Drotaverine 40 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction with swelling of face, lips, or throat, or difficulty breathing.
- Fast, irregular, or pounding heartbeat.
- Fainting or severe dizziness.
- Chest pain or shortness of breath.
- Yellowing of skin or eyes, dark urine, or severe abdominal pain.
- Unusual bleeding or bruising.
- Decreased urine output or swelling in the legs.
If experiencing severe symptoms, call emergency services immediately.
What is drot 40mg injection used for?
Drotaverine 40 mg tablet is an antispasmodic medicine used to relieve smooth muscle spasms in the stomach, intestines, bile ducts, and urinary tract. It works by relaxing the muscles, which helps reduce pain and cramping. It is usually taken 2-3 times a day as prescribed by a doctor.
- Generic Name: Drotaverine
- Manufacturer: Mapra Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 drot 40mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा ड्रोटावेरिन 40 मिलीग्राम की गोली है, जिसका उपयोग पेट, आंतों, पित्त नली और मूत्र मार्ग की मांसपेशियों में होने वाली ऐंठन और दर्द को कम करने के लिए किया जाता है। यह मांसपेशियों को आराम देकर काम करती है। इसे डॉक्टर के कहे अनुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, मुँह सूखना, सिरदर्द, चक्कर आना और शरीर में गर्मी लगना शामिल हैं। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। गंभीर दुष्प्रभाव जैसे तेज़ धड़कन, कम रक्तचाप, या एलर्जी होने पर तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपने आप मात्रा न बढ़ाएँ। इसे पानी के साथ निगलें। खाने के साथ लेने से पेट की जलन कम हो सकती है। दवा लेने के बाद चक्कर आने पर वाहन न चलाएँ। शराब न पिएँ। गर्भवती या स्तनपान कराने वाली महिलाएँ डॉक्टर से सलाह लें।
💊 drot 40mg injection Uses & Benefits
[{"condition":"Gastrointestinal spasms","description":"Relieves cramping and spasm in the stomach and intestines, often associated with irritable bowel syndrome or gastroenteritis.","evidence":"Well-established"},{"condition":"Biliary spasms","description":"Eases spasm in the bile ducts, which can occur in gallstones or after certain procedures.","evidence":"Well-established"},{"condition":"Renal colic","description":"Helps relax the smooth muscle of the urinary tract, reducing pain from kidney stones.","evidence":"Moderate"},{"condition":"Dysmenorrhea","description":"Reduces menstrual cramps by relaxing the uterine smooth muscle.","evidence":"Moderate"},{"condition":"Labor pain","description":"Sometimes used to help relax the cervix during labor, but only under strict medical supervision.","evidence":"Limited"}]
Off-label uses: [{"condition":"Tension headache","description":"Occasionally used off-label for tension-type headaches, but evidence is limited.","evidence":"Limited"},{"condition":"Esophageal spasm","description":"May be used off-label to relieve spasm in the esophagus, but not a standard treatment.","evidence":"Limited"}]
Primary treatment for: Gastrointestinal spasms
Also treats: Biliary spasms, Renal colic, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Drotaverine |
| Brand Name | Antispasmin DS 80mg Tablet |
| Manufacturer | Mapra Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Phosphodiesterase-IV inhibitors (Smooth Muscle Relaxant) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Keep away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the enzyme phosphodiesterase type 4 (PDE4), which leads to an increase in cyclic adenosine monophosphate (cAMP) inside smooth muscle cells. The higher cAMP levels reduce the availability of calcium ions needed for muscle contraction, causing the smooth muscle to relax. This action is selective for smooth muscle and does not significantly affect skeletal muscle or heart muscle at usual doses. By relaxing the smooth muscle, it relieves spasms and the pain associated with them.
Mechanism Steps
💡 How to Take drot 40mg injection
Strength: Drotaverine 40 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 40 mg to 80 mg taken two to three times a day, depending on the condition being treated. For acute spasms, a doctor may prescribe a higher initial dose. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and low blood pressure. Start with a lower dose and monitor closely. The dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with severe kidney impairment, this medicine should be used with caution. The dose may need to be reduced. Consult your doctor for individualized dosing. |
| Hepatic Impairment | In patients with severe liver impairment, this medicine is contraindicated. In mild to moderate liver impairment, use with caution and under medical supervision. Dose adjustment may be necessary. |
| Maximum Daily Dose | The maximum recommended daily dose is 240 mg, but this should not be exceeded without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of drot 40mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Levodopa | Major | |
| Sildenafil | Major | |
| Ketoconazole | Moderate | |
| Rifampicin | Moderate | |
| Amlodipine | Moderate | |
| Atropine | Minor | |
| Morphine | Minor | |
| Warfarin | Minor | |
| Metformin | Minor | |
| Omeprazole | Minor |
🚨 Major Interactions
- Levodopa
- PDE5 inhibitors (e.g., sildenafil, tadalafil)
⚡ Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin)
- Antihypertensives
🍷 Alcohol Interaction
Alcohol can increase the dizziness, drowsiness, and low blood pressure caused by this medicine. It is best to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe heart failure or other severe heart disease.","Severe liver disease.","Severe kidney disease.","Known allergy to drotaverine or any ingredient in the tablet.","Children under 12 years of age, unless prescribed by a pediatrician."]
⚠️ Warnings & Precautions
["Use with caution in patients with low blood pressure or heart rhythm problems.","Avoid driving or operating machinery if you feel dizzy.","Do not drink alcohol while taking this medicine.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Tell your doctor about all other medicines you are taking, especially for heart disease, Parkinson's disease, or erectile dysfunction.","Do not take this medicine for longer than prescribed without consulting your doctor."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because many drugs do, caution is advised. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose may cause severe low blood pressure, fast heartbeat, and dizziness. If you suspect an overdose, contact your doctor or a poison control center immediately. Treatment is supportive and symptomatic, with monitoring of vital signs.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase the dose or take it more often than advised. Swallow the tablet whole with a glass of water. It can be taken with or without food, but taking it with food may reduce stomach upset. Avoid driving or operating heavy machinery if you feel dizzy after taking this medicine. Do not drink alcohol while taking this medicine, as it can increase dizziness and low blood pressure. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Tell your doctor about all other medicines you are taking, especially blood pressure medicines, heart medicines, and antidepressants. Keep this medicine out of the reach of children. Store it at room temperature, away from direct sunlight and moisture.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine, especially dizziness and low blood pressure. They should start with a lower dose and be monitored closely. Falls are a risk if dizziness occurs.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It should only be used if clearly needed. Discuss any concerns with your healthcare provider.
🏥 Post-Surgery Considerations
After surgery, this medicine may be used to relieve spasms, but only under medical supervision. Inform your surgeon and anesthesiologist that you are taking this medicine.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with certain medications used during dental procedures, such as sedatives. No major precautions are typically needed, but always disclose your medication list.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise immediately after taking this medicine if you feel dizzy or lightheaded. Listen to your body and rest if needed. Gentle stretching and walking are usually safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause dry mouth, so keep water handy. Most people can continue their normal activities with caution.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as fast heartbeat, fainting, allergic reactions, or yellowing of the eyes. Do not stop taking it abruptly if you have been on it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine should be under medical supervision. It is generally well tolerated, but prolonged use may increase the risk of side effects such as dizziness, low blood pressure, and rarely liver problems. Regular monitoring of liver and kidney function may be advised if used for extended periods. Do not use it for longer than prescribed without consulting your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Applying a heating pad to the abdomen can help relax muscles and relieve cramps.
Evidence: Well-establishedEnteric-coated peppermint oil capsules may help with IBS-related spasms.
Evidence: ModerateMay improve gut health and reduce spasms in some individuals.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive vaccinations while taking this medicine, but inform your healthcare provider.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If you are crossing time zones, adjust your dosing schedule gradually, but consult your doctor for specific advice. Keep it in your carry-on luggage to avoid loss. Check local customs regulations regarding prescription medicines before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 to 60 minutes after you take it.
A: It can be taken with or without food, but taking it with food may reduce stomach upset.
A: It should only be used during pregnancy if clearly needed and prescribed by your doctor. Consult your doctor for advice.
A: There is no known major interaction between this medicine and paracetamol. However, always consult your doctor before combining medicines.
🤔 Common Patient Concerns
🔄 Substitutes for drot 40mg injection
View AllAlternative brands with exact same active ingredient:
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inorine 40mg injectionInd Swift Laboratories Ltd ₹8.18 17.8% CHEAPER
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Smoothspas 40mg InjectionP R G Pharma Pvt Ltd ₹10.31 3.6% COSTLIER
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Rotaspas 40mg InjectionBiological E Ltd ₹10.85 9% COSTLIER
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abdocin 40mg injectionAltar Healthcare Pvt Ltd ₹11.00 10.6% COSTLIER
-
diver 40mg injectionCorvin Pharmaceuticals ₹11.25 13.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Drotaverine is a general painkiller.
Fact: Drotaverine is not a general painkiller. It specifically relieves smooth muscle spasms and is not effective for headaches, muscle aches, or fever. - Myth: Drotaverine can be taken for any stomach pain.
Fact: Drotaverine is only for spasmodic pain. It should not be used for pain caused by conditions like appendicitis or bowel obstruction without medical evaluation. - Myth: Drotaverine is safe to take without a prescription.
Fact: Drotaverine is a prescription medicine. It should only be taken when prescribed by a doctor.
🔄 Alternative Options
Generic Alternatives
- Drotaverine 40 mg tablet
- Drotaverine hydrochloride 40 mg tablet
Brand Alternatives
- Drotin
- Drotin-M
- Drotikind
- Drotaverine