Durolane 20mg Injection: Complete Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Severe joint pain, swelling, or redness that worsens after injection.
- Fever, chills, or feeling unwell.
- Inability to move the injected joint.
- Signs of allergic reaction: rash, itching, swelling of face or throat, difficulty breathing.
- Bleeding or bruising around the injection site that is excessive or increasing.
- Chest pain, shortness of breath, or rapid heartbeat.
If experiencing severe symptoms, call emergency services immediately.
What is durolane 20mg injection used for?
This medicine is a hyaluronic acid injection used to treat knee osteoarthritis by improving joint lubrication and reducing pain. It is given by a healthcare professional directly into the joint.
- Generic Name: Hyaluronic Acid
- Manufacturer: Dr Reddy's Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 durolane 20mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा हायलूरोनिक एसिड का इंजेक्शन है, जिसका उपयोग घुटनों के ऑस्टियोआर्थराइटिस (जोड़ों की घिसावट) के इलाज में किया जाता है। यह जोड़ों में चिकनाई बढ़ाकर दर्द और अकड़न को कम करती है। यह इंजेक्शन डॉक्टर द्वारा सीधे प्रभावित जोड़ में लगाया जाता है। यह दवा उन रोगियों के लिए है जिन्हें सामान्य दर्द निवारक दवाओं और फिजियोथेरेपी से लाभ नहीं हुआ है।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन की जगह पर दर्द, सूजन, लालिमा या गर्माहट शामिल हैं। कुछ रोगियों को इंजेक्शन के बाद जोड़ों में दर्द या अकड़न बढ़ सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें तेज बुखार, ठंड लगना, जोड़ों में तेज दर्द या सूजन शामिल हो सकते हैं। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य डॉक्टर द्वारा ही लगाई जानी चाहिए। खुद से इंजेक्शन न लगाएं। अगर आपको हायलूरोनिक एसिड या किसी अन्य दवा से एलर्जी है, तो डॉक्टर को बताएं। इंजेक्शन के बाद 48 घंटे तक जोड़ पर ज्यादा जोर न डालें और भारी काम न करें। अगर इंजेक्शन की जगह पर लालिमा, सूजन या बुखार हो, तो तुरंत डॉक्टर से मिलें। गर्भावस्था या स्तनपान के दौरान इस दवा का उपयोग डॉक्टर की सलाह के बिना न करें।
💊 durolane 20mg injection Uses & Benefits
[{"condition":"Osteoarthritis of the knee","description":"Reduces pain and improves joint function in patients with knee osteoarthritis who have not responded to conservative measures.","evidence":"Well-established"},{"condition":"Osteoarthritis of the hip","description":"May be used for hip osteoarthritis, though evidence is less robust than for the knee.","evidence":"Moderate"},{"condition":"Osteoarthritis of the shoulder","description":"Sometimes used for shoulder osteoarthritis, but evidence is limited.","evidence":"Limited"}]
Off-label uses: [{"condition":"Temporomandibular joint disorders","description":"Intra-articular injection may be used off-label for TMJ pain and dysfunction.","evidence":"Limited"},{"condition":"Ankle osteoarthritis","description":"Occasionally used for ankle osteoarthritis, but evidence is insufficient.","evidence":"Limited"}]
Primary treatment for: Osteoarthritis of the knee
Also treats: Osteoarthritis of the hip, Osteoarthritis of the shoulder
📋 Drug Information
| Generic Name(s) | Hyaluronic Acid |
| Brand Name | Aquim 0.18% Eye Gel |
| Manufacturer | Dr Reddy's Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Osteoarthritis- Hyaluronic acid |
| Route of Administration | Intra-articular injection (into the joint space) |
| Storage | Store in a refrigerator at 2°C to 8°C. Do not freeze. Protect from light. Keep in the original package until use. |
| Shelf Life | Refer to the expiry date on the package. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Hyaluronic acid is a high-molecular-weight polysaccharide that naturally occurs in synovial fluid and cartilage. When injected into a joint, it supplements the viscoelastic properties of synovial fluid, improving lubrication and shock absorption. It also interacts with cell surface receptors such as CD44, which may modulate inflammatory responses and stimulate endogenous hyaluronic acid production. This leads to reduced pain and improved joint function.
Mechanism Steps
💡 How to Take durolane 20mg injection
Strength: 20 mg per injection (pre-filled syringe).
Dosage Information
| Adult Dosage | The usual adult dose is a single 20 mg intra-articular injection into the affected joint. The injection is typically given once weekly for 3 to 5 weeks, depending on the product and the patient's response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients. However, elderly patients may have reduced renal or hepatic function and should be monitored accordingly. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment is required for patients with renal impairment, as systemic absorption is negligible. |
| Hepatic Impairment | No dose adjustment is required for patients with hepatic impairment, as systemic absorption is negligible. |
| Maximum Daily Dose | Not applicable. This medicine is administered as a single injection per treatment session, typically not more than once weekly. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of durolane 20mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Heparin | Major | |
| Intra-articular corticosteroids | Moderate | |
| NSAIDs | Minor |
🚨 Major Interactions
- Anticoagulants (e.g., warfarin, heparin)
⚡ Moderate Interactions
- Corticosteroids (intra-articular)
🍷 Alcohol Interaction
No known interaction with alcohol. However, excessive alcohol consumption may worsen joint inflammation and should be avoided.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to hyaluronic acid or any component of the formulation.","Active joint infection or skin infection at the injection site.","Active bleeding or bleeding disorders.","Pregnancy and breastfeeding (unless clearly needed and advised by a doctor)."]
⚠️ Warnings & Precautions
["This medicine must be administered by a qualified healthcare professional.","Do not use if the packaging is damaged or the solution is discolored.","Avoid strenuous activity or prolonged weight-bearing on the injected joint for at least 48 hours.","Inform your doctor if you have a history of allergies, especially to avian products.","Use with caution in patients with bleeding disorders or those on anticoagulants.","Not recommended for children."]
🤱 Lactation Safety
It is not known whether hyaluronic acid is excreted in human milk. Consult your doctor before receiving this medicine while breastfeeding.
💊 Overdose Management
Overdose is unlikely as this medicine is administered by a healthcare professional. In case of accidental overdose, seek immediate medical attention. Treatment is symptomatic and supportive.
⏰ Missed Dose
This medicine is given as a single injection by a healthcare professional. If you miss a scheduled appointment for your injection, contact your doctor to reschedule as soon as possible. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be administered only by a qualified healthcare professional in a sterile environment. Do not attempt to self-inject. Inform your doctor if you are allergic to hyaluronic acid, avian products, or any other medications. Tell your doctor if you have an active infection, bleeding disorder, or are taking blood-thinning medications. Avoid strenuous activity or prolonged weight-bearing on the injected joint for at least 48 hours after the injection. Do not apply heat or ice packs unless advised by your doctor. If you experience signs of infection such as fever, chills, or increasing redness and swelling, contact your doctor immediately. This medicine is not recommended during pregnancy or breastfeeding unless clearly needed and advised by your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced renal or hepatic function and should be monitored accordingly. No specific dose adjustment is required, but the benefits and risks should be carefully weighed.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before receiving this medicine. It is not recommended during pregnancy unless clearly needed.
🏥 Post-Surgery Considerations
This medicine is not typically used immediately after joint surgery. Consult your surgeon before considering this injection.
🦷 Dental Procedures
No specific precautions for dental procedures. However, inform your dentist about any medications you are taking.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid high-impact activities such as running or jumping for at least 48 hours after the injection. Gradually resume your normal exercise routine as advised by your doctor. Listen to your body and stop if you experience increased pain or swelling.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
Most patients can return to work the next day, but if your job involves heavy lifting or prolonged standing, you may need to take it easy for a few days. Driving is generally safe, but avoid driving if you experience joint pain or swelling that impairs your ability to control the vehicle.
🛑 When to Stop This Medicine
Do not stop or change your treatment plan without consulting your doctor. If you experience severe side effects or no improvement after the full course, your doctor may recommend alternative treatments.
📅 Long-Term Use Effects
Long-term effects of repeated hyaluronic acid injections are not well established. Some patients may experience continued relief, while others may not. Regular follow-up with your doctor is recommended to assess the need for continued treatment and to monitor for any adverse effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Strengthening exercises and stretching can improve joint function and reduce pain.
Evidence: Well-establishedLosing excess weight reduces stress on weight-bearing joints.
Evidence: Well-establishedNSAIDs or acetaminophen may provide temporary pain relief.
Evidence: Well-establishedIntra-articular steroids can reduce inflammation and pain in the short term.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, if you are scheduled for a vaccination, inform your doctor about your injection schedule.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C.
❌ DON'T
Do not freeze.
✅ DO
Keep in the original package to protect from light.
❌ DON'T
Do not use if the packaging is damaged or the solution is discolored.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not store at room temperature for extended periods.
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label intact. Keep it refrigerated at 2°C to 8°C during travel using a cool pack. Carry a copy of your prescription to avoid issues at customs. If traveling across time zones, consult your doctor about scheduling the injection. Do not expose the medicine to extreme temperatures or direct sunlight.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief may begin within a few days to a week, but maximum benefit may take 2 to 4 weeks.
A: The typical schedule is once weekly for 3 to 5 weeks, but your doctor will determine the exact frequency.
A: This medicine is generally used for short-term relief. Long-term use should be discussed with your doctor.
A: Consult your doctor. It is not recommended during pregnancy unless clearly needed.
A: Common side effects include injection site pain, swelling, and stiffness. Serious side effects are rare.
🤔 Common Patient Concerns
🔄 Substitutes for durolane 20mg injection
View AllAlternative brands with exact same active ingredient:
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hyalosyn 20mg injectionDr Reddy's Laboratories Ltd ₹1,400.63 92.9% CHEAPER
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hyorth 20mg injectionVirchow Biotech Pvt Ltd ₹1,500.00 92.4% CHEAPER
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kineflex 20mg injectionKinedex Healthcare Pvt Ltd ₹1,668.75 91.6% CHEAPER
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hyalgan injectionLupin Ltd ₹1,922.80 90.3% CHEAPER
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lubrione 20mg injectionZuventus Healthcare Ltd ₹16,500.00 16.6% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure osteoarthritis.
Fact: This medicine provides symptomatic relief but does not cure osteoarthritis or reverse joint damage. - Myth: This medicine is a steroid.
Fact: This medicine contains hyaluronic acid, not a steroid. It works by lubricating the joint, not by reducing inflammation like steroids. - Myth: You can inject this medicine yourself at home.
Fact: This medicine must be administered by a qualified healthcare professional in a sterile environment.