dozil 5mg tablet - Donepezil (5mg) medicine

dozil 5mg tablet - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Zota Pharmaceuticals Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jul 1, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jul 01, 2026

What is dozil 5mg tablet used for?

Aricep 5 Tablet (Donepezil) is used to treat NEURO CNS. It contains Donepezil (5mg), which Reversible inhibition of acetylcholinesterase, increasing acetylcholine levels i. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Donepezil
  • Manufacturer: Zota Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š dozil 5mg tablet Uses & Benefits

Mild to moderate Alzheimer's disease; also used for severe Alzheimer's disease.

Off-label uses: Vascular dementia, Lewy body dementia, cognitive impairment in Parkinson's disease.

๐Ÿ“‹ Drug Information

Generic Name(s)Donepezil
Brand NameAricep 5 Tablet
ManufacturerZota Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassCholinesterase inhibitors - Alzheimer's disease
Route of AdministrationOral.
StorageStore at 20-25ยฐC (68-77ยฐF); protect from moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed after oral administration; peak plasma concentrations reached in 3-4 hours; food delays absorption but does not affect extent.
DistributionWidely distributed; steady-state volume of distribution is approximately 12 L/kg; crosses blood-brain barrier.
Protein BindingApproximately 96% bound to plasma proteins, mainly albumin.
MetabolismExtensively metabolized by CYP450 enzymes (CYP2D6 and CYP3A4) and glucuronidation; multiple active metabolites.
Half-LifeApproximately 70 hours (terminal half-life).
ExcretionRenal excretion of metabolites; unchanged drug accounts for less than 1% of dose.
BioavailabilityApproximately 100% (oral).
Onset of ActionWithin 2-4 weeks of therapy.
Peak Plasma Time3-4 hours.
Duration of Action24 hours (once-daily dosing).

How It Works

Reversible inhibition of acetylcholinesterase, increasing acetylcholine levels in the brain.

Mechanism Steps

1Donepezil binds reversibly to acetylcholinesterase (AChE) in the central nervous system.
2Inhibition of AChE prevents hydrolysis of acetylcholine (ACh).
3Increased ACh levels in synaptic clefts enhance cholinergic neurotransmission.

๐Ÿ’ก How to Take dozil 5mg tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of dozil 5mg tablet

โœ… Common Side Effects

  • Nausea
  • Diarrhea
  • Insomnia
  • Fatigue
  • Muscle cramps
  • Anorexia

๐Ÿšจ Serious Side Effects

  • Bradycardia
  • Syncope
  • Gastrointestinal bleeding
  • Seizures
  • QT prolongation

โš ๏ธ Rare Side Effects

  • Hepatotoxicity
  • Neuroleptic malignant syndrome
  • Rhabdomyolysis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Anticholinergics Major Reduced efficacy of donepezil
Succinylcholine Major Prolonged neuromuscular blockade
NSAIDs Major Increased risk of gastrointestinal bleeding
CYP2D6 inhibitors (e.g., quinidine) Moderate Increased donepezil levels
CYP3A4 inhibitors (e.g., ketoconazole) Moderate Increased donepezil levels
CYP2D6 inducers (e.g., carbamazepine) Moderate Decreased donepezil levels
CYP3A4 inducers (e.g., rifampin) Moderate Decreased donepezil levels
Antacids Minor Possible decreased absorption
Cimetidine Minor Possible increased donepezil levels

๐Ÿšจ Major Interactions

  • Anticholinergic drugs
  • Cholinergic agonists
  • Succinylcholine
  • NSAIDs

โšก Moderate Interactions

  • CYP2D6 inhibitors
  • CYP3A4 inhibitors
  • CYP2D6 inducers
  • CYP3A4 inducers

โ„น๏ธ Minor Interactions

  • Antacids
  • Cimetidine

๐Ÿฝ๏ธ Food Interactions

Food delays absorption but does not affect overall bioavailability.

๐Ÿท Alcohol Interaction

Alcohol may increase CNS depression; avoid concurrent use.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to donepezil or piperidine derivatives; history of gastrointestinal bleeding; sick sinus syndrome or other supraventricular conduction abnormalities.

๐Ÿ“Š Monitoring Parameters

Cognitive function, behavior, heart rate, gastrointestinal symptoms, weight.

๐Ÿคฑ Lactation Safety

Not recommended; excreted in animal milk, unknown in humans.

๐Ÿ’Š Overdose Management

Supportive care; atropine for cholinergic crisis; monitor for bradycardia and seizures.

โฐ Missed Dose

Take as soon as remembered; if close to next dose, skip missed dose; do not double.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jul 01, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for dozil 5mg tablet

View All

Alternative brands with exact same active ingredient (Donepezil (5mg)):

Medical Note: Always consult your doctor before switching medications.

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