Anace-SP Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is doloend-p tablet used for?
This medicine is a combination of aceclofenac and paracetamol used for relief of pain and inflammation in conditions like arthritis, musculoskeletal injuries, and dental pain. It works by reducing prostaglandins that cause pain and swelling. It should be taken with food and only as prescribed.
- Generic Name: Aceclofenac (NA) + Paracetamol (NA)
- Manufacturer: Denzai Innovations & Therapeutics Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 doloend-p tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसिटोक्लोफेनाक और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है। यह गठिया, जोड़ों के दर्द, मांसपेशियों की चोट, दांत दर्द, और मासिक धर्म के दर्द में प्रभावी है। यह दवा शरीर में प्रोस्टाग्लैंडिन नामक रसायन को कम करती है जो दर्द और सूजन का कारण बनता है। इसे डॉक्टर की सलाह के अनुसार ही लें और भोजन के साथ लें ताकि पेट में जलन न हो।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट या आंतों में रक्तस्राव, अल्सर, लीवर की समस्या, गुर्दे की समस्या, और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको काला मल, उल्टी में खून, त्वचा या आंखों का पीलापन, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। खुराक से अधिक न लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। शराब का सेवन न करें क्योंकि इससे लीवर और पेट की समस्याएं बढ़ सकती हैं। यदि आपको पेट अल्सर, गुर्दे या लीवर की बीमारी, हृदय रोग, या अस्थमा है, तो डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। बच्चों से दूर रखें। दवा को कमरे के तापमान पर सूखी जगह पर रखें।
💊 doloend-p tablet Uses & Benefits
[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces joint pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and stiffness in rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Helps alleviate back pain and stiffness associated with ankylosing spondylitis.","evidence":"Well-established"},{"condition":"Acute musculoskeletal pain","description":"Provides short-term relief for sprains, strains, and sports injuries.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate post-surgical pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Effective for relieving pain following dental procedures or toothache.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Fever","description":"May be used off-label for fever when other options are unsuitable, but not a primary use.","evidence":"Limited"}]
Primary treatment for: Pain and inflammation associated with musculoskeletal conditions
Also treats: Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Acute musculoskeletal injuries, Post-operative pain, Dental pain, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Aceclofenac (NA) + Paracetamol (NA) |
| Brand Name | doloend-p tablet |
| Manufacturer | Denzai Innovations & Therapeutics Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Aceclofenac, an NSAID, inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, leading to decreased synthesis of prostaglandins, prostacyclin, and thromboxane from arachidonic acid. This results in reduced inflammation, pain, and fever. Paracetamol, although its exact mechanism is not fully understood, primarily acts centrally in the brain to inhibit prostaglandin synthesis and modulate pain perception, with weak anti-inflammatory effects. Together, they provide enhanced analgesic and anti-inflammatory effects.
Mechanism Steps
💡 How to Take doloend-p tablet
Strength: Immediate-release tablet containing aceclofenac and paracetamol. The exact strength is not specified in the available information.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once or twice daily, preferably with food. The exact dose and frequency must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function, and response to treatment. Do not exceed the recommended dose. For acute pain, it is usually taken for short periods; for chronic conditions, regular monitoring is required. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine, especially gastrointestinal and kidney effects. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction may be necessary. Avoid in severe kidney impairment (eGFR <30 mL/min). Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose reduction may be necessary. Avoid in severe liver impairment. Monitor liver function regularly. |
| Maximum Daily Dose | The maximum daily dose should not exceed the equivalent of 200 mg of aceclofenac and 2000 mg of paracetamol, but the exact limit must be determined by a clinician. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of doloend-p tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Major | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs
- Methotrexate
- Lithium
- ACE inhibitors and ARBs
⚡ Moderate Interactions
- Diuretics
- Corticosteroids
- SSRIs
- Antihypertensives
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulceration, and liver toxicity, especially due to the paracetamol component. It can also enhance the central nervous system effects such as dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active peptic ulcer or history of recurrent ulcers.","Severe heart failure.","Severe kidney impairment (eGFR
⚠️ Warnings & Precautions
["Take with food to reduce gastrointestinal irritation.","Avoid alcohol consumption.","Do not exceed recommended dose or duration.","Use with caution in elderly patients.","Monitor liver and kidney function during prolonged use.","Inform your doctor if you have a history of gastrointestinal bleeding, kidney disease, liver disease, heart disease, or asthma.","Do not use concurrently with other NSAIDs or paracetamol-containing products.","May cause dizziness or drowsiness; avoid driving or operating machinery until you know how it affects you."]
🤱 Lactation Safety
Aceclofenac and paracetamol are excreted in breast milk in small amounts. Consult your doctor before using this medicine while breastfeeding. Short-term use may be considered if benefits outweigh risks.
💊 Overdose Management
Overdose of this medicine can cause severe liver toxicity due to paracetamol, and gastrointestinal bleeding, kidney failure, and central nervous system effects due to aceclofenac. Seek immediate medical attention. Treatment includes gastric lavage if within 1-2 hours, administration of activated charcoal, and acetylcysteine for paracetamol toxicity. Supportive care for gastrointestinal and kidney effects may be required.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take the tablet with a full glass of water and preferably with food or milk to reduce the risk of stomach upset. Avoid taking other medicines containing paracetamol or other NSAIDs while on this medicine, as this can increase the risk of liver and kidney damage. Do not consume alcohol while taking this medicine, as it can increase the risk of gastrointestinal bleeding and liver toxicity. If you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or asthma, inform your doctor before taking this medicine. Do not use this medicine for more than 7 days for pain relief without consulting your doctor. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of the reach of children. Store it at room temperature, away from moisture and direct sunlight. Do not use this medicine after the expiry date. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly. Avoid if possible in those with multiple comorbidities.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs may affect ovulation and are not recommended during pregnancy, especially in the third trimester. Use effective contraception if necessary and discuss alternative pain relief options.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain, but it can increase the risk of bleeding and kidney problems. Inform your surgeon if you are taking this medicine before surgery. It may need to be stopped before certain procedures.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may increase the risk of bleeding. Your dentist may advise stopping it temporarily or adjusting the dose.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may increase pain while taking this medicine. Gentle stretching and low-impact exercises are recommended. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food. Generally, it does not significantly impact daily activities if taken as prescribed.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as stomach pain, black stools, vomiting blood, yellowing of skin or eyes, decreased urine output, or allergic reactions. Do not stop abruptly if you are on long-term therapy without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, ulcers, kidney impairment, liver toxicity, and cardiovascular events. Regular monitoring of liver and kidney function, blood counts, and blood pressure is recommended. Use the lowest effective dose for the shortest duration. Consult your doctor if you need to use it for more than 7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay help reduce pain and inflammation in joints and muscles.
Evidence: LimitedSome evidence for pain relief in chronic conditions.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. However, if you are scheduled for vaccination, inform your doctor about this medicine. It is generally safe to continue, but your doctor may advise based on your condition.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking the medicine at the same intervals as prescribed, but consult your doctor for specific advice. Check customs regulations for carrying prescription medicines. Always keep it in your hand luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30-60 minutes after taking it.
A: It is best taken with food or milk to reduce the risk of stomach upset.
A: Consult your doctor before taking any other medicine, as interactions can occur.
A: Take it as soon as you remember, but if it's almost time for the next dose, skip the missed dose. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for doloend-p tablet
View AllAlternative brands with exact same active ingredient:
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temfix ace tabletNovartis India Ltd ₹7.03 72.9% CHEAPER
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acemax p tabletAnglo-French Drugs & Industries Ltd ₹8.37 67.8% CHEAPER
-
muvel tabletCeras Pharmaceutical ₹18.53 28.6% CHEAPER
-
aldigesic injectionAlkem Laboratories Ltd ₹19.69 24.2% CHEAPER
-
deck p tabletOmega Remedies Pvt Ltd ₹24.01 7.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food to reduce stomach upset and risk of ulcers. - Myth: This medicine is safe to take with other painkillers.
Fact: Combining with other NSAIDs or paracetamol can increase risk of side effects. - Myth: This medicine can be used for long-term without monitoring.
Fact: Long-term use requires regular monitoring of liver, kidney, and blood parameters.
🔄 Alternative Options
Generic Alternatives
- Aceclofenac + Paracetamol combination tablets from other manufacturers.
Brand Alternatives
- Not applicable as per policy.