Acodocet 20 Injection (Docetaxel 20 mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever of 38°C or higher, chills, or shivering
- Difficulty breathing, chest tightness, or swelling of the face, lips, or throat
- Severe or persistent vomiting or diarrhea
- Unusual bleeding or bruising, such as blood in stool or vomit
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain
- New or worsening numbness, tingling, or weakness in the hands or feet
- Rapid weight gain or swelling of the legs or abdomen
- Palpitations, dizziness, fainting, or chest discomfort
If experiencing severe symptoms, call emergency services immediately.
What is dc fill 20mg injection used for?
This medicine is a prescription-only intravenous chemotherapy medicine containing docetaxel. It is used by oncology specialists to treat advanced breast cancer, non-small cell lung cancer, prostate cancer, gastric cancer, and head and neck cancer. It works by stopping cancer cells from dividing. It must be given in a hospital or day-care setting and is not for self-administration at home.
- Generic Name: Docetaxel (20mg)
- Manufacturer: Fourrts India Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dc fill 20mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा डोसेटैक्सल नामक सक्रिय तत्व वाली एक प्रिस्क्रिप्शन-आधारित कीमोथेरेपी इंजेक्शन है, जिसे अस्पताल या डे-केयर सेंटर में डॉक्टर या प्रशिक्षित नर्स द्वारा नस के माध्यम से दिया जाता है। इसका उपयोग स्तन कैंसर, फेफड़ों के कैंसर, प्रोस्टेट कैंसर, पेट के कैंसर और सिर तथा गर्दन के कैंसर के इलाज में किया जाता है। यह दवा कैंसर कोशिकाओं को बढ़ने और विभाजित होने से रोकती है, जिससे ट्यूमर छोटा हो सकता है। यह दवा घर पर स्वयं नहीं लगाई जाती और इसे केवल कैंसर रोग विशेषज्ञ की देखरेख में ही दिया जाता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में बाल झड़ना, थकान, कमजोरी, मतली, उल्टी, दस्त, मुंह में छाले, मांसपेशियों और जोड़ों में दर्द, हाथ-पैरों में झुनझुनी या सुन्नपन, त्वचा पर दाने, नाखूनों में बदलाव और शरीर में सूजन शामिल हैं। गंभीर दुष्प्रभावों में रक्त कोशिकाओं की संख्या बहुत कम हो जाना, संक्रमण, इंजेक्शन के दौरान तेज एलर्जी, सांस लेने में कठिनाई, लीवर की समस्या और दिल की धड़कन में गड़बड़ी शामिल हैं। अगर आपको 38 डिग्री सेल्सियस या उससे अधिक बुखार, सांस लेने में तकलीफ, चेहरे या गले में सूजन, या अचानक बहुत कमजोरी महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल अस्पताल या डे-केयर सेंटर में प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। हर खुराक से पहले डॉक्टर आपके रक्त की जांच और लीवर की जांच करेंगे। आप जो भी अन्य दवाएं, विटामिन या हर्बल उत्पाद ले रहे हैं, उनके बारे में डॉक्टर को बताएं। इलाज के दौरान और उसके बाद कुछ समय तक गर्भनिरोधक उपाय अपनाएं और स्तनपान न कराएं। इलाज के दौरान लाइव टीके न लगवाएं। बुखार, ठंड लगना, असामान्य रक्तस्राव, सांस लेने में तकलीफ या सूजन होने पर तुरंत डॉक्टर को बताएं। अगर आपको चक्कर या बहुत थकान महसूस हो तो वाहन न चलाएं और भारी मशीनें न चलाएं।
💊 dc fill 20mg injection Uses & Benefits
[{"condition":"Breast cancer","description":"Used as part of chemotherapy regimens for locally advanced or metastatic breast cancer, often after anthracycline-based treatment has failed or is not suitable.","evidence":"Well-established"},{"condition":"Non-small cell lung cancer","description":"Used alone or with platinum-based chemotherapy for advanced or metastatic non-small cell lung cancer in patients who are not candidates for surgery.","evidence":"Well-established"},{"condition":"Hormone-refractory prostate cancer","description":"Used with prednisone or prednisolone to improve survival in metastatic castration-resistant prostate cancer.","evidence":"Well-established"},{"condition":"Gastric adenocarcinoma","description":"Used in combination with other chemotherapy agents for advanced gastric or gastroesophageal junction adenocarcinoma.","evidence":"Well-established"},{"condition":"Squamous cell carcinoma of head and neck","description":"Used as part of induction or palliative chemotherapy regimens for locally advanced or recurrent head and neck cancer.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Ovarian cancer","description":"Sometimes used in platinum-resistant or recurrent ovarian cancer when other options are limited.","evidence":"Limited"},{"condition":"Bladder cancer","description":"Occasionally used in chemotherapy regimens for advanced urothelial cancer, often in combination with other agents.","evidence":"Limited"},{"condition":"Esophageal cancer","description":"Sometimes included in chemotherapy combinations for advanced esophageal or gastroesophageal junction cancer.","evidence":"Limited"}]
Primary treatment for: Breast cancer
Also treats: Non-small cell lung cancer, Hormone-refractory prostate cancer, Gastric adenocarcinoma, Squamous cell carcinoma of head and neck
📋 Drug Information
| Generic Name(s) | Docetaxel (20mg) |
| Brand Name | dc fill 20mg injection |
| Manufacturer | Fourrts India Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimicrotubule agents- Taxanes |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store the unopened vial in a refrigerator between 2°C and 8°C, protected from light. Do not freeze. Once the concentrate is diluted for infusion, it should be used as soon as possible and handled according to the hospital's chemotherapy preparation guidelines. |
| Shelf Life | The shelf life of the unopened vial is usually stated on the pack and is typically 24 months from the date of manufacture when stored under the recommended conditions. Always check the expiry date before use. |
| WHO Guideline | Docetaxel is included in several World Health Organization essential medicines lists and cancer treatment guidelines for specific cancers, but the exact recommendation depends on the cancer type, stage, and setting. Always follow the advice of your treating oncologist. |
| ICMR Guideline | Indian Council of Medical Research guidelines for cancer management include docetaxel as part of chemotherapy regimens for several cancers, including breast, lung, and prostate cancer. The exact use depends on the cancer type, stage, and patient factors, and must be decided by a qualified oncologist. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine contains docetaxel, which binds to the beta-tubulin subunit of microtubules and stabilizes them against disassembly. This abnormal stabilization prevents the normal dynamic reorganization of the microtubule network that is required for mitosis and intracellular transport. As a result, cancer cells become unable to divide properly and are arrested in the G2/M phase of the cell cycle, which leads to programmed cell death. The effect is not selective for cancer cells alone, which explains why normal tissues that divide quickly, such as bone marrow, hair follicles, and the lining of the mouth and gut, are also affected.
Mechanism Steps
💡 How to Take dc fill 20mg injection
Strength: Concentrate for solution for infusion, 20 mg per vial
Dosage Information
| Adult Dosage | The dose of this medicine is determined by the treating oncologist and is usually calculated based on body surface area. Common regimens use 60 to 100 mg per square meter of body surface area given once every three weeks, or 35 to 40 mg per square meter given once weekly for several weeks. The exact dose depends on the type of cancer, previous treatments, blood counts, liver function, and whether it is used alone or with other chemotherapy. Premedication with a corticosteroid is usually given before the infusion to reduce fluid retention and allergic reactions. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Older adults may be more sensitive to the side effects of this medicine, especially low blood counts, fatigue, fluid retention, and nerve damage. The doctor will assess overall health, kidney and liver function, and other medicines before deciding the dose. Close monitoring is recommended during treatment. |
| Renal Impairment | Mild to moderate kidney impairment usually does not require a dose change because this medicine is mainly cleared by the liver. However, kidney function should be monitored, and the dose may need to be adjusted if kidney function worsens or if other kidney-toxic medicines are used. The exact adjustment is not established from the available information and must be decided by the treating clinician. |
| Hepatic Impairment | Patients with raised liver enzymes or bilirubin may need a reduced dose or may not be able to receive this medicine. The dose is usually adjusted based on the level of liver tests, and treatment may be delayed until liver function improves. The exact adjustment must be made by the treating oncologist. |
| Maximum Daily Dose | The maximum dose is not a fixed daily amount because this medicine is given in cycles. The highest commonly used single dose is 100 mg per square meter of body surface area every three weeks, but the exact maximum must be determined by the treating oncologist based on the patient's condition and tolerance. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dc fill 20mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Ritonavir | Major | |
| Rifampicin | Major | |
| Carbamazepine | Major | |
| Phenytoin | Major | |
| Warfarin | Moderate | |
| Live vaccines | Major | |
| Ciclosporin | Moderate | |
| Other myelosuppressive chemotherapy | Moderate | |
| St John's wort | Moderate |
🚨 Major Interactions
- Strong CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin, and ritonavir
- Strong CYP3A4 inducers such as rifampicin, carbamazepine, and phenytoin
- Live vaccines
⚡ Moderate Interactions
- Warfarin and other blood thinners
- Other chemotherapy agents that suppress bone marrow
- Ciclosporin and other medicines that affect liver enzymes
🍷 Alcohol Interaction
Alcohol should be avoided or strictly limited while receiving this medicine. Alcohol can increase the risk of liver problems, worsen nausea and dehydration, and add to fatigue and dizziness. If you drink alcohol regularly, discuss this with your treating oncologist so that your liver function can be monitored appropriately.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to docetaxel or to polysorbate 80","Absolute neutrophil count less than 1,500 cells/mm³","Severe liver impairment with raised bilirubin","Pregnancy and breastfeeding","Concurrent use of live vaccines","Severe uncontrolled infection"]
⚠️ Warnings & Precautions
["This medicine must be given only by a healthcare professional trained in chemotherapy administration.","Premedication with corticosteroids is usually required to reduce fluid retention and allergic reactions.","Blood counts must be checked before each cycle, and treatment may be delayed if counts are low.","Patients with liver problems may need a lower dose or may not be able to receive this medicine.","Report any fever, chills, or signs of infection immediately.","Avoid contact with people who have active infections when possible.","Use effective contraception during treatment and for the period advised by your doctor.","Do not receive live vaccines during treatment.","Tell your doctor about all other medicines, including herbal products, before starting treatment."]
🤱 Lactation Safety
This medicine passes into breast milk and could harm a nursing infant. Breastfeeding must be stopped before treatment begins and should not be restarted until the doctor confirms it is safe.
💊 Overdose Management
Overdose with this medicine is unlikely because it is given by a healthcare professional in a controlled setting. If an accidental overdose occurs, it can cause severe bone marrow suppression, nerve damage, and mucositis. Treatment is supportive, with close monitoring of blood counts, liver function, and vital signs, and management of any complications in a hospital setting. There is no specific antidote.
⏰ Missed Dose
Because this medicine is given by a healthcare professional in a hospital or day-care setting, a missed dose usually means a missed appointment. Contact your treating team as soon as possible to reschedule. Do not attempt to catch up on your own, and never self-administer this medicine at home.
Additional Safety Advice
This medicine must be given only by a qualified healthcare professional in a setting where emergency equipment and medicines are available. Before every dose, your doctor will check your blood counts and liver function, and treatment may be delayed or reduced if these are not satisfactory. Tell your doctor about all other medicines, vitamins, and herbal products you take, because some can increase the risk of side effects. Use effective contraception during treatment and for several months afterwards, and do not breastfeed while receiving this medicine. Avoid live vaccines during treatment. Drink enough fluids unless your doctor has told you to restrict fluids, and report any fever, chills, unusual bleeding, bruising, breathlessness, or swelling without delay. Do not drive or operate heavy machinery if you feel dizzy, tired, or unwell after treatment.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more sensitive to the side effects of this medicine, especially low blood counts, fatigue, fluid retention, and nerve damage. The doctor will assess overall health, kidney and liver function, and other medicines before deciding the dose. Close monitoring is recommended during treatment, and dose reductions may be needed.
🤰 Pregnancy Planning (TTC)
This medicine can harm an unborn baby. Both men and women should use effective contraception during treatment and for a period afterwards as advised by the doctor. If you are planning a pregnancy, discuss it with your oncologist before starting treatment. Fertility preservation options may be available and should be discussed before treatment begins.
🏥 Post-Surgery Considerations
If you have recently had surgery, tell your oncologist before receiving this medicine. Chemotherapy can affect wound healing and increase the risk of infection. The timing of treatment after surgery will be decided by your treating team based on your recovery and the type of surgery.
🦷 Dental Procedures
Tell your dentist that you are receiving this medicine before any dental procedure. Chemotherapy can increase the risk of bleeding and infection, and dental work may need to be delayed until your blood counts recover. Good oral hygiene and regular dental check-ups are important during treatment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Gentle exercise such as short walks can help with fatigue, but you should avoid strenuous activity during treatment, especially if your blood counts are low or you feel dizzy or weak. If you have numbness or tingling in your feet, choose exercises that do not require balance or quick movements. Always check with your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause fatigue, low blood counts, and nerve symptoms that may affect your ability to work. Many patients need to take time off during treatment cycles, especially around the infusion and the days when blood counts are lowest. Discuss your work schedule with your doctor and employer, and avoid driving or operating heavy machinery if you feel unwell. Flexible working arrangements or temporary leave may be helpful.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your oncologist will decide when to stop based on your response to treatment, side effects, and overall health. Treatment may be stopped if the cancer progresses, if side effects become severe, or if you complete the planned number of cycles. Always discuss any concerns with your treating team before making changes.
📅 Long-Term Use Effects
Long-term effects of this medicine can include persistent numbness or tingling in the hands and feet, ongoing fatigue, and changes in nail or skin appearance. Some patients may experience lasting fluid retention or heart rhythm changes. Regular follow-up with your oncologist is important to monitor for these effects and to check for any recurrence of cancer. Most side effects improve after treatment ends, but nerve symptoms may take months or longer to resolve.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another taxane medicine that may be used for similar cancers.
Evidence: Well-establishedMedicines that target specific features of cancer cells may be an option for some patients.
Evidence: Well-established for selected cancersMay be used for certain cancers, sometimes in combination with chemotherapy.
Evidence: Well-established for selected cancersNew treatments may be available through clinical trials for eligible patients.
Evidence: Varies💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should not be given during treatment with this medicine because the immune system is suppressed and the vaccine could cause a serious infection. Inactivated vaccines may be given, but their response may be reduced. Discuss all vaccinations with your oncologist, and make sure family members are up to date with their vaccines to reduce the risk of passing infections to you.
📦 Storage Guide
✅ DO
Store the unopened vial in a refrigerator between 2°C and 8°C.
❌ DON'T
Do not freeze the vial.
✅ DO
Keep the vial in its original carton to protect it from light.
❌ DON'T
Do not store it at room temperature for long periods.
✅ DO
Follow hospital guidelines for handling and disposing of chemotherapy waste.
❌ DON'T
Do not handle the medicine at home or dispose of it in regular trash.
✈️ Traveling with This Medicine
This medicine is given in a hospital or day-care setting, so travel should be planned around your treatment schedule. If you need to travel, carry a copy of your prescription and a letter from your oncologist explaining your treatment. Keep the medicine in its original packaging and store it as advised, usually in a refrigerator between 2°C and 8°C. Check airline and customs rules for carrying prescription medicines, and carry enough supply for your trip. Discuss any travel plans with your treating team well in advance.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine is given as an intravenous infusion by a trained healthcare professional in a hospital or day-care chemotherapy unit. It is not taken at home.
A: The infusion usually takes about one hour, but the exact time depends on the dose and your doctor's instructions.
A: Common side effects include low blood counts, hair loss, fatigue, nausea, mouth sores, muscle and joint pain, and numbness or tingling in the hands and feet.
A: You should not drive if you feel dizzy, tired, or unwell. Ask your doctor whether it is safe for you to drive after treatment.
A: This medicine can harm an unborn baby and is not recommended during pregnancy. Use effective contraception during treatment and for the period advised by your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for dc fill 20mg injection
View AllAlternative brands with exact same active ingredient:
-
Relidoce 20mg InjectionReliance Formulation Pvt Ltd ₹1,200.00 100.8% COSTLIER
-
docax 20mg injectionNeon Laboratories Ltd ₹1,284.30 114.9% COSTLIER
-
docetax 20mg injectionCipla Ltd ₹1,650.00 176.2% COSTLIER
-
innotubilin 20mg injectionInnova Formulations Pvt Ltd ₹1,895.63 217.3% COSTLIER
-
doxel 20mg injectionShantha Biotech ₹2,193.44 267.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken as a tablet at home.
Fact: This medicine is an intravenous infusion and must be given by a healthcare professional in a hospital or day-care setting. - Myth: This medicine cures all types of cancer.
Fact: This medicine is effective only for certain cancers and is used under the guidance of an oncologist as part of a specific treatment plan. - Myth: Hair loss from this medicine is permanent.
Fact: Hair loss is usually temporary, and hair generally grows back after treatment is completed. - Myth: You can stop this medicine whenever you feel better.
Fact: Treatment must be completed or adjusted only under the supervision of your oncologist. Stopping early can reduce the benefit.
🔄 Alternative Options
Generic Alternatives
- Docetaxel
Brand Alternatives
- Acodocet 20 injection