drojeen-plus tablet - Drotaverine (80mg) + Paracetamol (500mg) medicine

Dvn Forte 80 mg/500 mg Tablet: Complete Information

No reviews yet
🏭 Jeen Lifesciences Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is drojeen-plus tablet used for?

This medicine is a combination of Drotaverine and Paracetamol used to relieve pain and spasms in conditions like abdominal cramps, biliary colic, and menstrual cramps. It works by relaxing smooth muscles and reducing pain.

  • Generic Name: Drotaverine (80mg) + Paracetamol (500mg)
  • Manufacturer: Jeen Lifesciences Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 drojeen-plus tablet के बारे में (Hindi Summary)

उपयोग: यह दवा पेट की ऐंठन, पित्ताशय की ऐंठन, गुर्दे की ऐंठन और मासिक धर्म के दर्द में राहत देने के लिए उपयोग की जाती है। यह मांसपेशियों को आराम देकर दर्द कम करती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, मुंह सूखना, चक्कर आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन यकृत की क्षति या एलर्जी हो सकती है।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। शराब का सेवन न करें। यकृत या गुर्दे की समस्या हो तो डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 drojeen-plus tablet Uses & Benefits

[{"condition":"Abdominal cramps","description":"Relieves pain and spasms in the gastrointestinal tract.","evidence":"Well-established"},{"condition":"Biliary colic","description":"Helps relax the smooth muscles of the biliary tract, reducing pain.","evidence":"Well-established"},{"condition":"Renal colic","description":"Provides relief from pain caused by kidney stones by relaxing ureteral muscles.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Reduces menstrual cramps by relaxing uterine muscles.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Irritable bowel syndrome","description":"Sometimes used to relieve spasms and pain in IBS, but not a primary treatment.","evidence":"Limited"}]

Primary treatment for: Smooth muscle spasms

Also treats: Biliary colic, Renal colic, Dysmenorrhea

📋 Drug Information

Generic Name(s)Drotaverine (80mg) + Paracetamol (500mg)
Brand Namedrojeen-plus tablet
ManufacturerJeen Lifesciences Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) away from direct sunlight and moisture.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Stay well hydrated throughout the day.
3
Avoid alcohol while taking this medicine.
4
Do not take more than the prescribed dose.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Report any unusual bleeding or bruising immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Abdominal cramps
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDrotaverine is rapidly absorbed after oral administration. Paracetamol is also rapidly and completely absorbed from the gastrointestinal tract.
DistributionDrotaverine is highly protein-bound and distributes widely in tissues. Paracetamol distributes throughout most body fluids.
Protein BindingDrotaverine: High (approximately 95-98%). Paracetamol: Low (approximately 10-25%).
MetabolismDrotaverine is extensively metabolized in the liver. Paracetamol is metabolized primarily in the liver via glucuronidation and sulfation, with a small fraction via CYP2E1 to a toxic metabolite.
Half-LifeDrotaverine: Approximately 8-10 hours. Paracetamol: 2-3 hours.
ExcretionDrotaverine is excreted mainly in urine and feces. Paracetamol is excreted in urine as metabolites.
BioavailabilityDrotaverine: Approximately 25-91% (variable). Paracetamol: 80-100%.
Onset of ActionDrotaverine: 30-60 minutes. Paracetamol: 30-60 minutes.
Peak Plasma TimeDrotaverine: 1-2 hours. Paracetamol: 0.5-2 hours.
Duration of ActionDrotaverine: 4-6 hours. Paracetamol: 4-6 hours.

How It Works

Drotaverine works by inhibiting phosphodiesterase 4 (PDE4), leading to increased cyclic adenosine monophosphate (cAMP) levels, which results in relaxation of smooth muscle. Paracetamol acts centrally to inhibit prostaglandin synthesis, thereby reducing pain and fever.

Mechanism Steps

1
PDE4 inhibition by Drotaverine: Drotaverine inhibits PDE4, increasing cAMP levels in smooth muscle cells.
2
Smooth muscle relaxation: Elevated cAMP leads to relaxation of smooth muscle, relieving spasms.
3
Central COX inhibition by Paracetamol: Paracetamol inhibits COX enzymes in the central nervous system, reducing prostaglandin synthesis.
4
Analgesia and antipyresis: Decreased prostaglandins result in reduced pain perception and fever.

💡 How to Take drojeen-plus tablet

Strength: Tablet containing Drotaverine 80 mg and Paracetamol 500 mg.

1Take the tablet orally with a glass of water.
2Swallow whole; do not crush or chew.
3Take with or without food.
4Follow the prescribed schedule.
5Do not exceed the recommended dose.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken 2 to 3 times daily, depending on the severity of the condition. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may require dose adjustment based on renal and hepatic function. Consult a doctor.
Renal ImpairmentDose adjustment may be needed in patients with renal impairment. Consult a doctor.
Hepatic ImpairmentDose adjustment may be needed in patients with hepatic impairment. Consult a doctor.
Maximum Daily DoseThe maximum daily dose is 3 tablets (240 mg drotaverine and 1500 mg paracetamol). Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of drojeen-plus tablet

✅ Common Side Effects

Nausea (Common (1-10%))
Take with food to reduce nausea. Consult doctor if persistent.
Dry mouth (Common (1-10%))
Stay hydrated. Usually resolves on its own.
Dizziness (Common (1-10%))
Avoid driving or operating machinery until you know how it affects you.
Headache (Common (1-10%))
Rest and stay hydrated. Consult doctor if severe.

🚨 Serious Side Effects

Severe allergic reaction (Rare (<0.1%))
Seek immediate medical attention if you experience rash, itching, swelling, or difficulty breathing.
Liver damage (Rare (<0.1%))
Report symptoms like yellowing of skin or eyes, dark urine, or abdominal pain immediately.
Blood disorders (Very rare (<0.01%))
Consult doctor if you notice unusual bleeding or bruising.

⚠️ Rare Side Effects

Hypotension
Seek medical attention if you feel faint or have low blood pressure.
Thrombocytopenia
Report unusual bleeding or bruising to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Alcohol Major
Carbamazepine Moderate
Phenytoin Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Alcohol

⚡ Moderate Interactions

  • Carbamazepine
  • Phenytoin

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine as it can increase the risk of liver damage and enhance central nervous system depression.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to drotaverine or paracetamol","Severe liver disease","Severe kidney disease","Children under 12 years"]

⚠️ Warnings & Precautions

["Do not exceed recommended dose.","Avoid alcohol.","Use with caution in liver or kidney impairment.","May cause dizziness; avoid driving.","Consult doctor if symptoms persist."]

🤱 Lactation Safety

Not established from the available information. Consult your doctor before use.

💊 Overdose Management

Seek immediate medical attention. Overdose can cause severe liver damage. Treatment includes activated charcoal, N-acetylcysteine, and supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid alcohol while taking this medicine as it can increase the risk of liver damage. Inform your doctor if you have liver or kidney problems, or if you are pregnant or breastfeeding. Do not use this medicine for prolonged periods without medical advice. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine. Dose adjustment may be needed based on liver and kidney function.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy if you are taking this medicine. The safety of this medicine during pregnancy is not well established.

🏥 Post-Surgery Considerations

Consult your doctor before using this medicine after surgery, as it may interact with other medications or affect recovery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may interact with anesthetics or other medications used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming.
😴
Practice good posture.
💧
Include anti-inflammatory foods in your diet.
🧘
Get adequate sleep.

🏋️ Exercise Considerations

Avoid strenuous exercise if you experience dizziness or fatigue while taking this medicine. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods
Reduce processed food intake
Stay well hydrated

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. It may affect your ability to concentrate.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, seek medical advice immediately.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of liver and kidney damage, especially with high doses. Regular monitoring of liver and kidney function is recommended. Do not use for prolonged periods without medical advice.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain.

Evidence: Well-established
Heat therapy

Applying heat to the affected area can help relax muscles.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are known. Consult your doctor for personalized advice.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with severe menstrual cramps
She was prescribed this medicine for dysmenorrhea. She experienced significant relief within an hour of taking it. She was advised to take it with food to avoid nausea.
💡 Lesson: Taking the medicine with food improves tolerability and ensures better relief.
👤 A 50-year-old man with biliary colic
He received this medicine for biliary colic pain. The pain subsided within 30 minutes. He was monitored for liver function due to paracetamol content.
💡 Lesson: Regular monitoring of liver function is important when using this medicine, especially in patients with liver disease.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30-60 minutes after oral administration.

Q: Can I take it on an empty stomach?

A: It can be taken with or without food, but taking it with food may reduce stomach upset.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for drojeen-plus tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any type of pain.
    Fact: It is specifically for smooth muscle spasms and should not be used for all pain types.
  • Myth: It is safe to take without a prescription.
    Fact: It is a prescription medicine and should only be taken under medical supervision.

🔄 Alternative Options

Generic Alternatives

  • Drotaverine + Paracetamol generic tablets

Brand Alternatives

  • Dvn Forte 80 mg/500 mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Dicyclomine + Paracetamol","difference":"Dicyclomine is an anticholinergic antispasmodic, while Drotaverine is a PDE4 inhibitor."}]

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory