यदि आपको मांसपेशियों में दर्द, सांस लेने में कठिनाई, पेट में तेज दर्द, या चेहरे पर सूजन जैसे लक्षण दिखें, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। टैबलेट को चबाएं या तोड़ें नहीं, पूरा निगल लें। दवा लेते समय शराब का सेवन न करें, क्योंकि इससे लैक्टिक एसिडोसिस और लो ब्लड शुगर का खतरा बढ़ सकता है। अगर आपको किडनी या लीवर की समस्या है, तो डॉक्टर को बताएं। नियमित रूप से ब्लड शुगर की जांच करें। दवा बंद करने से पहले डॉक्टर से सलाह लें।
💊 genericart metformin hydrochloride+teneligliptin 500mg/20mg tablet er Uses & Benefits
[{"condition":"Type 2 Diabetes Mellitus","description":"Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus inadequately controlled on metformin alone or teneligliptin alone.","evidence":"Well-established"},{"condition":"Type 2 Diabetes Mellitus with inadequate control on monotherapy","description":"Combination therapy provides complementary mechanisms to lower fasting and postprandial blood glucose more effectively than either agent alone.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prediabetes","description":"Sometimes considered off-label to delay progression to diabetes, but not routinely recommended.","evidence":"Limited"},{"condition":"Polycystic Ovary Syndrome (PCOS)","description":"Metformin component may be used off-label for insulin resistance in PCOS, but teneligliptin is not established for this use.","evidence":"Limited"}]
Primary treatment for: Type 2 Diabetes Mellitus
Also treats: Obesity, Dyslipidemia, Hypertension
📋 Drug Information
| Generic Name(s) | Metformin (500mg) + Teneligliptin (20mg) |
| Brand Name | genericart metformin hydrochloride+teneligliptin 500mg/20mg tablet er |
| Manufacturer | Swast Aushadhi Seva Generic Medicine Store |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place. Protect from light and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. Guidelines generally recommend metformin as first-line therapy for type 2 diabetes, with DPP-4 inhibitors as add-on options. |
| ICMR Guideline | Not established from the available information. ICMR guidelines recommend metformin as first-line pharmacotherapy for type 2 diabetes in India, with DPP-4 inhibitors as add-on therapy. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antidiabetic agents with complementary mechanisms. Metformin reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Teneligliptin inhibits the enzyme dipeptidyl peptidase-4 (DPP-4), which normally breaks down incretin hormones such as GLP-1 and GIP. By inhibiting DPP-4, teneligliptin increases the active levels of these incretins, leading to enhanced glucose-dependent insulin secretion from pancreatic beta cells and reduced glucagon release from alpha cells. The combined effect is improved glycemic control with a lower risk of hypoglycemia compared to some other antidiabetic combinations.
Mechanism Steps
💡 How to Take genericart metformin hydrochloride+teneligliptin 500mg/20mg tablet er
Strength: Tablet containing Metformin 500 mg and Teneligliptin 20 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet once daily, preferably with a meal. The dose may be adjusted by your doctor based on your blood sugar levels, kidney function, and other medications. Do not exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Renal function should be assessed before starting and monitored regularly. Dose adjustment may be needed based on renal function. |
| Renal Impairment | Metformin is contraindicated in severe renal impairment (eGFR <30 mL/min/1.73 m2). In moderate renal impairment (eGFR 30-45 mL/min/1.73 m2), metformin should be used with caution and dose may need reduction. Teneligliptin dose should be reduced in moderate to severe renal impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be needed. Monitor liver function regularly. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet of this strength (metformin 500 mg + teneligliptin 20 mg) once daily. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of genericart metformin hydrochloride+teneligliptin 500mg/20mg tablet er
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Iodinated contrast media | Major | |
| Alcohol | Major | |
| Sulfonylureas | Major | |
| Insulin | Major | |
| Cationic drugs | Moderate | |
| CYP3A4 inhibitors | Moderate | |
| CYP3A4 inducers | Moderate | |
| Diuretics | Minor | |
| NSAIDs | Minor |
🚨 Major Interactions
- Iodinated contrast media
- Alcohol
- Sulfonylureas (e.g., glimepiride, gliclazide)
- Insulin
⚡ Moderate Interactions
- Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, ranitidine, triamterene, trimethoprim, vancomycin)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
- CYP3A4 inducers (e.g., rifampicin, carbamazepine)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of lactic acidosis, a rare but serious complication of metformin, and can also cause hypoglycemia. If you consume alcohol occasionally, discuss with your doctor about safe limits.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Lactic acidosis: Rare but serious. Discontinue and seek immediate medical help if symptoms occur.","Renal impairment: Dose adjustment may be needed. Monitor renal function regularly.","Hepatic impairment: Use with caution; monitor liver function.","Hypoglycemia: Risk increases when used with insulin or sulfonylureas. Monitor blood glucose.","Vitamin B12 deficiency: Long-term use may cause deficiency. Monitor levels.","Pancreatitis: Rare but serious. Discontinue if suspected.","Hypersensitivity reactions: Discontinue if allergic reactions occur.","Surgery: Temporarily discontinue before surgery and restart after renal function is confirmed normal.","Alcohol: Avoid due to increased risk of lactic acidosis."]
🤱 Lactation Safety
Metformin is excreted in human breast milk in small amounts. Teneligliptin is not established for use during breastfeeding. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose may cause hypoglycemia, lactic acidosis, or pancreatitis. Seek immediate medical attention. Treatment is supportive and symptomatic. Hemodialysis may be considered for metformin overdose. There is no specific antidote for teneligliptin.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually once daily with a meal to reduce stomach upset. Do not crush, chew, or break the tablet; swallow it whole with a glass of water. Do not skip meals while taking this medicine, as that can increase the risk of low blood sugar. Avoid alcohol, as it can increase the risk of lactic acidosis and low blood sugar. Inform your doctor if you have kidney or liver problems, heart failure, or if you are scheduled for surgery or imaging tests with contrast dyes. Your doctor may ask you to temporarily stop this medicine before such procedures. Check your blood sugar regularly as advised. Do not stop taking this medicine without consulting your doctor, even if you feel well. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Never double the dose. Store the tablets in a cool, dry place away from direct sunlight and out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced renal function and are at higher risk of lactic acidosis. Renal function should be assessed before starting and monitored regularly. Dose adjustment may be needed. Monitor for signs of hypoglycemia.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before conceiving. This medicine may not be suitable during pregnancy. Insulin is generally preferred for managing diabetes during pregnancy. Your doctor will advise on the best treatment plan.
🏥 Post-Surgery Considerations
This medicine should be temporarily discontinued before surgery and restarted after 48 hours once renal function is confirmed normal. Follow your surgeon's and doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. No specific precautions are usually needed for routine dental procedures, but monitor your blood sugar as stress can affect levels.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is beneficial for managing diabetes, but monitor your blood sugar before and after exercise, especially if you take insulin or sulfonylureas. Carry a fast-acting carbohydrate source in case of hypoglycemia. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or low blood sugar in some people, which can affect your ability to drive or operate machinery. Monitor your blood sugar regularly and avoid driving if you feel dizzy or shaky. Inform your employer about your condition if your job involves operating heavy machinery.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as lactic acidosis, pancreatitis, or severe allergic reactions, seek immediate medical attention and follow your doctor's advice on whether to continue. Your doctor may adjust or discontinue the medicine based on your condition and test results.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to vitamin B12 deficiency, which can cause anemia and nerve damage. Regular monitoring of vitamin B12 levels is recommended. Kidney function should be monitored periodically. Lactic acidosis is a rare but serious risk, especially in patients with kidney or liver problems. The combination has been shown to be effective in maintaining long-term glycemic control.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are cornerstone therapies for type 2 diabetes and can complement medicine.
Evidence: Well-establishedSulfonylureas, SGLT2 inhibitors, or GLP-1 receptor agonists may be alternatives based on individual needs.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, patients with diabetes should stay up to date with recommended vaccinations, including influenza and pneumococcal vaccines, as they are at higher risk of infections.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry your medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If traveling across time zones, consult your doctor about adjusting the timing of your dose. Carry enough supply for the entire trip plus extra in case of delays. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within a few days, but the full effect on HbA1c may take 2-3 months. Continue taking it as prescribed.
A: Your doctor will assess your kidney function before prescribing this medicine. It may not be suitable for severe kidney impairment. Regular monitoring is required.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Consult your doctor before taking this medicine during pregnancy. Insulin is generally preferred for managing diabetes during pregnancy.
🤔 Common Patient Concerns
🔄 Substitutes for genericart metformin hydrochloride+teneligliptin 500mg/20mg tablet er
View AllAlternative brands with exact same active ingredient:
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tenlizem-m500 sr tabletZeelab Pharmacy Pvt Ltd ₹25.00 77.7% CHEAPER
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kriptan m 500mg/20mg tablet srZylig Lifesciences ₹35.63 68.2% CHEAPER
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davaindia metformin+teneligliptin 500mg/20mg tablet srDavaindia Generic Pharmacy ₹46.00 59% CHEAPER
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ecoglip-tm tablet srOzone Pharmaceuticals Ltd ₹50.00 55.4% CHEAPER
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gudglip m 500mg/20mg tabletCurewin Hylico Pharma Pvt Ltd ₹51.56 54% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps control blood sugar but does not cure diabetes. Lifestyle changes and ongoing medication are usually needed. - Myth: This medicine can be taken without food.
Fact: It should be taken with food to reduce stomach upset and improve tolerability. - Myth: This medicine causes weight gain.
Fact: Metformin is weight-neutral or may cause slight weight loss. Teneligliptin is weight-neutral.
🔄 Alternative Options
Generic Alternatives
- Metformin 500 mg + Teneligliptin 20 mg tablet (generic)
Brand Alternatives
- Not established from the available information.