Dayclazide Mp 40 Tablet: Complete Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe hypoglycemia (confusion, seizures, loss of consciousness)
- Rapid weight gain or swelling of ankles, legs, or abdomen
- Shortness of breath or difficulty breathing
- Blood in urine or painful urination
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Unusual bruising or bleeding
- Persistent nausea, vomiting, or loss of appetite
If experiencing severe symptoms, call emergency services immediately.
What is dayclazide mp 40 tablet used for?
This medicine is a combination of gliclazide and pioglitazone used to treat type 2 diabetes. It works by increasing insulin secretion and improving insulin sensitivity. It is taken orally with food, usually once daily. Common side effects include low blood sugar, weight gain, and swelling. Regular monitoring is essential.
- Generic Name: Gliclazide (40mg) + Pioglitazone (15mg)
- Manufacturer: Daylon Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dayclazide mp 40 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा टाइप 2 डायबिटीज (मधुमेह) के इलाज के लिए इस्तेमाल की जाती है। इसमें ग्लिक्लाजाइड और पियोग्लिटाजोन दो दवाएं होती हैं। ग्लिक्लाजाइड अग्न्याशय से इंसुलिन निकालने में मदद करती है, जबकि पियोग्लिटाजोन शरीर की कोशिकाओं को इंसुलिन के प्रति संवेदनशील बनाती है। यह दवा उन मरीजों के लिए है जिनका ब्लड शुगर डाइट और एक्सरसाइज से कंट्रोल नहीं हो पाता। इसे डॉक्टर की सलाह पर ही लें।
साइड इफेक्ट्स: आम दुष्प्रभावों में लो ब्लड शुगर (हाइपोग्लाइसीमिया), वजन बढ़ना, पैरों में सूजन, सिरदर्द और पेट खराब होना शामिल हैं। गंभीर दुष्प्रभावों में हार्ट फेलियर, ब्लैडर कैंसर, लिवर की समस्या और फ्रैक्चर हो सकते हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा खाने के साथ लें ताकि लो ब्लड शुगर और पेट की समस्या से बचा जा सके। अपने ब्लड शुगर की नियमित जांच करें। शराब से बचें क्योंकि इससे लो ब्लड शुगर और लिवर की समस्या हो सकती है। डॉक्टर की सलाह के बिना दवा बंद या डोज न बदलें। अगर वजन अचानक बढ़े, सांस फूले या पेशाब में खून आए तो तुरंत डॉक्टर को बताएं।
💊 dayclazide mp 40 tablet Uses & Benefits
[{"condition":"Type 2 diabetes mellitus","description":"Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes who are not adequately controlled on monotherapy.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Polycystic ovary syndrome (PCOS)","description":"Pioglitazone, a component of this medicine, has been studied off-label for insulin resistance in PCOS, but this combination is not approved for this use.","evidence":"Limited"}]
Primary treatment for: Type 2 diabetes mellitus
Also treats: Insulin resistance, Metabolic syndrome, Dyslipidemia
📋 Drug Information
| Generic Name(s) | Gliclazide (40mg) + Pioglitazone (15mg) |
| Brand Name | dayclazide mp 40 tablet |
| Manufacturer | Daylon Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. Do not refrigerate. |
| Shelf Life | 24 months from the date of manufacture, or as stated on the packaging. |
| WHO Guideline | Not established from the available information. Guidelines for type 2 diabetes management generally recommend a stepwise approach, and combination therapy may be used when monotherapy fails. Consult current guidelines for specific recommendations. |
| ICMR Guideline | Not established from the available information. ICMR guidelines for type 2 diabetes emphasize lifestyle modification and individualized pharmacotherapy. Consult the latest ICMR guidelines for specific recommendations. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antidiabetic agents with complementary mechanisms. Gliclazide binds to sulfonylurea receptors on pancreatic beta cells, closing ATP-sensitive potassium channels, leading to depolarization and increased insulin secretion. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-γ), a nuclear receptor that regulates gene expression involved in glucose and lipid metabolism, thereby increasing insulin sensitivity in peripheral tissues and decreasing hepatic glucose production.
Mechanism Steps
💡 How to Take dayclazide mp 40 tablet
Strength: Tablet containing gliclazide 40 mg and pioglitazone 15 mg, immediate release.
Dosage Information
| Adult Dosage | The usual starting dose of this medicine is one tablet once daily, taken with the first main meal of the day. The dose may be adjusted by your doctor based on your blood sugar levels and response to treatment. The maximum recommended daily dose is one tablet of this strength, but your doctor may prescribe a different strength or frequency. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change the dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially the risk of hypoglycemia. The dose should be carefully adjusted by a clinician, starting with the lowest effective dose. Regular monitoring of blood glucose and renal function is recommended. |
| Renal Impairment | Gliclazide dose may need to be reduced in patients with mild to moderate renal impairment. In severe renal impairment, gliclazide is contraindicated. Pioglitazone does not require dose adjustment in renal impairment, but fluid retention may worsen renal function. Consult your doctor for dose adjustments. |
| Hepatic Impairment | This medicine is contraindicated in patients with severe hepatic impairment. In mild to moderate hepatic impairment, dose adjustment may be necessary, and liver function should be monitored closely. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet of this strength (gliclazide 40 mg + pioglitazone 15 mg) once daily. However, your doctor may prescribe a different strength or frequency based on your condition. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dayclazide mp 40 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Insulin | Major | |
| Beta-blockers | Major | |
| Fluconazole | Major | |
| Gemfibrozil | Major | |
| Rifampicin | Moderate | |
| Corticosteroids | Moderate | |
| Diuretics | Moderate | |
| Alcohol | Moderate | |
| MAO inhibitors | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Insulin or other oral antidiabetics
- Beta-blockers
- CYP2C9 inhibitors (e.g., fluconazole)
- CYP2C8 inhibitors (e.g., gemfibrozil)
⚡ Moderate Interactions
- Rifampicin
- Corticosteroids
- Diuretics
🍷 Alcohol Interaction
Alcohol can increase the risk of hypoglycemia and may worsen liver function. It is advisable to avoid alcohol while taking this medicine. If you choose to drink, do so in moderation and monitor your blood sugar closely.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe liver disease or active liver disease","Symptomatic heart failure","History of bladder cancer","Known hypersensitivity to gliclazide, pioglitazone, or any component of the formulation","Severe renal impairment (for gliclazide component)","Pregnancy and breastfeeding (unless clearly needed and advised by doctor)"]
⚠️ Warnings & Precautions
["May cause hypoglycemia, especially when combined with other antidiabetic agents. Educate patients on recognition and management.","Pioglitazone can cause fluid retention and heart failure. Monitor for rapid weight gain, swelling, or shortness of breath.","Pioglitazone may increase the risk of bladder cancer. Report any blood in urine or painful urination.","Pioglitazone may increase the risk of fractures, especially in women. Ensure adequate calcium and vitamin D intake.","Use with caution in patients with liver disease. Monitor liver enzymes regularly.","Dose adjustment may be needed in renal impairment for the gliclazide component.","Avoid alcohol due to increased risk of hypoglycemia and liver toxicity.","May cause weight gain. Encourage lifestyle modifications.","Not recommended for use in children and adolescents.","Elderly patients may be more susceptible to hypoglycemia. Use with caution."]
🤱 Lactation Safety
Not established from the available information. It is not known whether gliclazide or pioglitazone are excreted in human breast milk. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose may cause severe hypoglycemia. Symptoms include confusion, seizures, and loss of consciousness. If overdose is suspected, seek immediate medical attention. Treatment includes administration of glucose (oral or intravenous) and close monitoring of blood glucose and vital signs. Hemodialysis may be considered for gliclazide overdose, but pioglitazone is not effectively removed by dialysis.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. Consult your doctor if you are unsure.
Additional Safety Advice
Always take this medicine with food to reduce the risk of low blood sugar and stomach upset. Monitor your blood sugar regularly as advised by your doctor. Carry a fast-acting source of sugar, such as glucose tablets or candy, to treat hypoglycemia. Avoid alcohol because it can increase the risk of low blood sugar and liver problems. Inform your doctor about all other medicines, especially those for blood pressure, cholesterol, or infections. Do not stop or change the dose without consulting your doctor. Report any unusual weight gain, swelling, shortness of breath, or blood in urine immediately. Keep all appointments for blood tests and eye exams.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of hypoglycemia and may be more sensitive to the side effects of this medicine. Start with a low dose and monitor blood sugar closely. Assess renal and liver function regularly. Avoid in frail elderly patients with heart failure or liver disease.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before conception. This medicine is not recommended during pregnancy. Insulin is the preferred treatment for diabetes in pregnancy. Your doctor will adjust your treatment plan.
🏥 Post-Surgery Considerations
After surgery, blood sugar levels can fluctuate. Inform your surgeon and anesthesiologist that you are taking this medicine. Your doctor may temporarily switch you to insulin. Do not take this medicine without medical advice during the perioperative period.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. Dental procedures can affect blood sugar and increase the risk of infection. Maintain good oral hygiene and monitor blood sugar before and after procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can lower blood sugar and increase the risk of hypoglycemia, especially when starting this medicine. Monitor your blood sugar before and after exercise. Carry a source of fast-acting sugar. Consult your doctor before starting a new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause low blood sugar, which can affect your ability to drive or operate machinery. Do not drive if you feel shaky, dizzy, or confused. Take breaks and eat regular meals. Inform your employer about your condition if your job involves safety-sensitive tasks.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as heart failure, liver injury, or severe hypoglycemia, your doctor may advise stopping the medicine. Always seek medical advice before discontinuing.
📅 Long-Term Use Effects
Long-term use of this medicine requires regular monitoring of blood sugar, liver function, kidney function, and weight. Pioglitazone may increase the risk of bladder cancer, fractures, and heart failure with prolonged use. Gliclazide may lose effectiveness over time. Your doctor will adjust the dose or add other medicines as needed. Lifestyle modifications remain essential for long-term success.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are the cornerstone of diabetes management and can reduce the need for medicines.
Evidence: Well-establishedMetformin, DPP-4 inhibitors, SGLT2 inhibitors, or GLP-1 receptor agonists may be alternatives depending on individual factors.
Evidence: Well-establishedMay be required if oral agents fail to control blood sugar.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, patients with diabetes should receive routine vaccinations such as influenza and pneumococcal vaccines as recommended by their doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. If traveling across time zones, consult your doctor about adjusting the timing of your dose. Store at room temperature and protect from moisture. Check customs regulations for carrying prescription medicines to your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Gliclazide starts lowering blood sugar within 1 to 2 hours, but the full effect of pioglitazone may take several weeks. Your doctor will monitor your blood sugar to assess response.
A: It may be used with other antidiabetic agents, but this increases the risk of hypoglycemia. Only take additional medicines if prescribed by your doctor.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: It is advisable to avoid alcohol as it can increase the risk of low blood sugar and liver problems.
A: The safety of this medicine in pregnancy is not established. Consult your doctor; insulin is usually preferred for managing diabetes during pregnancy.
🤔 Common Patient Concerns
🔄 Substitutes for dayclazide mp 40 tablet
View AllAlternative brands with exact same active ingredient:
-
new triclazone 40 tabletSun Pharmaceutical Industries Ltd ₹83.00 1.2% CHEAPER
-
Triclazone 40mg/15mg/500mg TabletSun Pharmaceutical Industries Ltd ₹83.00 1.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps manage blood sugar levels but does not cure diabetes. It must be continued along with lifestyle modifications. - Myth: You can stop taking this medicine once your sugar levels are normal.
Fact: Diabetes is a chronic condition. Stopping the medicine without medical advice can lead to high blood sugar and complications. - Myth: This medicine is safe for everyone with diabetes.
Fact: It is not suitable for everyone. It is contraindicated in type 1 diabetes, severe liver disease, heart failure, and bladder cancer. - Myth: Taking this medicine means you can eat anything.
Fact: A healthy diet and regular exercise are essential for managing diabetes. Medicine works best when combined with lifestyle changes.
🔄 Alternative Options
Generic Alternatives
- Gliclazide + Pioglitazone
Brand Alternatives
- Dayclazide MP 40 Tablet