Gabritab 50-AT Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Thoughts of harming yourself or others
- Severe allergic reaction (rash, swelling, difficulty breathing)
- Irregular heartbeat or chest pain
- Seizures or convulsions
- Severe dizziness or fainting
- Yellowing of skin or eyes (jaundice)
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is gabritab 50-at tablet used for?
This medicine is a combination of Amitriptyline 10 mg and Pregabalin 50 mg used to treat nerve pain. It works by calming overactive nerves and reducing pain signals. It is taken orally, usually once or twice daily, and should not be stopped suddenly.
- Generic Name: Amitriptyline (10mg) + Pregabalin (50mg)
- Manufacturer: Sparsh Remedies Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 gabritab 50-at tablet के बारे में (Hindi Summary)
उपयोग: यह दवा अमित्रिप्टिलीन 10 मिलीग्राम और प्रीगाबालिन 50 मिलीग्राम का संयोजन है, जिसका उपयोग मुख्य रूप से तंत्रिका दर्द (न्यूरोपैथिक दर्द) के इलाज के लिए किया जाता है। यह मधुमेह से होने वाले तंत्रिका दर्द, दाद के बाद होने वाले दर्द, और फाइब्रोमायल्जिया जैसी स्थितियों में राहत देती है। यह दवा दिमाग और तंत्रिकाओं पर काम करती है और दर्द के संकेतों को कम करती है। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, वजन बढ़ना, और हाथ-पैरों में सूजन शामिल हैं। कुछ लोगों को धुंधली दृष्टि, कब्ज, या थकान भी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको तेज बुखार, मांसपेशियों में अकड़न, दौरे, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। शराब का सेवन न करें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। गाड़ी चलाने या मशीन चलाने से बचें जब तक कि आपको पता न चल जाए कि यह दवा आप पर कैसे असर करती है। इस दवा को अचानक बंद न करें, क्योंकि इससे withdrawal के लक्षण हो सकते हैं। डॉक्टर की सलाह के बिना डोज़ न बदलें।
💊 gabritab 50-at tablet Uses & Benefits
[{"condition":"Diabetic peripheral neuropathy","description":"This medicine helps relieve burning, shooting, or tingling pain in the feet and hands caused by nerve damage from diabetes.","evidence":"Well-established"},{"condition":"Postherpetic neuralgia","description":"It reduces persistent nerve pain that can occur after a shingles infection.","evidence":"Well-established"},{"condition":"Fibromyalgia","description":"This medicine may help reduce widespread muscle pain and improve sleep in some patients with fibromyalgia.","evidence":"Moderate"},{"condition":"Chronic musculoskeletal pain","description":"It can be used as part of a comprehensive pain management plan for chronic back pain or osteoarthritis when other treatments are insufficient.","evidence":"Limited"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label to prevent migraines, especially when other preventive medicines are not effective.","evidence":"Limited"},{"condition":"Neuropathic cancer pain","description":"May be used off-label to manage nerve pain in cancer patients, often in combination with other pain medicines.","evidence":"Limited"}]
Primary treatment for: Neuropathic pain
Also treats: Diabetic neuropathy, Postherpetic neuralgia, Fibromyalgia
📋 Drug Information
| Generic Name(s) | Amitriptyline (10mg) + Pregabalin (50mg) |
| Brand Name | gabritab 50-at tablet |
| Manufacturer | Sparsh Remedies Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients that work in different ways to reduce nerve pain. Amitriptyline increases the levels of certain chemical messengers in the brain, such as serotonin and norepinephrine, which helps dampen pain signals. Pregabalin binds to specific sites on calcium channels in the nervous system, reducing the release of excitatory neurotransmitters that contribute to pain. Together, they help calm overactive nerves and reduce the perception of pain.
Mechanism Steps
💡 How to Take gabritab 50-at tablet
Strength: Each tablet contains Amitriptyline 10 mg and Pregabalin 50 mg.
Dosage Information
| Adult Dosage | The usual starting dose for adults is one tablet taken orally once or twice daily, or as directed by your doctor. The dose may be increased gradually based on your response and tolerability. The maximum recommended dose is generally 2 tablets per day, but this can vary. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not adjust the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially drowsiness, dizziness, and confusion. Start with a lower dose and titrate slowly. Regular monitoring for falls and cognitive changes is recommended. |
| Renal Impairment | Pregabalin requires dose reduction in patients with renal impairment. Amitriptyline is not significantly affected by renal function, but caution is advised. Consult your doctor for dose adjustment based on creatinine clearance. |
| Hepatic Impairment | Amitriptyline is metabolized in the liver; dose reduction may be necessary in patients with hepatic impairment. Pregabalin is not metabolized in the liver, so no adjustment is needed for hepatic impairment alone. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose is generally 2 tablets (20 mg amitriptyline + 100 mg pregabalin) per day, but this may vary based on individual patient factors. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of gabritab 50-at tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Opioids | Major | |
| Benzodiazepines | Major | |
| SSRIs | Moderate | |
| CYP2D6 inhibitors | Moderate | |
| Diuretics | Moderate | |
| Anticholinergics | Moderate | |
| Antacids | Minor | |
| Cimetidine | Minor | |
| Warfarin | Moderate |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- CNS depressants (e.g., opioids, benzodiazepines, alcohol)
- Anticholinergic drugs (e.g., antihistamines, antipsychotics)
⚡ Moderate Interactions
- SSRIs and SNRIs
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- Diuretics
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase drowsiness, dizziness, and impair your ability to drive or operate machinery. It may also worsen the side effects of both amitriptyline and pregabalin.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to amitriptyline, pregabalin, or any component of the formulation","Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOIs","Recent myocardial infarction","Uncontrolled narrow-angle glaucoma","Severe liver disease","Pregnancy and breastfeeding (unless clearly needed)"]
⚠️ Warnings & Precautions
["May cause drowsiness and dizziness. Avoid driving or operating machinery until you know how it affects you.","Do not stop suddenly; withdrawal symptoms may occur. Taper gradually under medical supervision.","May increase risk of suicidal thoughts, especially in young adults. Monitor mood closely.","Use with caution in elderly patients due to increased risk of falls, confusion, and urinary retention.","May cause weight gain and fluid retention. Monitor weight and report rapid swelling.","Avoid alcohol and other CNS depressants.","Inform your doctor if you have kidney or liver disease, heart problems, or a history of seizures."]
🤱 Lactation Safety
This medicine passes into breast milk and may cause drowsiness in a nursing infant. It is not recommended during breastfeeding unless the benefits outweigh the risks. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of this medicine can be serious and potentially life-threatening. Symptoms may include severe drowsiness, confusion, agitation, hallucinations, fast heartbeat, irregular heart rhythm, seizures, and coma. If you suspect an overdose, seek emergency medical help immediately. Do not wait for symptoms to worsen. Treatment is supportive and may include activated charcoal, gastric lavage, and monitoring of vital signs and heart rhythm. There is no specific antidote for pregabalin; amitriptyline overdose may be treated with sodium bicarbonate for cardiac toxicity.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Before taking this medicine, tell your doctor if you have kidney problems, liver problems, heart disease, glaucoma, an enlarged prostate, or a history of seizures or depression. This medicine can interact with many other medicines, including painkillers, antidepressants, and blood thinners, so always inform your doctor about all the medicines you are taking. Do not stop taking this medicine suddenly, as it can cause withdrawal symptoms such as headache, nausea, anxiety, and sleep problems. If you need to stop, your doctor will reduce the dose gradually. Avoid alcohol while taking this medicine because it can increase drowsiness and dizziness. Do not drive or operate heavy machinery until you know how this medicine affects you. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before taking this medicine. Keep this medicine out of reach of children and store it at room temperature, away from moisture and heat. Do not share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of this medicine, especially drowsiness, dizziness, confusion, and urinary retention. Start with a lower dose and monitor closely for falls and cognitive changes. Regular review of kidney function is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is not recommended during pregnancy unless clearly needed. Your doctor may switch you to a safer alternative.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and increase sedation. Your doctor may advise you to stop it temporarily before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may cause dry mouth, which can increase the risk of dental problems. Also, it may interact with sedatives used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, so avoid activities that require alertness until you know how it affects you. Mild to moderate exercise is generally safe, but listen to your body and do not overexert. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness, dizziness, and difficulty concentrating, which can affect your ability to drive or operate machinery. It is advisable to avoid these activities until you know how the medicine affects you. Inform your employer if your job involves such tasks. Adjustments to your work schedule or tasks may be needed.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your condition improves, your doctor will decide if and how to taper the dose. Sudden discontinuation can cause withdrawal symptoms such as headache, nausea, anxiety, and sleep disturbances.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to weight gain, fluid retention, and tolerance. Regular monitoring of kidney and liver function, as well as mood and cognitive function, is recommended. Do not stop suddenly; taper gradually under medical supervision. Periodic review with your doctor is necessary to assess continued benefit and adjust the dose.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help improve strength and reduce pain in chronic conditions.
Evidence: Well-establishedMay help manage chronic pain and improve coping skills.
Evidence: ModerateSome evidence suggests it may help with certain types of pain.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, adjust your dosing schedule gradually in consultation with your doctor. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start to feel some relief within a few days, but it can take 1 to 2 weeks or longer for the full effect.
A: No, do not stop suddenly. Your doctor will gradually reduce the dose to prevent withdrawal symptoms.
A: It depends on the other painkillers. Always consult your doctor before combining any medicines.
A: Take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose. Do not double dose.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is a simple painkiller like paracetamol.
Fact: This medicine is not a simple painkiller; it works on the nervous system to reduce nerve pain and requires a prescription. - Myth: You can stop taking this medicine whenever you feel better.
Fact: Stopping suddenly can cause withdrawal symptoms. Always taper gradually under medical supervision. - Myth: This medicine is addictive.
Fact: Pregabalin has a potential for misuse, but when taken as prescribed for medical reasons, the risk is low. Amitriptyline is not addictive.
🔄 Alternative Options
Generic Alternatives
- Amitriptyline 10 mg + Pregabalin 50 mg tablet (generic)
Brand Alternatives
- Gabritab 50-AT Tablet