Elide Mr 100mg/250mg Tablet: Comprehensive Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Persistent fever or sore throat
If experiencing severe symptoms, call emergency services immediately.
What is enpex 100mg/250mg tablet used for?
This medicine is a combination of Nimesulide (an NSAID) and Chlorzoxazone (a muscle relaxant) used for short-term relief of acute musculoskeletal pain with muscle spasm. It works by reducing inflammation and relaxing muscles. It should be taken with food and used for the shortest duration possible due to the risk of liver toxicity.
- Generic Name: Nimesulide (100mg) + Chlorzoxazone (250mg)
- Manufacturer: Ester Formulations
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 enpex 100mg/250mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमेसुलाइड और क्लोरज़ोक्साज़ोन का संयोजन है, जिसका उपयोग मांसपेशियों में ऐंठन और दर्द के इलाज के लिए किया जाता है। यह पीठ दर्द, गर्दन दर्द, मोच और खिंचाव जैसी स्थितियों में राहत देती है। यह दवा सूजन को कम करती है और मांसपेशियों को आराम देती है। इसका उपयोग केवल अल्पकालिक उपचार के लिए किया जाना चाहिए और डॉक्टर की सलाह के बिना नहीं लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, नींद आना, चक्कर आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, अल्सर, लीवर की क्षति, गुर्दे की समस्या और गंभीर एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको काला मल, खून की उल्टी, त्वचा या आंखों का पीलापन, गहरे रंग का मूत्र, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक या उपचार की अवधि से अधिक न लें। इसे भोजन या दूध के साथ लें ताकि पेट की परेशानी कम हो। इस दवा के साथ शराब का सेवन न करें क्योंकि इससे लीवर की क्षति और नींद आने का खतरा बढ़ सकता है। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं, तो इस दवा को लेने से पहले अपने डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।
💊 enpex 100mg/250mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain with muscle spasm","description":"Relieves pain and reduces muscle spasm in conditions like back pain, neck pain, and sprains.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain and muscle spasm after surgery.","evidence":"Moderate"},{"condition":"Traumatic pain","description":"Helps alleviate pain and spasm following injuries like strains and contusions.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Tension headache","description":"Sometimes prescribed off-label for tension-type headaches with muscle spasm.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"May be used off-label for menstrual cramps with associated muscle spasm.","evidence":"Limited"}]
Primary treatment for: Acute musculoskeletal pain with muscle spasm
Also treats: Back pain, Neck pain, Sprains, Strains, Post-operative pain
📋 Drug Information
| Generic Name(s) | Nimesulide (100mg) + Chlorzoxazone (250mg) |
| Brand Name | enpex 100mg/250mg tablet |
| Manufacturer | Ester Formulations |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container, tightly closed. Do not refrigerate. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins, which are mediators of pain and inflammation. Chlorzoxazone is a centrally acting muscle relaxant that primarily acts on the spinal cord and subcortical areas of the brain to inhibit polysynaptic reflexes, thereby reducing skeletal muscle spasm. The combination provides both analgesic and muscle relaxant effects, making it effective for painful musculoskeletal conditions.
Mechanism Steps
💡 How to Take enpex 100mg/250mg tablet
Strength: Each tablet contains Nimesulide 100 mg and Chlorzoxazone 250 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily, preferably after meals. The dose may be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function. Do not exceed the recommended dose or duration of treatment. The maximum duration of use is typically 5-7 days unless otherwise directed by a doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine, especially gastrointestinal and renal side effects. Use with caution and at the lowest effective dose. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. Not recommended for patients with severe renal impairment (eGFR <30 mL/min). Consult a doctor for dose adjustment. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Contraindicated in severe hepatic impairment. Consult a doctor for dose adjustment. |
| Maximum Daily Dose | The maximum recommended daily dose is 3 tablets (300 mg Nimesulide and 750 mg Chlorzoxazone). Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of enpex 100mg/250mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Alcohol | Major | |
| Antihypertensives | Moderate | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| Methotrexate | Moderate | |
| Antacids | Minor | |
| Food | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, aspirin)
- Corticosteroids
- Alcohol
⚡ Moderate Interactions
- Antihypertensives (e.g., ACE inhibitors, ARBs)
- Diuretics
- Lithium
- Methotrexate
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of liver damage, gastrointestinal bleeding, and drowsiness. It may also exacerbate the central nervous system depressant effects of Chlorzoxazone.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Nimesulide, Chlorzoxazone, or any component of the formulation","History of gastrointestinal bleeding or perforation related to NSAID use","Active peptic ulcer or gastrointestinal bleeding","Severe liver impairment","Severe kidney impairment (eGFR
⚠️ Warnings & Precautions
["Use the lowest effective dose for the shortest duration possible.","Take with food to reduce gastrointestinal irritation.","Avoid alcohol consumption.","May cause drowsiness; avoid driving or operating machinery.","Monitor liver and kidney function during prolonged use.","Not recommended for patients with a history of liver disease.","Use with caution in elderly patients due to increased risk of side effects.","Inform your doctor if you have asthma, as NSAIDs may precipitate bronchospasm.","Do not use if you have a history of allergic reactions to NSAIDs.","Discontinue if signs of liver injury occur."]
🤱 Lactation Safety
Not established from the available information. It is not known whether Nimesulide and Chlorzoxazone are excreted in human breast milk. Due to the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
Overdose may cause nausea, vomiting, abdominal pain, drowsiness, dizziness, and in severe cases, liver or kidney damage. There is no specific antidote. Treatment is supportive and symptomatic. Gastric lavage may be considered if ingestion is recent. Monitor liver and kidney function, and provide supportive care. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and drowsiness. Do not take other NSAIDs or pain relievers without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, asthma, or bleeding disorders. This medicine may cause drowsiness; avoid driving or operating machinery until you know how it affects you. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) are at increased risk of gastrointestinal bleeding, kidney impairment, and liver toxicity from this medicine. Use with caution and at the lowest effective dose. Monitor renal and hepatic function regularly. Avoid long-term use. Consider alternative pain management strategies.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for women who are planning to become pregnant, as it may interfere with ovulation and increase the risk of miscarriage. Consult your doctor for safe alternatives for pain relief before conception and during pregnancy.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain and muscle spasm, but it should be used with caution due to the risk of bleeding and kidney impairment. Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with other medications used during surgery.
🦷 Dental Procedures
If you are scheduled for dental work, inform your dentist that you are taking this medicine. It may increase the risk of bleeding during procedures. Your dentist may advise you to stop the medicine temporarily before certain procedures. Do not stop without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, avoid strenuous exercise or activities that require mental alertness until you know how it affects you. Drowsiness and dizziness may impair your ability to perform certain tasks. Gentle stretching and low-impact exercises may be beneficial, but consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause stomach upset, so take it with food. Inform your employer if your work requires mental alertness. Generally, it does not affect office work, but caution is advised.
🛑 When to Stop This Medicine
Stop taking this medicine if you experience any serious side effects such as severe abdominal pain, black stools, vomiting blood, yellowing of skin or eyes, or signs of an allergic reaction. Do not stop abruptly without consulting your doctor if you have been taking it for more than a few days. Always follow your doctor's advice on the duration of treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of serious side effects, including liver damage, kidney impairment, gastrointestinal bleeding, and cardiovascular events. If long-term use is necessary, regular monitoring of liver and kidney function, complete blood count, and blood pressure is required. Consult your doctor for alternative treatments if you need pain relief for more than a few days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and muscle spasm.
Evidence: Well-establishedApplying heat or cold packs can help relieve muscle spasm and pain.
Evidence: Well-establishedMay provide pain relief for some individuals.
Evidence: ModerateCreams or gels containing NSAIDs or counterirritants can provide local relief.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a vaccine, inform your healthcare provider that you are taking this medicine. It is generally safe to continue, but your doctor may advise temporary discontinuation if you have an active infection or fever.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust dosing times gradually to avoid missed doses. Check local customs regulations regarding prescription medicines. Always keep it in your carry-on luggage to avoid loss or temperature extremes.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30-60 minutes after taking it.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, alcohol should be avoided while taking this medicine as it increases the risk of liver damage and drowsiness.
A: This medicine is for short-term use only, typically not exceeding 5-7 days unless directed by your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for enpex 100mg/250mg tablet
View AllAlternative brands with exact same active ingredient:
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nimo mr tabletZydus Cadila ₹10.22 55.5% CHEAPER
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nimula mr 100mg/250mg tabletJarson Pharmaceuticals ₹16.88 26.5% CHEAPER
-
nimox 100mg/250mg tabletGracure Pharmaceuticals Ltd ₹22.50 2% CHEAPER
-
nim mr 100mg/250mg tabletVarun Life Sciences Pvt Ltd ₹27.19 18.4% COSTLIER
-
nimuzox tabletStedman Pharmaceuticals Pvt Ltd ₹28.00 21.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is intended for short-term use only. Prolonged use can increase the risk of liver damage, kidney problems, and gastrointestinal bleeding. - Myth: This medicine can be taken on an empty stomach.
Fact: This medicine should be taken with food or milk to reduce the risk of stomach upset and gastrointestinal irritation. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol should be avoided while taking this medicine as it increases the risk of liver toxicity and drowsiness. - Myth: This medicine is safe for children.
Fact: This medicine is not recommended for children under 18 years of age due to lack of safety and efficacy data.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Chlorzoxazone combination tablets from other manufacturers
Brand Alternatives
- Nimsaid MR
- Nise MR
- Nimulid MR
- Nimodol MR
- Nimucet MR