Anxilox Tablet (Duloxetine 60mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Thoughts of harming yourself or others
- Agitation, hallucinations, rapid heart rate, fever, or muscle stiffness (serotonin syndrome)
- Unusual bleeding or bruising
- Yellowing of skin or eyes, dark urine, or severe abdominal pain (liver problems)
- Swelling of face, lips, tongue, or throat, or difficulty breathing (allergic reaction)
- Seizures or loss of consciousness
- Severe headache, confusion, or weakness (hyponatremia)
If experiencing severe symptoms, call emergency services immediately.
What is dulotin 60mg tablet used for?
Anxilox tablet contains duloxetine, an SNRI used to treat depression, anxiety, and chronic pain conditions. It works by increasing serotonin and norepinephrine in the brain. The usual adult dose is 40-60 mg daily, individualized by a doctor.
- Generic Name: Duloxetine (60mg)
- Manufacturer: Icon Life Sciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dulotin 60mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डुलोक्सेटीन नामक सक्रिय तत्व से बनी है, जिसका उपयोग अवसाद (डिप्रेशन), चिंता विकार, डायबिटिक न्यूरोपैथिक दर्द, फाइब्रोमायल्जिया और पुराने मस्कुलोस्केलेटल दर्द के इलाज के लिए किया जाता है। यह मस्तिष्क में सेरोटोनिन और नॉरएपिनेफ्रिन के स्तर को बढ़ाकर मूड को बेहतर बनाती है और दर्द को कम करती है। यह 60 मिलीग्राम की गोली के रूप में उपलब्ध है और मुंह से ली जाती है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, मुंह सूखना, नींद आना, थकान, कब्ज, भूख में कमी और पसीना आना शामिल हैं। गंभीर दुष्प्रभावों में सेरोटोनिन सिंड्रोम, रक्तस्राव का खतरा, लिवर की क्षति, गंभीर एलर्जी और युवाओं में आत्महत्या के विचार शामिल हो सकते हैं। यदि आपको बेचैनी, भ्रम, तेज धड़कन, बुखार या असामान्य रक्तस्राव हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अचानक बंद न करें, इससे दौरे, मतली और चिड़चिड़ापन जैसे लक्षण हो सकते हैं। शराब से बचें क्योंकि इससे नींद और लिवर पर असर बढ़ सकता है। ड्राइविंग या मशीन चलाते समय सावधानी बरतें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं। नियमित रूप से मूड, रक्तचाप और लिवर फंक्शन की जांच कराएं।
💊 dulotin 60mg tablet Uses & Benefits
[{"condition":"Major Depressive Disorder","description":"Helps improve mood, energy, and interest in daily activities by balancing neurotransmitters.","evidence":"Well-established"},{"condition":"Generalized Anxiety Disorder","description":"Reduces excessive worry and tension, improving overall functioning.","evidence":"Well-established"},{"condition":"Diabetic Peripheral Neuropathic Pain","description":"Relieves burning, stabbing, or tingling pain in the feet and hands due to nerve damage.","evidence":"Well-established"},{"condition":"Fibromyalgia","description":"Reduces widespread musculoskeletal pain and fatigue associated with fibromyalgia.","evidence":"Well-established"},{"condition":"Chronic Musculoskeletal Pain","description":"Provides relief from chronic pain related to back, neck, or osteoarthritis.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Stress Urinary Incontinence","description":"Sometimes used to improve bladder control by strengthening sphincter muscles.","evidence":"Limited"},{"condition":"Migraine Prophylaxis","description":"May help reduce frequency of migraines in some patients.","evidence":"Limited"},{"condition":"Chemotherapy-Induced Peripheral Neuropathy","description":"Occasionally prescribed to alleviate nerve pain from chemotherapy.","evidence":"Limited"}]
Primary treatment for: Major Depressive Disorder
Also treats: Generalized Anxiety Disorder, Diabetic Peripheral Neuropathic Pain, Fibromyalgia, Chronic Musculoskeletal Pain
📋 Drug Information
| Generic Name(s) | Duloxetine (60mg) |
| Brand Name | dulotin 60mg tablet |
| Manufacturer | Icon Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Serotonin-norepinephrine reuptake inhibitors (SNRIs) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and heat. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Duloxetine is a potent inhibitor of serotonin and norepinephrine reuptake transporters, which increases the synaptic availability of these neurotransmitters. This dual action is believed to underlie its efficacy in mood disorders and pain conditions. It has weak effects on dopamine reuptake and minimal activity at histaminergic, cholinergic, and adrenergic receptors, which contributes to its relatively favorable side effect profile compared to older antidepressants.
Mechanism Steps
💡 How to Take dulotin 60mg tablet
Strength: 60 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose for major depressive disorder and generalized anxiety disorder is 40-60 mg per day, which may be taken as a single dose or divided into two doses. For neuropathic pain and fibromyalgia, the recommended dose is 60 mg once daily. For chronic musculoskeletal pain, 30-60 mg once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed 120 mg per day. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of duloxetine. Start with a lower dose (e.g., 30 mg once daily) and titrate slowly. Monitor for hyponatremia and falls. |
| Renal Impairment | For patients with moderate renal impairment (CrCl 30-60 mL/min), no dose adjustment is needed. For severe renal impairment (CrCl <30 mL/min), duloxetine is not recommended. |
| Hepatic Impairment | For patients with mild to moderate hepatic impairment, the recommended dose is 30 mg once daily. Duloxetine is contraindicated in severe hepatic impairment. |
| Maximum Daily Dose | 120 mg per day. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dulotin 60mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| Thioridazine | Major | |
| CYP1A2 inhibitors | Major | |
| CYP2D6 inhibitors | Major | |
| NSAIDs | Moderate | |
| Warfarin | Moderate | |
| Antiplatelets | Moderate | |
| Tricyclic antidepressants | Moderate | |
| Triptans | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- Thioridazine
- CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen, naproxen)
- Anticoagulants (e.g., warfarin)
- Antiplatelet agents (e.g., aspirin, clopidogrel)
- Tricyclic antidepressants (e.g., amitriptyline)
- Triptans (e.g., sumatriptan)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase drowsiness, dizziness, and the risk of liver damage. It may also worsen depression and anxiety symptoms.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Concurrent use of MAO inhibitors","Uncontrolled narrow-angle glaucoma","Hypersensitivity to duloxetine or any component","Severe liver impairment","Severe renal impairment (CrCl
⚠️ Warnings & Precautions
["Increased risk of suicidal thoughts in children, adolescents, and young adults.","Serotonin syndrome risk when used with other serotonergic drugs.","May impair physical or mental abilities; avoid driving until effects known.","Risk of bleeding, especially with NSAIDs or anticoagulants.","May cause hyponatremia, particularly in elderly.","Do not stop abruptly; taper gradually to avoid withdrawal symptoms.","Use with caution in patients with a history of mania or bipolar disorder.","May worsen glaucoma; monitor intraocular pressure."]
🤱 Lactation Safety
Duloxetine is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
Overdose may cause serotonin syndrome, seizures, tachycardia, and vomiting. There is no specific antidote. Treatment is supportive and symptomatic. Gastric lavage may be considered if within 1 hour of ingestion. Monitor vital signs and cardiac rhythm. Contact a poison control center immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.
Additional Safety Advice
Take this medicine exactly as prescribed. Do not stop suddenly as it can cause withdrawal symptoms like dizziness, nausea, and irritability. Avoid alcohol as it can worsen drowsiness and liver effects. Inform your doctor about all other medicines, especially MAOIs, NSAIDs, and blood thinners. Use caution when driving or operating machinery until you know how this medicine affects you. Regular monitoring of mood, blood pressure, and liver function may be needed. Keep all appointments with your healthcare provider.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and hyponatremia. Start with a lower dose and monitor closely. Falls and fractures are a concern; advise caution.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before conceiving. This medicine is Pregnancy Category C and may pose risks to the fetus. Your doctor may consider switching to a safer alternative or adjusting the dose. Do not stop suddenly without medical advice.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with certain anesthetic agents and increase bleeding risk. Your doctor may advise temporary discontinuation before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, especially if you are undergoing procedures that may cause bleeding. It may increase bleeding risk when combined with certain dental anesthetics or NSAIDs.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness or dizziness, especially when you first start taking it. Avoid strenuous exercise or activities requiring alertness until you know how it affects you. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness, dizziness, or difficulty concentrating, especially during the first few weeks. Avoid driving or operating heavy machinery until you know how it affects you. It may also affect your ability to perform tasks that require mental alertness. Discuss with your employer if you need temporary adjustments.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects like serotonin syndrome, allergic reactions, or liver problems, seek immediate medical attention. Your doctor may decide to stop the medicine or switch to another treatment. Always taper gradually to avoid withdrawal symptoms.
📅 Long-Term Use Effects
Long-term use of this medicine may require periodic monitoring of liver function, blood pressure, and mood. Some patients may experience sexual dysfunction, weight changes, or emotional blunting. It is important to have regular follow-ups to assess the continued need and adjust the dose. Do not stop without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Talk therapy that can be as effective as medication for mild to moderate depression and anxiety.
Evidence: Well-establishedAerobic exercise can boost mood and reduce anxiety through endorphin release.
Evidence: Well-establishedHelps reduce stress and improve emotional regulation.
Evidence: ModerateMay help with chronic pain and depression in some patients.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. If traveling across time zones, adjust the timing of your dose gradually to avoid withdrawal symptoms. Store it in a cool, dry place away from direct sunlight. Check customs regulations for carrying prescription medicines. Always carry enough supply for the entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: For depression and anxiety, it may take 2-4 weeks to notice improvement. For nerve pain, some relief may occur within 1-2 weeks.
A: No, stopping suddenly can cause withdrawal symptoms like dizziness, nausea, and irritability. Always consult your doctor for a gradual taper.
A: Take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: It is best to avoid alcohol as it can increase drowsiness, dizziness, and the risk of liver damage.
A: It is classified as Pregnancy Category C. Consult your doctor to weigh the benefits and risks. It may not be recommended, especially in the third trimester.
🤔 Common Patient Concerns
🔄 Substitutes for dulotin 60mg tablet
View AllAlternative brands with exact same active ingredient:
-
dutin 60 mg capsuleSun Pharmaceutical Industries Ltd ₹109.37 52.4% CHEAPER
-
dxt 60mg tabletReliance Formulation Pvt Ltd ₹113.44 50.6% CHEAPER
-
cendu 60mg capsuleUSV Ltd ₹118.99 48.2% CHEAPER
-
dlx 60mg tabletSolitaire Pharmacia Pvt Ltd ₹119.50 48% CHEAPER
-
diligo 60mg tabletSalveo Lifecare ₹120.00 47.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Anxilox is addictive.
Fact: Duloxetine is not considered addictive, but it can cause withdrawal symptoms if stopped abruptly. It should be tapered gradually. - Myth: Anxilox works immediately.
Fact: It may take 2-4 weeks for full antidepressant effects, though pain relief may occur earlier. - Myth: You can stop Anxilox whenever you want.
Fact: Stopping suddenly can cause withdrawal symptoms like dizziness, nausea, and irritability. Always consult your doctor before stopping. - Myth: Anxilox is only for depression.
Fact: It is also approved for anxiety, nerve pain, fibromyalgia, and chronic musculoskeletal pain.
🔄 Alternative Options
Generic Alternatives
- Duloxetine 60 mg tablet
Brand Alternatives
- Anxilox