diavox 500 tablet er - Divalproex (500mg) medicine

Divaa OD 500 Tablet ER (Divalproex Sodium 500mg): Complete Guide

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🏭 Psycogen Captab 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 16, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for bipolar disorder, migraine prophylaxis, and epilepsy.
Reviewed by
SaathiMed Expert Panel | Oct 16, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Yellowing of the skin or eyes (jaundice)
  • Severe abdominal pain that may radiate to the back
  • Unusual bleeding or bruising
  • Confusion, lethargy, or vomiting (signs of high ammonia)
  • Suicidal thoughts or behavior
  • Severe skin rash with blisters or peeling
  • Seizures that worsen or new types of seizures
  • Swelling of face, lips, or throat

If experiencing severe symptoms, call emergency services immediately.

What is diavox 500 tablet er used for?

This medicine is an extended-release tablet containing Divalproex sodium 500 mg. It is used to treat bipolar disorder, prevent migraines, and control certain seizures. It works by increasing GABA levels in the brain. It requires a prescription and regular monitoring due to risks of liver damage and pancreatitis.

  • Generic Name: Divalproex
  • Manufacturer: Psycogen Captab
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 diavox 500 tablet er के बारे में (Hindi Summary)

उपयोग: यह दवा द्विवैल्प्रोएक्स सोडियम 500 मिलीग्राम का एक्सटेंडेड-रिलीज़ टैबलेट है। इसका उपयोग बाइपोलर डिसऑर्डर (मूड स्विंग्स), माइग्रेन सिरदर्द को रोकने और कुछ प्रकार के दौरे (मिर्गी) को नियंत्रित करने के लिए किया जाता है। यह मस्तिष्क में GABA नामक रसायन को बढ़ाकर काम करती है, जिससे अत्यधिक तंत्रिका गतिविधि शांत होती है। यह दवा केवल डॉक्टर के पर्चे पर मिलती है और इसे नियमित रूप से लेना जरूरी है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, कब्ज, सिरदर्द, चक्कर आना, नींद आना और वजन बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में लिवर की क्षति, अग्न्याशय की सूजन (पैन्क्रियाटाइटिस), खून की कमी, और आत्महत्या के विचार शामिल हो सकते हैं। अगर आपको पीलिया, गंभीर पेट दर्द, या असामान्य खून बहना दिखे तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को शुरू करने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं के बारे में बताएं, खासकर लिवर रोग, किडनी रोग, या पैन्क्रियाटाइटिस। इसे डॉक्टर के बताए अनुसार ही लें, अचानक बंद न करें। टैबलेट को चबाएं या तोड़ें नहीं। शराब न पिएं। नियमित रक्त परीक्षण कराएं। गर्भवती महिलाओं को यह दवा नहीं लेनी चाहिए।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 diavox 500 tablet er Uses & Benefits

[{"condition":"Bipolar disorder (manic episodes)","description":"This medicine helps stabilize mood and reduce the frequency and severity of manic episodes in bipolar disorder.","evidence":"Well-established"},{"condition":"Migraine prophylaxis","description":"This medicine is used to prevent migraine headaches in adults, reducing the frequency of attacks.","evidence":"Well-established"},{"condition":"Epilepsy (complex partial seizures)","description":"This medicine is used as an add-on or monotherapy to control certain types of seizures.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Neuropathic pain","description":"Sometimes prescribed off-label for nerve pain, though evidence is limited.","evidence":"Limited"},{"condition":"Agitation in dementia","description":"Occasionally used off-label to manage agitation in elderly patients with dementia, but with caution.","evidence":"Limited"}]

Primary treatment for: Bipolar disorder

Also treats: Migraine, Epilepsy

📋 Drug Information

Generic Name(s)Divalproex
Brand NameAlporate D 500mg Tablet ER
ManufacturerPsycogen Captab
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassSodium channel modulators (AED)
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Keep in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Shelf LifeTypically 24 months from the date of manufacture. Check the expiry date on the packaging.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine exactly as prescribed; do not change the dose without consulting your doctor.
2
Swallow the extended-release tablet whole; crushing or chewing can cause rapid release and increase side effects.
3
Take it at the same time each day to maintain steady blood levels.
4
Regular blood tests for liver function, blood counts, and drug levels are essential.
5
Avoid alcohol completely while on this medicine to prevent liver damage and increased drowsiness.
6
If you miss a dose, take it as soon as you remember, but skip if it's almost time for the next dose; never double dose.
7
Report any signs of liver problems (yellow eyes, dark urine) or pancreatitis (severe abdominal pain) immediately.
8
Use effective contraception if you are a woman of childbearing age, as this medicine can harm the unborn baby.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Mood swings
This medicine is commonly prescribed for bipolar disorder.
Likely Use
✅
Migraine headaches
This medicine is used for migraine prevention.
Likely Use
✅
Seizures
This medicine is used to control certain types of seizures.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is absorbed from the gastrointestinal tract. The extended-release formulation is designed to release the drug slowly, which helps maintain more stable blood levels compared to immediate-release forms. Food may affect the absorption rate, but the overall extent of absorption is generally not significantly altered.
DistributionThis medicine is widely distributed throughout the body. It crosses the blood-brain barrier and is found in cerebrospinal fluid. It also crosses the placenta and is excreted in breast milk.
Protein BindingThis medicine is highly protein-bound, primarily to albumin. Protein binding is concentration-dependent and can become saturated at higher concentrations, leading to increased free drug levels.
MetabolismThis medicine is extensively metabolized in the liver, primarily through glucuronidation and beta-oxidation. Some metabolites may have anticonvulsant activity. Liver function impairment can affect metabolism and increase the risk of toxicity.
Half-LifeThe elimination half-life of this medicine is typically 9 to 16 hours in adults. However, it may be shorter in children and longer in elderly patients or those with liver impairment.
ExcretionThis medicine and its metabolites are primarily excreted in the urine, with a small amount eliminated in feces. Renal impairment may affect excretion, but dose adjustment is usually not required unless severe.
BioavailabilityThe bioavailability of this medicine is high, approximately 90% or more, when taken orally. The extended-release formulation may have a slightly lower bioavailability compared to immediate-release, but it is designed to provide consistent drug levels over 24 hours.
Onset of ActionThe onset of action varies depending on the indication. For seizures, effects may be seen within days to weeks. For mood stabilization, it may take several days to weeks. For migraine prevention, it may take several weeks to achieve full effect.
Peak Plasma TimeFor the extended-release formulation, peak plasma concentrations are typically reached 4 to 8 hours after oral administration.
Duration of ActionThe duration of action is approximately 24 hours, allowing for once-daily dosing in most cases.

How It Works

This medicine works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter that inhibits excessive nerve activity. By enhancing GABA's effects, this medicine helps calm abnormal electrical activity in the brain, which is useful in seizures, mood stabilization, and migraine prevention. It may also affect other neurotransmitter systems, such as blocking sodium channels and modulating dopamine and serotonin, but the exact mechanism for its various effects is not fully understood.

Mechanism Steps

1
Increased GABA levels: This medicine inhibits the breakdown of GABA, leading to higher concentrations of this inhibitory neurotransmitter in the brain.
2
Enhanced GABA activity: Increased GABA enhances inhibitory signals in the brain, reducing excessive neuronal firing.
3
Stabilization of neuronal membranes: This medicine also blocks voltage-gated sodium channels, which helps stabilize neuronal membranes and prevent abnormal electrical discharges.
4
Mood stabilization and migraine prevention: The combined effects on GABA and other neurotransmitters help stabilize mood and prevent migraine attacks, though the exact pathways are not fully understood.

💡 How to Take diavox 500 tablet er

Strength: Extended-release tablet, 500 mg

1Take this medicine exactly as prescribed by your doctor.
2Swallow the extended-release tablet whole with a glass of water.
3Do not crush, chew, or break the tablet.
4Take it at the same time each day, with or without food.
5If it upsets your stomach, take it with a meal or snack.
6Do not stop taking this medicine suddenly without consulting your doctor.

Dosage Information

Adult DosageThe usual adult dose for bipolar disorder is 750 mg to 1500 mg per day, divided into one or two doses. For migraine prevention, the typical dose is 500 mg to 1000 mg per day. For epilepsy, the dose ranges from 1000 mg to 2500 mg per day. The extended-release tablet is usually taken once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and clinical response.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. Start with a lower dose and titrate slowly. Monitor liver and kidney function closely. Dose must be individualized by a qualified clinician.
Renal ImpairmentNo specific dose adjustment is usually required for mild to moderate renal impairment. In severe renal impairment, use with caution and monitor closely. Dose must be individualized by a qualified clinician.
Hepatic ImpairmentThis medicine is contraindicated in patients with significant hepatic impairment. In mild hepatic impairment, dose reduction may be necessary. Regular monitoring of liver function is essential. Dose must be individualized by a qualified clinician.
Maximum Daily DoseThe maximum recommended dose is 60 mg/kg/day for epilepsy, but not to exceed 2500 mg/day. For bipolar disorder, the maximum is 1500 mg/day. For migraine prevention, the maximum is 1000 mg/day. Doses above these should be used with caution and only under specialist supervision.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and nausea.
Grapefruit
No known interaction
Grapefruit does not appear to affect this medicine.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of diavox 500 tablet er

✅ Common Side Effects

Nausea (Common (up to 20%))
Take with food to reduce nausea. If it persists, consult your doctor.
Headache (Common (up to 15%))
Rest and stay hydrated. Consult doctor if severe or persistent.
Drowsiness (Common (up to 15%))
Avoid driving or operating machinery until you know how it affects you.
Dizziness (Common (up to 12%))
Rise slowly from sitting or lying positions. Consult doctor if persistent.
Weight gain (Common (up to 10%))
Monitor weight and diet. Discuss with doctor if concerned.

🚨 Serious Side Effects

Liver damage (hepatotoxicity) (Rare but serious)
Seek immediate medical attention if you notice yellowing of skin or eyes, dark urine, or severe fatigue.
Pancreatitis (Rare but serious)
Seek immediate medical attention if you experience severe abdominal pain that may radiate to the back.
Low platelet count (thrombocytopenia) (Uncommon)
Report unusual bruising or bleeding to your doctor immediately.
Hyperammonemia (Rare)
Seek medical help if you experience confusion, lethargy, or vomiting.
Suicidal thoughts (Rare)
Contact your doctor or a mental health professional immediately if you have thoughts of harming yourself.

⚠️ Rare Side Effects

Severe skin reactions (Stevens-Johnson syndrome)
Seek emergency medical care if you develop a rash, blisters, or peeling skin.
Aplastic anemia
Report symptoms like fatigue, pale skin, or frequent infections to your doctor.
Encephalopathy
Seek immediate medical attention if you experience confusion, seizures, or decreased consciousness.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Aspirin Major
Carbamazepine Major
Lamotrigine Major
Alcohol Moderate
Oral contraceptives Moderate
Rifampin Moderate
Antacids Minor
Cimetidine Minor

🚨 Major Interactions

  • Warfarin
  • Aspirin
  • Carbamazepine
  • Lamotrigine

⚡ Moderate Interactions

  • Alcohol
  • Oral contraceptives
  • Rifampin

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine. Alcohol can increase the sedative effects of this medicine and raise the risk of liver damage. It may also increase the risk of seizures. If you consume alcohol, discuss it with your doctor.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to divalproex sodium or any component of the formulation.","Liver disease or significant hepatic impairment.","Urea cycle disorders.","Known mitochondrial disorders caused by mutations in the POLG gene, such as Alpers-Huttenlocher syndrome.","Pregnancy for migraine prevention unless clearly necessary."]

⚠️ Warnings & Precautions

["Black box warning for hepatotoxicity: can cause fatal liver failure. Monitor liver function closely.","Black box warning for pancreatitis: can cause life-threatening pancreatitis. Seek immediate care for severe abdominal pain.","Black box warning for fetal risk: can cause birth defects. Use effective contraception.","May cause suicidal thoughts or behavior. Monitor mood closely.","May cause thrombocytopenia. Monitor platelet counts.","May cause hyperammonemia. Monitor for symptoms.","Do not stop abruptly as it can cause seizures.","May cause drowsiness. Avoid driving until you know how it affects you."]

🤱 Lactation Safety

This medicine passes into breast milk and may cause side effects in a nursing infant. Breastfeeding is not recommended while taking this medicine. Consult your doctor to discuss alternatives.

💊 Overdose Management

Overdose of this medicine can cause serious symptoms including deep coma, respiratory depression, and death. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive, with attention to airway, breathing, and circulation. Hemodialysis or charcoal hemoperfusion may be considered in severe cases. There is no specific antidote.

⏰ Missed Dose

If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure, consult your doctor or pharmacist.

Additional Safety Advice

General Safety

Before starting this medicine, tell your doctor about all your medical conditions, especially liver disease, kidney disease, pancreatitis, urea cycle disorders, or bleeding disorders. Do not start or stop this medicine without consulting your doctor, as sudden withdrawal can cause seizures. Take this medicine exactly as prescribed, usually once daily with or without food, but consistently. Swallow the extended-release tablet whole; do not crush, chew, or break it. Avoid alcohol while taking this medicine, as it can increase the risk of liver damage and drowsiness. If you miss a dose, take it as soon as you remember unless it is almost time for your next dose; do not double the dose. Regular blood tests to check liver function, blood counts, and drug levels are important. If you experience symptoms like severe abdominal pain, yellowing of eyes, or unusual bleeding, seek medical help immediately. This medicine can cause drowsiness; avoid driving or operating heavy machinery until you know how it affects you. Use effective contraception if you are of childbearing age, as this medicine can harm an unborn baby.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and cognitive impairment. They are also at higher risk of liver and kidney problems. Start with a lower dose and monitor closely. Regular blood tests are essential.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before conception. This medicine can cause birth defects, especially neural tube defects. Your doctor may switch you to a safer alternative or adjust the dose. Use effective contraception while taking this medicine.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect bleeding. Your doctor may advise temporary discontinuation or dose adjustment before surgery. Do not stop without medical advice.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. It may cause dry mouth or bleeding tendencies. Your dentist may take precautions. Do not stop the medicine before dental work without consulting your doctor.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight through diet and exercise to reduce the risk of weight gain.
🥗
Avoid alcohol completely to prevent liver damage and increased drowsiness.
😴
Get regular sleep and manage stress to help stabilize mood.
💧
Take the medicine at the same time each day to maintain steady levels.
🧘
Keep all follow-up appointments and blood tests.
🌞
Report any new or worsening symptoms to your doctor promptly.

🏋️ Exercise Considerations

This medicine may cause drowsiness and dizziness. Avoid driving or operating heavy machinery until you know how it affects you. Moderate exercise is generally safe, but listen to your body and avoid activities that require high alertness if you feel drowsy.

🥗 Diet Recommendations

Eat a balanced diet rich in fruits, vegetables, and whole grains.
Limit high-fat and processed foods to reduce weight gain risk.
Stay well hydrated.
Avoid alcohol.
If you have nausea, eat small, frequent meals.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. It may also cause cognitive slowing. Adjust your work schedule if needed and avoid hazardous activities until you know how the medicine affects you. Discuss any work-related concerns with your doctor.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. Abrupt withdrawal can cause seizures or mood instability. Your doctor will gradually reduce the dose if discontinuation is necessary. If you experience serious side effects like liver problems or pancreatitis, your doctor may advise stopping immediately.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to weight gain, hair loss, and bone density loss. It can also cause liver and pancreatic toxicity, so regular monitoring is required. Some patients may experience cognitive slowing. Periodic assessment of liver function, blood counts, and drug levels is essential. Do not stop the medicine without medical advice.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Cognitive behavioral therapy (CBT)

Can complement medicine for bipolar disorder and migraine.

Evidence: Well-established
Lifestyle modifications

Regular sleep, stress management, and avoiding triggers can help reduce migraine frequency.

Evidence: Well-established
Other medications

Lithium, lamotrigine, or topiramate may be alternatives depending on the condition.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you are on immunosuppressants, consult your doctor before receiving live vaccines. Routine vaccinations are generally safe.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, adjust dosing times gradually in consultation with your doctor. Check customs regulations for controlled substances before traveling internationally.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with bipolar disorder
She was started on this medicine for manic episodes. After a few weeks, her mood swings decreased significantly. She experienced mild nausea initially, which went away when she took it with food. She emphasizes the importance of regular blood tests and not missing doses.
💡 Lesson: Consistency and regular monitoring are key to managing bipolar disorder with this medicine.
👤 A 45-year-old man with chronic migraines
He had frequent migraines that affected his work. His doctor prescribed this medicine for prevention. After two months, his migraine frequency reduced by half. He notes that it took several weeks to see full effect and that he had to avoid alcohol.
💡 Lesson: Migraine prevention with this medicine requires patience and lifestyle adjustments.
👤 A 28-year-old woman with epilepsy
She was prescribed this medicine as add-on therapy for complex partial seizures. Her seizure frequency decreased, but she had to monitor her liver function regularly. She advises others to never stop the medicine suddenly.
💡 Lesson: Regular monitoring and adherence are crucial for epilepsy control with this medicine.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: For seizures, effects may be seen within days to weeks. For mood stabilization, it may take several days to weeks. For migraine prevention, it may take several weeks to achieve full effect.

Q: Can I stop taking this medicine if I feel better?

A: No, do not stop suddenly. Stopping can cause seizures or mood instability. Always consult your doctor before stopping.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember. If it's almost time for your next dose, skip the missed dose. Do not double dose.

Q: Is it safe to take during pregnancy?

A: This medicine can cause birth defects. It should be avoided during pregnancy unless clearly necessary. Use effective contraception and consult your doctor if you plan to become pregnant.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my liver function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe during pregnancy?
  • How often do I need blood tests?

🔄 Substitutes for diavox 500 tablet er

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is a sleeping pill.
    Fact: This medicine is a mood stabilizer and anticonvulsant, not a sleeping pill. It may cause drowsiness as a side effect.
  • Myth: This medicine can be stopped suddenly once you feel better.
    Fact: Stopping this medicine suddenly can cause seizures or mood instability. Always consult your doctor before stopping.
  • Myth: This medicine is safe to take during pregnancy.
    Fact: This medicine can cause birth defects and should be avoided during pregnancy unless clearly necessary.

🔄 Alternative Options

Generic Alternatives

  • Divalproex sodium extended-release tablets

Brand Alternatives

  • Divaa OD 500 Tablet ER
  • Valprol CR 500 Tablet
  • Dicorate ER 500 Tablet
  • Valparin XR 500 Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Divalproex sodium","class":"Mood stabilizer/anticonvulsant","main_uses":"Bipolar disorder, migraine, epilepsy","key_side_effects":"Liver toxicity, pancreatitis, weight gain"},{"medicine":"Lithium","class":"Mood stabilizer","main_uses":"Bipolar disorder","key_side_effects":"Tremor, kidney toxicity, thyroid issues"},{"medicine":"Lamotrigine","class":"Mood stabilizer/anticonvulsant","main_uses":"Bipolar depression, epilepsy","key_side_effects":"Skin rash, Stevens-Johnson syndrome"}]

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