daslemia 100 tablet - Uses, Price, Side Effects & Substitutes
What is daslemia 100 tablet used for?
Alsatinib (Dasatinib) is used to treat ANTI NEOPLASTICS. It contains Dasatinib (100mg), which Inhibits BCR-ABL tyrosine kinase, SRC family kinases, and other oncogenic kinase. Always consult your doctor before use. Take as prescribed.
- Generic Name: Dasatinib
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ daslemia 100 tablet Uses & Benefits
Chronic myeloid leukemia (CML) in chronic, accelerated, or blast phase; Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).
Off-label uses: GIST (gastrointestinal stromal tumor) with specific mutations; other solid tumors with SRC activation.
๐ Drug Information
| Generic Name(s) | Dasatinib |
| Brand Name | Alsatinib |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Tyrosine kinase inhibitors |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits BCR-ABL tyrosine kinase, SRC family kinases, and other oncogenic kinases.
Mechanism Steps
๐ก How to Take daslemia 100 tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of daslemia 100 tablet
โ Common Side Effects
- Myelosuppression (neutropenia, thrombocytopenia, anemia)
- Fluid retention (pleural effusion, peripheral edema)
- Diarrhea
- Headache
- Fatigue
- Nausea
๐จ Serious Side Effects
- Pleural effusion
- Pulmonary arterial hypertension
- QT prolongation
- Severe hemorrhage
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Pancreatitis
- Colitis
- Severe skin reactions (Stevens-Johnson syndrome)
- Tumor lysis syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | Increased dasatinib exposure (AUC increased 5-fold) |
| Rifampin | Major | Decreased dasatinib exposure (AUC decreased 82%) |
| Antacids | Major | Reduced absorption; separate by at least 2 hours |
| Grapefruit juice | Moderate | Increased dasatinib levels |
| Warfarin | Minor | Potential increased INR; monitor |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
- CYP3A4 inducers (e.g., rifampin, phenytoin)
- Antacids
- H2 antagonists
- Proton pump inhibitors
โก Moderate Interactions
- Grapefruit juice
- St. John's wort
- Calcium channel blockers
- Statins
โน๏ธ Minor Interactions
- Acetaminophen
- Warfarin (monitor INR)
๐ฝ๏ธ Food Interactions
Avoid grapefruit juice; take with or without food.
๐ท Alcohol Interaction
May increase risk of liver toxicity; avoid excessive alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to dasatinib or any excipients; pregnancy; severe hepatic impairment.
๐ Monitoring Parameters
Complete blood count (CBC), liver function tests, renal function, ECG for QT interval, pleural effusion symptoms.
๐คฑ Lactation Safety
Not recommended; excreted in animal milk, unknown in humans.
๐ Overdose Management
No specific antidote; supportive care, monitor for myelosuppression and bleeding.
โฐ Missed Dose
Take as soon as remembered unless within 12 hours of next dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for daslemia 100 tablet
View AllAlternative brands with exact same active ingredient (Dasatinib (100mg)):
-
alsatinib tabletAlkem Laboratories Ltd โน2,717.81 22.6% CHEAPER
-
dasamyl 100mg tabletMylan Pharmaceuticals Pvt Ltd โน3,450.00 1.7% CHEAPER
-
nextki 100mg tabletEmcure Pharmaceuticals Ltd โน3,515.63 0.1% COSTLIER
-
dasamed 100mg tabletMedicamen Biotech Ltd โน4,978.13 41.8% COSTLIER
-
dasashil 100mg tabletShilpa Medicare Ltd โน6,328.13 80.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.