dydrograce tablet - Dydrogesterone (10mg) medicine

Dydrograce Tablet

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🏭 Menida Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 30, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Oct 30, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

What is dydrograce tablet used for?

This medicine contains Dydrogesterone (10mg) and is used to treat GYNAECOLOGICAL. Selective progestogen that binds to progesterone receptors, inducing secretory transformation of the. Always consult your doctor before use.

  • Generic Name: Dydrogesterone
  • Manufacturer: Menida Healthcare
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 dydrograce tablet Uses & Benefits

Progesterone supplementation in assisted reproductive technology; treatment of threatened and recurrent miscarriage; dysmenorrhea; endometriosis; secondary amenorrhea; dysfunctional uterine bleeding.

Off-label uses: Premenstrual syndrome; luteal phase support in IVF; hormone replacement therapy.

📋 Drug Information

Generic Name(s)Dydrogesterone
Brand NameCelogest 100mg Capsule
ManufacturerMenida Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGYNAECOLOGICAL
Action ClassProgestins (First generation)
Route of AdministrationOral
StorageStore at room temperature (20-25°C); protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionWell absorbed orally; peak plasma concentration reached within 2-5 hours.
DistributionDistributed widely; crosses placenta; enters breast milk.
Protein Binding>90% bound to albumin and sex hormone-binding globulin.
MetabolismExtensively metabolized in the liver via reduction and conjugation; major metabolite is 20α-dihydrodydrogesterone.
Half-Life5-7 hours for parent drug; 14-17 hours for active metabolite.
ExcretionPrimarily in urine (as metabolites); small amount in feces.
Bioavailability28% (oral) due to first-pass metabolism.
Onset of ActionWithin 24-48 hours for endometrial transformation.
Peak Plasma Time2-5 hours.
Duration of ActionApproximately 24 hours.

How It Works

Selective progestogen that binds to progesterone receptors, inducing secretory transformation of the endometrium and maintaining pregnancy.

Mechanism Steps

1Binds to progesterone receptors in target tissues.
2Induces conformational change and receptor dimerization.
3Translocation to nucleus and binding to progesterone response elements.
4Modulates gene transcription leading to secretory endometrial transformation.
5Suppresses uterine contractility and maintains pregnancy.

💡 How to Take dydrograce tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of dydrograce tablet

✅ Common Side Effects

Headache
Nausea
Abdominal pain
Breast tenderness
Dizziness
Vaginal spotting

🚨 Serious Side Effects

Thromboembolism
Severe allergic reaction
Liver dysfunction
Depression

⚠️ Rare Side Effects

Cholestatic jaundice
Anaphylaxis
Stevens-Johnson syndrome

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Rifampin Major Decreased dydrogesterone efficacy due to CYP3A4 induction.
Ketoconazole Major Increased dydrogesterone exposure; risk of side effects.
Warfarin Moderate Possible altered anticoagulant effect; monitor INR.
Corticosteroids Moderate Potential increased corticosteroid effects.
Grapefruit juice Minor May slightly increase dydrogesterone levels.

🚨 Major Interactions

  • CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)
  • CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)

⚡ Moderate Interactions

  • Warfarin
  • Corticosteroids
  • Antidiabetic agents

🍷 Alcohol Interaction

No known interaction; moderate consumption unlikely to affect efficacy.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to dydrogesterone; known or suspected progestogen-dependent tumors; undiagnosed vaginal bleeding; severe liver disease.

🤱 Lactation Safety

Excreted in breast milk in small amounts; considered compatible with breastfeeding.

💊 Overdose Management

No specific antidote; symptomatic and supportive care; gastric lavage if recent ingestion.

⏰ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose; do not double dose.

🔄 Substitutes for dydrograce tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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