Geftinat 250mg Tablet (Gefitinib): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- New or worsening shortness of breath, cough, or fever
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain
- Severe skin rash with blistering or peeling, or sores in the mouth, eyes, or genitals
- Eye pain, redness, blurred vision, or sensitivity to light
- Severe or persistent diarrhoea, nausea, or vomiting
- Blood in vomit, stool, or urine, or unexplained bruising or bleeding
- Decreased urine output or swelling in the legs
If experiencing severe symptoms, call emergency services immediately.
What is g-nib 250mg tablet used for?
This medicine is a targeted therapy used to treat non-small cell lung cancer with specific EGFR mutations. It works by blocking the EGFR protein to slow cancer growth. The usual dose is 250 mg once daily.
- Generic Name: Gefitinib (250mg)
- Manufacturer: BDR Pharmaceuticals Internationals Pvt
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 g-nib 250mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा गैफिटिनिब 250 मिलीग्राम टैबलेट के रूप में उपलब्ध है और इसका उपयोग मुख्य रूप से उन फेफड़ों के कैंसर (नॉन-स्मॉल सेल लंग कैंसर) के इलाज के लिए किया जाता है जिनमें EGFR म्यूटेशन होता है। यह दवा कैंसर कोशिकाओं की वृद्धि को रोकने में मदद करती है। यह दवा केवल उन रोगियों में प्रभावी होती है जिनके ट्यूमर में EGFR म्यूटेशन पाया जाता है, इसलिए इलाज से पहले जांच कराना आवश्यक है। यह दवा कैंसर को पूरी तरह से ठीक नहीं करती है, लेकिन बीमारी को नियंत्रित करने और जीवन की गुणवत्ता में सुधार करने में मदद करती है। इस दवा को केवल कैंसर रोग विशेषज्ञ की देखरेख में ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में त्वचा पर दाने, सूखी त्वचा, खुजली, दस्त, मतली, उल्टी, भूख न लगना और मुंह के छाले शामिल हैं। कुछ रोगियों में आंखों में जलन या सूखापन भी हो सकता है। गंभीर दुष्प्रभावों में फेफड़ों में सूजन (इंटरस्टिशियल लंग डिजीज), लीवर की समस्या, और गंभीर त्वचा प्रतिक्रियाएं शामिल हैं। यदि आपको सांस लेने में कठिनाई, लगातार खांसी, पीलिया, या गंभीर त्वचा दाने हों तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। गर्भवती या स्तनपान कराने वाली महिलाओं को यह दवा नहीं लेनी चाहिए। इस दवा के साथ अंगूर या अंगूर का रस न लें। उपचार के दौरान और आखिरी खुराक के कम से कम दो सप्ताह बाद तक गर्भनिरोधक का उपयोग करें। दवा को कमरे के तापमान पर, नमी और गर्मी से दूर रखें। बच्चों की पहुंच से दूर रखें।
💊 g-nib 250mg tablet Uses & Benefits
- [{"condition":"Non-small cell lung cancer (NSCLC) with EGFR mutations","description":"This medicine is used as a first-line treatment for patients with locally advanced or metastatic NSCLC whose tumours have activating EGFR mutations.
- It helps to shrink tumours and slow disease progression.","evidence":"Well-established"},{"condition":"Previously treated NSCLC","description":"It is also used in patients with NSCLC who have previously received chemotherapy and whose tumours have EGFR mutations.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Other EGFR-mutated cancers","description":"Sometimes used off-label in other cancers that overexpress EGFR, such as certain types of head and neck cancer, colorectal cancer, or breast cancer, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Non-small cell lung cancer (NSCLC) with EGFR mutations
Also treats: Other EGFR-mutated solid tumours
📋 Drug Information
| Generic Name(s) | Gefitinib (250mg) |
| Brand Name | g-nib 250mg tablet |
| Manufacturer | BDR Pharmaceuticals Internationals Pvt |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Tyrosine kinase inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container, tightly closed, away from moisture and heat. Do not refrigerate. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a tyrosine kinase inhibitor that selectively targets the epidermal growth factor receptor (EGFR). It binds reversibly to the ATP-binding site of the EGFR tyrosine kinase domain, thereby inhibiting autophosphorylation and blocking downstream signalling pathways that promote cell proliferation, survival, and angiogenesis. This leads to inhibition of cancer cell growth and induction of apoptosis in EGFR-mutant tumour cells.
Mechanism Steps
💡 How to Take g-nib 250mg tablet
Strength: 250 mg immediate-release tablet
Dosage Information
| Adult Dosage | The recommended dose of this medicine for adults is 250 mg taken orally once daily, with or without food. The dose may be adjusted by your doctor based on your individual condition, response to treatment, and any side effects. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change your dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients based on age alone. However, elderly patients may be more sensitive to side effects. Dose should be individualized by a qualified clinician based on renal and hepatic function and overall health. |
| Renal Impairment | No dose adjustment is required for patients with mild to moderate renal impairment. Caution is advised in patients with severe renal impairment. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with severe hepatic impairment (Child-Pugh C), the dose should be reduced or the medicine should be avoided. In mild to moderate hepatic impairment, no initial dose adjustment is needed, but monitor closely. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 250 mg. Do not exceed this dose without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of g-nib 250mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Rifampicin | Major | |
| Ketoconazole | Major | |
| Omeprazole | Moderate | |
| Warfarin | Moderate | |
| Ibuprofen | Moderate | |
| Metoprolol | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor | |
| St. John's wort | Major | |
| Phenytoin | Major |
🚨 Major Interactions
- CYP3A4 inducers (e.g., rifampicin, phenytoin, carbamazepine, St. John's wort)
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir)
- Gastric acid reducing agents (e.g., proton pump inhibitors, H2 blockers)
⚡ Moderate Interactions
- Warfarin
- NSAIDs (e.g., ibuprofen, naproxen)
- CYP2D6 substrates (e.g., metoprolol, flecainide)
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and gastrointestinal side effects. It is advisable to avoid or limit alcohol consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to gefitinib or any component of the formulation","Severe hepatic impairment","Pregnancy and breastfeeding","Concurrent use with strong CYP3A4 inducers (unless dose adjustment is made)"]
⚠️ Warnings & Precautions
["Interstitial lung disease (ILD): This medicine can cause ILD, which can be fatal. Monitor for respiratory symptoms and discontinue if ILD is suspected.","Hepatotoxicity: Monitor liver function tests regularly. Discontinue if severe liver injury occurs.","Severe skin reactions: Discontinue if severe bullous, blistering, or exfoliative skin conditions occur.","Ocular toxicity: Monitor for signs of keratitis or corneal ulceration. Discontinue if severe.","Gastrointestinal perforation: Discontinue if perforation occurs.","Diarrhoea: May require dose interruption or reduction if severe.","Drug interactions: Avoid strong CYP3A4 inducers and inhibitors. Adjust dose if necessary."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment and for at least two weeks after the last dose.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of suspected overdose, stop the medicine and seek immediate medical attention. Treatment should be symptomatic and supportive. Monitor vital signs and provide appropriate care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose (within 12 hours), skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Before starting this medicine, inform your doctor if you have any liver or lung problems, or if you are pregnant or breastfeeding. This medicine can interact with other medicines, so always tell your doctor about all the medicines you are taking, including over-the-counter drugs and herbal supplements. Avoid grapefruit and grapefruit juice while taking this medicine, as it can increase the levels of the medicine in your blood. Use effective contraception during treatment and for at least two weeks after the last dose, as this medicine can harm an unborn baby. Do not breastfeed while taking this medicine. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose. Store this medicine at room temperature, away from moisture and heat. Keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially diarrhoea, skin rash, and fatigue. Close monitoring is recommended. Dose adjustment is not usually required based on age alone, but individualised dosing based on liver and kidney function is important.
🤰 Pregnancy Planning (TTC)
This medicine can harm an unborn baby. Women of childbearing potential should use effective contraception during treatment and for at least two weeks after the last dose. If you are planning to become pregnant, discuss with your doctor before stopping contraception. Men with female partners of childbearing potential should also use effective contraception during treatment and for at least two weeks after the last dose.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon that you are taking this medicine. Your doctor may advise you to temporarily stop the medicine before surgery due to the risk of bleeding and impaired wound healing. Do not stop the medicine without consulting your doctor.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. This medicine may increase the risk of bleeding and infection. Your dentist may recommend postponing non-urgent procedures until your blood counts and overall health are stable.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause fatigue, weakness, or eye problems that can affect your ability to exercise. Start slowly and gradually increase activity as tolerated. Avoid activities that require sharp vision or coordination if you have eye side effects. Consult your doctor before starting any new exercise programme.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, skin rash, diarrhoea, or eye problems that could affect your ability to work or perform daily activities. You may need to adjust your work schedule or take time off during treatment. Driving may be affected if you experience fatigue or vision changes. Discuss any work-related concerns with your doctor and employer.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor will decide when to stop based on your response to treatment, side effects, and overall health. If you experience severe side effects, your doctor may temporarily interrupt or permanently discontinue the medicine.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to chronic side effects such as persistent skin changes, diarrhoea, and fatigue. Regular monitoring of liver function, lung health, and eye health is necessary. Some patients may develop resistance to the medicine over time, requiring a change in treatment. It is important to attend all follow-up appointments and report any new symptoms to your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Erlotinib, afatinib, or osimertinib may be used as alternatives based on the specific EGFR mutation and prior treatments.
Evidence: Well-establishedTraditional chemotherapy may be used alone or in combination with targeted therapy.
Evidence: Well-establishedImmune checkpoint inhibitors may be an option for some patients with NSCLC.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided while taking this medicine due to the potential for increased risk of infection. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before receiving any vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate or freeze.
✅ DO
Keep in the original container, tightly closed.
❌ DON'T
Do not transfer to another container.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom.
✅ DO
Keep out of reach of children and pets.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking your dose at the same time each day as close as possible. Check customs regulations for carrying prescription medicines in your destination country. Carry enough supply for your entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take several weeks to months to see the full effects of this medicine. Your doctor will monitor your response with regular scans and tests.
A: Yes, you can take this medicine with or without food. Taking it with food may help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose (within 12 hours), skip the missed dose and continue with your regular schedule. Do not double dose.
A: Avoid grapefruit and grapefruit juice while taking this medicine, as they can increase the levels of the medicine in your blood.
A: No, do not stop taking this medicine without consulting your doctor. Stopping suddenly may cause the cancer to grow.
A: No, this medicine can harm an unborn baby. Use effective contraception during treatment and for at least two weeks after the last dose. Consult your doctor if you are pregnant or planning to become pregnant.
A: Seek immediate medical attention if you experience new or worsening shortness of breath, cough, fever, yellowing of the skin or eyes, severe skin rash, eye pain, or severe abdominal pain.
A: Some medicines can interact with this medicine. Always inform your doctor about all medicines you are taking, including over-the-counter drugs and herbal supplements.
A: Store at room temperature between 15°C and 30°C, in the original container, away from moisture and heat. Keep out of reach of children.
A: This medicine is not a cure for cancer, but it can help control the disease and improve quality of life. It is used as part of a comprehensive treatment plan.
🤔 Common Patient Concerns
🔄 Substitutes for g-nib 250mg tablet
View AllAlternative brands with exact same active ingredient:
-
gefires 250mg tabletResonance Laboratories Pvt Ltd ₹318.75 88.2% CHEAPER
-
fitnib 250mg tabletZen Pharma Pvt Ltd ₹450.00 83.3% CHEAPER
-
chemogef 250mg tabletNeon Laboratories Ltd ₹1,102.00 59.2% CHEAPER
-
unigef 250mg tabletSamarth Life Sciences Pvt Ltd ₹1,341.00 50.3% CHEAPER
-
gefimipsa 250mg capsuleArk Life Sciences Pvt Ltd ₹1,396.88 48.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure all types of lung cancer.
Fact: This medicine is only effective in cancers with specific EGFR mutations. It is not a cure but can control the disease. - Myth: This medicine has no side effects.
Fact: This medicine can cause side effects, some of which can be serious. Regular monitoring is required. - Myth: You can stop taking this medicine once you feel better.
Fact: You should not stop taking this medicine without consulting your doctor. Stopping suddenly may cause the cancer to grow.
🔄 Alternative Options
Generic Alternatives
- Gefitinib
Brand Alternatives
- Geftinat 250mg Tablet
- Iressa 250mg Tablet
- Gefitinib 250mg Tablet