Dobipile Plus 500mg/500mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden severe pain, redness, or swelling in one leg, which may indicate a deep vein clot.
- Chest pain, shortness of breath, or coughing up blood, which may indicate a clot in the lungs.
- Severe allergic reaction with swelling of the face, lips, tongue, or throat, or difficulty breathing.
- Unusual bleeding, such as blood in vomit or stool, bleeding gums, or easy bruising.
- Severe abdominal pain, persistent vomiting, or black tarry stools.
- Yellowing of the skin or eyes, dark urine, or severe tiredness, which may indicate liver problems.
- Decreased urine output, swelling of the face or ankles, or sudden weight gain, which may indicate kidney problems.
- Fever with sore throat, mouth ulcers, or unusual tiredness, which may indicate a blood disorder.
If experiencing severe symptoms, call emergency services immediately.
What is dobipile plus 500mg/500mg tablet used for?
This medicine is a combination of Calcium Dobesilate and Troxerutin used to treat chronic venous insufficiency and haemorrhoids. It works by strengthening blood vessels, reducing swelling, and improving circulation in the legs. It is a prescription medicine and should be taken exactly as directed by a doctor.
- Generic Name: Calcium Dobesilate + Troxerutin
- Manufacturer: Scutonix Lifesciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dobipile plus 500mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा कैल्शियम डोबेसिलेट और ट्रोक्सरुटिन का संयोजन है, जिसका उपयोग पैरों की नसों की समस्या (क्रोनिक वेनस इनसफिशिएंसी) और बवासीर (हैमरॉइड्स) के इलाज में किया जाता है। यह पैरों में भारीपन, दर्द, सूजन और थकान को कम करने में मदद करती है। यह दवा रक्त वाहिकाओं को मजबूत बनाती है और सूजन को कम करती है। यह एक प्रिस्क्रिप्शन दवा है और इसे डॉक्टर के निर्देशानुसार ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, पेट में हल्का दर्द, दस्त, सिरदर्द और चक्कर आना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ दिनों में ठीक हो जाते हैं। कभी-कभी त्वचा पर चकत्ते या खुजली हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर सांस लेने में कठिनाई, चेहरे या गले में सूजन, या असामान्य रक्तस्राव हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ या भोजन के तुरंत बाद पानी के साथ निगलें। शराब का सेवन न करें क्योंकि इससे पेट में जलन और नसों की समस्या बढ़ सकती है। अगर आपको किडनी या लीवर की बीमारी है, तो डॉक्टर को बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं बिना डॉक्टर की सलाह के यह दवा न लें। दवा को बच्चों की पहुंच से दूर रखें और इसकी मूल पैकेजिंग में ही स्टोर करें।
💊 dobipile plus 500mg/500mg tablet Uses & Benefits
- [{"condition":"Chronic venous insufficiency","description":"This medicine is used to relieve heaviness, aching, tiredness, and ankle inflammation" class="semantic-link" title="Medicines for swelling">swelling caused by poor return of blood from the legs to the heart.
- It helps improve vein tone and reduces capillary leakage.","evidence":"Moderate"},{"condition":"Haemorrhoidal disease","description":"This medicine is prescribed to reduce pain, swelling, and bleeding associated with swollen veins in the anal region, often alongside other local treatments.","evidence":"Moderate"},{"condition":"Diabetic retinopathy","description":"Calcium Dobesilate, one of the ingredients, has been studied for reducing capillary leakage in the retina of people with diabetes, although results are mixed and it is not a replacement for standard eye care.","evidence":"Limited"},{"condition":"Symptomatic relief of capillary fragility","description":"This medicine may be used when small blood vessels leak easily, causing easy bruising or tiny red spots on the skin, after other causes have been ruled out.","evidence":"Limited"}]
Off-label uses: [{"condition":"Lymphedema","description":"Sometimes prescribed to help reduce swelling in limbs affected by lymph fluid build-up, but strong evidence is lacking.","evidence":"Limited"},{"condition":"Post-thrombotic syndrome","description":"May be used after a deep vein clot to reduce long-term leg swelling and discomfort, but it is not a standard first-line treatment.","evidence":"Limited"}]
Primary treatment for: Chronic venous insufficiency
Also treats: Haemorrhoidal disease, Diabetic retinopathy, Capillary fragility
📋 Drug Information
| Generic Name(s) | Calcium Dobesilate + Troxerutin |
| Brand Name | Dobipile Plus |
| Manufacturer | Scutonix Lifesciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Vascular protectant |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature, between 15°C and 30°C, in a dry place. Keep it in the original container or blister pack, tightly closed, and protect it from direct sunlight and moisture. Do not store it in the bathroom or near the kitchen sink. Keep all medicines out of the reach and sight of children and pets. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture, but you should always check the expiry date printed on the pack. Do not use the medicine after the expiry date has passed. Dispose of expired medicines safely according to your local pharmacy or medicine take-back programme. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients that work in complementary ways to support blood vessel health. Calcium Dobesilate reduces the permeability of capillary walls, helping to stop fluid from leaking into surrounding tissues, and it improves the flexibility of red blood cells so they can pass more easily through small vessels. Troxerutin is a flavonoid that strengthens vein walls, reduces inflammation, and helps to reduce swelling by making the veins less leaky. Together, these actions improve venous tone, reduce oedema, and relieve the heaviness and aching associated with poor venous circulation.
Mechanism Steps
💡 How to Take dobipile plus 500mg/500mg tablet
Strength: This medicine is available as an immediate-release oral tablet containing Calcium Dobesilate 500 mg and Troxerutin 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken by mouth one to two times daily, or as directed by your doctor. The exact dose and duration depend on the condition being treated, your response to treatment, and your kidney and liver function. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change the dose or stop the medicine without consulting your doctor. Take the tablet with a glass of water, preferably with or just after a meal, to reduce stomach upset. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Older adults can usually take the same adult dose, but they may be more sensitive to the effects of this medicine, especially dizziness and low blood pressure. Your doctor may start with a lower dose and monitor you more closely, particularly if you have kidney or liver problems or take other medicines. Regular follow-up is important to check for side effects and to adjust the dose if needed. |
| Renal Impairment | The dose of this medicine may need to be reduced in people with kidney impairment. Calcium Dobesilate is excreted by the kidneys, so if your kidney function is reduced, the medicine may build up in your body. Your doctor will assess your kidney function before starting treatment and may adjust the dose or recommend an alternative. Do not change your dose without medical advice. |
| Hepatic Impairment | There is limited information on the use of this medicine in people with liver disease. If you have mild to moderate liver impairment, your doctor may prescribe the usual dose with caution. In severe liver disease, this medicine should be used only if clearly needed and under close medical supervision. Your doctor may monitor your liver function during treatment. |
| Maximum Daily Dose | The maximum daily dose of this medicine is generally two tablets (providing 1000 mg Calcium Dobesilate and 1000 mg Troxerutin) per day, but this must be confirmed by your doctor. Do not exceed the dose prescribed by your clinician. Taking more than the recommended dose can increase the risk of side effects such as stomach upset, dizziness, and bleeding. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dobipile plus 500mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Clopidogrel | Major | |
| Ibuprofen | Moderate | |
| Diclofenac | Moderate | |
| Amlodipine | Moderate | |
| Furosemide | Minor | |
| Omeprazole | Minor | |
| Metformin | Minor | |
| Atorvastatin | Minor |
🚨 Major Interactions
- Anticoagulants (e.g., warfarin, acenocoumarol)
- Antiplatelet drugs (e.g., aspirin, clopidogrel)
⚡ Moderate Interactions
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Antihypertensive drugs
🍷 Alcohol Interaction
It is advisable to avoid alcohol while taking this medicine. Alcohol can increase the risk of stomach irritation and bleeding, and it can also worsen the swelling and discomfort associated with venous insufficiency. If you choose to drink alcohol, do so only in moderation and never on an empty stomach, and inform your doctor about your alcohol intake.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to Calcium Dobesilate, Troxerutin, or any other ingredient of this medicine.","Severe kidney impairment, unless specifically advised by a specialist.","Active bleeding or bleeding disorders, unless under specialist supervision.","Pregnancy and breastfeeding, unless clearly needed and advised by a doctor.","Children and adolescents under 18 years of age, as safety and effectiveness have not been established."]
⚠️ Warnings & Precautions
["Do not take this medicine if you are allergic to any of its ingredients.","Inform your doctor if you have kidney or liver disease before starting this medicine.","Tell your doctor if you are taking blood thinners, antiplatelet drugs, or NSAIDs, as the risk of bleeding may increase.","Avoid alcohol while taking this medicine to reduce the risk of stomach irritation and worsening of vein symptoms.","This medicine may cause dizziness. Do not drive or operate heavy machinery until you know how it affects you.","Do not use this medicine to treat sudden severe leg pain, redness, or swelling, which may be a sign of a blood clot.","Keep all follow-up appointments and report any new or unusual symptoms to your doctor.","Do not share this medicine with others, even if they have similar symptoms.","Store the tablets in their original packaging, away from moisture and direct sunlight.","If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine."]
🤱 Lactation Safety
It is not known whether the ingredients of this medicine pass into breast milk in significant amounts. Breastfeeding mothers should consult their doctor before using this medicine. If use is considered necessary, monitor the baby for any unusual symptoms such as drowsiness, feeding problems, or rash.
💊 Overdose Management
If you or someone else takes too much of this medicine, seek immediate medical attention at the nearest hospital or call your local emergency number. Take the medicine pack with you so that the medical team knows exactly what was taken. There is no specific antidote for this medicine. Treatment is supportive and may include monitoring of vital signs, blood tests, and management of any symptoms such as severe stomach pain, vomiting, or dizziness. Do not try to make yourself vomit unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember, provided there is still a long time before your next scheduled dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure what to do, contact your doctor or pharmacist for advice.
Additional Safety Advice
Always take this medicine exactly as your doctor has prescribed. Do not increase or decrease the dose on your own, and do not stop it suddenly without medical advice, especially if you have been taking it for a long time. Swallow the tablet whole with a glass of water, preferably with or just after a meal, to reduce the chance of stomach upset. Avoid drinking alcohol while taking this medicine, as alcohol can worsen vein swelling and may increase the risk of stomach irritation. If you have kidney or liver problems, tell your doctor before starting this medicine, because the dose may need to be adjusted or an alternative may be safer. Do not use this medicine to treat sudden, severe leg pain, redness, or swelling, because these can be signs of a deep vein clot that needs urgent medical care. Keep all follow-up appointments so your doctor can check how well the medicine is working and monitor for any unwanted effects. Store the tablets in their original packaging, away from moisture and direct sunlight, and keep them out of reach of children. If you are pregnant, planning pregnancy, or breastfeeding, speak to your doctor before using this medicine. Do not share this medicine with anyone else, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more sensitive to the effects of this medicine, particularly dizziness and low blood pressure. They may also have reduced kidney function, which can affect how the medicine is cleared from the body. Your doctor may start with a lower dose and monitor you more closely. Regular follow-up and blood tests may be advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss this medicine with your doctor before conception. The safety of this medicine during pregnancy is not well established. Your doctor may recommend stopping it or switching to an alternative. Do not start or stop this medicine without medical advice.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anaesthetist that you are taking this medicine. It may increase the risk of bleeding when combined with other medicines used during surgery. Your doctor may advise you to stop this medicine for a few days before surgery. Do not stop it on your own without medical advice.
🦷 Dental Procedures
Before any dental procedure, inform your dentist that you are taking this medicine. It may increase the risk of bleeding during dental work, especially if you are also taking blood thinners or antiplatelet drugs. Your dentist may take extra precautions or consult your doctor before the procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular exercise is beneficial for venous circulation, but avoid high-impact activities that may strain your legs if you have severe venous insufficiency or haemorrhoids. Swimming, walking, and cycling are generally safe. If you experience pain or swelling during exercise, stop and rest. Consult your doctor before starting any new exercise programme.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness in some people, especially when standing up quickly. If you experience dizziness, avoid driving or operating heavy machinery until you know how the medicine affects you. For most people, it does not significantly interfere with daily activities. If your job involves prolonged standing or sitting, take regular breaks to move around and elevate your legs when possible.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects such as allergic reactions, unusual bleeding, or severe stomach pain, stop the medicine and seek immediate medical attention. Your doctor may advise stopping the medicine if your symptoms have resolved or if you develop a condition where it is no longer safe to continue. Always follow your doctor's guidance regarding the duration of treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well tolerated, but it should be reviewed regularly by your doctor. Prolonged use may rarely affect blood counts or liver enzymes, so periodic blood tests may be advised. Do not continue this medicine for months or years without medical supervision. If your symptoms improve, your doctor may reduce the dose or stop the medicine. If symptoms persist or worsen, further evaluation may be needed to rule out other causes.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Wearing compression stockings can help improve venous return and reduce swelling in the legs.
Evidence: Well-establishedElevating the legs above heart level several times a day can reduce swelling and discomfort.
Evidence: Well-establishedProcedures that close off problematic veins may be recommended for severe varicose veins.
Evidence: Well-establishedA high-fibre diet and adequate fluids help prevent constipation and reduce haemorrhoid symptoms.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive routine vaccinations while taking this medicine. However, if you are scheduled for any vaccine, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your hand luggage to avoid loss or exposure to extreme temperatures. Store it at room temperature, away from direct sunlight and moisture. If you are crossing time zones, continue taking your doses at the same intervals as prescribed; you may need to adjust the timing gradually. Check the customs regulations of your destination country regarding prescription medicines. Carry enough supply for your entire trip, plus a little extra in case of delays. If you have any medical condition or are taking other medicines, carry a letter from your doctor summarising your treatment.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Some people notice improvement in leg heaviness and swelling within one to two weeks, but it may take up to four weeks for full benefits. Continue taking it as prescribed and attend follow-up appointments.
A: Yes, it is best taken with or just after a meal to reduce the chance of stomach upset.
A: Common side effects include nausea, stomach pain, diarrhoea, headache, and dizziness. These are usually mild and settle with time.
A: The safety of this medicine during pregnancy is not well established. It should only be used if clearly needed and advised by your doctor.
A: It is advisable to avoid alcohol as it can worsen vein symptoms and increase the risk of stomach irritation.
A: If you remember within a short time, take the missed dose. If it is almost time for your next dose, skip it and continue with your regular schedule. Do not double dose.
A: Store at room temperature, away from moisture and direct sunlight, in the original packaging. Keep out of reach of children.
A: This medicine may increase the risk of bleeding when taken with blood thinners. Inform your doctor if you are on such medicines; they may need to monitor you closely.
🤔 Common Patient Concerns
🔄 Substitutes for dobipile plus 500mg/500mg tablet
View AllAlternative brands with exact same active ingredient:
-
rutin tabletLupin Ltd ₹223.13 7.7% COSTLIER
-
oxerute cd tabletFourrts India Laboratories Pvt Ltd ₹299.00 44.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure varicose veins completely.
Fact: This medicine helps relieve symptoms such as pain and swelling, but it does not cure varicose veins. Lifestyle measures and other treatments may also be needed. - Myth: It is safe to take this medicine without a prescription.
Fact: This is a prescription medicine. It should only be taken under the supervision of a qualified doctor. - Myth: More tablets will give faster relief.
Fact: Taking more than the prescribed dose can increase the risk of side effects and does not necessarily improve results. Always follow your doctor's instructions. - Myth: This medicine can be taken on an empty stomach without any problem.
Fact: Taking this medicine with food reduces the chance of stomach upset. It is best taken with or just after a meal.
🔄 Alternative Options
Generic Alternatives
- Calcium Dobesilate + Troxerutin 500 mg/500 mg tablet
Brand Alternatives
- Dobipile Plus 500mg/500mg Tablet