doximax tablet - Uses, Price, Side Effects & Substitutes
What is doximax tablet used for?
Azidox MT 400mg/10mg Tablet (Doxofylline + Montelukast) is used to treat RESPIRATORY. It contains Doxofylline (400mg) + Montelukast (10mg), which Doxofylline: Inhibits phosphodiesterase (PDE) leading to increased cAMP, broncho. Always consult your doctor before use. Take as prescribed.
- Generic Name: Doxofylline + Montelukast
- Manufacturer: Lemford Biotech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ doximax tablet Uses & Benefits
Maintenance treatment of asthma; symptomatic relief of COPD
Off-label uses: Allergic rhinitis (montelukast component); exercise-induced bronchoconstriction
๐ Drug Information
| Generic Name(s) | Doxofylline + Montelukast |
| Brand Name | Azidox MT 400mg/10mg Tablet |
| Manufacturer | Lemford Biotech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Bronchodilator + Leukotriene Receptor Antagonist |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Doxofylline: Inhibits phosphodiesterase (PDE) leading to increased cAMP, bronchodilation; Montelukast: Blocks leukotriene D4 receptors, reducing inflammation and bronchoconstriction
Mechanism Steps
๐ก How to Take doximax tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of doximax tablet
โ Common Side Effects
- Headache
- Nausea
- Diarrhea
- Abdominal pain
- Insomnia
- Dizziness
๐จ Serious Side Effects
- Seizures
- Arrhythmias
- Severe allergic reactions
- Hepatotoxicity
- Churg-Strauss syndrome (rare)
โ ๏ธ Rare Side Effects
- Tremor
- Palpitations
- Urticaria
- Angioedema
- Eosinophilic granulomatosis with polyangiitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Theophylline | Major | Increased risk of theophylline toxicity |
| Warfarin | Major | Increased bleeding risk |
| Phenytoin | Major | Decreased phenytoin levels |
| Lithium | Major | Increased lithium toxicity |
| Cimetidine | Moderate | Increased doxofylline levels |
| Ciprofloxacin | Moderate | Increased doxofylline levels |
| Erythromycin | Moderate | Increased doxofylline levels |
| Fluconazole | Moderate | Increased montelukast levels |
| Beta-agonists | Minor | Additive bronchodilation |
| Corticosteroids | Minor | Additive anti-inflammatory effect |
| Antacids | Minor | Reduced montelukast absorption |
๐จ Major Interactions
- Theophylline
- Warfarin
- Phenytoin
- Lithium
โก Moderate Interactions
- Cimetidine
- Ciprofloxacin
- Erythromycin
- Fluconazole
โน๏ธ Minor Interactions
- Beta-agonists
- Corticosteroids
- Antacids
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase doxofylline levels; high-fat meal may reduce montelukast absorption
๐ท Alcohol Interaction
Alcohol may increase CNS side effects of doxofylline
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to doxofylline, montelukast, or any excipients; acute myocardial infarction; hypotension; seizure disorders
๐ Monitoring Parameters
Lung function tests (FEV1, PEFR); serum doxofylline levels if toxicity suspected; hepatic function
๐คฑ Lactation Safety
Not recommended; montelukast excreted in breast milk
๐ Overdose Management
Symptomatic and supportive; monitor cardiac and CNS effects; activated charcoal may be considered
โฐ Missed Dose
Take as soon as remembered; if close to next dose, skip missed dose; do not double dose