Endol Plus 650mg/10mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Irregular heartbeat or palpitations
If experiencing severe symptoms, call emergency services immediately.
What is endol plus 650mg/10mg tablet used for?
This medicine is a combination of Paracetamol 650 mg and Promethazine 10 mg used for short-term relief of moderate to severe pain with restlessness, insomnia, and nausea. It works by reducing pain and fever and inducing sedation. It should be taken exactly as prescribed and avoided in severe liver disease, glaucoma, and children under 12.
- Generic Name: Paracetamol (650mg) + Promethazine (10mg)
- Manufacturer: Bangalore Antibiotics & Biologicals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 endol plus 650mg/10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पैरासिटामोल 650 मिलीग्राम और प्रोमेथाज़ीन 10 मिलीग्राम का संयोजन है। इसका उपयोग मध्यम से गंभीर दर्द, बेचैनी, अनिद्रा और मतली के इलाज के लिए किया जाता है। यह दर्द को कम करने, बुखार को कम करने और नींद लाने में मदद करती है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, धुंधली दृष्टि और थकान शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, यकृत की समस्या, रक्त विकार और अनियमित हृदय गति शामिल हो सकते हैं। यदि आपको त्वचा या आँखों का पीलापन, गहरे रंग का मूत्र, गंभीर पेट दर्द, साँस लेने में कठिनाई या चेहरे पर सूजन हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। निर्धारित मात्रा से अधिक न लें। इस दवा के साथ शराब का सेवन न करें। जब तक आपको पता न चले कि यह दवा आपको कैसे प्रभावित करती है, वाहन न चलाएँ और मशीनरी न चलाएँ। यदि आपको यकृत या गुर्दे की बीमारी, ग्लूकोमा, मूत्र प्रतिधारण या साँस की समस्या है, तो अपने डॉक्टर को बताएं।
💊 endol plus 650mg/10mg tablet Uses & Benefits
[{"condition":"Moderate to severe pain with restlessness","description":"Provides relief from pain and helps calm restlessness or anxiety associated with painful conditions.","evidence":"Well-established"},{"condition":"Insomnia associated with pain","description":"Promethazine induces sedation, helping patients with pain to sleep.","evidence":"Well-established"},{"condition":"Nausea and vomiting","description":"Promethazine has antiemetic properties, useful when nausea accompanies pain.","evidence":"Well-established"},{"condition":"Fever","description":"Paracetamol reduces fever by acting on the hypothalamus.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Preoperative sedation","description":"Sometimes used off-label to reduce anxiety and induce sedation before surgery.","evidence":"Limited"},{"condition":"Migraine headache","description":"May be used off-label for acute migraine relief due to analgesic and antiemetic effects.","evidence":"Limited"}]
Primary treatment for: Pain with restlessness
Also treats: Insomnia, Nausea and vomiting, Fever
📋 Drug Information
| Generic Name(s) | Paracetamol (650mg) + Promethazine (10mg) |
| Brand Name | endol plus 650mg/10mg tablet |
| Manufacturer | Bangalore Antibiotics & Biologicals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis, which reduces pain and fever. Promethazine is a phenothiazine antihistamine that blocks histamine H1 receptors, leading to sedation, antiemetic effects, and anticholinergic actions. The combination provides both analgesia and sedation.
Mechanism Steps
💡 How to Take endol plus 650mg/10mg tablet
Strength: Each tablet contains Paracetamol 650 mg and Promethazine 10 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally every 6 to 8 hours as needed for pain and restlessness, not to exceed 4 tablets in 24 hours. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not self-medicate or exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the sedative and anticholinergic effects of promethazine. Start with a lower dose and monitor closely for confusion, falls, and urinary retention. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary based on creatinine clearance. Consult a clinician for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Paracetamol dose should be reduced or avoided in severe liver disease. Consult a clinician for individualized dosing. |
| Maximum Daily Dose | Paracetamol: 4000 mg per day (including from all sources). Promethazine: 100 mg per day. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of endol plus 650mg/10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Benzodiazepines | Major | |
| MAOIs | Major | |
| Fluoxetine | Moderate | |
| Atropine | Moderate | |
| Antacids | Minor | |
| Caffeine | Minor | |
| Opioids | Major | |
| Tricyclic antidepressants | Moderate |
🚨 Major Interactions
- Alcohol
- CNS depressants (e.g., benzodiazepines, opioids, antidepressants)
- Warfarin
- Monoamine oxidase inhibitors (MAOIs)
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
- Antihypertensives
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. It increases the risk of liver toxicity from paracetamol and enhances the sedative effects of promethazine, leading to severe drowsiness, respiratory depression, and impaired motor skills.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to paracetamol, promethazine, or any component of the formulation","Severe liver disease or active liver failure","Children under 12 years of age","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","Severe respiratory depression or asthma","Concurrent use with MAO inhibitors"]
⚠️ Warnings & Precautions
["Do not exceed the recommended dose of paracetamol; overdose can cause severe liver damage.","Avoid alcohol and other CNS depressants while taking this medicine.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Use with caution in elderly patients due to increased risk of confusion, falls, and anticholinergic effects.","Consult your doctor if you have liver or kidney disease, glaucoma, or breathing problems.","Do not use for longer than prescribed without medical supervision.","Keep out of reach of children."]
🤱 Lactation Safety
Paracetamol is considered safe during breastfeeding. Promethazine may pass into breast milk and cause drowsiness in the infant. Consult your doctor before use.
💊 Overdose Management
Overdose can cause severe liver damage from paracetamol and severe sedation, respiratory depression, and anticholinergic effects from promethazine. Seek emergency medical attention immediately. Treatment includes activated charcoal if within 1-2 hours, N-acetylcysteine for paracetamol toxicity, and supportive care for promethazine toxicity.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Avoid alcohol and other central nervous system depressants while taking this medicine, as they can increase drowsiness and the risk of liver damage. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have liver or kidney disease, glaucoma, urinary retention, or breathing problems. Do not use this medicine for more than the recommended period without consulting your doctor. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative and anticholinergic effects of promethazine. Use with caution and monitor for confusion, falls, and urinary retention. Lower doses may be required.
🤰 Pregnancy Planning (TTC)
Consult your doctor before planning pregnancy if you are taking this medicine. Paracetamol is generally considered safe, but promethazine should be used with caution.
🏥 Post-Surgery Considerations
This medicine may be used for post-surgical pain and nausea. Inform your surgeon and anesthesiologist about all medications you are taking.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with anesthetics and increase sedation.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities requiring alertness until you know how this medicine affects you. Drowsiness and dizziness may impair your ability to exercise safely.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause significant drowsiness and impair your ability to drive or operate machinery. Avoid these activities until you know how it affects you. It may also affect your ability to concentrate at work.
🛑 When to Stop This Medicine
Stop taking this medicine if you experience severe side effects or if your symptoms resolve. Do not stop abruptly if you have been taking it for a long time; consult your doctor for a tapering schedule.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to dependence, liver damage from paracetamol, and tardive dyskinesia from promethazine. Regular monitoring of liver function and blood counts is recommended. Consult your doctor for periodic review.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help with restlessness and insomnia.
Evidence: ModerateEffective for chronic pain and insomnia.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. Consult your doctor before vaccination if you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for controlled substances. Do not pack in checked luggage; keep in carry-on for easy access.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Paracetamol starts relieving pain within 30-60 minutes, while promethazine induces sedation within 20-30 minutes.
A: It is best taken with food or milk to reduce stomach upset.
A: Consult your doctor before combining with other painkillers, especially those containing paracetamol, to avoid overdose.
A: It is intended for short-term use only. Do not use for more than 7 days without consulting your doctor.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe to take with alcohol.
Fact: Alcohol increases the risk of liver toxicity and severe drowsiness. Avoid alcohol completely. - Myth: This medicine can be taken for any type of pain.
Fact: It is intended for specific types of pain with restlessness and should only be used as prescribed. - Myth: It is safe to take more than the recommended dose if pain is severe.
Fact: Exceeding the dose can cause severe liver damage and other serious side effects.
🔄 Alternative Options
Generic Alternatives
- Paracetamol 650 mg + Promethazine 10 mg tablet