Coldant Syrup: Complete Medicine Guide for Cold, Fever, and Nasal Congestion
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe headache with blurred vision or confusion
- Chest pain, palpitations, or difficulty breathing
- Sudden weakness or numbness on one side of the body
- Yellowing of the eyes or skin, dark urine, or severe upper abdominal pain
- Inability to pass urine or severe lower abdominal pain
- Rash with blisters, peeling skin, or swelling of the face, lips, or throat
- High fever that does not settle or symptoms that worsen after 3 days
If experiencing severe symptoms, call emergency services immediately.
What is coldant syrup used for?
This medicine is an oral syrup combining paracetamol and phenylpropanolamine. It is used for short-term relief of nasal congestion, fever, headache, and body ache due to colds and flu. It should not be used in people with uncontrolled high blood pressure, heart disease, or within 14 days of a monoamine oxidase inhibitor, and it is not recommended for children unless prescribed by a doctor.
- Generic Name: Paracetamol + Phenylpropanolamine
- Manufacturer: Uniroyal Biotech
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 coldant syrup के बारे में (Hindi Summary)
उपयोग: यह दवा पैरासिटामोल और फेनिलप्रोपेनॉलामाइन का मिश्रण है, जो सिरप के रूप में मिलती है। इसका उपयोग सर्दी-जुकाम में नाक बंद होने, बुखार, सिरदर्द और शरीर दर्द से राहत के लिए किया जाता है। पैरासिटामोल बुखार और दर्द कम करता है, जबकि फेनिलप्रोपेनॉलामाइन नाक की रक्त वाहिकाओं को सिकोड़कर जमाव कम करता है। यह दवा केवल कुछ दिनों के लिए ही लेनी चाहिए और उच्च रक्तचाप, हृदय रोग, थायरॉइड की समस्या, ग्लूकोमा या प्रोस्टेट बढ़ने वाले मरीजों को इससे बचना चाहिए। गर्भवती और स्तनपान कराने वाली महिलाओं को डॉक्टर की सलाह के बिना यह दवा नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा से आमतौर पर मतली, पेट में असहजता, मुँह सूखना, चक्कर आना, घबराहट, बेचैनी और हल्का सिरदर्द हो सकता है। कुछ लोगों को धड़कन तेज होना या रक्तचाप बढ़ना महसूस हो सकता है। कभी-कभी पेशाब करने में कठिनाई, धुंधली दृष्टि या पसीना अधिक आ सकता है। यदि तेज सिरदर्द, सीने में दर्द, सांस लेने में तकलीफ, त्वचा पर चकत्ते या चेहरे-होंठों में सूजन हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें और मात्रा या अवधि से अधिक न लें। हर बार उपयोग से पहले बोतल को अच्छी तरह हिलाएँ और साथ दिए गए चम्मच या कप से ही मात्रा नापें। पैरासिटामोल वाली अन्य दवाओं के साथ इसे न लें, क्योंकि इससे लिवर को नुकसान हो सकता है। शराब न पिएँ। यदि आपको उच्च रक्तचाप, हृदय रोग, थायरॉइड, ग्लूकोमा, प्रोस्टेट या लिवर-किडनी की समस्या है, तो डॉक्टर से पूछकर ही लें। बच्चों को डॉक्टर की सलाह के बिना यह दवा न दें।
💊 coldant syrup Uses & Benefits
[{"condition":"Nasal congestion due to common cold","description":"The phenylpropanolamine component temporarily reduces inflammation" class="semantic-link" title="Medicines for swelling">swelling of nasal blood vessels, making it easier to breathe through the nose.","evidence":"Established for short-term symptomatic relief"},{"condition":"Fever associated with cold or flu","description":"Paracetamol lowers body temperature by acting on the temperature-regulating centre in the brain.","evidence":"Well-established"},{"condition":"Mild to moderate headache and body ache","description":"Paracetamol provides temporary relief of aches and pains that commonly accompany colds and flu.","evidence":"Well-established"},{"condition":"Sinus pressure and stuffiness","description":"The decongestant action may help reduce the feeling of pressure in the sinuses during a cold.","evidence":"Limited to short-term symptomatic use"}]
Off-label uses: [{"condition":"Weight loss","description":"Phenylpropanolamine was formerly used as an appetite suppressant, but this use is no longer recommended because of safety concerns.","evidence":"Not recommended"},{"condition":"Allergic rhinitis congestion","description":"Sometimes used for short-term nasal stuffiness in allergic rhinitis, but safer alternatives are usually preferred.","evidence":"Limited"}]
Primary treatment for: Common cold and flu with nasal congestion, fever, and body ache
Also treats: Sinus congestion, Allergic rhinitis with nasal stuffiness, Upper respiratory tract infection symptoms
📋 Drug Information
| Generic Name(s) | Paracetamol + Phenylpropanolamine |
| Brand Name | Anglocet Plus Tablet |
| Manufacturer | Uniroyal Biotech |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Analgesic, Antipyretic, Decongestant |
| Route of Administration | Oral |
| Storage | Store at room temperature, between 15°C and 30°C, in a dry place away from direct sunlight. Keep the bottle tightly closed and do not freeze the syrup. Keep all medicines out of the reach of children. |
| Shelf Life | The shelf life is usually 24 to 36 months from the date of manufacture, depending on the manufacturer. Always check the expiry date printed on the bottle and do not use the medicine after that date. |
| WHO Guideline | Not established from the available information. Phenylpropanolamine has been withdrawn or restricted in several countries because of safety concerns, and current guidelines generally prefer safer decongestants. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works through two separate mechanisms. Paracetamol reduces fever and pain mainly by acting on the central nervous system, where it inhibits prostaglandin synthesis and affects pain and temperature pathways. Phenylpropanolamine is a sympathomimetic amine that both directly stimulates alpha-adrenergic receptors and causes release of noradrenaline from nerve endings. This leads to constriction of blood vessels in the nasal mucosa, which reduces swelling and congestion. The same alpha-adrenergic action can also raise blood pressure and heart rate, which explains many of the precautions associated with this medicine.
Mechanism Steps
💡 How to Take coldant syrup
Strength: Each 5 ml of this oral syrup contains 125 mg of paracetamol and 12.5 mg of phenylpropanolamine.
Dosage Information
| Adult Dosage | For adults, this medicine is usually given as a measured oral dose every 4 to 6 hours as needed for cold symptoms, but the exact amount and frequency depend on the indication, the patient's age, weight, blood pressure, and liver and kidney function. The dose must be individualized by a qualified clinician. Do not exceed the maximum daily dose stated on the label or by your doctor, and do not continue for more than a few days without medical review. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this combination. Consult a pediatrician for an appropriate dose based on the child's age and weight. This medicine should not be given to newborns or to children for whom the doctor has not recommended it. |
| Elderly Dosage | Older adults are more sensitive to the effects of phenylpropanolamine, especially rises in blood pressure, palpitations, dizziness, and difficulty passing urine. The dose must be individualized by a qualified clinician, and blood pressure and urinary symptoms should be monitored. This medicine is generally avoided in elderly patients with heart disease, hypertension, or prostate enlargement. |
| Renal Impairment | Phenylpropanolamine is excreted largely unchanged by the kidneys, so its effects may be prolonged in people with kidney impairment. The dose must be individualized by a qualified clinician, and this medicine should be used with caution or avoided in severe kidney disease. |
| Hepatic Impairment | Paracetamol is metabolised by the liver, and the risk of liver injury is higher in people with liver disease or those who drink alcohol heavily. The dose must be individualized by a qualified clinician, and this medicine should be avoided in severe liver disease. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on the patient's age, weight, blood pressure, and liver and kidney function. Do not exceed the dose printed on the label or advised by your doctor, because too much paracetamol can damage the liver and too much phenylpropanolamine can raise blood pressure dangerously. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of coldant syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Monoamine oxidase inhibitors | Major | |
| Other decongestants | Major | |
| Warfarin | Major | |
| Antihypertensives | Major | |
| Tricyclic antidepressants | Moderate | |
| Beta blockers | Moderate | |
| Caffeine | Moderate | |
| Thyroid hormones | Moderate | |
| Antacids | Minor | |
| Activated charcoal | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors
- Other sympathomimetic decongestants
- Warfarin
- Antihypertensive medicines
⚡ Moderate Interactions
- Caffeine
- Tricyclic antidepressants
- Beta blockers
- Thyroid hormones
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. It increases the risk of paracetamol-related liver damage, especially with repeated or higher doses, and can add to dizziness, drowsiness, and stomach irritation. If you drink heavily or have liver disease, speak to your doctor before using this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to paracetamol, phenylpropanolamine, or any ingredient of this medicine","Uncontrolled high blood pressure or severe coronary artery disease","Use within 14 days of a monoamine oxidase inhibitor","Severe liver disease or active liver failure","Closed-angle glaucoma","Hyperthyroidism","Phaeochromocytoma","Urinary retention due to prostate enlargement","Children below the age recommended by the doctor for this syrup"]
⚠️ Warnings & Precautions
["Do not exceed the recommended dose because of the risk of liver damage from paracetamol.","Avoid other paracetamol-containing products while taking this medicine.","Use with caution in people with heart disease, hypertension, diabetes, or thyroid disease.","Avoid alcohol during treatment.","Do not drive or operate machinery if you feel dizzy or drowsy.","Do not use for more than a few days without medical advice.","Tell your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Keep out of reach of children and use the measuring device provided."]
🤱 Lactation Safety
Paracetamol passes into breast milk in small amounts and is generally considered compatible with breastfeeding. Phenylpropanolamine may also pass into breast milk and can cause irritability or sleep disturbance in a nursing infant. Because of this, the combination is usually avoided during breastfeeding, and a safer alternative should be discussed with a doctor.
💊 Overdose Management
Overdose of this medicine is a medical emergency because of the risk of severe liver damage from paracetamol and dangerous hypertension from phenylpropanolamine. If you suspect an overdose, contact emergency services or go to the nearest hospital immediately, even if you feel well at first. Do not wait for symptoms to appear. Treatment may include activated charcoal, acetylcysteine for paracetamol toxicity, and blood pressure monitoring. Carry the medicine bottle or label with you so that the medical team knows exactly what was taken.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, provided it is not almost time for the next dose. If it is nearly time for the next dose, skip the missed dose and continue with your regular schedule. Never take two doses at the same time to make up for a missed dose. If you are unsure, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as directed by your doctor or as printed on the label, and never exceed the stated dose or duration. Shake the bottle well before each use and measure the dose with the spoon or cup provided, not with a household spoon. Avoid taking other products that contain paracetamol at the same time, because the combined amount can harm your liver. Do not use this medicine for more than a few days without medical advice, and do not use it to stay awake or to lose weight. Check your blood pressure regularly if you have hypertension, and tell your doctor if you notice palpitations, nervousness, or a persistent headache. Avoid alcohol while taking this medicine. Keep it out of the reach of children, and store it at room temperature away from direct sunlight. If you are pregnant, planning pregnancy, breastfeeding, or have heart, thyroid, prostate, liver, or kidney problems, speak to a doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more likely to experience dizziness, confusion, urinary retention, and rises in blood pressure from phenylpropanolamine. This medicine should be used with caution or avoided in elderly people with heart disease, hypertension, prostate enlargement, or glaucoma. The dose must be individualized by a qualified clinician, and blood pressure and urinary symptoms should be monitored.
🤰 Pregnancy Planning (TTC)
If you are trying to conceive or are pregnant, avoid this medicine unless a doctor specifically recommends it. Paracetamol alone is generally preferred for fever and pain in pregnancy, while phenylpropanolamine is not recommended because it can reduce blood flow to the placenta. Discuss safer options with your doctor or pharmacist.
🏥 Post-Surgery Considerations
After surgery, pain and fever should be managed with medicines chosen by your surgical team. Do not take this medicine without asking your surgeon or anaesthetist, because the decongestant can raise blood pressure and heart rate, and paracetamol may interact with other pain medicines you have been given.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine before any dental procedure. The paracetamol component may add to other pain medicines, and the decongestant can raise blood pressure and heart rate, which is important if you need local anaesthesia with adrenaline. Your dentist may advise you to stop it or use an alternative before the procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Mild activity such as walking is usually fine if you feel well, but avoid strenuous exercise while you have a fever or while taking this medicine, because the decongestant can increase heart rate and blood pressure. If you feel dizzy, breathless, or have palpitations, stop exercising and rest. Return to your normal routine gradually after your symptoms settle.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, nervousness, or restlessness in some people. Avoid driving, operating heavy machinery, or working at heights until you know how it affects you. If your job involves safety-sensitive tasks, ask your doctor whether you can take time off or use a safer alternative. Most people can continue light desk work, but take breaks and stay hydrated.
🛑 When to Stop This Medicine
Stop this medicine once your cold symptoms improve or after the short course advised by your doctor. Stop immediately and seek medical advice if you develop a severe headache, chest pain, palpitations, difficulty passing urine, a skin rash, or yellowing of the eyes or skin. Do not stop any other prescribed medicine without talking to your doctor first.
📅 Long-Term Use Effects
This medicine is not intended for long-term use. Prolonged or repeated use of paracetamol can increase the risk of liver and kidney problems, especially with alcohol or other paracetamol-containing products. Long-term use of phenylpropanolamine can lead to persistent blood pressure elevation, heart rhythm problems, nervousness, and urinary difficulties. If your cold symptoms last more than a few days or keep returning, you should see a doctor to find the underlying cause instead of continuing this medicine.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Saltwater rinses help clear nasal passages and reduce stuffiness without systemic side effects.
Evidence: Well-established for symptom reliefBreathing warm, moist air can temporarily ease nasal congestion and throat irritation.
Evidence: Traditionally used, limited clinical evidenceControls fever and aches without the cardiovascular effects of a decongestant.
Evidence: Well-establishedSupports natural recovery from a viral cold and reduces the need for medicines.
Evidence: Well-established supportive care💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There is no known interaction between this medicine and routine vaccines. If you have a fever, it is usually better to postpone vaccination until you have recovered, because fever can be confused with a vaccine reaction. Follow your doctor's advice about the timing of vaccination.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not freeze or refrigerate the syrup unless the label says so
✅ DO
Keep the bottle tightly closed in its original carton
❌ DON'T
Do not transfer the syrup to another unlabelled container
✅ DO
Keep away from direct sunlight and heat
❌ DON'T
Do not store near a stove, radiator, or in a hot car
✅ DO
Keep out of the reach of children
❌ DON'T
Do not leave the bottle open or within a child's reach
✅ DO
Check the expiry date before each use
❌ DON'T
Do not use the medicine after the expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original labelled bottle with the prescription or a copy of it, especially when travelling internationally. Keep it in your hand luggage if you need it during the journey, and store it at room temperature away from direct sunlight and heat. Do not leave it in a hot car or in checked baggage that may be exposed to extreme temperatures. If you are crossing time zones, continue the medicine at the interval advised by your doctor rather than adjusting it to local meal times. Declare it to customs if required and check the rules of your destination country, because some countries restrict decongestant medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Paracetamol usually starts reducing fever and pain within 30 to 60 minutes, and the decongestant effect on the nose also begins within about an hour. The effect generally lasts 4 to 6 hours.
A: You should avoid combining it with other products that contain paracetamol or decongestants, because this can lead to overdose or a dangerous rise in blood pressure. Always show your full medicine list to your doctor or pharmacist.
A: Pediatric dosing is not established from available information for this combination. Consult a pediatrician before giving this medicine to a child.
A: No. Alcohol increases the risk of liver damage from paracetamol and can worsen dizziness and stomach upset.
A: If you remember within half the dosing interval, take the missed dose. If more time has passed, skip it and take the next dose at the usual time. Never double the dose.
A: Yes, the phenylpropanolamine component can raise blood pressure and heart rate. It should be avoided in people with uncontrolled hypertension or heart disease.
🤔 Common Patient Concerns
🔄 Substitutes for coldant syrup
View AllAlternative brands with exact same active ingredient:
-
synfast syrupSansill Formulations ₹20.86 11.3% COSTLIER
-
winnow syrupTyrant Pharma Pvt Ltd ₹25.31 35% COSTLIER
-
fevacold syrupArvincare Pharma ₹35.63 90% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used for weight loss.
Fact: Phenylpropanolamine was once used as an appetite suppressant, but this use is no longer recommended because of the risk of serious cardiovascular events. - Myth: This medicine is safe for everyone with a cold.
Fact: It is not safe for people with uncontrolled high blood pressure, heart disease, hyperthyroidism, glaucoma, or prostate enlargement, and it should be avoided in pregnancy and breastfeeding. - Myth: More syrup means faster relief.
Fact: Taking more than the recommended dose can cause liver damage from paracetamol and dangerous rises in blood pressure from phenylpropanolamine. - Myth: This medicine can be taken for weeks without any problem.
Fact: It is meant only for short-term relief. Prolonged use increases the risk of side effects and should be avoided unless a doctor advises otherwise.
🔄 Alternative Options
Generic Alternatives
- Paracetamol oral syrup alone
- Paracetamol with a safer decongestant such as pseudoephedrine, if prescribed
- Paracetamol with an antihistamine for cold symptoms, if appropriate