Diplonim P 100mg/350mg Tablet: Complete Information
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Yellowing of skin or eyes
- Decreased urine output
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Difficulty breathing
If experiencing severe symptoms, call emergency services immediately.
What is diplonim p 100mg/350mg tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain and inflammation. It should be taken with food and not exceeding the prescribed dose.
- Generic Name: Nimesulide (100mg) + Paracetamol (350mg)
- Manufacturer: Pharmatech Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 diplonim p 100mg/350mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमेसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग तीव्र दर्द और सूजन के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, और बुखार में राहत देती है। इसे भोजन के साथ लेना चाहिए और डॉक्टर की सलाह के बिना लंबे समय तक नहीं लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, पेट दर्द, दस्त, और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन जिगर की क्षति, गुर्दे की समस्या, और गंभीर त्वचा प्रतिक्रियाएं हो सकती हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक या अवधि से अधिक न लें। इसे भोजन के साथ लें। शराब का सेवन न करें। अन्य पैरासिटामोल युक्त दवाओं के साथ न लें। यदि आपको जिगर या गुर्दे की बीमारी है तो डॉक्टर को बताएं।
💊 diplonim p 100mg/350mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in conditions such as sprains, strains, and back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and post-dental procedure pain.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after minor surgeries.","evidence":"Moderate"},{"condition":"Fever","description":"Reduces fever due to the paracetamol component.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine relief, but not first-line.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Fever, Musculoskeletal pain, Dental pain
📋 Drug Information
| Generic Name(s) | Nimesulide (100mg) + Paracetamol (350mg) |
| Brand Name | diplonim p 100mg/350mg tablet |
| Manufacturer | Pharmatech Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Nimesulide selectively inhibits cyclooxygenase-2 (COX-2), reducing the synthesis of prostaglandins, which are mediators of inflammation and pain. Paracetamol acts centrally to inhibit prostaglandin synthesis in the brain, elevating the pain threshold and reducing fever. Together, they provide analgesic, anti-inflammatory, and antipyretic effects.
Mechanism Steps
💡 How to Take diplonim p 100mg/350mg tablet
Strength: Tablet containing nimesulide 100 mg and paracetamol 350 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily, preferably after meals. The maximum daily dose should not exceed three tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not use for more than 5-7 days without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not recommended for children under 12 years. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction may be necessary. Consult your doctor. |
| Hepatic Impairment | Contraindicated in severe liver impairment. Use with caution in mild to moderate impairment. Dose reduction may be necessary. |
| Maximum Daily Dose | Maximum 3 tablets in 24 hours (nimesulide 300 mg and paracetamol 1050 mg). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of diplonim p 100mg/350mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Other NSAIDs | Major |
🚨 Major Interactions
- Warfarin
- Other NSAIDs
- Methotrexate
⚡ Moderate Interactions
- ACE inhibitors
- Diuretics
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver toxicity from paracetamol and gastrointestinal bleeding from nimesulide.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nimesulide, paracetamol, or any component","Active peptic ulcer or history of recurrent ulcers","Severe liver impairment","Severe kidney impairment","History of NSAID-induced asthma or allergic reactions","Children under 12 years","Third trimester of pregnancy","Concurrent use with other NSAIDs"]
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Do not exceed recommended dose or duration.","Avoid alcohol.","Use with caution in elderly patients.","Monitor liver and kidney function with prolonged use.","Discontinue if signs of liver injury occur.","Not for children under 12 years."]
🤱 Lactation Safety
Not established from the available information. Nimesulide and paracetamol are excreted in breast milk. Consult your doctor before use.
💊 Overdose Management
Overdose can cause severe liver damage, especially from paracetamol. Symptoms include nausea, vomiting, abdominal pain, and confusion. Seek immediate medical attention. Treatment includes activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach irritation. Avoid alcohol while taking this medicine as it can increase the risk of liver damage and gastrointestinal bleeding. Do not take other paracetamol-containing products simultaneously to prevent overdose. Inform your doctor if you have a history of liver or kidney disease, stomach ulcers, or bleeding disorders. Do not use this medicine for more than 5-7 days without medical advice. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney, liver, and gastrointestinal side effects. Use the lowest effective dose for the shortest duration and monitor closely.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor for alternative pain relief options.
🏥 Post-Surgery Considerations
Use with caution after surgery due to increased risk of bleeding and kidney stress. Follow your surgeon's advice.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while taking this medicine if you have pain or inflammation. Consult your doctor before resuming intense physical activity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness in some people. Avoid driving or operating heavy machinery if you feel dizzy. It may also cause stomach upset, so take it with food.
🛑 When to Stop This Medicine
Stop taking this medicine if you experience any serious side effects such as severe stomach pain, yellowing of eyes, or allergic reactions. Do not stop abruptly if you are on a prescribed course; consult your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to liver damage, kidney impairment, and gastrointestinal bleeding. It is not intended for chronic use. Regular monitoring of liver and kidney function is advised if prolonged use is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help relieve localized pain and inflammation.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 30 to 60 minutes after taking the tablet.
A: It is best taken with food or milk to reduce the risk of stomach upset.
A: It is not recommended during pregnancy, especially in the third trimester. Consult your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for diplonim p 100mg/350mg tablet
View AllAlternative brands with exact same active ingredient:
-
medinip 100mg/350mg tabletMediwin Pharmaceuticals ₹15.00 12.1% CHEAPER
-
elide p 100mg/350mg tabletEden Healthcare Pvt Ltd ₹16.88 1.1% CHEAPER
-
nimic plus 100mg/350mg tabletTunic Healthcare ₹16.88 1.1% CHEAPER
-
olnim p tabletOlcare Laboratories ₹17.11 0.3% COSTLIER
-
nimuson p 100mg/350mg tabletEsquire Drug House ₹18.00 5.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: It is intended for short-term use only. Prolonged use can cause liver and kidney damage. - Myth: It can be taken on an empty stomach.
Fact: It should be taken with food to reduce stomach upset.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol combination tablets
Brand Alternatives
- Diplonim P 100mg/350mg Tablet