drot 40mg injection

4.3 (13 reviews)

Drotaverine (40mg)

🏭 Mapra Laboratories Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is drot 40mg injection used for?

Antispasmin DS 80mg Tablet (Drotaverine) is used to treat GASTRO INTESTINAL. It contains Drotaverine (40mg), which Inhibits phosphodiesterase-4 (PDE4), increasing cAMP, leading to smooth muscle r. Always consult your doctor before use. Take as prescribed.

Generic Name: Drotaverine
Manufacturer: Mapra Laboratories Pvt Ltd
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 drot 40mg injection Uses & Benefits

Smooth muscle spasms in GI disorders, biliary colic, renal colic, dysmenorrhea.

Off-label uses: Premature labor (not FDA approved).

📋 Drug Information

Generic Name(s)	Drotaverine
Brand Name	Antispasmin DS 80mg Tablet
Manufacturer	Mapra Laboratories Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	GASTRO INTESTINAL
Action Class	Phosphodiesterase-IV inhibitors (Smooth Muscle Relaxant)
Route of Administration	Oral
Storage	Store at room temperature (20-25°C), protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration.

DistributionWidely distributed in body tissues.

Protein Binding95-98%

MetabolismHepatic, primarily via CYP2D6 and CYP3A4.

Half-Life7-12 hours

ExcretionRenal (50% as metabolites, 10% unchanged) and fecal.

Bioavailability~50%

Onset of Action30-60 minutes

Peak Plasma Time1-2 hours

Duration of Action4-6 hours

How It Works

Inhibits phosphodiesterase-4 (PDE4), increasing cAMP, leading to smooth muscle relaxation.

Mechanism Steps

1Inhibition of PDE4 enzyme

2Increased intracellular cAMP levels

3Activation of protein kinase A

💡 How to Take drot 40mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of drot 40mg injection

✅ Common Side Effects

Nausea
Vomiting
Dizziness
Headache
Dry mouth

🚨 Serious Side Effects

Hypotension
Arrhythmias
Allergic reactions

⚠️ Rare Side Effects

Hepatotoxicity
Leukopenia
Thrombocytopenia

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Levodopa	Major	Reduced efficacy of levodopa
Tricyclic antidepressants	Major	Increased anticholinergic effects
Antihypertensives	Moderate	Additive hypotensive effect
Other anticholinergics	Moderate	Increased anticholinergic side effects
Cimetidine	Minor	Possible increased drotaverine levels
Ranitidine	Minor	Possible increased drotaverine levels

🚨 Major Interactions

Levodopa
Tricyclic antidepressants

⚡ Moderate Interactions

Antihypertensives
Other anticholinergics

ℹ️ Minor Interactions

Cimetidine
Ranitidine

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

May increase risk of hypotension and dizziness.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to drotaverine, severe hepatic or renal impairment, porphyria.

📊 Monitoring Parameters

Blood pressure, liver function tests in long-term use.

🤱 Lactation Safety

Caution advised; excreted in breast milk.

💊 Overdose Management

Symptomatic and supportive treatment; no specific antidote.

⏰ Missed Dose

Take as soon as remembered; skip if almost time for next dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

🔗 View Profile

🔄 Substitutes for drot 40mg injection

View All

Alternative brands with exact same active ingredient (Drotaverine (40mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Trusted Reviewer Jul 10, 2026

Found this to be a helpful product. Good results.

Regular Customer Jul 10, 2026