Alexim AZ 200mg/500mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing
- Severe or bloody diarrhea, or diarrhea that lasts more than a few days
- Yellowing of the eyes or skin, dark urine, or severe upper abdominal pain
- Irregular heartbeat, fainting, or palpitations
- Widespread skin rash with blistering or peeling, or sores in the mouth or eyes
- Decreased urine output or swelling of the legs and feet
- Persistent high fever that does not improve after 48 to 72 hours of treatment
If experiencing severe symptoms, call emergency services immediately.
What is g-thro cf 200mg/500mg tablet used for?
This medicine is a prescription antibiotic tablet containing cefixime 200 mg and azithromycin 500 mg. It is used to treat certain bacterial infections when a clinician decides that both antibiotics are needed. It does not treat viral infections, and it must be taken exactly as prescribed.
- Generic Name: Cefixime (200mg) + Azithromycin (500mg)
- Manufacturer: Globus Remedies Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 g-thro cf 200mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सेफिक्सिम 200 मिलीग्राम और एज़िथ्रोमाइसिन 500 मिलीग्राम का संयोजन है, जिसका उपयोग डॉक्टर की सलाह पर कुछ बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह श्वसन तंत्र, मूत्र मार्ग, त्वचा और कुछ अन्य संक्रमणों में दी जा सकती है, लेकिन यह वायरल बीमारियों जैसे सर्दी-जुकाम या फ्लू पर असर नहीं करती। इसे डॉक्टर के बताए अनुसार पूरा कोर्स करना बहुत जरूरी है, भले ही लक्षण जल्दी ठीक होने लगें। बिना सलाह इस दवा को शुरू या बंद न करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में पेट खराब होना, दस्त, जी मिचलाना, पेट दर्द, सिरदर्द और हल्की थकान शामिल हैं। कुछ लोगों को त्वचा पर हल्का दाना या स्वाद में बदलाव भी महसूस हो सकता है। गंभीर दुष्प्रभाव कम होते हैं, लेकिन अगर चेहरे, होंठ, जीभ या गले में सूजन, सांस लेने में कठिनाई, खूनी दस्त, पीलिया, या दिल की धड़कन में अनियमितता हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें और पूरा कोर्स पूरा करें। इसे पानी के साथ निगलें और अगर पेट खराब हो तो भोजन के साथ लें। दवा लेते समय शराब न पिएं। एंटासिड या मिनरल सप्लीमेंट लेने से पहले या बाद में कम से कम दो घंटे का अंतर रखें। गर्भवती महिलाएं, स्तनपान कराने वाली महिलाएं और किडनी या लीवर की बीमारी वाले मरीज डॉक्टर से सलाह लें। दवा को ठंडी और सूखी जगह पर रखें और बच्चों से दूर रखें।
💊 g-thro cf 200mg/500mg tablet Uses & Benefits
[{"condition":"Community-acquired respiratory tract infections","description":"This medicine may be prescribed for bacterial bronchitis, pneumonia, or sinus infections when a clinician determines that combined cefixime and azithromycin coverage is appropriate.","evidence":"Moderate"},{"condition":"Urinary tract infections","description":"Cefixime component provides activity against common urinary pathogens, and this medicine may be used for uncomplicated or complicated urinary tract infections based on culture results and clinical judgment.","evidence":"Moderate"},{"condition":"Skin and soft tissue infections","description":"This medicine can be considered for certain bacterial skin infections when the suspected organisms are likely to respond to the combination.","evidence":"Limited"},{"condition":"Typhoid fever","description":"Cefixime is sometimes used for enteric fever, and azithromycin may add coverage in selected cases, but the combination is not a standard first-line regimen in all regions.","evidence":"Limited"},{"condition":"Sexually transmitted infections","description":"Azithromycin has a role in treating certain sexually transmitted infections, but this specific combination is not a routine regimen for all such infections and must be guided by local guidelines and testing.","evidence":"Limited"}]
Off-label uses: [{"condition":"Atypical mycobacterial infections","description":"Azithromycin is sometimes used off-label as part of multidrug regimens for certain atypical mycobacterial infections, but this combination tablet is not a standard formulation for that purpose.","evidence":"Limited"},{"condition":"Chronic obstructive pulmonary disease exacerbations","description":"Antibiotics including azithromycin may be used in selected COPD exacerbations, but the fixed combination with cefixime is not a standard off-label regimen.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Skin and soft tissue infections, Typhoid fever
📋 Drug Information
| Generic Name(s) | Cefixime (200mg) + Azithromycin (500mg) |
| Brand Name | g-thro cf 200mg/500mg tablet |
| Manufacturer | Globus Remedies Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep the tablets in their original blister pack or container until you are ready to take them. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture, but you should always check the expiry date printed on the pack. Do not use the medicine after the expiry date. |
| WHO Guideline | Not established from the available information for this specific fixed-dose combination. Antibiotic choice should follow local resistance patterns and national guidelines. |
| ICMR Guideline | Not established from the available information for this specific fixed-dose combination. Clinicians should refer to current ICMR antimicrobial use guidelines for the relevant infection. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine contains two antibiotics that attack bacteria in different ways. Cefixime is a third-generation cephalosporin that binds to penicillin-binding proteins on the bacterial cell wall, blocking the cross-linking of peptidoglycan and causing the bacterium to weaken and burst. Azithromycin is a macrolide that binds to the 50S ribosomal subunit and prevents the addition of new amino acids to the growing protein chain, which stops bacterial protein synthesis. Because the two agents act on different targets, the combination can provide broader coverage against susceptible organisms and may reduce the chance that a single mutation will make the bacterium resistant to both drugs at once. Neither agent works against viruses, and they are not effective against bacteria that produce certain beta-lactamases or that carry macrolide resistance genes.
Mechanism Steps
💡 How to Take g-thro cf 200mg/500mg tablet
Strength: Immediate-release tablet containing cefixime 200 mg and azithromycin 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily, but the exact dose and duration depend on the type and severity of the infection, your kidney and liver function, and other medicines you take. Some clinicians may prescribe a different schedule. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change the dose or stop the medicine without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this fixed-dose combination tablet. Consult a pediatrician for appropriate dosing and formulation. |
| Elderly Dosage | Older adults may need a lower dose or longer dosing interval if kidney function is reduced. A clinician should assess kidney function before prescribing and adjust the dose accordingly. Older adults are also more likely to take other medicines that can interact with this product. |
| Renal Impairment | Cefixime is excreted by the kidneys, so the dose may need to be reduced in people with moderate to severe kidney impairment. Azithromycin usually does not require major dose adjustment for kidney disease, but the combination should be used with caution. A clinician should determine the appropriate dose based on creatinine clearance or estimated glomerular filtration rate. |
| Hepatic Impairment | People with liver disease should use this medicine with caution because azithromycin can rarely cause liver injury. A clinician may choose a different antibiotic or monitor liver function closely. Dose adjustment may be needed depending on the severity of liver impairment. |
| Maximum Daily Dose | The maximum daily dose for this fixed combination is generally one tablet containing cefixime 200 mg and azithromycin 500 mg, but the exact maximum must be determined by a qualified clinician based on the indication and the patient's kidney and liver function. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of g-thro cf 200mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Amiodarone | Major | |
| Ergotamine | Major | |
| Antacids with aluminum or magnesium | Moderate | |
| Carbamazepine | Moderate | |
| Digoxin | Moderate | |
| Cyclosporine | Moderate | |
| Atorvastatin | Moderate | |
| Oral contraceptives | Minor | |
| Multivitamins with minerals | Minor |
🚨 Major Interactions
- Warfarin and other oral anticoagulants
- QT-prolonging drugs such as amiodarone, sotalol, or certain antipsychotics
- Ergot alkaloids such as ergotamine
- Live bacterial vaccines such as oral typhoid vaccine
⚡ Moderate Interactions
- Antacids containing aluminum or magnesium
- Carbamazepine
- Digoxin
- Cyclosporine
- HMG-CoA reductase inhibitors such as atorvastatin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. It can worsen nausea, stomach pain, and diarrhea, and it may increase the risk of liver-related side effects. Alcohol can also make it harder to judge whether symptoms are improving or worsening, so it is best to wait until the course is finished and your doctor confirms it is safe.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to cefixime, other cephalosporins, or azithromycin","Previous severe allergic reaction to penicillins or macrolides","History of cholestatic jaundice or liver dysfunction associated with azithromycin use","Certain heart rhythm conditions such as long QT syndrome, unless a specialist approves","Use of live bacterial vaccines during the course, unless approved by a clinician"]
⚠️ Warnings & Precautions
["Tell your doctor about all medicines you take, especially blood thinners, heart rhythm medicines, and other antibiotics.","Use with caution if you have kidney disease, liver disease, or a heart rhythm disorder.","Stop the medicine and seek immediate care if you develop signs of a severe allergic reaction.","Do not use anti-diarrheal medicines without medical advice if you develop severe or bloody diarrhea.","Complete the full prescribed course to reduce the risk of antibiotic resistance.","Avoid alcohol during treatment.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Keep the medicine out of reach of children and store it as directed."]
🤱 Lactation Safety
Cefixime and azithromycin can pass into breast milk in small amounts. Many clinicians consider short courses acceptable during breastfeeding, but you should discuss the risks and benefits with your doctor. Watch the infant for diarrhea, thrush, or rash, and seek medical advice if these occur.
💊 Overdose Management
If you suspect an overdose of this medicine, seek emergency medical care immediately. Overdose symptoms may include severe nausea, vomiting, diarrhea, stomach pain, dizziness, or changes in heart rhythm. Treatment is supportive and may include monitoring of vital signs, electrolytes, and heart rhythm. Do not try to induce vomiting unless a healthcare professional tells you to do so.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, provided there is enough time before your next scheduled dose. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure what to do, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your clinician, at the same times each day, and complete the entire course even if you start feeling better after a few doses. Swallow the tablet whole with a full glass of water, and take it with food if it upsets your stomach. Do not crush, chew, or split the tablet unless your pharmacist or doctor has told you it is safe to do so. Avoid alcohol while taking this medicine because it can worsen stomach upset and may increase the strain on your liver. Do not take antacids or mineral supplements containing aluminum or magnesium within two hours of this medicine, as they can reduce absorption. Inform your doctor about all other medicines you take, especially blood thinners, heart rhythm medicines, and other antibiotics. If you are pregnant, planning pregnancy, or breastfeeding, speak with your clinician before starting this medicine. Keep the tablets in their original packaging, store them at room temperature away from moisture and direct sunlight, and keep them out of reach of children. Do not save leftover antibiotics for future use, and do not share them with anyone else.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more likely to have reduced kidney function, heart conditions, and other medicines that can interact with this product. A clinician should check kidney function and review all medicines before prescribing. Watch for dizziness, confusion, diarrhea, or signs of dehydration, and seek medical advice if these occur.
🤰 Pregnancy Planning (TTC)
If you are trying to conceive, discuss this medicine with your doctor before starting it. Both cefixime and azithromycin are sometimes used in pregnancy when needed, but the decision should be individualized. Do not start or stop this medicine without medical advice if you are planning pregnancy.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, tell your surgeon and anesthesiologist that you are taking this medicine. Antibiotics can interact with other medicines used during surgery and can affect wound healing and infection risk. Your surgical team will decide whether to continue, adjust, or temporarily stop the medicine.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Antibiotics can affect the mouth's normal bacteria and may interact with other medicines used during dental work. Your dentist may coordinate with your doctor about timing and whether prophylaxis is needed.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You can continue light activity if you feel well, but avoid strenuous exercise while you are recovering from an infection. Dizziness or fatigue may occur in some people, so stop exercising if you feel unwell. Ask your doctor when it is safe to return to your normal routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
Most people can continue their usual daily activities while taking this medicine, but some may feel tired, dizzy, or have stomach upset. Avoid driving or operating heavy machinery if you feel unwell or dizzy. Follow your doctor's advice about rest and return to work, especially if you have a fever or a contagious infection.
🛑 When to Stop This Medicine
Do not stop this medicine early unless your doctor tells you to. If you develop a severe allergic reaction, bloody diarrhea, jaundice, or an irregular heartbeat, stop the medicine and seek medical care immediately. If you have completed the prescribed course and symptoms persist, contact your doctor for further evaluation rather than restarting the medicine on your own.
📅 Long-Term Use Effects
This medicine is usually prescribed for a short course, so long-term effects are uncommon. Prolonged or repeated use of antibiotics can lead to antibiotic resistance, disruption of normal gut bacteria, and a higher risk of Clostridioides difficile infection. Rarely, liver or kidney problems can occur. If you need repeated courses, your doctor should review the underlying condition and consider whether another treatment approach is better.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A narrower antibiotic may be safer and equally effective once the exact bacteria are identified.
Evidence: Well-establishedRest, fluids, and symptom relief are appropriate for viral illnesses where antibiotics are not helpful.
Evidence: Well-establishedSome evidence suggests probiotics may reduce antibiotic-associated diarrhea, but they should be discussed with your doctor.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Antibiotics can reduce the effectiveness of live bacterial vaccines such as the oral typhoid vaccine. Tell your doctor about any recent or planned vaccinations. Inactivated vaccines are generally not affected by this medicine, but timing should still be discussed with your clinician.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless the label says so
✅ DO
Keep in the original blister pack or container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription, especially when travelling internationally. Keep it in your hand luggage so it stays at room temperature and does not get lost. If you are crossing time zones, ask your doctor how to adjust the timing of your doses. Store the tablets away from heat, moisture, and direct sunlight during travel. Check the customs rules of your destination country for prescription antibiotics, and carry enough supply for the entire trip plus a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Most people notice some improvement within 48 to 72 hours, but it can take longer depending on the infection. Complete the full course as prescribed.
A: Yes, taking it with food can reduce stomach upset. Avoid taking it with antacids or mineral supplements within two hours.
A: Take it as soon as you remember if there is enough time before the next dose. If it is almost time for the next dose, skip the missed dose and do not double dose.
A: No. Stopping early can allow bacteria to survive and become resistant. Finish the full course unless your doctor tells you otherwise.
A: It should only be used during pregnancy if a qualified clinician decides it is clearly needed. Discuss the risks and benefits with your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for g-thro cf 200mg/500mg tablet
View AllAlternative brands with exact same active ingredient:
-
cefolac-az tabletMacleods Pharmaceuticals Pvt Ltd ₹129.28 50.8% CHEAPER
-
cefivin-az 200mg/500mg tabletAsvins Lifecare ₹149.00 43.2% CHEAPER
-
zimnic az 200 mg/500 mg tabletAbbott ₹215.53 17.9% CHEAPER
-
Skifi AZ 200mg/500mg TabletSun Pharmaceutical Industries Ltd ₹219.00 16.6% CHEAPER
-
cefo az 200mg/500mg tabletMedley Pharmaceuticals ₹235.00 10.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure the common cold.
Fact: This medicine only works against bacteria and will not help viral infections such as the common cold or flu. - Myth: You can stop antibiotics as soon as you feel better.
Fact: Stopping early can allow surviving bacteria to regrow and become resistant. Complete the full prescribed course. - Myth: This medicine is safe for everyone.
Fact: It can cause allergic reactions and interactions, and it may not be suitable for people with certain heart, liver, or kidney conditions. - Myth: Taking two antibiotics together is always stronger.
Fact: Combining antibiotics is only helpful when the specific bacteria are likely to respond to both. Unnecessary combinations increase side effects and resistance.
🔄 Alternative Options
Generic Alternatives
- Cefixime 200 mg tablet
- Azithromycin 500 mg tablet
Brand Alternatives
- Alexim AZ 200 mg/500 mg tablet