Afenac TH Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Severe rash or blistering of skin
- Persistent high fever
If experiencing severe symptoms, call emergency services immediately.
What is doloend-mr tablet used for?
This medicine is a combination of aceclofenac (an NSAID) and thiocolchicoside (a muscle relaxant) used to treat pain and muscle spasm in conditions like low back pain, osteoarthritis, and post-operative pain. It works by reducing inflammation and relaxing muscles. It should be taken with food and under medical supervision.
- Generic Name: Aceclofenac (NA) + Thiocolchicoside (NA)
- Manufacturer: Denzai Innovations & Therapeutics Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 doloend-mr tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसिटोक्लोफेनाक और थायोकोल्चिकोसाइड का संयोजन है, जिसका उपयोग दर्द और मांसपेशियों की ऐंठन के इलाज के लिए किया जाता है। यह कमर दर्द, गर्दन दर्द, ऑस्टियोआर्थराइटिस, रूमेटॉइड आर्थराइटिस, और सर्जरी या चोट के बाद होने वाले दर्द में राहत देती है। यह सूजन को कम करती है और मांसपेशियों को आराम देती है। इसका सेवन डॉक्टर की सलाह के अनुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट या आंतों में रक्तस्राव, एलर्जी, गुर्दे या यकृत की समस्या हो सकती है। यदि आपको काला मल, खून की उल्टी, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या पेशाब कम आना जैसे लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब का सेवन न करें। यदि आपको चक्कर आते हैं या नींद आती है तो वाहन न चलाएं। अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। गर्भावस्था या स्तनपान के दौरान इसका उपयोग करने से पहले डॉक्टर से सलाह लें।
💊 doloend-mr tablet Uses & Benefits
[{"condition":"Acute low back pain","description":"Relieves pain and reduces muscle spasm associated with acute lumbar strain or disc problems.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Reduces joint pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and stiffness, improving mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Helps control pain and inflammation as part of a comprehensive treatment plan.","evidence":"Well-established"},{"condition":"Neck pain and cervical spondylosis","description":"Alleviates pain and muscle spasm in the neck and upper back.","evidence":"Moderate"},{"condition":"Post-operative pain","description":"Used for short-term management of pain and muscle spasm after surgery.","evidence":"Moderate"},{"condition":"Post-traumatic pain","description":"Provides relief from pain and spasm following injuries such as sprains and strains.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label to reduce frequency of migraines associated with muscle tension.","evidence":"Limited"},{"condition":"Tension-type headache","description":"May be used off-label for tension headaches with associated muscle spasm.","evidence":"Limited"}]
Primary treatment for: Musculoskeletal pain and inflammation with muscle spasm
Also treats: Osteoarthritis, Rheumatoid arthritis, Low back pain, Neck pain, Post-operative pain, Post-traumatic pain
📋 Drug Information
| Generic Name(s) | Aceclofenac (NA) + Thiocolchicoside (NA) |
| Brand Name | doloend-mr tablet |
| Manufacturer | Denzai Innovations & Therapeutics Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Aceclofenac is a non-steroidal anti-inflammatory drug that inhibits the cyclooxygenase (COX) enzymes, particularly COX-2, thereby reducing the production of prostaglandins which are mediators of pain, inflammation, and fever. Thiocolchicoside is a centrally acting muscle relaxant that acts as a selective gamma-aminobutyric acid (GABA) type A receptor agonist, possibly modulating GABAergic transmission in the spinal cord and brainstem, leading to relief of muscle spasm and associated pain. The combination provides both anti-inflammatory and muscle relaxant effects, which is beneficial in musculoskeletal conditions where both components contribute to symptoms.
Mechanism Steps
💡 How to Take doloend-mr tablet
Strength: Aceclofenac 100 mg + Thiocolchicoside 4 mg tablet (immediate release).
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once or twice daily, preferably with food. The exact dose and duration must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function, and response to treatment. Do not exceed the prescribed dose. For acute conditions, short-term use is recommended. For chronic conditions, periodic review is necessary. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine, especially gastrointestinal and renal side effects. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function closely. Consult a doctor for individualized dosing. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. In severe renal impairment (creatinine clearance <30 mL/min), this medicine is contraindicated. Consult a doctor for dose adjustment. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. In severe hepatic impairment, this medicine is contraindicated. Consult a doctor for dose adjustment. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet twice daily, but the exact maximum must be determined by a qualified clinician based on individual patient factors. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of doloend-mr tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Moderate | |
| SSRIs | Moderate | |
| Cyclosporine | Moderate | |
| Digoxin | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, naproxen)
- Corticosteroids
- Methotrexate
- Lithium
⚡ Moderate Interactions
- Antihypertensives (e.g., ACE inhibitors, ARBs, diuretics)
- Selective serotonin reuptake inhibitors (SSRIs)
- Cyclosporine
- Digoxin
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of gastrointestinal bleeding, ulceration, and liver damage. It may also enhance drowsiness and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to aceclofenac, thiocolchicoside, or any component of the formulation","Active peptic ulcer or history of recurrent peptic ulcer","Severe heart failure","Severe renal impairment (e.g., creatinine clearance
⚠️ Warnings & Precautions
["Take with food to minimize gastrointestinal irritation.","Avoid alcohol consumption.","Use with caution in elderly patients due to increased risk of side effects.","Monitor for signs of gastrointestinal bleeding.","Use with caution in patients with cardiovascular risk factors.","Do not use for prolonged periods without medical supervision.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you have a history of kidney or liver disease.","Do not take other NSAIDs concurrently.","Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding."]
🤱 Lactation Safety
It is not known whether aceclofenac or thiocolchicoside are excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, abdominal pain, drowsiness, and in severe cases, gastrointestinal bleeding, kidney failure, or liver damage. There is no specific antidote. Treatment is supportive and symptomatic. If overdose is suspected, seek immediate medical attention. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not self-medicate or adjust the dose. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of gastrointestinal bleeding and liver problems. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Inform your doctor if you have a history of stomach ulcers, heart disease, kidney or liver problems, asthma, or bleeding disorders. Do not take other NSAIDs or pain relievers without consulting your doctor. Use the lowest effective dose for the shortest duration possible. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children. Store at room temperature away from moisture and direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events with NSAIDs. Use the lowest effective dose for the shortest duration. Monitor renal and hepatic function regularly. Avoid concurrent use with other NSAIDs or anticoagulants. Consult a doctor for dose adjustments.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. NSAIDs like aceclofenac may affect ovulation and are generally avoided during conception and early pregnancy. Thiocolchicoside is not recommended. Discuss safe alternatives for pain management.
🏥 Post-Surgery Considerations
This medicine may be prescribed after surgery for pain and muscle spasm. However, it should be used with caution as it can increase bleeding risk and affect kidney function. Inform your surgeon about all medicines you are taking. Follow your surgeon's instructions regarding when to start and stop this medicine.
🦷 Dental Procedures
If you are scheduled for dental procedures, inform your dentist that you are taking this medicine. It may increase bleeding risk during dental surgery. Your dentist may advise you to stop the medicine temporarily before the procedure. Do not stop without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, avoid strenuous or high-impact exercises that may exacerbate pain or cause injury. Gentle stretching and low-impact activities are generally safe. If you experience dizziness or drowsiness, avoid activities that require balance or coordination. Consult your doctor or physiotherapist for an individualized exercise plan.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness in some people, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause stomach upset, so take it with food. Inform your employer if your work involves operating heavy machinery. Generally, it does not affect office work, but listen to your body and rest if needed.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor immediately if you experience severe side effects such as gastrointestinal bleeding, allergic reactions, chest pain, difficulty breathing, or signs of liver or kidney problems. Do not stop the medicine abruptly without consulting your doctor, especially if you have been taking it for a long time. Your doctor will advise on tapering or stopping based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, ulcers, kidney impairment, liver toxicity, and cardiovascular events. Regular monitoring of liver and kidney function, blood counts, and blood pressure is advised. Use the lowest effective dose for the shortest duration. Periodic review by a doctor is necessary to assess the need for continued therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve muscle strength and flexibility.
Evidence: Well-establishedApplying heat or cold packs can help reduce pain and inflammation locally.
Evidence: ModerateMay provide pain relief for some musculoskeletal conditions.
Evidence: LimitedCan improve flexibility and reduce muscle tension.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking. It is generally safe to receive vaccines while on this medicine, but consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking the medicine at the same intervals as prescribed; consult your doctor for specific advice. Check customs regulations for carrying prescription medicines. Do not pack it in checked luggage; keep it in your carry-on bag.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30-60 minutes after taking it. The muscle relaxant effect may take 1-2 hours. However, the full benefit may take a few days of regular use.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset. Taking it on an empty stomach may increase the chance of gastrointestinal side effects.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.
A: No, alcohol should be avoided while taking this medicine as it can increase the risk of gastrointestinal bleeding and liver damage.
A: This medicine is not recommended during pregnancy, especially in the third trimester. Consult your doctor for safe alternatives.
🤔 Common Patient Concerns
🔄 Substitutes for doloend-mr tablet
View AllAlternative brands with exact same active ingredient:
-
afenac th tabletStrides shasun Ltd ₹107.14 10% CHEAPER
-
Thiko A Forte TabletTulip Lab Pvt Ltd ₹177.72 49.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken long-term without any risk.
Fact: Long-term use of NSAIDs like aceclofenac can increase the risk of gastrointestinal, cardiovascular, and renal side effects. It should be used for the shortest duration necessary under medical supervision. - Myth: This medicine is safe to take without a prescription.
Fact: This is a prescription medicine. It should only be taken under the guidance of a qualified healthcare professional. - Myth: Taking this medicine with alcohol is safe.
Fact: Alcohol increases the risk of gastrointestinal bleeding and liver damage when taken with this medicine. It should be avoided.
🔄 Alternative Options
Generic Alternatives
- Aceclofenac + Thiocolchicoside combination tablets from other manufacturers
Brand Alternatives
- Afenac TH
- Aceclo TH
- Thioace
- Aceclofenac Thiocolchicoside