dixval 500mg tablet - Uses, Price, Side Effects & Substitutes
What is dixval 500mg tablet used for?
Alporate D 500mg Tablet ER (Divalproex) is used to treat NEURO CNS. It contains Divalproex (500mg), which Increases GABA levels by inhibiting GABA transaminase and enhancing GABA synthes. Always consult your doctor before use. Take as prescribed.
- Generic Name: Divalproex
- Manufacturer: Reliance Formulation Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ dixval 500mg tablet Uses & Benefits
Epilepsy (complex partial, absence, generalized tonic-clonic), bipolar disorder (mania), migraine prophylaxis.
Off-label uses: Neuropathic pain, status epilepticus (IV), agitation in dementia, schizophrenia augmentation.
๐ Drug Information
| Generic Name(s) | Divalproex |
| Brand Name | Alporate D 500mg Tablet ER |
| Manufacturer | Reliance Formulation Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Sodium channel modulators (AED) |
| Route of Administration | Oral (extended-release tablet). |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Increases GABA levels by inhibiting GABA transaminase and enhancing GABA synthesis; also blocks voltage-gated sodium channels and T-type calcium channels.
Mechanism Steps
๐ก How to Take dixval 500mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of dixval 500mg tablet
โ Common Side Effects
- Nausea
- vomiting
- dizziness
- somnolence
- tremor
- weight gain
- thrombocytopenia
- alopecia
- asthenia
๐จ Serious Side Effects
- Hepatotoxicity
- pancreatitis
- hyperammonemic encephalopathy
- teratogenicity
- bone marrow suppression
- Stevens-Johnson syndrome
โ ๏ธ Rare Side Effects
- Fanconi syndrome
- polycystic ovary syndrome
- hypothyroidism
- vasculitis
- lupus-like syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Carbamazepine | Major | Decreased valproate levels; increased carbamazepine toxicity |
| Lamotrigine | Major | Increased lamotrigine levels; risk of Stevens-Johnson syndrome |
| Phenytoin | Major | Altered phenytoin levels; increased valproate toxicity |
| Phenobarbital | Major | Increased phenobarbital levels; sedation |
| Rifampin | Major | Decreased valproate levels |
| Topiramate | Major | Increased risk of hyperammonemia |
| Warfarin | Major | Increased bleeding risk |
| Aspirin | Moderate | Increased valproate levels; bleeding risk |
| Cimetidine | Moderate | Increased valproate levels |
| Erythromycin | Moderate | Increased valproate levels |
| Felbamate | Moderate | Increased valproate levels |
| Fluoxetine | Moderate | Increased valproate levels |
| Ibuprofen | Moderate | Increased valproate levels; bleeding risk |
| Olanzapine | Moderate | Increased valproate levels |
| Risperidone | Moderate | Increased valproate levels |
| Tricyclic antidepressants | Moderate | Increased CNS depression |
| Acetaminophen | Minor | Possible increased hepatotoxicity |
| Antacids | Minor | Decreased valproate absorption |
| Cholestyramine | Minor | Decreased valproate absorption |
| Oral contraceptives | Minor | Decreased contraceptive efficacy |
๐จ Major Interactions
- Carbamazepine
- Lamotrigine
- Phenytoin
- Phenobarbital
- Rifampin
- Topiramate
- Warfarin
โก Moderate Interactions
- Aspirin
- Cimetidine
- Erythromycin
- Felbamate
- Fluoxetine
- Ibuprofen
- Olanzapine
- Risperidone
- Tricyclic antidepressants
โน๏ธ Minor Interactions
- Acetaminophen
- Antacids
- Cholestyramine
- Oral contraceptives
๐ฝ๏ธ Food Interactions
Food may delay absorption but not extent; avoid grapefruit juice (may increase levels).
๐ท Alcohol Interaction
Avoid alcohol; increases CNS depression and hepatotoxicity risk.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, hepatic disease, urea cycle disorders, mitochondrial disorders, porphyria, pregnancy (for migraine prophylaxis).
๐ Monitoring Parameters
Liver function tests, CBC, serum valproate levels (therapeutic: 50-100 mcg/mL), ammonia levels, coagulation parameters.
๐คฑ Lactation Safety
Excreted in breast milk; caution advised (risk of hepatotoxicity in infant).
๐ Overdose Management
Supportive care; activated charcoal if early; hemodialysis may be effective; monitor for CNS depression, respiratory depression, and hepatic failure.
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for dixval 500mg tablet
View AllAlternative brands with exact same active ingredient (Divalproex (500mg)):
-
kayval 500mg tabletSolitaire Pharmacia Pvt Ltd โน32.00 55% CHEAPER
-
divozant 500 tabletZeelab Pharmacy Pvt Ltd โน40.00 43.8% CHEAPER
-
oriprex 500mg tabletOrison Pharmaceuticals โน40.61 42.9% CHEAPER
-
esdival 500mg tablet erEsteem Pharmaceuticals โน42.19 40.7% CHEAPER
-
davaindia divalproex 500mg tablet erDavaindia Generic Pharmacy โน46.00 35.3% CHEAPER
-
cylenc ds 500mg tabletD.S. Lab โน51.00 28.3% CHEAPER
-
diavox 500 tablet erPsycogen Captab โน55.31 22.3% CHEAPER
-
vat 500mg tablet crPulse Pharmaceuticals โน60.00 15.7% CHEAPER
-
divalop 500mg tabletRKG Pharma โน60.19 15.4% CHEAPER
-
diproex 500mg tabletTorrent Pharmaceuticals Ltd โน61.74 13.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.