dol proxyvon 50mg tablet er - Tapentadol (50mg) medicine

dol proxyvon 50mg tablet er

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Tapentadol (50mg)
🏭 Wockhardt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
🤰 Pregnancy Category C 📋 Prescription Required 💊 Generic Available
Medically Reviewed
12 min read
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

What is dol proxyvon 50mg tablet er used for?

This medicine contains Tapentadol (50mg) and is used to treat PAIN ANALGESICS. Dual mechanism: mu-opioid receptor agonist and norepinephrine reuptake inhibitor.. Always consult your doctor before use.

  • Generic Name: Tapentadol
  • Manufacturer: Wockhardt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 dol proxyvon 50mg tablet er Uses & Benefits

Management of moderate to severe acute pain; chronic pain when other treatments are inadequate.

Off-label uses: Neuropathic pain, fibromyalgia (limited evidence).

📋 Drug Information

Generic Name(s)Tapentadol
Brand NameAlenfast 50mg Tablet
ManufacturerWockhardt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action Classμ-opioid receptor & norepinephrine reuptake inhibitor (NRI)
Route of AdministrationOral
StorageStore at 20-25°C (68-77°F); protect from moisture and light.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration; peak plasma concentration achieved in about 1.25 hours.
DistributionVolume of distribution approximately 540 L; extensively distributed to tissues.
Protein BindingApproximately 20% bound to plasma proteins.
MetabolismPrimarily metabolized by glucuronidation (UGT1A6, UGT1A9, UGT2B7) and to a lesser extent by CYP2C9 and CYP2D6; major metabolite is tapentadol-O-glucuronide (inactive).
Half-LifeApproximately 4 hours.
ExcretionRenal excretion: 99% as metabolites (70% conjugated, 3% unchanged); fecal excretion: 1%.
BioavailabilityApproximately 32% due to first-pass metabolism.
Onset of ActionWithin 30-60 minutes.
Peak Plasma Time1.25 hours (range 0.5-2 hours).
Duration of Action4-6 hours.

How It Works

Dual mechanism: mu-opioid receptor agonist and norepinephrine reuptake inhibitor.

Mechanism Steps

1Tapentadol binds to mu-opioid receptors in the central nervous system, activating G-protein coupled signaling.
2Inhibits norepinephrine reuptake by blocking the norepinephrine transporter (NET) in descending pain pathways.
3Increased noradrenergic activity enhances descending inhibition of pain transmission.
4Combined opioid and noradrenergic effects result in analgesia.

💡 How to Take dol proxyvon 50mg tablet er

Follow your doctor's prescription exactly.

⚠️ Side Effects of dol proxyvon 50mg tablet er

✅ Common Side Effects

Nausea
Dizziness
Headache
Somnolence
Constipation
Vomiting

🚨 Serious Side Effects

Respiratory depression
Serotonin syndrome
Seizures
Adrenal insufficiency
Hypotension

⚠️ Rare Side Effects

Anaphylaxis
Angioedema
Pancreatitis
Hepatic enzyme elevation

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major Increased risk of serotonin syndrome; contraindicated within 14 days.
SSRIs Major Increased risk of serotonin syndrome.
Benzodiazepines Major Additive CNS depression, respiratory depression.
Alcohol Major Additive CNS depression, respiratory depression.
CYP2D6 inhibitors Moderate May increase tapentadol levels; monitor for adverse effects.
Anticholinergics Moderate Increased risk of urinary retention, constipation.

🚨 Major Interactions

  • MAOIs
  • Serotonergic drugs (e.g., SSRIs, SNRIs, triptans)
  • CNS depressants (e.g., benzodiazepines, alcohol, opioids)

⚡ Moderate Interactions

  • CYP2D6 inhibitors (e.g., paroxetine, fluoxetine)
  • CYP2C9 inhibitors (e.g., amiodarone, fluconazole)
  • Anticholinergics

🍷 Alcohol Interaction

Avoid alcohol; additive CNS depression and increased risk of respiratory depression.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, significant respiratory depression, acute or severe bronchial asthma, paralytic ileus, MAOI use within 14 days.

🤱 Lactation Safety

Not recommended; tapentadol is excreted in breast milk.

💊 Overdose Management

Supportive care; naloxone may reverse opioid effects but not noradrenergic effects; monitor for respiratory depression.

⏰ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose; do not double dose.

🔄 Substitutes for dol proxyvon 50mg tablet er

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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