dulotin 60mg tablet - Duloxetine (60mg) medicine

Anxilox Tablet (Duloxetine 60mg): Complete Medicine Guide

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🏭 Icon Life Sciences 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 24, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: High
Reviewed by
SaathiMed Expert Panel | Sep 24, 2026

When to Call Your Doctor IMMEDIATELY

  • Thoughts of harming yourself or others
  • Agitation, hallucinations, rapid heart rate, fever, or muscle stiffness (serotonin syndrome)
  • Unusual bleeding or bruising
  • Yellowing of skin or eyes, dark urine, or severe abdominal pain (liver problems)
  • Swelling of face, lips, tongue, or throat, or difficulty breathing (allergic reaction)
  • Seizures or loss of consciousness
  • Severe headache, confusion, or weakness (hyponatremia)

If experiencing severe symptoms, call emergency services immediately.

What is dulotin 60mg tablet used for?

Anxilox tablet contains duloxetine, an SNRI used to treat depression, anxiety, and chronic pain conditions. It works by increasing serotonin and norepinephrine in the brain. The usual adult dose is 40-60 mg daily, individualized by a doctor.

  • Generic Name: Duloxetine (60mg)
  • Manufacturer: Icon Life Sciences
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 dulotin 60mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डुलोक्सेटीन नामक सक्रिय तत्व से बनी है, जिसका उपयोग अवसाद (डिप्रेशन), चिंता विकार, डायबिटिक न्यूरोपैथिक दर्द, फाइब्रोमायल्जिया और पुराने मस्कुलोस्केलेटल दर्द के इलाज के लिए किया जाता है। यह मस्तिष्क में सेरोटोनिन और नॉरएपिनेफ्रिन के स्तर को बढ़ाकर मूड को बेहतर बनाती है और दर्द को कम करती है। यह 60 मिलीग्राम की गोली के रूप में उपलब्ध है और मुंह से ली जाती है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, मुंह सूखना, नींद आना, थकान, कब्ज, भूख में कमी और पसीना आना शामिल हैं। गंभीर दुष्प्रभावों में सेरोटोनिन सिंड्रोम, रक्तस्राव का खतरा, लिवर की क्षति, गंभीर एलर्जी और युवाओं में आत्महत्या के विचार शामिल हो सकते हैं। यदि आपको बेचैनी, भ्रम, तेज धड़कन, बुखार या असामान्य रक्तस्राव हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अचानक बंद न करें, इससे दौरे, मतली और चिड़चिड़ापन जैसे लक्षण हो सकते हैं। शराब से बचें क्योंकि इससे नींद और लिवर पर असर बढ़ सकता है। ड्राइविंग या मशीन चलाते समय सावधानी बरतें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं। नियमित रूप से मूड, रक्तचाप और लिवर फंक्शन की जांच कराएं।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 dulotin 60mg tablet Uses & Benefits

[{"condition":"Major Depressive Disorder","description":"Helps improve mood, energy, and interest in daily activities by balancing neurotransmitters.","evidence":"Well-established"},{"condition":"Generalized Anxiety Disorder","description":"Reduces excessive worry and tension, improving overall functioning.","evidence":"Well-established"},{"condition":"Diabetic Peripheral Neuropathic Pain","description":"Relieves burning, stabbing, or tingling pain in the feet and hands due to nerve damage.","evidence":"Well-established"},{"condition":"Fibromyalgia","description":"Reduces widespread musculoskeletal pain and fatigue associated with fibromyalgia.","evidence":"Well-established"},{"condition":"Chronic Musculoskeletal Pain","description":"Provides relief from chronic pain related to back, neck, or osteoarthritis.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Stress Urinary Incontinence","description":"Sometimes used to improve bladder control by strengthening sphincter muscles.","evidence":"Limited"},{"condition":"Migraine Prophylaxis","description":"May help reduce frequency of migraines in some patients.","evidence":"Limited"},{"condition":"Chemotherapy-Induced Peripheral Neuropathy","description":"Occasionally prescribed to alleviate nerve pain from chemotherapy.","evidence":"Limited"}]

Primary treatment for: Major Depressive Disorder

Also treats: Generalized Anxiety Disorder, Diabetic Peripheral Neuropathic Pain, Fibromyalgia, Chronic Musculoskeletal Pain

📋 Drug Information

Generic Name(s)Duloxetine (60mg)
Brand Namedulotin 60mg tablet
ManufacturerIcon Life Sciences
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassSerotonin-norepinephrine reuptake inhibitors (SNRIs)
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and heat. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain consistent blood levels.
2
Do not stop this medicine abruptly; your doctor will taper the dose gradually to prevent withdrawal symptoms.
3
Inform your doctor if you experience mood swings, suicidal thoughts, or unusual behavior, especially in the first few weeks.
4
Avoid alcohol and recreational drugs while taking this medicine as they can worsen side effects.
5
Monitor your blood pressure regularly, as this medicine can cause slight increases.
6
If you miss a dose, take it as soon as you remember, but skip it if it's almost time for the next dose. Never double dose.
7
Keep all follow-up appointments to monitor your response and adjust the dose if needed.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Chronic joint pain
This medicine is commonly prescribed for chronic musculoskeletal pain.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary
Persistent sadness
This medicine is used for major depressive disorder.
Likely Use
Excessive worry
This medicine is used for generalized anxiety disorder.
Likely Use
Burning feet
This medicine is used for diabetic peripheral neuropathic pain.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDuloxetine is well absorbed after oral administration, with a bioavailability of approximately 50% (range 30-80%). Food does not significantly affect the extent of absorption but may delay the time to peak concentration by about 2 hours.
DistributionDuloxetine is widely distributed throughout the body. It is highly bound to plasma proteins, primarily albumin and alpha-1 acid glycoprotein. The volume of distribution is approximately 1.6 L/kg.
Protein BindingApproximately 96% bound to plasma proteins.
MetabolismDuloxetine is extensively metabolized in the liver by cytochrome P450 enzymes CYP1A2 and CYP2D6, and to a lesser extent by CYP2C19. The major metabolites are inactive.
Half-LifeThe elimination half-life of duloxetine is approximately 12 hours (range 8-17 hours).
ExcretionAbout 70% of the dose is excreted in urine as metabolites, and about 20% in feces. Less than 1% is excreted unchanged.
BioavailabilityApproximately 50% (range 30-80%).
Onset of ActionTherapeutic effects on mood may take 2-4 weeks to become noticeable, while pain relief may occur within 1-2 weeks.
Peak Plasma TimePeak plasma concentrations are reached 6 hours after oral administration.
Duration of ActionThe effects last approximately 24 hours, allowing for once-daily dosing.

How It Works

Duloxetine is a potent inhibitor of serotonin and norepinephrine reuptake transporters, which increases the synaptic availability of these neurotransmitters. This dual action is believed to underlie its efficacy in mood disorders and pain conditions. It has weak effects on dopamine reuptake and minimal activity at histaminergic, cholinergic, and adrenergic receptors, which contributes to its relatively favorable side effect profile compared to older antidepressants.

Mechanism Steps

1
Binding to transporters: Duloxetine binds to serotonin and norepinephrine transporters in the brain and spinal cord.
2
Inhibition of reuptake: It blocks the reuptake of serotonin and norepinephrine into presynaptic neurons, increasing their concentration in the synaptic cleft.
3
Enhanced neurotransmission: Elevated neurotransmitter levels lead to improved mood regulation and pain signal modulation.
4
Downstream effects: Chronic administration may lead to adaptive changes in receptor sensitivity and neuroplasticity, contributing to sustained therapeutic effects.

💡 How to Take dulotin 60mg tablet

Strength: 60 mg immediate-release tablet

1Take this medicine exactly as prescribed by your doctor.
2Swallow the tablet whole with a glass of water.
3You may take it with or without food, but taking it with food may reduce nausea.
4Take it at the same time each day to maintain consistent blood levels.
5Do not crush, chew, or break the tablet unless instructed.
6If you miss a dose, follow the missed dose instructions.
7Do not stop taking this medicine suddenly without consulting your doctor.

Dosage Information

Adult DosageThe usual adult dose for major depressive disorder and generalized anxiety disorder is 40-60 mg per day, which may be taken as a single dose or divided into two doses. For neuropathic pain and fibromyalgia, the recommended dose is 60 mg once daily. For chronic musculoskeletal pain, 30-60 mg once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed 120 mg per day.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of duloxetine. Start with a lower dose (e.g., 30 mg once daily) and titrate slowly. Monitor for hyponatremia and falls.
Renal ImpairmentFor patients with moderate renal impairment (CrCl 30-60 mL/min), no dose adjustment is needed. For severe renal impairment (CrCl <30 mL/min), duloxetine is not recommended.
Hepatic ImpairmentFor patients with mild to moderate hepatic impairment, the recommended dose is 30 mg once daily. Duloxetine is contraindicated in severe hepatic impairment.
Maximum Daily Dose120 mg per day.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and nausea.
Grapefruit
Avoid
May increase drug levels by inhibiting CYP1A2.
Alcohol
Avoid
Increases drowsiness and risk of liver damage.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of dulotin 60mg tablet

✅ Common Side Effects

Nausea (Common (10-20%))
Take with food and stay hydrated. If persistent, consult your doctor.
Dry mouth (Common (10-15%))
Sip water frequently, chew sugar-free gum, or use saliva substitutes.
Drowsiness (Common (10-15%))
Avoid driving or operating machinery until you know how it affects you. Taking at bedtime may help.
Fatigue (Common (5-10%))
Ensure adequate rest and a balanced diet. Consult if severe.
Constipation (Common (5-10%))
Increase fiber and fluid intake. Use stool softeners if needed after consulting your doctor.
Decreased appetite (Common (5-10%))
Eat small, frequent meals. Monitor weight.
Increased sweating (Common (5-10%))
Stay cool and hydrated. Consult if excessive.

🚨 Serious Side Effects

Serotonin syndrome (Rare (<0.1%))
Seek immediate medical attention if you experience agitation, hallucinations, rapid heart rate, fever, muscle stiffness, or seizures.
Increased bleeding risk (Uncommon (0.1-1%))
Report unusual bruising or bleeding. Avoid NSAIDs unless prescribed.
Liver damage (Rare (<0.1%))
Seek medical help if you notice yellowing of skin or eyes, dark urine, or severe abdominal pain.
Severe allergic reactions (Rare (<0.1%))
Get emergency help if you have swelling of face, lips, tongue, or throat, or difficulty breathing.
Suicidal thoughts (Uncommon (0.1-1%))
Contact your doctor immediately if you have new or worsening thoughts of self-harm.
Hyponatremia (low sodium) (Rare (<0.1%))
Report symptoms like headache, confusion, weakness, or seizures.

⚠️ Rare Side Effects

Angle-closure glaucoma
Seek immediate care for eye pain, vision changes, or swelling around eyes.
Pancreatitis
Go to emergency if you have severe abdominal pain radiating to back.
Seizures
Call emergency services if seizures occur.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAO inhibitors Major
Thioridazine Major
CYP1A2 inhibitors Major
CYP2D6 inhibitors Major
NSAIDs Moderate
Warfarin Moderate
Antiplatelets Moderate
Tricyclic antidepressants Moderate
Triptans Moderate
Antacids Minor

🚨 Major Interactions

  • MAO inhibitors (e.g., phenelzine, tranylcypromine)
  • Thioridazine
  • CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)

⚡ Moderate Interactions

  • NSAIDs (e.g., ibuprofen, naproxen)
  • Anticoagulants (e.g., warfarin)
  • Antiplatelet agents (e.g., aspirin, clopidogrel)
  • Tricyclic antidepressants (e.g., amitriptyline)
  • Triptans (e.g., sumatriptan)

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase drowsiness, dizziness, and the risk of liver damage. It may also worsen depression and anxiety symptoms.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Concurrent use of MAO inhibitors","Uncontrolled narrow-angle glaucoma","Hypersensitivity to duloxetine or any component","Severe liver impairment","Severe renal impairment (CrCl

⚠️ Warnings & Precautions

["Increased risk of suicidal thoughts in children, adolescents, and young adults.","Serotonin syndrome risk when used with other serotonergic drugs.","May impair physical or mental abilities; avoid driving until effects known.","Risk of bleeding, especially with NSAIDs or anticoagulants.","May cause hyponatremia, particularly in elderly.","Do not stop abruptly; taper gradually to avoid withdrawal symptoms.","Use with caution in patients with a history of mania or bipolar disorder.","May worsen glaucoma; monitor intraocular pressure."]

🤱 Lactation Safety

Duloxetine is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

💊 Overdose Management

Overdose may cause serotonin syndrome, seizures, tachycardia, and vomiting. There is no specific antidote. Treatment is supportive and symptomatic. Gastric lavage may be considered if within 1 hour of ingestion. Monitor vital signs and cardiac rhythm. Contact a poison control center immediately.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed. Do not stop suddenly as it can cause withdrawal symptoms like dizziness, nausea, and irritability. Avoid alcohol as it can worsen drowsiness and liver effects. Inform your doctor about all other medicines, especially MAOIs, NSAIDs, and blood thinners. Use caution when driving or operating machinery until you know how this medicine affects you. Regular monitoring of mood, blood pressure, and liver function may be needed. Keep all appointments with your healthcare provider.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and hyponatremia. Start with a lower dose and monitor closely. Falls and fractures are a concern; advise caution.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, discuss with your doctor before conceiving. This medicine is Pregnancy Category C and may pose risks to the fetus. Your doctor may consider switching to a safer alternative or adjusting the dose. Do not stop suddenly without medical advice.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with certain anesthetic agents and increase bleeding risk. Your doctor may advise temporary discontinuation before surgery.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine, especially if you are undergoing procedures that may cause bleeding. It may increase bleeding risk when combined with certain dental anesthetics or NSAIDs.

💚 Lifestyle Tips for Better Results

🏃
Maintain a regular sleep schedule to support mood stability.
🥗
Engage in regular physical activity like walking or yoga to boost serotonin naturally.
😴
Practice stress-reduction techniques such as deep breathing or meditation.
💧
Eat a balanced diet rich in fruits, vegetables, and whole grains.
🧘
Avoid alcohol and recreational drugs.
🌞
Stay connected with friends and family for emotional support.
🚭
Keep a mood diary to track your progress and share with your doctor.

🏋️ Exercise Considerations

This medicine may cause drowsiness or dizziness, especially when you first start taking it. Avoid strenuous exercise or activities requiring alertness until you know how it affects you. Stay hydrated during exercise.

🥗 Diet Recommendations

Include omega-3 rich foods like fish, flaxseeds, and walnuts.
Reduce intake of processed foods and added sugars.
Stay well hydrated throughout the day.
Limit caffeine as it may increase anxiety and insomnia.
Eat regular meals to maintain stable blood sugar levels.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness, dizziness, or difficulty concentrating, especially during the first few weeks. Avoid driving or operating heavy machinery until you know how it affects you. It may also affect your ability to perform tasks that require mental alertness. Discuss with your employer if you need temporary adjustments.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience serious side effects like serotonin syndrome, allergic reactions, or liver problems, seek immediate medical attention. Your doctor may decide to stop the medicine or switch to another treatment. Always taper gradually to avoid withdrawal symptoms.

📅 Long-Term Use Effects

Long-term use of this medicine may require periodic monitoring of liver function, blood pressure, and mood. Some patients may experience sexual dysfunction, weight changes, or emotional blunting. It is important to have regular follow-ups to assess the continued need and adjust the dose. Do not stop without medical advice.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Cognitive Behavioral Therapy (CBT)

Talk therapy that can be as effective as medication for mild to moderate depression and anxiety.

Evidence: Well-established
Regular Exercise

Aerobic exercise can boost mood and reduce anxiety through endorphin release.

Evidence: Well-established
Mindfulness Meditation

Helps reduce stress and improve emotional regulation.

Evidence: Moderate
Acupuncture

May help with chronic pain and depression in some patients.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your healthcare provider about all medicines you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. If traveling across time zones, adjust the timing of your dose gradually to avoid withdrawal symptoms. Store it in a cool, dry place away from direct sunlight. Check customs regulations for carrying prescription medicines. Always carry enough supply for the entire trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old woman with diabetic nerve pain
She started this medicine 60 mg daily for burning pain in her feet. After 2 weeks, the pain reduced significantly, and she could sleep better. She experienced mild nausea initially, which went away after taking the tablet with breakfast.
💡 Lesson: Taking this medicine with food can reduce nausea, and pain relief may start within 1-2 weeks.
👤 A 32-year-old man with generalized anxiety disorder
He was prescribed this medicine 60 mg daily. After 4 weeks, his anxiety symptoms improved, and he felt more relaxed. He was advised not to stop suddenly and to attend regular follow-ups.
💡 Lesson: Full benefits for anxiety may take 4-6 weeks, and gradual tapering is essential when stopping.
👤 A 58-year-old woman with fibromyalgia
She had widespread pain and fatigue for years. After starting this medicine, her pain scores dropped by half, and her energy levels improved. She combined it with gentle yoga and a balanced diet.
💡 Lesson: This medicine can be effective for fibromyalgia, and lifestyle modifications enhance outcomes.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: For depression and anxiety, it may take 2-4 weeks to notice improvement. For nerve pain, some relief may occur within 1-2 weeks.

Q: Can I stop taking this medicine suddenly?

A: No, stopping suddenly can cause withdrawal symptoms like dizziness, nausea, and irritability. Always consult your doctor for a gradual taper.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Q: Is it safe to drink alcohol while taking this medicine?

A: It is best to avoid alcohol as it can increase drowsiness, dizziness, and the risk of liver damage.

Q: Can I take this medicine during pregnancy?

A: It is classified as Pregnancy Category C. Consult your doctor to weigh the benefits and risks. It may not be recommended, especially in the third trimester.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Will I gain weight on this medicine?
  • Is it safe to take during pregnancy?

🔄 Substitutes for dulotin 60mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: Anxilox is addictive.
    Fact: Duloxetine is not considered addictive, but it can cause withdrawal symptoms if stopped abruptly. It should be tapered gradually.
  • Myth: Anxilox works immediately.
    Fact: It may take 2-4 weeks for full antidepressant effects, though pain relief may occur earlier.
  • Myth: You can stop Anxilox whenever you want.
    Fact: Stopping suddenly can cause withdrawal symptoms like dizziness, nausea, and irritability. Always consult your doctor before stopping.
  • Myth: Anxilox is only for depression.
    Fact: It is also approved for anxiety, nerve pain, fibromyalgia, and chronic musculoskeletal pain.

🔄 Alternative Options

Generic Alternatives

  • Duloxetine 60 mg tablet

Brand Alternatives

  • Anxilox

📊 Comparison with Similar Medicines

[{"medicine":"Anxilox (Duloxetine)","class":"SNRI","primary_use":"Depression, anxiety, pain","half_life":"12 hours","common_side_effects":"Nausea, dry mouth, drowsiness"},{"medicine":"Venlafaxine","class":"SNRI","primary_use":"Depression, anxiety","half_life":"5 hours","common_side_effects":"Nausea, headache, sweating"},{"medicine":"Fluoxetine","class":"SSRI","primary_use":"Depression, OCD, bulimia","half_life":"4-6 days","common_side_effects":"Insomnia, anxiety, sexual dysfunction"}]

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