Afogatran 110 Capsule: Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe or unusual headache, confusion, or weakness on one side of the body.
- Vomiting blood or material that looks like coffee grounds.
- Black, tarry stools or bright red blood in stool.
- Coughing up blood or bleeding from the nose that does not stop.
- Sudden severe back pain, numbness, or paralysis after a spinal procedure.
- Signs of allergic reaction: rash, itching, swelling of face, lips, or throat, difficulty breathing.
- Unusual bruising or bleeding that you cannot explain.
If experiencing severe symptoms, call emergency services immediately.
What is dabistar 110 capsule used for?
This medicine is an oral anticoagulant containing dabigatran etexilate 110 mg. It prevents stroke and blood clots in people with non-valvular atrial fibrillation and treats deep vein thrombosis and pulmonary embolism. It works by directly inhibiting thrombin. It is taken by mouth, usually twice daily, and requires regular kidney function monitoring.
- Generic Name: Dabigatran Etexilate
- Manufacturer: Lupin Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dabistar 110 capsule के बारे में (Hindi Summary)
उपयोग: यह दवा एक ओरल एंटीकोआगुलेंट है जिसमें डाबिगाट्रान एटेक्सिलेट 110 मिलीग्राम होता है। यह अट्रियल फाइब्रिलेशन वाले मरीजों में स्ट्रोक और खून के थक्के बनने से बचाती है। यह डीप वेन थ्रोम्बोसिस और पल्मोनरी एम्बोलिज्म के इलाज और रोकथाम में भी इस्तेमाल होती है। यह खून को पतला करती है और थ्रोम्बिन को ब्लॉक करती है। इसे मुँह से लिया जाता है, आमतौर पर दिन में दो बार। इसे डॉक्टर के बताए अनुसार ही लें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में पेट की गड़बड़ी, जी मिचलाना, और आसानी से चोट लगने या खून बहने की प्रवृत्ति शामिल है। कुछ लोगों को दस्त या पेट दर्द हो सकता है। गंभीर दुष्प्रभावों में ब्रेन ब्लीडिंग, गैस्ट्रोइंटेस्टाइनल ब्लीडिंग, या आँख में ब्लीडिंग शामिल है। अगर काला मल, खून की उल्टी, गंभीर सिरदर्द, या शरीर के एक तरफ कमजोरी महसूस हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। कैप्सूल को पूरा निगलें, चबाएं या तोड़ें नहीं। इसे भोजन के साथ या बिना भोजन के ले सकते हैं, लेकिन पेट की गड़बड़ी हो तो भोजन के साथ लें। खून बहने का खतरा बढ़ सकता है, इसलिए चोट लगने वाली गतिविधियों से बचें। डॉक्टर, दंत चिकित्सक, या सर्जन को इस दवा के बारे में जरूर बताएं। बिना डॉक्टर की सलाह के कोई अन्य दवा न लें।
💊 dabistar 110 capsule Uses & Benefits
[{"condition":"Stroke prevention in non-valvular atrial fibrillation","description":"Reduces the risk of stroke and systemic embolism in adults with non-valvular atrial fibrillation.","evidence":"Well-established"},{"condition":"Treatment of deep vein thrombosis and pulmonary embolism","description":"Used after initial parenteral anticoagulation to treat and prevent recurrence of deep vein thrombosis and pulmonary embolism.","evidence":"Well-established"},{"condition":"Prevention of deep vein thrombosis and pulmonary embolism after hip or knee replacement surgery","description":"Used to prevent blood clots after major orthopedic surgery.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prevention of thrombosis in antiphospholipid syndrome","description":"Sometimes used off-label in patients with antiphospholipid syndrome who cannot take warfarin, but evidence is limited.","evidence":"Limited"},{"condition":"Prevention of stroke in mechanical heart valves","description":"Not recommended and potentially harmful; this medicine should not be used for mechanical heart valves.","evidence":"Not established from the available information."}]
Primary treatment for: Non-valvular atrial fibrillation
Also treats: Deep vein thrombosis, Pulmonary embolism, Venous thromboembolism prophylaxis after orthopedic surgery
📋 Drug Information
| Generic Name(s) | Dabigatran Etexilate |
| Brand Name | Afogatran 110 Capsule |
| Manufacturer | Lupin Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Direct thrombin inhibitor- oral |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep the capsules in their original blister pack or bottle to protect from moisture. Do not remove the desiccant from the bottle. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization includes dabigatran in its Model List of Essential Medicines for the treatment and prevention of thromboembolic disorders. However, specific recommendations should be based on local guidelines and patient factors. |
| ICMR Guideline | The Indian Council of Medical Research has not issued specific guidelines for dabigatran. Clinical decisions should follow standard international guidelines and institutional protocols. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a direct thrombin inhibitor. After being taken by mouth, dabigatran etexilate is converted to dabigatran, which binds directly to thrombin and blocks its ability to convert fibrinogen into fibrin. This prevents the formation of blood clots. It also inhibits thrombin-induced platelet aggregation. Because it works directly on thrombin, it does not require a cofactor like antithrombin to exert its effect.
Mechanism Steps
💡 How to Take dabistar 110 capsule
Strength: Capsule, 110 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine for stroke prevention in non-valvular atrial fibrillation is 150 mg twice daily for most patients, but a reduced dose of 110 mg twice daily may be used in certain patients such as those over 80 years, those with increased bleeding risk, or those with moderate renal impairment. For treatment of deep vein thrombosis and pulmonary embolism, the dose is 150 mg twice daily after initial parenteral anticoagulation. For prevention after hip or knee replacement surgery, the dose is 110 mg on the first day followed by 220 mg once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients, especially those over 80 years, may have reduced renal function and are at higher risk of bleeding. A reduced dose of 110 mg twice daily may be considered for stroke prevention in atrial fibrillation. Renal function should be assessed before and during treatment. Dose must be individualized by a qualified clinician. |
| Renal Impairment | For patients with moderate renal impairment (CrCl 30-50 mL/min), the dose may be reduced to 110 mg twice daily for stroke prevention in atrial fibrillation, or 75 mg twice daily for other indications. This medicine is contraindicated in severe renal impairment (CrCl <30 mL/min). Renal function should be monitored regularly. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No dose adjustment is required for mild to moderate hepatic impairment, but this medicine should be used with caution. It is not recommended in severe hepatic impairment. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 300 mg (150 mg twice daily) for most indications, but in certain cases, a lower dose is used. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dabistar 110 capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Rifampin | Major | |
| Ketoconazole | Major | |
| Dronedarone | Major | |
| Verapamil | Moderate | |
| Amiodarone | Moderate | |
| Clarithromycin | Moderate | |
| NSAIDs | Moderate | |
| Antacids | Minor | |
| Pantoprazole | Minor |
🚨 Major Interactions
- Warfarin
- Rifampin
- Ketoconazole
- Dronedarone
⚡ Moderate Interactions
- Verapamil
- Amiodarone
- Clarithromycin
- NSAIDs
🍷 Alcohol Interaction
Alcohol may increase the risk of bleeding by affecting platelet function and irritating the stomach lining. It is advisable to limit or avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active pathological bleeding.","Severe renal impairment (CrCl
⚠️ Warnings & Precautions
["Increased risk of bleeding: This medicine can cause serious and potentially fatal bleeding. Monitor for signs of bleeding.","Spinal/epidural hematoma: Patients receiving spinal anesthesia or spinal puncture are at risk. Monitor for signs of neurological impairment.","Renal impairment: Dose adjustment is required. Assess renal function before and during therapy.","Surgery and invasive procedures: Temporarily discontinue as advised by your doctor to reduce bleeding risk.","Pregnancy: Avoid use; may cause fetal harm.","Lactation: Use with caution; consider alternative anticoagulant.","Pediatric use: Safety and efficacy not established.","Elderly: Increased risk of bleeding, especially with renal impairment."]
🤱 Lactation Safety
It is not known whether dabigatran is excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or discontinue the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
Overdose may lead to excessive bleeding. There is no specific antidote for dabigatran, but idarucizumab is available as a reversal agent in some settings. In case of overdose, seek emergency medical attention immediately. Treatment may include discontinuation of the medicine, supportive care, and measures to control bleeding. Hemodialysis can remove dabigatran from the blood.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or double up. Swallow the capsule whole with a full glass of water; do not crush, chew, or open the capsule because this can increase the medicine's effect and bleeding risk. You may take it with or without food, but taking it with food may reduce stomach upset. Tell your doctor if you have kidney problems, liver problems, or a history of bleeding. Avoid activities that increase the risk of injury or falls. Use a soft toothbrush and an electric razor to reduce bleeding. Inform all healthcare providers, including dentists, that you are taking this medicine. Do not take other blood thinners, NSAIDs, or herbal supplements without your doctor's approval. If you miss a dose, follow your doctor's instructions; do not double dose. Store this medicine at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients, especially those over 80 years, are at higher risk of bleeding and may have reduced kidney function. A reduced dose of 110 mg twice daily may be considered for stroke prevention in atrial fibrillation. Renal function should be assessed before and during treatment. Falls prevention and regular monitoring are important.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning to become pregnant, consult your doctor to discuss alternative anticoagulant options. Effective contraception should be used while taking this medicine. If you become pregnant, contact your doctor immediately.
🏥 Post-Surgery Considerations
This medicine may need to be temporarily stopped before surgery to reduce bleeding risk. Your doctor will advise when to stop and when to restart. After surgery, monitor for signs of bleeding and follow your doctor's instructions carefully.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. You may need to stop the medicine temporarily for procedures that involve bleeding. Your dentist or doctor will advise on the appropriate management.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid contact sports or activities that increase the risk of injury or falls, as this medicine increases bleeding risk. Low-impact exercises like walking, swimming, and cycling are generally safe. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people, which can affect your ability to drive or operate machinery. If you experience these effects, avoid driving or operating heavy machinery until you know how the medicine affects you. Most people can continue their normal daily activities with caution to avoid injuries.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping suddenly can increase the risk of stroke or blood clots. Your doctor may advise stopping temporarily before surgery or if you develop serious bleeding. Always follow your doctor's instructions.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of bleeding, especially in the elderly and those with kidney impairment. Regular monitoring of kidney function and signs of bleeding is essential. It does not require routine INR monitoring, but periodic assessment of renal function is necessary. Long-term use may also be associated with an increased risk of gastrointestinal bleeding. Discuss with your doctor about the risks and benefits of continuing therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another oral anticoagulant that inhibits factor Xa.
Evidence: Well-establishedAnother oral anticoagulant that inhibits factor Xa.
Evidence: Well-establishedVitamin K antagonist that requires INR monitoring.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are due for any vaccination, inform the healthcare provider that you are taking this medicine, especially if the vaccine is given intramuscularly, as there is a risk of bleeding at the injection site.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, adjust dosing times gradually in consultation with your doctor. Ensure you have enough supply for your trip. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1 to 2 hours after taking a dose, but its full protective effect builds up over time with regular use.
A: No, taking this medicine with other blood thinners can increase the risk of serious bleeding. Always consult your doctor before combining any medicines.
A: If you miss a dose, take it as soon as you remember on the same day. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is not recommended during pregnancy as it may cause bleeding in the mother and fetus. Consult your doctor if you are pregnant or planning to become pregnant.
🤔 Common Patient Concerns
🔄 Substitutes for dabistar 110 capsule
View AllAlternative brands with exact same active ingredient:
-
dabigo 110mg capsuleSun Pharmaceutical Industries Ltd ₹154.51 53.8% CHEAPER
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dabimend 110 capsuleMendcure Life Sciences Pvt Ltd ₹210.94 36.9% CHEAPER
-
dabxiga 110mg capsuleLupin Ltd ₹225.00 32.7% CHEAPER
-
dabitra 110 capsuleEmcure Pharmaceuticals Ltd ₹225.00 32.7% CHEAPER
-
dabanex 110mg capsuleAjanta Pharma Ltd ₹234.38 29.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can dissolve existing blood clots.
Fact: This medicine prevents new clots from forming but does not dissolve existing clots. Other medicines are used to dissolve clots. - Myth: This medicine requires regular INR monitoring like warfarin.
Fact: This medicine does not require routine INR monitoring, but kidney function should be checked regularly. - Myth: This medicine is safe to take with any other medicine.
Fact: This medicine interacts with many drugs, especially those affecting P-glycoprotein. Always consult your doctor before taking any new medicine.
🔄 Alternative Options
Generic Alternatives
- Dabigatran etexilate 110 mg capsule
Brand Alternatives
- Afogatran 110 capsule