Emvoid Injection (Aprepitant 150 mg): Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swallowing
- Swelling of face, lips, or throat
- Severe rash or blistering skin
- Yellowing of eyes or skin
- Severe abdominal pain
- Decreased urine output
- Chest pain or irregular heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is emvoid injection used for?
This medicine is an injectable antiemetic containing Aprepitant 150 mg. It is used to prevent nausea and vomiting after surgery or chemotherapy. It works by blocking NK1 receptors in the brain. It is given by a healthcare professional as an intravenous injection.
- Generic Name: Aprepitant (150mg)
- Manufacturer: Torrent Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 emvoid injection के बारे में (Hindi Summary)
उपयोग: यह दवा एप्रेपिटेंट 150 मिलीग्राम इंजेक्शन है, जिसका उपयोग सर्जरी के बाद और कीमोथेरेपी के कारण होने वाली मतली और उल्टी को रोकने के लिए किया जाता है। यह दवा मस्तिष्क में एनके1 रिसेप्टर्स को ब्लॉक करके काम करती है, जिससे उल्टी की प्रतिक्रिया रुक जाती है। यह केवल एक डॉक्टर या स्वास्थ्य पेशेवर द्वारा नस के माध्यम से दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में थकान, सिरदर्द, कब्ज और कम रक्तचाप शामिल हैं। कुछ रोगियों को इंजेक्शन की जगह पर दर्द या लालिमा हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी प्रतिक्रिया, जैसे सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दाने हो सकते हैं। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल एक योग्य स्वास्थ्य पेशेवर द्वारा अस्पताल या क्लिनिक में ही दी जानी चाहिए। इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों और दवाओं के बारे में बताएं। इंजेक्शन लेने के बाद तुरंत वाहन न चलाएं या मशीनरी न चलाएं। कम से कम 24 घंटे तक शराब का सेवन न करें। यदि आप गर्भवती या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें।
💊 emvoid injection Uses & Benefits
- [{"condition":"Postoperative nausea and vomiting (PONV)","description":"This medicine is used to prevent nausea and vomiting after surgery in adults.
- It is often given before the surgery or immediately after.","evidence":"Well-established"},{"condition":"Chemotherapy-induced nausea and vomiting (CINV)","description":"This medicine is used in combination with other antiemetics to prevent nausea and vomiting caused by highly emetogenic chemotherapy.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Refractory nausea and vomiting","description":"In some cases, this medicine may be used off-label for severe nausea and vomiting that has not responded to other treatments.","evidence":"Limited"}]
Primary treatment for: Postoperative nausea and vomiting
Also treats: Chemotherapy-induced nausea and vomiting
📋 Drug Information
| Generic Name(s) | Aprepitant (150mg) |
| Brand Name | emvoid injection |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | NK1 Antagonists |
| Route of Administration | Parenteral (intravenous) |
| Storage | Store vials refrigerated at 2°C to 8°C (36°F to 46°F). Protect from light. Do not freeze. Once reconstituted, the solution should be used immediately or stored as per the manufacturer's instructions. |
| Shelf Life | 24 months from the date of manufacture when stored under recommended conditions. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Aprepitant is a selective high-affinity antagonist at the neurokinin-1 (NK1) receptor. It works by blocking the binding of substance P, a neuropeptide that is involved in the vomiting reflex. By preventing substance P from binding to NK1 receptors in the brain and gastrointestinal tract, aprepitant inhibits the signals that trigger nausea and vomiting. This action is particularly effective in preventing delayed nausea and vomiting associated with chemotherapy and surgery.
Mechanism Steps
💡 How to Take emvoid injection
Strength: Aprepitant 150 mg injection (single-use vial)
Dosage Information
| Adult Dosage | The recommended dose of this medicine for prevention of postoperative nausea and vomiting is 150 mg administered as a single intravenous injection over 30 minutes, starting approximately 30 minutes before induction of anesthesia. For prevention of chemotherapy-induced nausea and vomiting, the dose is typically 150 mg on Day 1, followed by 80 mg orally on Days 2 and 3, in combination with other antiemetics. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No dose adjustment is required for elderly patients based on age alone. However, elderly patients may be more sensitive to the effects of the drug, and monitoring for side effects is recommended. |
| Renal Impairment | No dose adjustment is necessary for patients with renal impairment. However, aprepitant has not been studied extensively in patients with severe renal impairment. |
| Hepatic Impairment | For patients with mild to moderate hepatic impairment (Child-Pugh Class A or B), no dose adjustment is needed. For severe hepatic impairment (Child-Pugh Class C), there are no clinical data; use with caution and consider alternative therapy. |
| Maximum Daily Dose | The maximum recommended daily dose is 150 mg for the injectable form when used for PONV. For CINV, the maximum daily dose is 150 mg on Day 1 and 80 mg on Days 2 and 3. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of emvoid injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampin | Major | |
| Warfarin | Moderate | |
| Oral contraceptives | Moderate | |
| Dexamethasone | Minor |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
- CYP3A4 inducers (e.g., rifampin, carbamazepine)
⚡ Moderate Interactions
- Warfarin
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol may increase the risk of dizziness and drowsiness when taken with this medicine. It is advisable to avoid alcohol for at least 24 hours after receiving this injection.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to aprepitant or any component of the formulation","Severe hepatic impairment (Child-Pugh Class C)","Concomitant use with pimozide (due to risk of serious cardiac arrhythmias)"]
⚠️ Warnings & Precautions
["Use with caution in patients with moderate hepatic impairment; dose adjustment may be needed.","May cause dizziness; avoid driving or operating machinery until effects are known.","May reduce the efficacy of hormonal contraceptives; use backup contraception.","Monitor for signs of allergic reactions during and after infusion.","Use with caution in elderly patients; no specific dose adjustment is required but monitor closely."]
🤱 Lactation Safety
It is not known whether aprepitant is excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a nursing woman. Consult your doctor to decide whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
There is limited information on overdose with aprepitant. In case of overdose, discontinue the drug and provide supportive care. Monitor vital signs and treat symptoms as they occur. Aprepitant is not removed by hemodialysis.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional in a controlled setting, missed doses are unlikely. If a dose is missed, it should be administered as soon as possible if the patient is still in the clinical setting. Otherwise, the next dose should be given according to the prescribed schedule. Do not double the dose.
Additional Safety Advice
This medicine should only be administered by a qualified healthcare professional in a properly equipped medical facility. Before receiving this medicine, inform your doctor about all your medical conditions, especially liver problems, and all medications you are taking, including over-the-counter drugs and herbal supplements. Do not drive or operate heavy machinery immediately after receiving this injection, as it may cause dizziness or fatigue. Avoid alcohol consumption for at least 24 hours after receiving this medicine, as it may increase drowsiness. If you are pregnant or breastfeeding, discuss the risks and benefits with your doctor before receiving this medicine. Keep all follow-up appointments and report any side effects to your healthcare provider.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, such as dizziness and low blood pressure. Close monitoring is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before receiving this medicine. It is classified as Pregnancy Category B, but use only if clearly needed.
🏥 Post-Surgery Considerations
This medicine is often used to prevent nausea and vomiting after surgery. It is usually given before or during surgery. Follow your surgeon's instructions for postoperative care.
🦷 Dental Procedures
If you are scheduled for dental procedures, inform your dentist if you have recently received this medicine. It may interact with other medications used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise immediately after receiving this medicine, especially if you feel dizzy or fatigued. Gradually resume activities as tolerated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, which can affect your ability to drive or operate machinery. It is best to rest after receiving the injection and avoid demanding tasks until you feel fully alert.
🛑 When to Stop This Medicine
This medicine is given as a single dose or short course. Do not stop any prescribed medication without consulting your doctor. If you experience severe side effects, seek medical attention immediately.
📅 Long-Term Use Effects
This medicine is typically used for short-term prevention of nausea and vomiting. Long-term effects are not well studied as it is not intended for chronic use. Monitoring of liver function may be required if used repeatedly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
These can be used alone or in combination with aprepitant for prevention of nausea and vomiting.
Evidence: Well-establishedMay help with mild nausea but not a substitute for medical treatment.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine around the time of treatment.
📦 Storage Guide
✅ DO
Store refrigerated at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Use immediately after reconstitution
❌ DON'T
Do not store reconstituted solution for later use
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel advice is not applicable. However, if you are traveling after receiving this medicine, carry a copy of your prescription and medical records. Store any take-home medications as directed. Inform your doctor if you plan to travel across time zones, as it may affect dosing schedules for other medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1 hour after administration and its effects last for about 24 hours.
A: It is advisable to avoid driving or operating machinery immediately after receiving this medicine, as it may cause dizziness or fatigue.
A: Pediatric dosing is not established. Consult a pediatrician for use in children.
🤔 Common Patient Concerns
🔄 Substitutes for emvoid injection
View AllAlternative brands with exact same active ingredient:
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fosa 150mg injectionMylan Pharmaceuticals Pvt Ltd ₹1,540.00 33.3% CHEAPER
-
aprecap 150mg injectionGlenmark Pharmaceuticals Ltd ₹2,134.00 7.6% CHEAPER
-
fosapretero injectionHetero Drugs Ltd ₹2,226.00 3.6% CHEAPER
-
fosup injectionZydus Cadila ₹2,250.00 2.6% CHEAPER
-
fosaprepit 150mg injectionCipla Ltd ₹2,250.00 2.6% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is an injection and must be given intravenously by a healthcare professional. - Myth: This medicine can be used to treat existing nausea.
Fact: This medicine is for prevention of nausea and vomiting, not for treating it once it has started.
🔄 Alternative Options
Generic Alternatives
- Aprepitant injection
Brand Alternatives
- Emend
- Aprepit
- Aprecap