Divaa OD 500 Tablet ER (Divalproex Sodium 500mg): Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes (jaundice)
- Severe abdominal pain that may radiate to the back
- Unusual bleeding or bruising
- Confusion, lethargy, or vomiting (signs of high ammonia)
- Suicidal thoughts or behavior
- Severe skin rash with blisters or peeling
- Seizures that worsen or new types of seizures
- Swelling of face, lips, or throat
If experiencing severe symptoms, call emergency services immediately.
What is diavox 500 tablet er used for?
This medicine is an extended-release tablet containing Divalproex sodium 500 mg. It is used to treat bipolar disorder, prevent migraines, and control certain seizures. It works by increasing GABA levels in the brain. It requires a prescription and regular monitoring due to risks of liver damage and pancreatitis.
- Generic Name: Divalproex
- Manufacturer: Psycogen Captab
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 diavox 500 tablet er के बारे में (Hindi Summary)
उपयोग: यह दवा द्विवैल्प्रोएक्स सोडियम 500 मिलीग्राम का एक्सटेंडेड-रिलीज़ टैबलेट है। इसका उपयोग बाइपोलर डिसऑर्डर (मूड स्विंग्स), माइग्रेन सिरदर्द को रोकने और कुछ प्रकार के दौरे (मिर्गी) को नियंत्रित करने के लिए किया जाता है। यह मस्तिष्क में GABA नामक रसायन को बढ़ाकर काम करती है, जिससे अत्यधिक तंत्रिका गतिविधि शांत होती है। यह दवा केवल डॉक्टर के पर्चे पर मिलती है और इसे नियमित रूप से लेना जरूरी है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, कब्ज, सिरदर्द, चक्कर आना, नींद आना और वजन बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में लिवर की क्षति, अग्न्याशय की सूजन (पैन्क्रियाटाइटिस), खून की कमी, और आत्महत्या के विचार शामिल हो सकते हैं। अगर आपको पीलिया, गंभीर पेट दर्द, या असामान्य खून बहना दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को शुरू करने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं के बारे में बताएं, खासकर लिवर रोग, किडनी रोग, या पैन्क्रियाटाइटिस। इसे डॉक्टर के बताए अनुसार ही लें, अचानक बंद न करें। टैबलेट को चबाएं या तोड़ें नहीं। शराब न पिएं। नियमित रक्त परीक्षण कराएं। गर्भवती महिलाओं को यह दवा नहीं लेनी चाहिए।
💊 diavox 500 tablet er Uses & Benefits
[{"condition":"Bipolar disorder (manic episodes)","description":"This medicine helps stabilize mood and reduce the frequency and severity of manic episodes in bipolar disorder.","evidence":"Well-established"},{"condition":"Migraine prophylaxis","description":"This medicine is used to prevent migraine headaches in adults, reducing the frequency of attacks.","evidence":"Well-established"},{"condition":"Epilepsy (complex partial seizures)","description":"This medicine is used as an add-on or monotherapy to control certain types of seizures.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Neuropathic pain","description":"Sometimes prescribed off-label for nerve pain, though evidence is limited.","evidence":"Limited"},{"condition":"Agitation in dementia","description":"Occasionally used off-label to manage agitation in elderly patients with dementia, but with caution.","evidence":"Limited"}]
Primary treatment for: Bipolar disorder
📋 Drug Information
| Generic Name(s) | Divalproex |
| Brand Name | Alporate D 500mg Tablet ER |
| Manufacturer | Psycogen Captab |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Sodium channel modulators (AED) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | Typically 24 months from the date of manufacture. Check the expiry date on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter that inhibits excessive nerve activity. By enhancing GABA's effects, this medicine helps calm abnormal electrical activity in the brain, which is useful in seizures, mood stabilization, and migraine prevention. It may also affect other neurotransmitter systems, such as blocking sodium channels and modulating dopamine and serotonin, but the exact mechanism for its various effects is not fully understood.
Mechanism Steps
💡 How to Take diavox 500 tablet er
Strength: Extended-release tablet, 500 mg
Dosage Information
| Adult Dosage | The usual adult dose for bipolar disorder is 750 mg to 1500 mg per day, divided into one or two doses. For migraine prevention, the typical dose is 500 mg to 1000 mg per day. For epilepsy, the dose ranges from 1000 mg to 2500 mg per day. The extended-release tablet is usually taken once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and clinical response. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. Start with a lower dose and titrate slowly. Monitor liver and kidney function closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is usually required for mild to moderate renal impairment. In severe renal impairment, use with caution and monitor closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | This medicine is contraindicated in patients with significant hepatic impairment. In mild hepatic impairment, dose reduction may be necessary. Regular monitoring of liver function is essential. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended dose is 60 mg/kg/day for epilepsy, but not to exceed 2500 mg/day. For bipolar disorder, the maximum is 1500 mg/day. For migraine prevention, the maximum is 1000 mg/day. Doses above these should be used with caution and only under specialist supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of diavox 500 tablet er
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Carbamazepine | Major | |
| Lamotrigine | Major | |
| Alcohol | Moderate | |
| Oral contraceptives | Moderate | |
| Rifampin | Moderate | |
| Antacids | Minor | |
| Cimetidine | Minor |
🚨 Major Interactions
- Warfarin
- Aspirin
- Carbamazepine
- Lamotrigine
⚡ Moderate Interactions
- Alcohol
- Oral contraceptives
- Rifampin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase the sedative effects of this medicine and raise the risk of liver damage. It may also increase the risk of seizures. If you consume alcohol, discuss it with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to divalproex sodium or any component of the formulation.","Liver disease or significant hepatic impairment.","Urea cycle disorders.","Known mitochondrial disorders caused by mutations in the POLG gene, such as Alpers-Huttenlocher syndrome.","Pregnancy for migraine prevention unless clearly necessary."]
⚠️ Warnings & Precautions
["Black box warning for hepatotoxicity: can cause fatal liver failure. Monitor liver function closely.","Black box warning for pancreatitis: can cause life-threatening pancreatitis. Seek immediate care for severe abdominal pain.","Black box warning for fetal risk: can cause birth defects. Use effective contraception.","May cause suicidal thoughts or behavior. Monitor mood closely.","May cause thrombocytopenia. Monitor platelet counts.","May cause hyperammonemia. Monitor for symptoms.","Do not stop abruptly as it can cause seizures.","May cause drowsiness. Avoid driving until you know how it affects you."]
🤱 Lactation Safety
This medicine passes into breast milk and may cause side effects in a nursing infant. Breastfeeding is not recommended while taking this medicine. Consult your doctor to discuss alternatives.
💊 Overdose Management
Overdose of this medicine can cause serious symptoms including deep coma, respiratory depression, and death. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive, with attention to airway, breathing, and circulation. Hemodialysis or charcoal hemoperfusion may be considered in severe cases. There is no specific antidote.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Before starting this medicine, tell your doctor about all your medical conditions, especially liver disease, kidney disease, pancreatitis, urea cycle disorders, or bleeding disorders. Do not start or stop this medicine without consulting your doctor, as sudden withdrawal can cause seizures. Take this medicine exactly as prescribed, usually once daily with or without food, but consistently. Swallow the extended-release tablet whole; do not crush, chew, or break it. Avoid alcohol while taking this medicine, as it can increase the risk of liver damage and drowsiness. If you miss a dose, take it as soon as you remember unless it is almost time for your next dose; do not double the dose. Regular blood tests to check liver function, blood counts, and drug levels are important. If you experience symptoms like severe abdominal pain, yellowing of eyes, or unusual bleeding, seek medical help immediately. This medicine can cause drowsiness; avoid driving or operating heavy machinery until you know how it affects you. Use effective contraception if you are of childbearing age, as this medicine can harm an unborn baby.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and cognitive impairment. They are also at higher risk of liver and kidney problems. Start with a lower dose and monitor closely. Regular blood tests are essential.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conception. This medicine can cause birth defects, especially neural tube defects. Your doctor may switch you to a safer alternative or adjust the dose. Use effective contraception while taking this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect bleeding. Your doctor may advise temporary discontinuation or dose adjustment before surgery. Do not stop without medical advice.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth or bleeding tendencies. Your dentist may take precautions. Do not stop the medicine before dental work without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid driving or operating heavy machinery until you know how it affects you. Moderate exercise is generally safe, but listen to your body and avoid activities that require high alertness if you feel drowsy.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. It may also cause cognitive slowing. Adjust your work schedule if needed and avoid hazardous activities until you know how the medicine affects you. Discuss any work-related concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Abrupt withdrawal can cause seizures or mood instability. Your doctor will gradually reduce the dose if discontinuation is necessary. If you experience serious side effects like liver problems or pancreatitis, your doctor may advise stopping immediately.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to weight gain, hair loss, and bone density loss. It can also cause liver and pancreatic toxicity, so regular monitoring is required. Some patients may experience cognitive slowing. Periodic assessment of liver function, blood counts, and drug levels is essential. Do not stop the medicine without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for bipolar disorder and migraine.
Evidence: Well-establishedRegular sleep, stress management, and avoiding triggers can help reduce migraine frequency.
Evidence: Well-establishedLithium, lamotrigine, or topiramate may be alternatives depending on the condition.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are on immunosuppressants, consult your doctor before receiving live vaccines. Routine vaccinations are generally safe.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, adjust dosing times gradually in consultation with your doctor. Check customs regulations for controlled substances before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: For seizures, effects may be seen within days to weeks. For mood stabilization, it may take several days to weeks. For migraine prevention, it may take several weeks to achieve full effect.
A: No, do not stop suddenly. Stopping can cause seizures or mood instability. Always consult your doctor before stopping.
A: Take it as soon as you remember. If it's almost time for your next dose, skip the missed dose. Do not double dose.
A: This medicine can cause birth defects. It should be avoided during pregnancy unless clearly necessary. Use effective contraception and consult your doctor if you plan to become pregnant.
🤔 Common Patient Concerns
🔄 Substitutes for diavox 500 tablet er
View AllAlternative brands with exact same active ingredient:
-
kayval 500mg tabletSolitaire Pharmacia Pvt Ltd ₹32.00 42.1% CHEAPER
-
divozant 500 tabletZeelab Pharmacy Pvt Ltd ₹40.00 27.7% CHEAPER
-
oriprex 500mg tabletOrison Pharmaceuticals ₹40.61 26.6% CHEAPER
-
esdival 500mg tablet erEsteem Pharmaceuticals ₹42.19 23.7% CHEAPER
-
davaindia divalproex 500mg tablet erDavaindia Generic Pharmacy ₹46.00 16.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: This medicine is a mood stabilizer and anticonvulsant, not a sleeping pill. It may cause drowsiness as a side effect. - Myth: This medicine can be stopped suddenly once you feel better.
Fact: Stopping this medicine suddenly can cause seizures or mood instability. Always consult your doctor before stopping. - Myth: This medicine is safe to take during pregnancy.
Fact: This medicine can cause birth defects and should be avoided during pregnancy unless clearly necessary.
🔄 Alternative Options
Generic Alternatives
- Divalproex sodium extended-release tablets
Brand Alternatives
- Divaa OD 500 Tablet ER
- Valprol CR 500 Tablet
- Dicorate ER 500 Tablet
- Valparin XR 500 Tablet