Cycloxan 50mg Tablet (Cyclophosphamide): Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Fever above 100.4°F (38°C) or chills
- Blood in urine or painful urination
- Unusual bleeding or bruising
- Severe abdominal pain or vomiting blood
- Chest pain, shortness of breath, or irregular heartbeat
- Yellowing of skin or eyes (jaundice)
- Decreased urine output or swelling in legs
- Severe headache, confusion, or seizures
- New or worsening cough or difficulty breathing
- Sudden swelling of face, lips, or throat
If experiencing severe symptoms, call emergency services immediately.
What is cyclomet 50mg tablet used for?
Cycloxan 50mg tablet contains cyclophosphamide, a chemotherapy and immunosuppressant medicine used to treat cancers like lymphoma and leukemia, and severe autoimmune diseases like lupus. It works by damaging DNA in rapidly dividing cells. It must be taken under strict medical supervision with regular blood tests.
- Generic Name: Cyclophosphamide
- Manufacturer: BDH Industries Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cyclomet 50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा साइक्लोफॉस्फामाइड 50 मिलीग्राम की गोली है, जिसका उपयोग कैंसर जैसे लिम्फोमा, ल्यूकेमिया, स्तन कैंसर, डिम्बग्रंथि कैंसर और कुछ ऑटोइम्यून बीमारियों जैसे लूपस नेफ्राइटिस और रूमेटॉइड आर्थराइटिस के इलाज में किया जाता है। यह दवा शरीर में तेजी से बढ़ने वाली कोशिकाओं के डीएनए को नुकसान पहुंचाकर उन्हें नष्ट करती है। यह दवा केवल कैंसर विशेषज्ञ या रुमेटोलॉजिस्ट की देखरेख में ही लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, भूख न लगना, बाल झड़ना, थकान, मुंह के छाले और दस्त शामिल हैं। गंभीर दुष्प्रभावों में पेशाब में खून आना, संक्रमण, खून की कमी, हृदय और फेफड़ों को नुकसान शामिल हो सकते हैं। अगर आपको बुखार, ठंड लगना, असामान्य रक्तस्राव या पेशाब में खून दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपने आप डोज न बदलें। रोजाना 2 से 3 लीटर पानी पिएं ताकि मूत्राशय की सुरक्षा हो सके। दवा को भोजन के साथ लें। टैबलेट को चबाएं नहीं, पूरा निगल लें। संक्रमण से बचने के लिए भीड़-भाड़ वाली जगहों से बचें और हाथ धोते रहें। गर्भवती महिलाएं या स्तनपान कराने वाली महिलाएं इस दवा का सेवन न करें। नियमित रक्त जांच और डॉक्टर के फॉलो-अप जरूर कराएं।
💊 cyclomet 50mg tablet Uses & Benefits
[{"condition":"Hodgkin and non-Hodgkin lymphoma","description":"Used as part of combination chemotherapy regimens to treat various lymphomas.","evidence":"Well-established"},{"condition":"Breast cancer","description":"Included in chemotherapy protocols for early and advanced breast cancer.","evidence":"Well-established"},{"condition":"Ovarian cancer","description":"Used in combination regimens for ovarian cancer treatment.","evidence":"Well-established"},{"condition":"Chronic lymphocytic leukemia","description":"Prescribed as part of treatment for CLL and other leukemias.","evidence":"Well-established"},{"condition":"Multiple myeloma","description":"Used in combination with other agents for multiple myeloma.","evidence":"Well-established"},{"condition":"Lupus nephritis","description":"Used as an immunosuppressant to control severe kidney involvement in lupus.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reserved for severe cases not responding to other treatments.","evidence":"Moderate"},{"condition":"Vasculitis","description":"Used to induce remission in systemic vasculitis such as granulomatosis with polyangiitis.","evidence":"Well-established"},{"condition":"Nephrotic syndrome","description":"Sometimes used in steroid-resistant nephrotic syndrome.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Multiple sclerosis","description":"Occasionally used in aggressive multiple sclerosis unresponsive to standard therapy.","evidence":"Limited"},{"condition":"Scleroderma lung disease","description":"Sometimes used to treat interstitial lung disease associated with scleroderma.","evidence":"Limited"},{"condition":"Refractory myasthenia gravis","description":"Rarely used in severe myasthenia gravis not controlled by other medicines.","evidence":"Limited"}]
Primary treatment for: Cancer (various types) and severe autoimmune diseases
Also treats: Lymphoma, Leukemia, Breast cancer, Ovarian cancer, Lupus nephritis, Rheumatoid arthritis, Vasculitis
📋 Drug Information
| Generic Name(s) | Cyclophosphamide |
| Brand Name | Adcyclo Tablet |
| Manufacturer | BDH Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkylating agent |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep away from moisture and direct sunlight. Keep the container tightly closed. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Cyclophosphamide is included in the WHO Model List of Essential Medicines for the treatment of certain cancers and autoimmune diseases. Specific treatment protocols should follow institutional guidelines. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) recognizes cyclophosphamide as an essential medicine for cancer and autoimmune conditions. Treatment should be supervised by a qualified specialist. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is an alkylating agent that belongs to the nitrogen mustard family. After being activated by liver enzymes, it attaches alkyl groups to DNA, forming cross-links between DNA strands. These cross-links prevent DNA replication and transcription, leading to cell cycle arrest and programmed cell death. Because it affects all rapidly dividing cells, it is effective against cancer cells and also suppresses the immune system.
Mechanism Steps
💡 How to Take cyclomet 50mg tablet
Strength: This medicine is available as an immediate-release tablet containing 50 mg of cyclophosphamide.
Dosage Information
| Adult Dosage | The dose of this medicine is highly individualized and depends on the condition being treated, the patient's body weight, kidney and liver function, and whether it is used alone or with other medicines. For cancer treatment, doses may range from 40 to 50 mg per kg given intravenously over several days, or lower oral doses daily. For autoimmune diseases, oral doses of 1 to 2 mg per kg per day are often used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Never adjust the dose without your doctor's guidance. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist or rheumatologist for individualized dosing. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially bone marrow suppression and cardiotoxicity. Doses may need to be reduced based on kidney and liver function. Close monitoring is required. |
| Renal Impairment | In patients with kidney impairment, the dose of this medicine may need to be reduced. For patients with a creatinine clearance less than 10 mL/min, the dose may be reduced by 25 to 50 percent. Close monitoring of kidney function and blood counts is essential. |
| Hepatic Impairment | In patients with liver impairment, the metabolism of this medicine may be reduced, increasing the risk of toxicity. Dose reduction may be necessary. Liver function should be monitored closely. |
| Maximum Daily Dose | The maximum daily dose varies depending on the indication and route. For oral use, doses up to 100 mg per day are common for autoimmune diseases, but higher doses may be used in cancer treatment under close supervision. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cyclomet 50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Live vaccines | Major | |
| Allopurinol | Major | |
| Succinylcholine | Major | |
| Doxorubicin | Major | |
| Rifampin | Moderate | |
| Fluoxetine | Moderate | |
| Corticosteroids | Moderate | |
| Ondansetron | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Live vaccines
- Warfarin
- Allopurinol
- Succinylcholine
- Anthracyclines (e.g., doxorubicin)
⚡ Moderate Interactions
- CYP2B6 inducers (e.g., rifampin)
- CYP2B6 inhibitors (e.g., fluoxetine)
- Corticosteroids
- Ondansetron
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase the risk of liver damage and worsen stomach irritation. It may also increase dizziness and fatigue.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to cyclophosphamide or any component of the formulation","Severe bone marrow suppression (low white blood cells, platelets, or red blood cells)","Active serious infections","Pregnancy","Breastfeeding","Severe liver impairment","Severe kidney impairment","Urinary outflow obstruction"]
⚠️ Warnings & Precautions
["This medicine can cause severe bone marrow suppression. Regular blood tests are mandatory.","Hemorrhagic cystitis can occur. Drink plenty of fluids and empty your bladder frequently.","This medicine may increase the risk of infections. Avoid contact with sick people and practice good hygiene.","Live vaccines should not be given during treatment.","This medicine can cause fetal harm. Use effective contraception.","Do not breastfeed while taking this medicine.","This medicine may cause secondary cancers. Long-term follow-up is important.","Inform your doctor if you have liver or kidney problems.","Avoid alcohol while taking this medicine.","This medicine may impair your ability to drive or operate machinery. Use caution."]
🤱 Lactation Safety
This medicine is excreted in breast milk and may harm a nursing infant. Breastfeeding is not recommended during treatment and for at least 1 month after the last dose.
💊 Overdose Management
Overdose of this medicine can cause severe bone marrow suppression, cardiotoxicity, and hemorrhagic cystitis. There is no specific antidote. Treatment is supportive and may include hospitalization, blood transfusions, and management of complications. If you suspect an overdose, contact your doctor or poison control center immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is within a few hours of the scheduled time. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once to make up for a missed dose. Contact your doctor if you are unsure.
Additional Safety Advice
Take this medicine exactly as prescribed by your cancer specialist or rheumatologist. Never adjust the dose on your own. Drink at least two to three liters of water every day unless your doctor restricts fluids, because good hydration helps protect your bladder from irritation. Take the tablet with food to reduce nausea. Do not crush or chew the tablet; swallow it whole with water. Avoid contact with people who have colds, flu, or other infections, and wash your hands frequently. Use a soft toothbrush and an electric razor to reduce bleeding risk. Do not receive live vaccines while on this medicine. Inform every doctor, dentist, or nurse that you are taking this medicine before any procedure. Use reliable contraception during treatment and for some time after, as this medicine can harm an unborn baby. Do not breastfeed while taking this medicine. Keep all scheduled blood tests and follow-up appointments without fail.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Patients above 65 years may be more sensitive to the side effects of this medicine, especially bone marrow suppression, cardiotoxicity, and kidney toxicity. Doses may need to be reduced based on kidney and liver function. Close monitoring is essential.
🤰 Pregnancy Planning (TTC)
This medicine can cause birth defects and fetal death. Women of childbearing age should use effective contraception during treatment and for at least 12 months after stopping. Men should use condoms during treatment and for at least 6 months after stopping. If you are planning pregnancy, discuss with your doctor before starting treatment. Fertility preservation options should be considered before treatment.
🏥 Post-Surgery Considerations
This medicine can impair wound healing and increase the risk of infections after surgery. Inform your surgeon that you are taking this medicine. Your doctor may advise you to stop the medicine temporarily before surgery. Close monitoring is required after surgery.
🦷 Dental Procedures
This medicine can increase the risk of bleeding and infections after dental procedures. Inform your dentist that you are taking this medicine. Your dentist may recommend antibiotics or other precautions. Maintain good oral hygiene to prevent dental problems.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause fatigue, dizziness, and low blood counts. Avoid strenuous exercise or activities that increase the risk of bleeding or injury. Light activities like walking or yoga may be beneficial, but consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause fatigue, dizziness, and difficulty concentrating, which may affect your ability to drive or operate machinery. You may need to take time off work during treatment, especially around infusion days or when blood counts are low. Discuss your work schedule with your doctor and employer to make necessary adjustments.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping suddenly can lead to relapse of your condition. Your doctor will decide when to stop based on your response to treatment, side effects, and overall health. If you experience severe side effects, contact your doctor immediately; they may adjust the dose or switch to another medicine.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of secondary cancers, particularly bladder cancer and leukemia. It can also cause permanent infertility, especially in men. Regular monitoring of blood counts, liver and kidney function, and urine analysis is necessary. Some patients may experience chronic fatigue or heart problems. Long-term follow-up with your specialist is essential to detect and manage these effects early.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Medicines like mycophenolate mofetil or azathioprine may be used for autoimmune diseases.
Evidence: Well-establishedNewer drugs that target specific cancer cell mutations may be options for some cancers.
Evidence: Well-establishedCan help maintain mobility and reduce pain in autoimmune joint diseases.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should not be given while taking this medicine because they can cause serious infections. Inactivated vaccines may be given, but the immune response may be reduced. Inform your doctor about your vaccination history and avoid live vaccines during treatment and for some time after.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children and pets
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from moisture and direct sunlight. If crossing time zones, consult your doctor about adjusting the timing of your doses. Carry enough supply for the entire trip and a few extra days. Check customs regulations for controlled medicines in your destination country. Drink plenty of water during travel to stay hydrated.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The effects of this medicine are not immediate. It may take several weeks to months to see improvement in your condition. Your doctor will monitor your progress with regular tests.
A: You must inform your doctor about all other medicines, supplements, and herbal products you are taking. Some medicines can interact with cyclophosphamide and increase the risk of side effects.
A: If you miss a dose, take it as soon as you remember if it is within a few hours. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, this medicine can harm an unborn baby. Use effective contraception during treatment and for at least 12 months after stopping. Discuss family planning with your doctor before starting treatment.
A: No, this medicine passes into breast milk and can harm the baby. Breastfeeding is not recommended during treatment and for at least 1 month after the last dose.
🤔 Common Patient Concerns
🔄 Substitutes for cyclomet 50mg tablet
View AllAlternative brands with exact same active ingredient:
-
eldamide 50mg tabletElder Pharmaceuticals Ltd ₹22.60 15.2% CHEAPER
-
phosmid 50mg tabletNeon Laboratories Ltd ₹33.33 25.1% COSTLIER
-
cysmide 50mg tabletSamarth Life Sciences Pvt Ltd ₹35.00 31.3% COSTLIER
-
bdcyclo tabletBDR Pharmaceuticals Internationals Pvt ₹36.00 35.1% COSTLIER
-
adcyclo tabletAdley Formulations ₹38.00 42.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Cyclophosphamide is a painkiller.
Fact: Cyclophosphamide is not a painkiller. It is a chemotherapy and immunosuppressant medicine used for specific serious conditions. - Myth: You can stop taking cyclophosphamide once you feel better.
Fact: You must complete the full course as prescribed. Stopping early can lead to relapse or treatment failure. - Myth: Cyclophosphamide is safe to take during pregnancy.
Fact: Cyclophosphamide is contraindicated in pregnancy as it can harm the unborn baby. - Myth: Cyclophosphamide does not affect fertility.
Fact: Cyclophosphamide can affect fertility in both men and women. Discuss fertility preservation options with your doctor before starting treatment.
🔄 Alternative Options
Generic Alternatives
- Cyclophosphamide 50mg tablet
Brand Alternatives
- Cycloxan 50mg tablet