Ameto P 15 mg/500 mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Rapid breathing or difficulty breathing
- Severe weakness or unusual muscle pain
- Stomach discomfort with nausea and vomiting
- Sudden weight gain or swelling of legs and ankles
- Yellowing of skin or eyes
- Blood in urine or painful urination
- Severe hypoglycemia symptoms (confusion, sweating, shakiness)
If experiencing severe symptoms, call emergency services immediately.
What is g tase m 15 mg/500 mg tablet used for?
This medicine is a combination of Pioglitazone 15 mg and Metformin 500 mg used to treat type 2 diabetes. It helps lower blood sugar by improving insulin sensitivity and reducing glucose production in the liver. It is taken orally with meals, usually once or twice daily, as prescribed by your doctor.
- Generic Name: Pioglitazone (15mg) + Metformin (500mg)
- Manufacturer: Torrent Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 g tase m 15 mg/500 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पायोग्लिटाज़ोन 15 मिलीग्राम और मेटफॉर्मिन 500 मिलीग्राम का संयोजन है, जिसका उपयोग टाइप 2 डायबिटीज (मधुमेह) के इलाज के लिए किया जाता है। यह शरीर में इंसुलिन की संवेदनशीलता को बढ़ाकर और लीवर में ग्लूकोज के उत्पादन को कम करके रक्त शर्करा को नियंत्रित करने में मदद करती है। इसे भोजन के साथ मुँह से लिया जाता है, आमतौर पर दिन में एक या दो बार, डॉक्टर के निर्देशानुसार। यह दवा उन वयस्कों के लिए है जिनका रक्त शर्करा आहार और व्यायाम से नियंत्रित नहीं हो पाता। इसे टाइप 1 डायबिटीज, गंभीर गुर्दे या यकृत रोग, या हृदय विफलता वाले रोगियों के लिए नहीं लिया जाना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, मतली, दस्त, पेट की गड़बड़ी, मांसपेशियों में दर्द, और वजन बढ़ना शामिल हैं। कभी-कभी रक्त शर्करा बहुत कम हो सकती है, खासकर अगर इंसुलिन या सल्फोनिलयूरिया के साथ लिया जाए। गंभीर दुष्प्रभावों में लैक्टिक एसिडोसिस, हृदय विफलता, यकृत की समस्या, और हड्डियों के फ्रैक्चर का खतरा शामिल है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा भोजन के साथ लें ताकि पेट की गड़बड़ी कम हो। इस दवा को लेते समय भोजन न छोड़ें, खासकर अगर आप इंसुलिन या सल्फोनिलयूरिया भी ले रहे हैं, क्योंकि इससे रक्त शर्करा बहुत कम हो सकती है। शराब से पूरी तरह बचें, क्योंकि इससे लैक्टिक एसिडोसिस और हाइपोग्लाइसीमिया का खतरा बढ़ जाता है। दिन भर पर्याप्त पानी पिएं। डॉक्टर की सलाह के बिना इस दवा को शुरू या बंद न करें। अगर आपको गुर्दे या यकृत की समस्या, हृदय विफलता है, या आप गर्भवती होने की योजना बना रही हैं, तो अपने डॉक्टर को बताएं। नियमित रूप से रक्त शर्करा, गुर्दे की कार्यप्रणाली, यकृत की कार्यप्रणाली, और विटामिन बी12 की जांच कराएं।
💊 g tase m 15 mg/500 mg tablet Uses & Benefits
[{"condition":"Type 2 Diabetes Mellitus","description":"Used as an add-on therapy to diet and exercise to improve glycemic control in adults whose blood sugar is not adequately controlled with metformin or pioglitazone alone.","evidence":"Well-established"},{"condition":"Insulin Resistance Syndrome","description":"Pioglitazone component improves insulin sensitivity, which may benefit patients with marked insulin resistance.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Polycystic Ovary Syndrome (PCOS)","description":"Pioglitazone has been studied off-label for improving insulin sensitivity and menstrual regularity in women with PCOS, but it is not a first-line treatment.","evidence":"Limited"},{"condition":"Non-alcoholic Fatty Liver Disease (NAFLD)","description":"Pioglitazone has shown some benefit in improving liver enzymes and histology in NAFLD, but this is not an approved indication.","evidence":"Moderate"}]
Primary treatment for: Type 2 Diabetes Mellitus
Also treats: Insulin resistance, Metabolic syndrome
📋 Drug Information
| Generic Name(s) | Pioglitazone (15mg) + Metformin (500mg) |
| Brand Name | g tase m 15 mg/500 mg tablet |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antidiabetic agents with complementary mechanisms. Pioglitazone is a thiazolidinedione that activates peroxisome proliferator-activated receptor gamma (PPAR-γ), primarily in adipose tissue, leading to increased insulin sensitivity, enhanced glucose uptake, and reduced hepatic glucose output. Metformin is a biguanide that decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Together, they lower blood glucose levels through different but synergistic pathways.
Mechanism Steps
💡 How to Take g tase m 15 mg/500 mg tablet
Strength: Tablet containing Pioglitazone 15 mg and Metformin 500 mg.
Dosage Information
| Adult Dosage | The usual starting dose of this medicine is one tablet taken orally once daily with a meal. The dose may be adjusted by your doctor based on your blood sugar levels, kidney function, and tolerance. The maximum recommended dose is one tablet of 15 mg/500 mg three times daily, but the exact dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially the risk of hypoglycemia and lactic acidosis. Kidney function should be assessed before starting and monitored regularly. Dose adjustments may be necessary based on renal function. Consult your doctor for personalized dosing. |
| Renal Impairment | Metformin is contraindicated in severe renal impairment (eGFR <30 mL/min/1.73 m²). In mild to moderate renal impairment, dose adjustment or discontinuation may be required. Pioglitazone does not require dose adjustment in renal impairment. Consult your doctor for personalized dosing. |
| Hepatic Impairment | Pioglitazone is contraindicated in patients with active liver disease or unexplained elevated liver enzymes. Metformin should be used with caution in hepatic impairment. Consult your doctor for personalized dosing. |
| Maximum Daily Dose | The maximum recommended dose is 15 mg pioglitazone and 500 mg metformin three times daily, but the exact maximum must be determined by a qualified clinician based on individual factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of g tase m 15 mg/500 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Insulin | Major | |
| Sulfonylureas | Major | |
| Alcohol | Major | |
| Contrast media | Major | |
| Gemfibrozil | Moderate | |
| Rifampicin | Moderate | |
| Cimetidine | Moderate | |
| Diuretics | Moderate | |
| ACE inhibitors | Minor | |
| NSAIDs | Minor |
🚨 Major Interactions
- Insulin
- Sulfonylureas
- Alcohol
- Contrast media (iodinated)
⚡ Moderate Interactions
- Gemfibrozil
- Rifampicin
- Cimetidine
- Diuretics
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. It increases the risk of lactic acidosis, a rare but serious complication of metformin, and can also cause hypoglycemia. If you consume alcohol, discuss with your doctor about safe limits.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Lactic acidosis: rare but serious; seek immediate medical help if symptoms occur.","Heart failure: may worsen; monitor for signs like swelling, weight gain, shortness of breath.","Liver injury: monitor liver function; stop if signs of liver damage.","Bladder cancer: long-term use may increase risk; report blood in urine.","Bone fractures: increased risk, especially in women.","Hypoglycemia: risk increases when combined with insulin or sulfonylureas.","Vitamin B12 deficiency: long-term metformin use may cause low B12 levels.","Alcohol: avoid due to increased risk of lactic acidosis.","Surgery: may need to temporarily stop metformin before surgery.","Contrast media: temporarily discontinue metformin before procedures."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause hypoglycemia, lactic acidosis, or other serious effects. Seek immediate medical attention. Treatment is supportive and symptomatic. Hemodialysis may be considered for metformin overdose. Monitor blood glucose, kidney function, and acid-base balance.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine with meals to reduce stomach upset and improve absorption. Do not skip meals while on this medicine, especially if you are also taking insulin or sulfonylureas, as this can cause low blood sugar. Avoid alcohol completely, as it increases the risk of lactic acidosis and low blood sugar. Drink plenty of water throughout the day. Do not start or stop this medicine without consulting your doctor. Inform your doctor if you have kidney or liver problems, heart failure, or are planning to become pregnant. Regular monitoring of blood sugar, kidney function, liver function, and vitamin B12 levels is important. Stop the medicine and seek immediate medical help if you experience rapid breathing, severe weakness, unusual muscle pain, or stomach discomfort, as these may be signs of lactic acidosis.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of hypoglycemia and lactic acidosis. Kidney function should be assessed before starting and monitored regularly. Dose adjustments may be necessary. Consult your doctor for personalized dosing.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning to become pregnant, consult your doctor to discuss alternative treatments. Effective contraception should be used while taking this medicine.
🏥 Post-Surgery Considerations
Metformin may need to be temporarily discontinued before surgery due to the risk of lactic acidosis. Inform your surgeon and anesthesiologist about this medicine. Follow your doctor's instructions regarding restarting after surgery.
🦷 Dental Procedures
Inform your dentist about this medicine before any dental procedure. Maintain good oral hygiene and monitor blood sugar levels, as dental procedures can affect blood sugar control.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is beneficial for managing diabetes, but monitor your blood sugar levels before and after exercise, especially if you are also taking insulin or sulfonylureas. Carry a source of fast-acting sugar in case of hypoglycemia.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause hypoglycemia, which can affect your ability to drive or operate machinery. Be cautious until you know how it affects you. Take regular breaks and monitor your blood sugar if your work involves physical activity.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects like lactic acidosis, heart failure, or liver problems, seek immediate medical attention and follow your doctor's advice regarding discontinuation.
📅 Long-Term Use Effects
Long-term use of this medicine may be associated with vitamin B12 deficiency, bone fractures, and a possible increased risk of bladder cancer. Regular monitoring of kidney function, liver function, and vitamin B12 levels is recommended. Weight gain and fluid retention may occur. Discuss with your doctor about periodic evaluations.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are essential for managing type 2 diabetes and can complement medicine.
Evidence: Well-establishedDepending on your condition, your doctor may consider other medicines like sulfonylureas, DPP-4 inhibitors, or SGLT2 inhibitors.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, people with diabetes should stay up to date with recommended vaccinations, including influenza and pneumococcal vaccines, as advised by their doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, consult your doctor about adjusting the timing of doses. Store at room temperature and avoid direct sunlight. Check customs regulations for carrying prescription medicines to your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine may take several days to weeks to show its full effect on blood sugar levels. Regular monitoring is important.
A: It depends on the severity of kidney problems. Metformin is contraindicated in severe renal impairment. Consult your doctor.
A: Pioglitazone can cause weight gain due to fluid retention. Lifestyle modifications and monitoring can help manage this.
🤔 Common Patient Concerns
🔄 Substitutes for g tase m 15 mg/500 mg tablet
View AllAlternative brands with exact same active ingredient:
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walaphage pz 15mg/500mg tabletWallace Pharmaceuticals Pvt Ltd ₹21.09 28.8% CHEAPER
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glita m 15 mg/500 mg tabletStadmed Pvt Ltd ₹26.31 11.1% CHEAPER
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glito m 15 mg/500 mg tabletMedley Pharmaceuticals ₹29.25 1.2% CHEAPER
-
zipio m 15mg/500mg tablet srFDC Ltd ₹30.80 4% COSTLIER
-
lita m 15mg/500mg tabletIntra Labs India Pvt Ltd ₹34.13 15.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps manage blood sugar levels but does not cure diabetes. Lifestyle changes and ongoing treatment are essential. - Myth: This medicine can be taken without food.
Fact: It should be taken with meals to reduce stomach upset and improve tolerance. - Myth: This medicine is safe for everyone with diabetes.
Fact: It is not suitable for people with type 1 diabetes, severe kidney or liver disease, or heart failure.
🔄 Alternative Options
Generic Alternatives
- Pioglitazone + Metformin generic tablets