fevacold syrup - Paracetamol (125mg/5ml) + Phenylpropanolamine (12.5mg/5ml) medicine

Fevacold Syrup: Complete Medicine Guide

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🏭 Arvincare Pharma 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for symptomatic relief of cold symptoms; limited for phenylpropanolamine due to safety concerns.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe headache with blurred vision or confusion
  • Chest pain, shortness of breath, or irregular heartbeat
  • Swelling of the face, lips, tongue, or throat
  • Yellowing of the skin or eyes (jaundice)
  • Dark urine or severe abdominal pain
  • Seizures or loss of consciousness
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is fevacold syrup used for?

This medicine is a combination syrup containing paracetamol and phenylpropanolamine, used for temporary relief of cold and flu symptoms such as nasal congestion, fever, and body ache. It works by reducing fever and pain (paracetamol) and shrinking nasal blood vessels (phenylpropanolamine). It should not be used for more than 5 days without medical advice.

  • Generic Name: Paracetamol (125mg/5ml) + Phenylpropanolamine (12.5mg/5ml)
  • Manufacturer: Arvincare Pharma
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 fevacold syrup के बारे में (Hindi Summary)

उपयोग: यह दवा पैरासिटामोल और फेनिलप्रोपेनॉलामाइन का संयोजन है, जिसका उपयोग सर्दी-जुकाम और फ्लू के लक्षणों जैसे नाक बंद होना, बुखार, सिरदर्द और शरीर दर्द से राहत के लिए किया जाता है। यह दवा बुखार और दर्द को कम करने में मदद करती है और नाक के बंद होने को खोलती है। इसका उपयोग केवल अल्पकालिक राहत के लिए किया जाना चाहिए और बिना डॉक्टर की सलाह के 5 दिनों से अधिक नहीं लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में असुविधा, मुँह सूखना, सिरदर्द, घबराहट और नींद न आना शामिल हो सकते हैं। फेनिलप्रोपेनॉलामाइन के कारण हृदय गति बढ़ सकती है और रक्तचाप बढ़ सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, यकृत क्षति या उच्च रक्तचाप संकट हो सकता है। यदि आपको सीने में दर्द, सांस लेने में कठिनाई, या चेहरे, होंठ या गले में सूजन हो, तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा की अनुशंसित खुराक से अधिक न लें। पैरासिटामोल या फेनिलप्रोपेनॉलामाइन युक्त अन्य दवाओं के साथ इसका सेवन न करें। बिना डॉक्टर की सलाह के 5 दिनों से अधिक इसका उपयोग न करें। शराब का सेवन न करें क्योंकि इससे यकृत को नुकसान का खतरा बढ़ सकता है। यदि आपको उच्च रक्तचाप, हृदय रोग, मधुमेह, थायरॉइड की समस्या है या आप अवसादरोधी दवाएं ले रहे हैं, तो उपयोग से पहले डॉक्टर से परामर्श करें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 fevacold syrup Uses & Benefits

[{"condition":"Common cold","description":"Provides temporary relief of nasal congestion, headache, body ache, and fever associated with the common cold.","evidence":"Well-established for symptomatic relief"},{"condition":"Influenza (flu)","description":"Helps reduce fever and alleviate muscle aches and nasal stuffiness during flu episodes.","evidence":"Well-established for symptomatic relief"},{"condition":"Allergic rhinitis","description":"May relieve nasal congestion associated with allergic rhinitis due to the decongestant action of phenylpropanolamine.","evidence":"Limited, as antihistamines are preferred"}]

Off-label uses: []

Primary treatment for: Common cold

Also treats: Influenza, Allergic rhinitis

📋 Drug Information

Generic Name(s)Paracetamol (125mg/5ml) + Phenylpropanolamine (12.5mg/5ml)
Brand Namefevacold syrup
ManufacturerArvincare Pharma
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place, away from direct sunlight. Do not refrigerate. Keep the bottle tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always measure the dose accurately using a measuring cup or spoon; household spoons are not reliable.
2
Take this medicine with food or milk if it upsets your stomach.
3
Avoid taking other cold medicines that contain paracetamol or decongestants to prevent overdose.
4
Do not use this medicine for more than 5 days without consulting a doctor.
5
If you have high blood pressure, heart disease, or are taking antidepressants, consult your doctor before use.
6
Keep a record of when you take this medicine to avoid exceeding the maximum daily dose.
7
Stay well hydrated while taking this medicine to help thin mucus and soothe your throat.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Nasal congestion
This medicine is commonly used for this symptom.
Likely Use
✅
Fever
Paracetamol in this medicine helps reduce fever.
Likely Use
✅
Headache
Paracetamol provides relief from headache.
Likely Use
✅
Body ache
Paracetamol helps alleviate body aches.
Likely Use
✅
Sore throat
This medicine may provide symptomatic relief.
Likely Use
❌
Cough
This medicine does not contain a cough suppressant or expectorant.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionParacetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Phenylpropanolamine is also absorbed from the gastrointestinal tract, but its bioavailability is subject to first-pass metabolism.
DistributionParacetamol distributes widely into most body tissues, with a volume of distribution of about 0.9 L/kg. Phenylpropanolamine distributes into body tissues and crosses the blood-brain barrier.
Protein BindingParacetamol is approximately 10-25% bound to plasma proteins. Phenylpropanolamine binding is not well established.
MetabolismParacetamol is metabolized primarily in the liver via glucuronidation and sulfation, with a small fraction metabolized by cytochrome P450 2E1 to a toxic intermediate (NAPQI) that is normally detoxified by glutathione. Phenylpropanolamine undergoes limited metabolism, mainly by monoamine oxidase and catechol-O-methyltransferase.
Half-LifeParacetamol half-life is about 2-3 hours in adults. Phenylpropanolamine half-life is approximately 3-4 hours.
ExcretionParacetamol metabolites are excreted primarily in urine. Phenylpropanolamine is excreted largely unchanged in urine, with about 80-90% of a dose recovered in urine within 24 hours.
BioavailabilityParacetamol oral bioavailability is about 80-100%. Phenylpropanolamine oral bioavailability is approximately 40-50% due to first-pass metabolism.
Onset of ActionParacetamol onset of action is within 30-60 minutes. Phenylpropanolamine onset of decongestant effect is within 15-30 minutes.
Peak Plasma TimeParacetamol peak plasma concentration occurs at 0.5-2 hours. Phenylpropanolamine peak plasma concentration occurs at 1-2 hours.
Duration of ActionParacetamol duration of action is 4-6 hours. Phenylpropanolamine duration of action is 4-6 hours.

How It Works

This medicine combines two active ingredients with distinct mechanisms. Paracetamol acts primarily in the central nervous system to reduce fever and pain by inhibiting prostaglandin synthesis, though its exact mechanism is not fully understood. Phenylpropanolamine is a sympathomimetic amine that stimulates alpha-adrenergic receptors, causing vasoconstriction in the nasal mucosa, which reduces swelling and congestion. It also has some beta-adrenergic activity that can increase heart rate and blood pressure.

Mechanism Steps

1
Paracetamol central action: Paracetamol inhibits prostaglandin synthesis in the central nervous system, raising the pain threshold and lowering fever.
2
Phenylpropanolamine alpha-adrenergic stimulation: Phenylpropanolamine binds to alpha-adrenergic receptors on nasal blood vessels, causing vasoconstriction and reduced nasal congestion.
3
Phenylpropanolamine beta-adrenergic effects: It also stimulates beta-adrenergic receptors, which can increase heart rate and blood pressure, and may cause nervousness.

💡 How to Take fevacold syrup

Strength: Each 5 ml of syrup contains paracetamol 125 mg and phenylpropanolamine 12.5 mg.

1Shake the bottle well before use.
2Use a measuring cup or spoon to measure the correct dose.
3Take orally, with or without food.
4Follow the dosage instructions on the label or as prescribed by your doctor.
5Do not exceed the recommended dose.
6Wash the measuring cup after each use.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 10-15 ml (2-3 teaspoons) every 4-6 hours as needed for symptoms, not to exceed 60 ml in 24 hours. However, the dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children.
Elderly DosageElderly patients may be more sensitive to the cardiovascular effects of phenylpropanolamine. Use with caution and consider lower doses. Consult a doctor for individualized dosing.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Paracetamol dose should be reduced or avoided in severe liver disease. Consult a doctor.
Maximum Daily DoseFor adults, the maximum daily dose is 60 ml of this syrup, providing 1500 mg paracetamol and 150 mg phenylpropanolamine. Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of liver damage and cardiovascular effects.
Caffeine
Limit
May increase nervousness and insomnia.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of fevacold syrup

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk to reduce stomach upset. If nausea persists, consult your doctor.
Dry mouth (Common (5-10%))
Sip water or chew sugarless gum. This usually resolves on its own.
Headache (Common (5-10%))
Rest and stay hydrated. If headache is severe or persistent, consult your doctor.
Nervousness (Common (5-10%))
Avoid caffeine and get adequate rest. If nervousness interferes with daily activities, consult your doctor.
Insomnia (Common (5-10%))
Avoid taking this medicine close to bedtime. If sleep disturbances continue, consult your doctor.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling of the face, lips, tongue, or throat, or difficulty breathing.
Liver damage (Rare (<0.1%))
Seek immediate medical attention if you notice yellowing of the skin or eyes, dark urine, or severe abdominal pain.
Hypertensive crisis (Rare (<0.1%))
Seek immediate medical attention if you experience severe headache, blurred vision, chest pain, or shortness of breath.
Seizures (Rare (<0.1%))
Seek immediate medical attention if you experience convulsions or loss of consciousness.

⚠️ Rare Side Effects

Blood dyscrasias (e.g., thrombocytopenia, leukopenia)
Consult your doctor if you notice unusual bruising, bleeding, or signs of infection.
Stevens-Johnson syndrome
Seek immediate medical attention if you develop a painful rash with blisters or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major
Other sympathomimetics Major
Warfarin Major
Beta-blockers Moderate
Tricyclic antidepressants Moderate
Caffeine Moderate
Antacids Minor
Cholestyramine Minor

🚨 Major Interactions

  • Monoamine oxidase inhibitors (MAOIs)
  • Other sympathomimetic amines
  • Warfarin

⚡ Moderate Interactions

  • Beta-blockers
  • Tricyclic antidepressants
  • Caffeine

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of paracetamol-induced liver damage and may intensify the cardiovascular effects of phenylpropanolamine, such as increased heart rate and blood pressure.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to paracetamol, phenylpropanolamine, or any component of the formulation","Severe hypertension or uncontrolled high blood pressure","Severe coronary artery disease or recent myocardial infarction","Hyperthyroidism","Closed-angle glaucoma","Urinary retention or prostatic hypertrophy","Use within 14 days of monoamine oxidase inhibitors","Severe liver or kidney impairment"]

⚠️ Warnings & Precautions

["Do not exceed the recommended dose; taking more than the recommended dose of paracetamol can cause serious liver damage.","Avoid alcohol while taking this medicine.","Use with caution in patients with cardiovascular disease, hypertension, diabetes, or thyroid disorders.","May cause drowsiness or dizziness; avoid driving or operating machinery until you know how this medicine affects you.","Do not use for more than 5 days without consulting a doctor.","Keep out of reach of children.","If symptoms persist or worsen, consult a doctor.","Do not use other products containing paracetamol or phenylpropanolamine concurrently."]

🤱 Lactation Safety

Paracetamol is excreted in breast milk in small amounts and is generally considered safe during breastfeeding. Phenylpropanolamine may also pass into breast milk and could cause stimulation or other effects in the nursing infant. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose of this medicine can cause severe liver damage due to paracetamol and hypertensive crisis due to phenylpropanolamine. Seek immediate medical attention. Treatment includes activated charcoal if within 1-2 hours of ingestion, acetylcysteine for paracetamol toxicity, and supportive care for cardiovascular effects. Monitor liver function, blood pressure, and heart rate.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.

Additional Safety Advice

General Safety

Do not exceed the recommended dose of this medicine. Avoid using other products containing paracetamol or phenylpropanolamine while taking this medicine to prevent overdose. Do not use this medicine for more than 5 days without consulting a doctor. Avoid alcohol consumption as it may increase the risk of liver damage. If you have high blood pressure, heart disease, diabetes, thyroid problems, or are taking antidepressants, consult your doctor before use. Keep out of reach of children. Store in a cool, dry place, away from direct sunlight. Do not use if the seal is broken or the syrup is discolored.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the cardiovascular effects of phenylpropanolamine, such as increased blood pressure and heart rate. They may also be more prone to side effects like dizziness and confusion. Use with caution and consult a doctor for appropriate dosing.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before using this medicine. Phenylpropanolamine is not recommended during pregnancy, especially in the first trimester, due to potential risks to the fetus. Paracetamol is generally considered safe when used at recommended doses for short periods.

🏥 Post-Surgery Considerations

Consult your doctor before using this medicine after surgery. Phenylpropanolamine can increase blood pressure and heart rate, which may be undesirable during the postoperative period. Paracetamol may be used for pain relief if approved by your surgeon.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure. Phenylpropanolamine can interact with local anesthetics containing epinephrine, potentially causing cardiovascular effects. Your dentist may recommend adjusting your medication or using an alternative anesthetic.

💚 Lifestyle Tips for Better Results

🏃
Get plenty of rest to help your body recover from the cold.
🥗
Stay well hydrated by drinking water, soups, and warm fluids.
😴
Use a humidifier or take steamy showers to help relieve nasal congestion.
💧
Avoid smoking and exposure to secondhand smoke, which can worsen symptoms.
🧘
Practice good hand hygiene to prevent spreading the infection to others.
🌞
Eat a balanced diet rich in fruits and vegetables to support your immune system.

🏋️ Exercise Considerations

This medicine may cause dizziness or drowsiness in some individuals. Avoid strenuous exercise or activities requiring alertness until you know how this medicine affects you. If you feel dizzy or lightheaded, stop exercising and rest.

🥗 Diet Recommendations

Drink warm fluids like herbal tea, soup, and broth to soothe your throat and loosen mucus.
Include foods rich in vitamin C, such as oranges, lemons, and bell peppers, to support immune function.
Avoid alcohol and caffeine, which can worsen dehydration and interact with this medicine.
Eat small, frequent meals if you have a reduced appetite.
Include anti-inflammatory foods like ginger, turmeric, and garlic.

💼 Impact on Daily Work & Life

This medicine may cause dizziness, drowsiness, or nervousness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to rest at home while you recover from the cold to prevent spreading the infection to others.

🛑 When to Stop This Medicine

Stop taking this medicine if your symptoms do not improve within 5 days or if they worsen. Also stop if you experience any serious side effects such as severe headache, chest pain, or allergic reactions. Consult your doctor before stopping if you have been taking it regularly for a medical condition.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended. Prolonged use of paracetamol can increase the risk of liver damage, especially with high doses or alcohol consumption. Phenylpropanolamine can cause cardiovascular effects such as increased blood pressure and heart rate. Regular monitoring of liver function and blood pressure may be required if used for extended periods under medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Saline nasal spray

Helps relieve nasal congestion without systemic side effects.

Evidence: Well-established
Steam inhalation

Can temporarily relieve nasal stuffiness.

Evidence: Limited
Rest and hydration

Supports the body's natural recovery from viral infections.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a vaccine, inform your healthcare provider that you are taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling with this medicine, carry it in its original packaging along with a copy of the prescription. Store it in a cool, dry place away from direct sunlight. If traveling across time zones, continue with your regular dosing schedule as needed for symptoms, but do not exceed the maximum daily dose. Check the customs regulations of your destination country regarding import of medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with a common cold and nasal congestion
He took this medicine as directed and experienced relief from nasal stuffiness and fever within an hour. He noted that taking it with food helped prevent stomach upset. He was advised not to exceed the dose and to stop after 5 days.
💡 Lesson: Taking this medicine with food can improve tolerability, and adhering to the recommended duration is important to avoid side effects.
👤 A 50-year-old woman with hypertension who wanted to use this medicine for cold symptoms
She consulted her doctor first because she had high blood pressure. The doctor advised against using this medicine due to the risk of blood pressure elevation from phenylpropanolamine and recommended a safer alternative.
💡 Lesson: Patients with high blood pressure should avoid this medicine and seek medical advice for safe cold relief options.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving symptoms within 30-60 minutes after taking a dose.

Q: Can I take this medicine on an empty stomach?

A: It is generally recommended to take this medicine with food or milk to reduce the risk of stomach upset.

Q: Is it safe to take this medicine for a long time?

A: No, this medicine should not be used for more than 5 days without consulting a doctor due to the risk of side effects.

Q: Can I take this medicine if I am pregnant?

A: Consult your doctor before using this medicine if you are pregnant or planning to become pregnant. Phenylpropanolamine is not recommended during pregnancy.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine with high blood pressure?
  • Is it safe for children?
  • How long can I use this medicine?
  • Does it cause drowsiness?
  • Can I take it with other cold medicines?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for fevacold syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure the common cold.
    Fact: This medicine only relieves symptoms; it does not cure the underlying viral infection.
  • Myth: It is safe to take this medicine for weeks.
    Fact: Prolonged use can lead to serious side effects; it should not be used for more than 5 days without medical supervision.
  • Myth: More medicine means faster relief.
    Fact: Taking more than the recommended dose can cause severe liver damage and hypertensive crisis.

🔄 Alternative Options

Generic Alternatives

  • Paracetamol + Phenylpropanolamine syrup

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","active_ingredients":"Paracetamol + Phenylpropanolamine","primary_use":"Cold and flu symptoms","route":"Oral"},{"medicine":"Paracetamol + Phenylephrine","active_ingredients":"Paracetamol + Phenylephrine","primary_use":"Cold and flu symptoms","route":"Oral"},{"medicine":"Paracetamol + Pseudoephedrine","active_ingredients":"Paracetamol + Pseudoephedrine","primary_use":"Cold and flu symptoms","route":"Oral"}]

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