doxin 25mg capsule - Uses, Price, Side Effects & Substitutes
What is doxin 25mg capsule used for?
Sinequan (Doxepin) is used to treat NEURO CNS. It contains Doxepin (25mg), which Inhibits reuptake of serotonin and norepinephrine in the central nervous system,. Always consult your doctor before use. Take as prescribed.
- Generic Name: Doxepin
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ doxin 25mg capsule Uses & Benefits
Major depressive disorder; anxiety disorders; insomnia; chronic pain; neuropathic pain.
Off-label uses: Insomnia, chronic pain, fibromyalgia, migraine prophylaxis.
๐ Drug Information
| Generic Name(s) | Doxepin |
| Brand Name | Sinequan |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressants |
| Route of Administration | Oral. |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits reuptake of serotonin and norepinephrine in the central nervous system, increasing their levels in the synaptic cleft.
Mechanism Steps
๐ก How to Take doxin 25mg capsule
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of doxin 25mg capsule
โ Common Side Effects
- Drowsiness
- Dry mouth
- Constipation
- Blurred vision
- Urinary retention
- Weight gain
๐จ Serious Side Effects
- QT prolongation
- Arrhythmias
- Seizures
- Serotonin syndrome
- Suicidal ideation
โ ๏ธ Rare Side Effects
- Agranulocytosis
- Jaundice
- Hepatitis
- Extrapyramidal symptoms
- Photosensitivity
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Risk of serotonin syndrome, hypertensive crisis |
| Warfarin | Moderate | Increased anticoagulant effect |
| CNS depressants | Moderate | Enhanced sedation and respiratory depression |
๐จ Major Interactions
- MAOIs
- Linezolid
- Methylene blue
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
- CYP3A4 inhibitors (e.g., ketoconazole)
โก Moderate Interactions
- CNS depressants (e.g., alcohol, benzodiazepines)
- Anticholinergic drugs
- Sympathomimetics
- Warfarin
- Cimetidine
โน๏ธ Minor Interactions
- Smoking
- Barbiturates
- Carbamazepine
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase levels; avoid excessive alcohol.
๐ท Alcohol Interaction
Avoid alcohol; increased CNS depression and sedation.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to doxepin or other tricyclic antidepressants; recent myocardial infarction; concurrent use of MAOIs; narrow-angle glaucoma; urinary retention.
๐ Monitoring Parameters
Blood pressure, heart rate, ECG, liver function tests, serum drug levels, mental status.
๐คฑ Lactation Safety
Not recommended; excreted in breast milk, may cause sedation in infant.
๐ Overdose Management
Activated charcoal; supportive care; sodium bicarbonate for arrhythmias; physostigmine for severe anticholinergic effects.
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for doxin 25mg capsule
View AllAlternative brands with exact same active ingredient (Doxepin (25mg)):
-
actipin 25mg tabletHinglaj Laboratories โน20.20 75.8% CHEAPER
-
psychopin 25mg capsuleRKG Pharma โน22.50 73% CHEAPER
-
doxetar 25mg capsuleTorrent Pharmaceuticals Ltd โน26.16 68.6% CHEAPER
-
doxe p 25mg capsuleHaryana Formulations Pvt Ltd โน26.25 68.5% CHEAPER
-
doxicar 25mg tabletDensa Pharmaceuticals Pvt Ltd โน26.25 68.5% CHEAPER
-
dox 25mg tabletD D Pharmaceuticals โน28.13 66.3% CHEAPER
-
doxinurin 25mg tabletEast West Pharma โน32.53 61% CHEAPER
-
dermapin tabletDerma Prime โน32.81 60.7% CHEAPER
-
doxyril 25mg tabletReliance Formulation Pvt Ltd โน38.00 54.5% CHEAPER
-
shidopin 25mg capsuleShine Pharmaceuticals Ltd โน44.00 47.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.