Gracyfol Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of face, lips, tongue, or throat
- Difficulty breathing or wheezing
- Severe skin rash, blisters, or peeling skin
- Irregular heartbeat or palpitations
- Muscle weakness or cramps
- Yellowing of skin or eyes
- Severe abdominal pain or persistent vomiting
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is foligram tablet used for?
This medicine is a combination of L-Methyl Folate (1 mg) and Methylcobalamin (1500 mcg), used to treat or prevent deficiencies of these vitamins. It supports nerve health, red blood cell production, and lowers homocysteine. It is taken orally once daily with a meal, as prescribed by a doctor.
- Generic Name: L-Methyl Folate (1mg) + Methylcobalamin (1500mcg)
- Manufacturer: Grawish Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 foligram tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ल-मिथाइल फोलेट और मिथाइलकोबालामिन का संयोजन है, जो शरीर में विटामिन बी12 और फोलेट की कमी को पूरा करती है। यह तंत्रिका स्वास्थ्य, लाल रक्त कोशिकाओं के निर्माण और हृदय स्वास्थ्य के लिए फायदेमंद है। इसका उपयोग एनीमिया, न्यूरोपैथी, और हाइपरहोमोसिस्टीनमिया में किया जाता है। गर्भावस्था में भी यह दवा डॉक्टर की सलाह पर ली जा सकती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, पेट खराब, दस्त, धातु जैसा स्वाद, सिरदर्द और चक्कर आना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि चेहरे, होंठ या गले में सूजन, सांस लेने में कठिनाई, या गंभीर दाने हों तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपनी मर्जी से खुराक न बढ़ाएं या घटाएं। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या गर्भधारण की योजना बना रही हैं, तो डॉक्टर को बताएं। अन्य दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में भी जानकारी दें। शराब का सेवन न करें। गुर्दे या लीवर की बीमारी हो तो डॉक्टर की सलाह से ही लें। बच्चों से दूर रखें।
💊 foligram tablet Uses & Benefits
[{"condition":"Folate deficiency","description":"Treats or prevents low folate levels, especially in people who cannot convert folic acid to its active form due to MTHFR gene variants.","evidence":"Well-established"},{"condition":"Vitamin B12 deficiency","description":"Corrects methylcobalamin deficiency, which can cause anemia, fatigue, and neurological symptoms.","evidence":"Well-established"},{"condition":"Peripheral neuropathy","description":"May help improve nerve function and reduce symptoms like tingling, numbness, and burning in hands and feet.","evidence":"Moderate"},{"condition":"Hyperhomocysteinemia","description":"Lowers elevated homocysteine levels, which are linked to cardiovascular and neurological risks.","evidence":"Moderate"},{"condition":"Megaloblastic anemia","description":"Supports red blood cell production in anemia caused by folate or B12 deficiency.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Depression adjunct","description":"Sometimes used alongside antidepressants to improve mood, especially in people with MTHFR mutations.","evidence":"Limited"},{"condition":"Cognitive decline","description":"May be used off-label to support memory and cognitive function in older adults with vitamin deficiencies.","evidence":"Limited"},{"condition":"Migraine prophylaxis","description":"Occasionally prescribed to reduce migraine frequency in patients with high homocysteine levels.","evidence":"Limited"}]
Primary treatment for: Vitamin B12 and folate deficiency
Also treats: Peripheral neuropathy, Megaloblastic anemia, Hyperhomocysteinemia, MTHFR gene mutation-related deficiencies
📋 Drug Information
| Generic Name(s) | L-Methyl Folate (1mg) + Methylcobalamin (1500mcg) |
| Brand Name | foligram tablet |
| Manufacturer | Grawish Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | VITAMINS MINERALS NUTRIENTS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by supplying the body with already-active forms of folate and vitamin B12. L-Methyl Folate is the reduced, active form of folate that participates directly in one-carbon transfer reactions. It is essential for the conversion of homocysteine to methionine and for the synthesis of DNA and RNA. Methylcobalamin is a cofactor for methionine synthase, the enzyme that converts homocysteine to methionine. Together, they support methylation reactions, red blood cell formation, and maintenance of the myelin sheath around nerves. By bypassing the need for enzymatic conversion, this medicine is especially useful for individuals with MTHFR polymorphisms or malabsorption issues.
Mechanism Steps
💡 How to Take foligram tablet
Strength: Tablet: L-Methyl Folate 1 mg + Methylcobalamin 1500 mcg
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once daily, preferably with a meal, or as directed by your physician. The dose may be adjusted based on your specific condition, blood levels of folate and B12, and response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may take the same adult dose unless otherwise directed by a doctor. However, kidney function should be considered, and dose adjustment may be needed in those with renal impairment. Consult your doctor. |
| Renal Impairment | No specific dose adjustment is established for renal impairment. Use with caution in patients with severe kidney disease. Consult your doctor for individualized dosing. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution in patients with severe liver disease. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet (1 mg L-Methyl Folate + 1500 mcg Methylcobalamin) unless otherwise prescribed by your doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of foligram tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Methotrexate | Major | |
| Phenytoin | Major | |
| Trimethoprim | Major | |
| Metformin | Moderate | |
| Omeprazole | Moderate | |
| Colchicine | Moderate | |
| Antacids | Minor | |
| Alcohol | Minor |
🚨 Major Interactions
- Methotrexate
- Phenytoin
- Trimethoprim
⚡ Moderate Interactions
- Metformin
- Proton pump inhibitors (e.g., omeprazole)
- Colchicine
🍷 Alcohol Interaction
Alcohol can interfere with the absorption and metabolism of both L-Methyl Folate and Methylcobalamin. Chronic alcohol use may worsen deficiencies and reduce the effectiveness of this medicine. It is advisable to avoid alcohol or limit intake while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to L-Methyl Folate, Methylcobalamin, or any inactive ingredient","Untreated vitamin B12 deficiency with neurological symptoms (folate alone may mask B12 deficiency)","Leber's disease (hereditary optic nerve atrophy)","Severe kidney disease without medical supervision"]
⚠️ Warnings & Precautions
["Do not use this medicine to treat a condition for which it was not prescribed.","Folate supplementation can mask vitamin B12 deficiency; ensure B12 levels are checked.","Use with caution in patients with epilepsy, as folate may interact with anti-seizure medications.","Avoid alcohol while taking this medicine.","Inform your doctor if you have kidney disease, liver disease, or cancer.","Do not exceed the recommended dose without medical advice.","Keep out of reach of children.","If you are pregnant or breastfeeding, consult your doctor before use."]
🤱 Lactation Safety
L-Methyl Folate and Methylcobalamin are safe to use during breastfeeding when taken as prescribed. They are natural components of breast milk and are important for infant development. Consult your doctor for appropriate dosing.
💊 Overdose Management
Overdose with this medicine is unlikely to cause serious harm because it contains water-soluble vitamins. However, very high doses of L-Methyl Folate may cause stomach upset, insomnia, or irritability. Methylcobalamin is generally non-toxic. If you suspect an overdose, contact your doctor or a poison control center immediately. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose without consulting your healthcare provider. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Tell your doctor about all other medicines, supplements, and herbal products you are taking, especially antibiotics, methotrexate, or anti-seizure drugs. Avoid alcohol while taking this medicine, as it can reduce absorption of B vitamins. If you have kidney disease, liver disease, or cancer, use this medicine only under medical supervision. Do not use this medicine to treat a condition for which it was not prescribed. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more prone to vitamin B12 deficiency due to reduced absorption. This medicine is generally safe, but kidney function should be monitored. Dose adjustment may be needed in renal impairment. Consult your doctor for personalized advice.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, this medicine may be beneficial, especially if you have MTHFR mutations or a history of neural tube defects. Consult your doctor for appropriate dosing before conception and during early pregnancy.
🏥 Post-Surgery Considerations
After surgery, your doctor may prescribe this medicine to support healing and prevent deficiency, especially if you have had gastrointestinal surgery that affects absorption. Follow your doctor's instructions.
🦷 Dental Procedures
This medicine does not interact with dental anesthetics or procedures. However, inform your dentist about all medicines you are taking. Maintain good oral hygiene as B vitamin deficiency can cause mouth ulcers.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine does not usually restrict exercise. However, if you have peripheral neuropathy, avoid high-impact activities that could cause injury to numb feet. Consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to work or drive. However, if you experience dizziness or drowsiness, avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their daily activities as usual.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor will determine when it is safe to stop based on your condition and blood test results. If you experience severe side effects, stop the medicine and seek medical advice immediately.
📅 Long-Term Use Effects
Long-term use of this medicine at prescribed doses is generally safe. It helps maintain normal vitamin levels and may reduce the risk of complications from deficiency. However, long-term high doses of folate may mask B12 deficiency and cause nerve damage if B12 deficiency is not treated. Regular monitoring of B12, folate, and homocysteine levels is recommended. Some people may experience mild side effects like nausea or skin rash. Consult your doctor for periodic check-ups.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Increasing intake of folate and B12-rich foods can help prevent deficiency.
Evidence: Well-establishedFor severe deficiency or malabsorption, injections may be needed.
Evidence: Well-establishedSynthetic folic acid can be used, but requires conversion to active form.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interfere with vaccines. You can receive vaccinations while taking this medicine. However, if you are scheduled for surgery or have a compromised immune system, consult your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry your medicine in its original packaging with the prescription label. Bring a copy of your prescription in case you need to show it at customs. Store it in a cool, dry place away from direct sunlight. If you are crossing time zones, continue taking your dose at the same time each day as much as possible. Do not pack it in checked luggage; keep it in your carry-on bag.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start noticing improvements in fatigue within a few days to weeks. Neurological symptoms may take several weeks to months to improve.
A: It is generally safe, but inform your doctor about all supplements you take to avoid interactions.
A: No, this medicine is not habit-forming. It is a vitamin supplement.
A: Take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Do not stop without consulting your doctor. Your doctor will advise you based on your condition and blood levels.
🤔 Common Patient Concerns
🔄 Substitutes for foligram tablet
View AllAlternative brands with exact same active ingredient:
-
davaindia l-methyl folate+methylcobalamin+pyridoxal-5-phasphate 1mg/1500mcg/0.5mg tabletDavaindia Generic Pharmacy ₹50.00 46.1% CHEAPER
-
desifol-plus tabletSyndicate Life Sciences Pvt Ltd ₹83.44 10.1% CHEAPER
-
smartfol tabletMedgrow Health Care ₹102.19 10.1% COSTLIER
-
foliboon tabletMeckley Life Sciences Pvt Ltd ₹106.88 15.2% COSTLIER
-
calcordia m tabletConcordia Healthcare Private Limited ₹112.50 21.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller.
Fact: This medicine is a vitamin supplement, not a painkiller. It does not provide immediate pain relief. - Myth: It can be taken without a prescription.
Fact: This is a prescription medicine. It should be taken only under medical supervision. - Myth: More is better.
Fact: Taking more than the prescribed dose can cause side effects and is not beneficial. - Myth: It is only for vegetarians.
Fact: While vegetarians are at higher risk of B12 deficiency, anyone with a deficiency can benefit from this medicine.
🔄 Alternative Options
Generic Alternatives
- L-Methyl Folate + Methylcobalamin tablets (various manufacturers)
Brand Alternatives
- Gracyfol Tablet