Endoxan Tablet (Cyclophosphamide 50 mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in urine or painful urination
- Fever, chills, or signs of infection
- Unusual bleeding or bruising
- Severe fatigue or shortness of breath
- Chest pain or irregular heartbeat
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is eldamide 50mg tablet used for?
This medicine is an oral chemotherapy and immunosuppressant containing cyclophosphamide 50 mg. It is used to treat certain cancers and autoimmune diseases by slowing or stopping cell growth. It requires strict medical supervision and regular monitoring.
- Generic Name: Cyclophosphamide (50mg)
- Manufacturer: Elder Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 eldamide 50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा साइक्लोफॉस्फामाइड 50 मिलीग्राम युक्त एक मौखिक गोली है, जिसका उपयोग कैंसर जैसे लिम्फोमा, ल्यूकेमिया, मल्टीपल मायलोमा और स्तन कैंसर के इलाज में किया जाता है। इसका उपयोग ल्यूपस नेफ्राइटिस और रूमेटॉइड आर्थराइटिस जैसी ऑटोइम्यून बीमारियों में भी किया जाता है। यह दवा कोशिकाओं के विकास को रोककर काम करती है। इसका सेवन केवल डॉक्टर की सलाह पर ही करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, भूख न लगना, बालों का झड़ना और थकान शामिल हैं। गंभीर दुष्प्रभावों में अस्थि मज्जा का दमन, संक्रमण का खतरा, मूत्र में रक्त आना और दूसरे कैंसर का खतरा शामिल है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। गोली को पूरा निगलें, चबाएं नहीं। पर्याप्त पानी पिएं और बार-बार पेशाब करें। संक्रमण से बचें, भीड़-भाड़ वाली जगहों पर न जाएं। गर्भावस्था के दौरान और स्तनपान कराते समय इसका सेवन न करें। नियमित रक्त जांच कराते रहें।
💊 eldamide 50mg tablet Uses & Benefits
[{"condition":"Lymphomas","description":"Used in combination chemotherapy regimens for Hodgkin and non-Hodgkin lymphoma.","evidence":"Well-established"},{"condition":"Leukemias","description":"Used in the treatment of chronic lymphocytic leukemia and acute lymphoblastic leukemia.","evidence":"Well-established"},{"condition":"Multiple myeloma","description":"Part of combination therapy for multiple myeloma.","evidence":"Well-established"},{"condition":"Breast cancer","description":"Used in adjuvant and metastatic breast cancer regimens.","evidence":"Well-established"},{"condition":"Lupus nephritis","description":"Used as an immunosuppressant to treat severe kidney involvement in systemic lupus erythematosus.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Used in severe cases unresponsive to other treatments.","evidence":"Established"}]
Off-label uses: [{"condition":"Multiple sclerosis","description":"Sometimes used off-label for aggressive multiple sclerosis.","evidence":"Limited"},{"condition":"Scleroderma","description":"May be used off-label for severe scleroderma lung disease.","evidence":"Limited"}]
Primary treatment for: Cancer
Also treats: Lymphoma, Leukemia, Multiple myeloma, Breast cancer, Lupus nephritis, Rheumatoid arthritis
📋 Drug Information
| Generic Name(s) | Cyclophosphamide (50mg) |
| Brand Name | eldamide 50mg tablet |
| Manufacturer | Elder Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkylating agent |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Cyclophosphamide is a prodrug that requires activation by liver enzymes. Its active metabolite, phosphoramide mustard, cross-links DNA strands, preventing cell division and leading to cell death. This affects rapidly dividing cells, including cancer cells and immune cells.
Mechanism Steps
💡 How to Take eldamide 50mg tablet
Strength: Tablet, 50 mg
Dosage Information
| Adult Dosage | The dose of this medicine is highly individualized and depends on the specific condition being treated, the patient's body weight, kidney and liver function, and whether it is used alone or with other medicines. It is typically prescribed as part of a chemotherapy regimen or for autoimmune diseases. The dose may range from 1 to 5 mg per kg of body weight per day, or higher doses may be given intermittently. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Never self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist for appropriate dosing. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially bone marrow suppression and cardiotoxicity. Doses may need to be reduced based on kidney and liver function. Close monitoring is required. |
| Renal Impairment | In patients with renal impairment, dose reduction may be necessary. Monitor renal function closely. Consult a clinician for specific dose adjustments. |
| Hepatic Impairment | In patients with hepatic impairment, dose reduction may be necessary. Monitor liver function closely. Consult a clinician for specific dose adjustments. |
| Maximum Daily Dose | The maximum daily dose varies by indication and is determined by the treating clinician. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of eldamide 50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Allopurinol | Major | |
| Live vaccines | Major | |
| Cimetidine | Moderate | |
| Thiazide diuretics | Moderate |
🚨 Major Interactions
- Warfarin
- Allopurinol
- Live vaccines
⚡ Moderate Interactions
- Cimetidine
- Thiazide diuretics
🍷 Alcohol Interaction
Alcohol may increase the risk of stomach irritation and liver toxicity. It is best to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to cyclophosphamide","Severe bone marrow suppression","Active infection","Pregnancy","Breastfeeding"]
⚠️ Warnings & Precautions
["May cause severe bone marrow suppression; monitor blood counts.","Can cause hemorrhagic cystitis; maintain adequate hydration.","May increase risk of infections; avoid live vaccines.","Can cause secondary malignancies; long-term follow-up needed.","May impair fertility; discuss fertility preservation options.","Avoid pregnancy during and after treatment."]
🤱 Lactation Safety
Cyclophosphamide is excreted in breast milk and may harm a nursing infant. Breastfeeding is not recommended during treatment.
💊 Overdose Management
Overdose may cause severe bone marrow suppression, cardiotoxicity, and hemorrhagic cystitis. Treatment is supportive and symptomatic. There is no specific antidote. In case of overdose, seek emergency medical attention immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
This medicine must be taken exactly as prescribed by your doctor. Do not crush, chew, or break the tablet; swallow it whole with a full glass of water. To reduce the risk of bladder irritation, drink plenty of fluids (unless otherwise directed) and empty your bladder frequently. Avoid contact with people who have infections. Wash your hands frequently. Use effective contraception during treatment and for at least 6 months after stopping, as this medicine can harm an unborn baby. Do not receive live vaccines while on this medicine. Inform your doctor if you have liver or kidney problems. Regular blood tests are necessary to monitor your blood counts and organ function.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of bone marrow suppression, infections, and cardiotoxicity. Doses may need to be adjusted based on kidney and liver function. Close monitoring is required.
🤰 Pregnancy Planning (TTC)
This medicine can harm an unborn baby. Effective contraception is required during treatment and for at least 6 months after stopping. Discuss fertility preservation options with your doctor before starting treatment.
🏥 Post-Surgery Considerations
This medicine may impair wound healing and increase the risk of infections after surgery. Inform your surgeon that you are taking this medicine. Your doctor may advise temporarily stopping it before surgery.
🦷 Dental Procedures
This medicine can increase the risk of bleeding and infections during dental procedures. Inform your dentist that you are taking this medicine. Your dentist may recommend postponing non-urgent procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Mild to moderate exercise is generally safe, but avoid strenuous activities if you feel fatigued or have low blood counts. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or nausea, which can affect your ability to drive or operate machinery. Avoid driving if you feel unwell. Discuss work adjustments with your employer if needed.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping suddenly can worsen your condition. Your doctor will decide when to stop based on your response and side effects.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of secondary cancers, infertility, and organ toxicity. Regular monitoring of blood counts, liver and kidney function is essential. Discuss long-term risks and benefits with your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Medicines like mycophenolate mofetil or azathioprine may be used for autoimmune conditions.
Evidence: Well-establishedNewer targeted drugs may be options for certain cancers.
Evidence: Established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid temperature extremes. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Ensure you have enough supply for the entire trip. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of effect varies depending on the condition being treated. It may take several weeks to months to see full benefits.
A: Always inform your doctor about all medicines you are taking, as this medicine can interact with many drugs.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for eldamide 50mg tablet
View AllAlternative brands with exact same active ingredient:
-
cyclomet 50mg tabletBDH Industries Ltd ₹26.65 17.9% COSTLIER
-
phosmid 50mg tabletNeon Laboratories Ltd ₹33.33 47.5% COSTLIER
-
cysmide 50mg tabletSamarth Life Sciences Pvt Ltd ₹35.00 54.9% COSTLIER
-
bdcyclo tabletBDR Pharmaceuticals Internationals Pvt ₹36.00 59.3% COSTLIER
-
adcyclo tabletAdley Formulations ₹38.00 68.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Cyclophosphamide is safe for everyone.
Fact: It is a potent medicine with serious side effects and is only used under specialist supervision. - Myth: You can stop taking cyclophosphamide once you feel better.
Fact: You must complete the full course as prescribed; stopping early can lead to treatment failure.
🔄 Alternative Options
Generic Alternatives
- Cyclophosphamide 50 mg tablet
Brand Alternatives
- Endoxan
- Cycloxan
- Cyclophosphamide