calzed 500mg tablet - Calcium Dobesilate (500mg) medicine

calzed 500mg tablet

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🏭 Zedawn Life Sciences Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 18, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Oct 18, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

What is calzed 500mg tablet used for?

This medicine contains Calcium Dobesilate (500mg) and is used to treat CARDIAC. Reduces capillary permeability and improves microcirculation by inhibiting platelet aggregation and . Always consult your doctor before use.

  • Generic Name: Calcium Dobesilate
  • Manufacturer: Zedawn Life Sciences Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 calzed 500mg tablet Uses & Benefits

Chronic venous insufficiency, diabetic retinopathy, hemorrhoids, and other microvascular disorders.

Off-label uses: Treatment of lymphedema, Prevention of contrast-induced nephropathy

📋 Drug Information

Generic Name(s)Calcium Dobesilate
Brand NameAlvitral Tablet
ManufacturerZedawn Life Sciences Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassCapillary permeability reducer
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from moisture and light.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRapidly absorbed from the gastrointestinal tract after oral administration.
DistributionDistributes widely in body tissues, including vascular endothelium.
Protein BindingApproximately 20-25% bound to plasma proteins.
MetabolismMinimally metabolized; primarily excreted unchanged.
Half-LifeApproximately 5-6 hours.
ExcretionPrimarily excreted unchanged in urine (about 70-80%).
BioavailabilityNot well established; estimated around 50-60%.
Onset of ActionWithin 1-2 hours after oral administration.
Peak Plasma Time2-3 hours after oral administration.
Duration of ActionApproximately 8-12 hours.

How It Works

Reduces capillary permeability and improves microcirculation by inhibiting platelet aggregation and reducing blood viscosity.

Mechanism Steps

1Inhibits platelet aggregation by reducing thromboxane A2 synthesis.
2Decreases capillary permeability by stabilizing endothelial cell junctions.
3Reduces blood viscosity by decreasing erythrocyte aggregation and improving deformability.
4Increases venous tone by enhancing sympathetic activity on venous smooth muscle.

💡 How to Take calzed 500mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of calzed 500mg tablet

✅ Common Side Effects

Gastrointestinal disturbances (nausea, diarrhea)
Headache
Dizziness
Skin rash

🚨 Serious Side Effects

Gastrointestinal bleeding
Thrombocytopenia
Agranulocytosis (rare)

⚠️ Rare Side Effects

Fever
Arthralgia
Hepatitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk
Aspirin Major Increased bleeding risk
Clopidogrel Major Increased bleeding risk
NSAIDs Moderate Increased risk of gastrointestinal bleeding
Corticosteroids Moderate Increased risk of gastrointestinal bleeding
Antacids Minor Possible reduced absorption of calcium dobesilate
Iron supplements Minor Possible reduced absorption of iron

🚨 Major Interactions

  • Anticoagulants (e.g., Warfarin)
  • Antiplatelet agents (e.g., Aspirin, Clopidogrel)

⚡ Moderate Interactions

  • NSAIDs
  • Corticosteroids

🍷 Alcohol Interaction

May increase risk of gastrointestinal bleeding; avoid excessive alcohol consumption.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to calcium dobesilate or any excipients; severe renal impairment.

🤱 Lactation Safety

Excretion in breast milk unknown; caution advised.

💊 Overdose Management

Symptomatic and supportive treatment; no specific antidote.

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

🔄 Substitutes for calzed 500mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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