Sulfasalazine 500 mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Sore throat with fever
- Rash with blisters or peeling skin
If experiencing severe symptoms, call emergency services immediately.
What is davaindia sulfasalazine 500mg tablet used for?
Sulfasalazine 500 mg is a disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. It works by reducing inflammation in the joints and intestines. It is taken orally, usually with food, and requires regular blood monitoring.
- Generic Name: Sulfasalazine (500mg)
- Manufacturer: Davaindia Generic Pharmacy
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 davaindia sulfasalazine 500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सल्फासालाज़ीन 500 मिलीग्राम टैबलेट के रूप में उपलब्ध है और मुख्य रूप से रूमेटॉयड आर्थराइटिस (जोड़ों की सूजन), अल्सरेटिव कोलाइटिस और क्रोहन रोग के इलाज में उपयोग की जाती है। यह जोड़ों और आंतों की सूजन को कम करने में मदद करती है, जिससे दर्द, सूजन और अकड़न में राहत मिलती है। यह दवा तुरंत असर नहीं करती; इसे पूरा असर दिखाने में कई सप्ताह लग सकते हैं। इसे डॉक्टर की सलाह के अनुसार ही लें और नियमित रक्त जांच कराते रहें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट खराब, भूख न लगना, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें रक्त विकार, लीवर की समस्या, गुर्दे की समस्या, त्वचा पर गंभीर प्रतिक्रिया और फेफड़ों में सूजन हो सकती है। यदि आपको असामान्य रक्तस्राव, गले में खराश, बुखार, आंखों या त्वचा का पीलापन, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट खराब न हो। पर्याप्त पानी पिएं। शराब का सेवन न करें। गर्भावस्था के दौरान इस दवा का उपयोग केवल डॉक्टर की सलाह पर करें। नियमित रक्त जांच कराते रहें। यदि आपको सल्फासालाज़ीन, सल्फोनामाइड या सैलिसिलेट से एलर्जी है, तो यह दवा न लें।
💊 davaindia sulfasalazine 500mg tablet Uses & Benefits
[{"condition":"Rheumatoid arthritis","description":"Reduces joint inflammation, pain, and swelling, and slows joint damage.","evidence":"Well-established"},{"condition":"Ulcerative colitis","description":"Helps control inflammation in the colon, reducing diarrhea, bleeding, and urgency.","evidence":"Well-established"},{"condition":"Crohn's disease","description":"May help reduce intestinal inflammation and prevent flare-ups.","evidence":"Moderate"},{"condition":"Ankylosing spondylitis","description":"May reduce pain and stiffness in the spine and joints.","evidence":"Limited"},{"condition":"Psoriatic arthritis","description":"May help control joint inflammation and skin symptoms.","evidence":"Limited"}]
Off-label uses: [{"condition":"Behçet's disease","description":"Sometimes used to manage symptoms of this rare inflammatory disorder.","evidence":"Limited"},{"condition":"Uveitis","description":"May be used to reduce eye inflammation in certain autoimmune conditions.","evidence":"Limited"}]
Primary treatment for: Rheumatoid arthritis
Also treats: Ulcerative colitis, Crohn's disease, Ankylosing spondylitis, Psoriatic arthritis
📋 Drug Information
| Generic Name(s) | Sulfasalazine (500mg) |
| Brand Name | davaindia sulfasalazine 500mg tablet |
| Manufacturer | Davaindia Generic Pharmacy |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Disease Modifying Anti-Rheumatoid Drugs (DMARDs)- Non biologics |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Sulfasalazine is a prodrug that is broken down by intestinal bacteria into sulfapyridine and 5-aminosalicylic acid (5-ASA). The 5-ASA component acts locally in the intestines to reduce inflammation by inhibiting prostaglandin synthesis and scavenging free radicals. The sulfapyridine component is absorbed systemically and is thought to contribute to the effects in rheumatoid arthritis by suppressing immune cell function and reducing inflammatory cytokines. Overall, this medicine modulates the immune response and decreases inflammation in both joints and the gut.
Mechanism Steps
💡 How to Take davaindia sulfasalazine 500mg tablet
Strength: 500 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose for rheumatoid arthritis is 500 mg once or twice daily initially, increased gradually to a maintenance dose of 1000 mg twice daily. For ulcerative colitis, the typical dose is 500 mg 2-4 times daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always follow your doctor's prescription. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Start with a lower dose and monitor closely for side effects. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose adjustment may be necessary. Monitor kidney function regularly. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose adjustment may be necessary. Monitor liver function regularly. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 3000 mg, but doses above 2000 mg are rarely used. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of davaindia sulfasalazine 500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Digoxin | Major | |
| Rifampicin | Moderate | |
| Trimethoprim | Moderate | |
| Thiazide diuretics | Moderate | |
| Oral hypoglycemics | Moderate | |
| Phenytoin | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Digoxin
- Rifampicin
⚡ Moderate Interactions
- Folic acid antagonists (e.g., trimethoprim)
- Thiazide diuretics
- Oral hypoglycemics
- Phenytoin
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol may increase the risk of liver problems and stomach bleeding. It can also worsen dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to sulfasalazine, sulfonamides, or salicylates","Severe liver impairment","Severe kidney impairment","Blood dyscrasias (e.g., porphyria)","Intestinal or urinary obstruction","Children under 2 years of age","Pregnancy at term or during lactation unless clearly needed"]
⚠️ Warnings & Precautions
["Regular blood tests are required to monitor for blood disorders, liver, and kidney function.","Serious skin reactions can occur; seek immediate care for rash, blisters, or peeling skin.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Use effective contraception during treatment and for at least 3 months after stopping if you are male, as it may affect sperm.","Avoid alcohol to reduce risk of liver problems.","Inform your doctor if you have G6PD deficiency, asthma, or a history of kidney stones.","Do not take this medicine if you are allergic to sulfonamides or salicylates.","This medicine may cause photosensitivity; use sun protection."]
🤱 Lactation Safety
Sulfasalazine and its metabolites pass into breast milk in small amounts. It is generally considered compatible with breastfeeding, but monitor the infant for diarrhea or rash. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose can cause nausea, vomiting, abdominal pain, and blood disorders. Seek immediate medical attention. Treatment is supportive and may include gastric lavage, activated charcoal, and monitoring of blood counts and liver/kidney function. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor. Take each dose with a full glass of water, preferably with food to reduce stomach upset. Swallow the tablet whole; do not crush or chew. Maintain good hydration. Avoid alcohol while taking this medicine as it may increase the risk of liver problems. Inform your doctor if you have kidney or liver disease, asthma, or a history of blood disorders. Use effective contraception during treatment if you are of childbearing age, as this medicine may harm an unborn baby. Regular blood tests are essential to monitor your blood counts, liver, and kidney function. Do not take this medicine if you are allergic to sulfasalazine, sulfonamides, or salicylates. Keep all appointments with your doctor and laboratory.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and blood disorders. Start with a lower dose and monitor closely. Regular blood tests are essential.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting or continuing this medicine. It is generally considered safe but may require folic acid supplementation. Use effective contraception during treatment and for at least 3 months after stopping if you are male.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be temporarily stopped before surgery due to bleeding risk and interactions with other medications. Follow your doctor's instructions.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may increase bleeding risk during dental procedures. Your dentist may recommend stopping it temporarily or taking precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe and beneficial, but avoid high-impact activities that stress joints. If you have joint pain or swelling, consult a physiotherapist for tailored exercises. Stop exercise if you experience severe pain, dizziness, or shortness of breath.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people. Avoid driving or operating heavy machinery until you know how it affects you. It should not affect your ability to work, but take precautions if you feel drowsy. Inform your employer if your job involves operating machinery.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe rash, difficulty breathing, yellowing of eyes, or unusual bleeding, seek immediate medical attention and your doctor may advise stopping. Otherwise, continue as prescribed and attend regular follow-ups.
📅 Long-Term Use Effects
Long-term use may require regular monitoring of blood counts, liver, and kidney function. Rarely, it can cause blood disorders, liver injury, or kidney problems. It may also cause folate deficiency, so supplementation may be needed. Regular follow-up with your doctor is essential to adjust treatment and detect any complications early.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and joint mobility.
Evidence: Well-establishedAnti-inflammatory diet may help reduce symptoms.
Evidence: ModerateMindfulness and relaxation can improve quality of life.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce your immune response to vaccines. Live vaccines should be avoided while taking this medicine. Consult your doctor before receiving any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from light and moisture. If traveling across time zones, adjust dosing times gradually in consultation with your doctor. Check customs regulations for carrying prescription medicines. Carry enough supply for your entire trip plus extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine may take several weeks to months to show full effect. Some improvement in ulcerative colitis may be seen within days to weeks, while rheumatoid arthritis may take 6-12 weeks.
A: Yes, take it with food or milk to reduce stomach upset.
A: Avoid alcohol, and do not take antacids or iron supplements within 2 hours of this medicine. Inform your doctor of all other medications.
A: It is generally considered safe when clearly needed, but consult your doctor. Folic acid supplementation is often recommended.
A: No, do not stop without consulting your doctor. Stopping suddenly can cause flare-ups.
🤔 Common Patient Concerns
🔄 Substitutes for davaindia sulfasalazine 500mg tablet
View AllAlternative brands with exact same active ingredient:
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salazopyrin 500mg tabletWallace Pharmaceuticals Pvt Ltd ₹38.83 2.9% CHEAPER
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sazolet 500mg tabletIkon Remedies Pvt Ltd ₹40.54 1.4% COSTLIER
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conisazz 500mg tablet drNovalab Healthcare Pvt Ltd ₹43.60 9% COSTLIER
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salazed 500 tabletJagsonpal Pharmaceuticals Ltd ₹46.88 17.2% COSTLIER
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dalazosaz 500mg tablet drChemo Biological ₹48.10 20.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Sulfasalazine works immediately like a painkiller.
Fact: Sulfasalazine is a slow-acting DMARD and may take several weeks to months to show full effect. - Myth: Sulfasalazine is safe for everyone.
Fact: It is not safe for people with sulfonamide allergy, severe liver or kidney disease, or blood disorders. - Myth: You can stop sulfasalazine once you feel better.
Fact: Stopping suddenly can cause flare-ups. Always consult your doctor before stopping. - Myth: Sulfasalazine causes orange urine, which is dangerous.
Fact: Orange-yellow discoloration of urine is a harmless and expected side effect.
🔄 Alternative Options
Generic Alternatives
- Sulfasalazine 500 mg tablet (various manufacturers)
Brand Alternatives
- Saaz 500 mg tablet
- Sulfasalazine 500 mg tablet (various brands)