Bigatra 110mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe or unusual bleeding that does not stop
- Black, tarry stools or vomiting blood
- Sudden severe headache, confusion, or weakness
- Chest pain or difficulty breathing
- Swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is dabitra 110 capsule used for?
This medicine is an anticoagulant used to prevent blood clots and stroke in conditions like atrial fibrillation. It works by directly inhibiting thrombin.
- Generic Name: Dabigatran Etexilate (110mg)
- Manufacturer: Emcure Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dabitra 110 capsule के बारे में (Hindi Summary)
उपयोग: यह दवा एक ओरल एंटीकोआगुलेंट है जिसका उपयोग रक्त के थक्के बनने से रोकने के लिए किया जाता है। यह अट्रियल फिब्रिलेशन, डीप वेन थ्रोम्बोसिस और पल्मोनरी एम्बोलिज्म जैसी स्थितियों में स्ट्रोक और थक्के को रोकने में मदद करती है। यह थ्रोम्बिन को सीधे ब्लॉक करके काम करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मसूड़ों से खून आना, नाक से खून आना, आसानी से चोट लगना, पेट खराब होना, दस्त और जी मिचलाना शामिल हैं। गंभीर दुष्प्रभावों में बड़ी मात्रा में रक्तस्राव, जैसे गैस्ट्रोइंटेस्टाइनल ब्लीडिंग या मस्तिष्क में रक्तस्राव शामिल हो सकते हैं। किसी भी असामान्य रक्तस्राव पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे अचानक बंद न करें क्योंकि इससे थक्के बनने का खतरा बढ़ सकता है। किसी भी सर्जरी या डेंटल प्रोसीजर से पहले अपने डॉक्टर को इस दवा के बारे में बताएं। चोट लगने से बचें और नरम टूथब्रश का उपयोग करें। बिना डॉक्टर की सलाह के अन्य रक्त पतला करने वाली दवाएं न लें। नियमित रूप से किडनी फंक्शन की जांच कराएं।
💊 dabitra 110 capsule Uses & Benefits
[{"condition":"Prevention of stroke and systemic embolism in non-valvular atrial fibrillation","description":"This medicine reduces the risk of stroke and blood clots in patients with atrial fibrillation not caused by heart valve problems.","evidence":"Well-established"},{"condition":"Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE)","description":"Used to treat existing blood clots in the legs or lungs and to prevent their recurrence.","evidence":"Well-established"},{"condition":"Prevention of venous thromboembolism after hip or knee replacement surgery","description":"Helps prevent blood clots forming after major orthopedic surgery.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Anticoagulation in patients with mechanical heart valves","description":"Not recommended due to increased risk of thromboembolic events compared to warfarin.","evidence":"Limited and not recommended"},{"condition":"Prevention of thrombosis in antiphospholipid syndrome","description":"May be considered in some cases but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Atrial fibrillation
Also treats: Deep vein thrombosis, Pulmonary embolism, Venous thromboembolism prophylaxis
📋 Drug Information
| Generic Name(s) | Dabigatran Etexilate (110mg) |
| Brand Name | dabitra 110 capsule |
| Manufacturer | Emcure Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Direct thrombin inhibitor- oral |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in the original container. Protect from moisture and direct sunlight. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by directly and reversibly inhibiting thrombin, both free and clot-bound, thereby preventing the conversion of fibrinogen to fibrin and inhibiting platelet aggregation. This results in a predictable anticoagulant effect without the need for routine coagulation monitoring.
Mechanism Steps
💡 How to Take dabitra 110 capsule
Strength: 110 mg immediate-release tablet
Dosage Information
| Adult Dosage | The typical adult dose for prevention of stroke in atrial fibrillation is 150 mg twice daily, but for patients over 80 years or with increased bleeding risk, 110 mg twice daily may be used. For treatment of DVT/PE, the dose is 150 mg twice daily after initial parenteral anticoagulation. For post-orthopedic surgery prophylaxis, 110 mg is taken 1-4 hours after surgery and then 220 mg once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may require dose reduction based on renal function and bleeding risk. The 110 mg dose is often used in patients over 80 years. |
| Renal Impairment | For patients with CrCl 30-50 mL/min, dose reduction or avoidance may be necessary. For CrCl <30 mL/min, use is contraindicated. For CrCl 15-30 mL/min, dose should be reduced or avoided. Consult a clinician for individualized dosing. |
| Hepatic Impairment | No specific dose adjustment is recommended for mild to moderate hepatic impairment, but use with caution in severe hepatic impairment. |
| Maximum Daily Dose | 300 mg per day (as 150 mg twice daily) for most indications; 220 mg once daily for post-surgical prophylaxis. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dabitra 110 capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| NSAIDs | Major | |
| Ketoconazole | Major | |
| Amiodarone | Moderate | |
| Clopidogrel | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- NSAIDs (e.g., ibuprofen, naproxen)
- P-glycoprotein inhibitors (e.g., ketoconazole, verapamil)
⚡ Moderate Interactions
- Amiodarone
- Clopidogrel
🍷 Alcohol Interaction
Alcohol may increase the risk of gastrointestinal bleeding and should be avoided or limited while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active pathological bleeding","Severe renal impairment (CrCl
⚠️ Warnings & Precautions
["Increased risk of bleeding, especially in patients with renal impairment, elderly, or those on other anticoagulants.","Premature discontinuation increases risk of thrombotic events.","Spinal/epidural hematoma risk with neuraxial anesthesia.","Not recommended in patients with mechanical heart valves.","Use with caution in patients with moderate renal impairment.","Avoid in patients with active bleeding."]
🤱 Lactation Safety
Not established from the available information. Breastfeeding is not recommended while taking this medicine. Consult your doctor.
💊 Overdose Management
There is no specific antidote for dabigatran, but idarucizumab is available as a reversal agent. In case of overdose, immediate medical attention is required. Supportive measures and monitoring for bleeding are essential. Hemodialysis may remove dabigatran from the blood.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is more than 6 hours until your next scheduled dose. If it is less than 6 hours, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not stop taking it suddenly without medical advice, as this can increase the risk of blood clots. Inform all healthcare providers, including dentists, that you are taking this medicine before any procedure. Avoid activities that increase the risk of injury or bleeding. Use a soft toothbrush and electric razor to minimize bleeding. Do not take other blood-thinning medicines or NSAIDs without consulting your doctor. Keep all appointments for blood tests to monitor kidney function and clotting parameters. Store this medicine at room temperature away from moisture and heat. If you miss a dose, follow your doctor's instructions; do not double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of bleeding and may require dose reduction. Regular monitoring of renal function is essential.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning pregnancy, consult your doctor to discuss alternative anticoagulation options.
🏥 Post-Surgery Considerations
This medicine may be used after surgery to prevent blood clots. Follow your surgeon's instructions regarding when to restart and dosing.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. You may need to stop it temporarily or take precautions to control bleeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid contact sports or activities with a high risk of injury or bleeding. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may not affect your ability to work, but if you experience dizziness or bleeding, avoid driving or operating heavy machinery. Inform your employer if your job involves a risk of injury.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor may decide to stop it based on your condition, bleeding risk, or before surgery. Abrupt discontinuation can increase the risk of blood clots.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of bleeding, especially in elderly patients or those with renal impairment. Regular monitoring of kidney function and hemoglobin is recommended. It is important to weigh the benefits of stroke prevention against bleeding risks.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another anticoagulant that requires regular INR monitoring.
Evidence: Well-establishedA factor Xa inhibitor with once-daily dosing.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, inform your healthcare provider about this medicine before receiving any vaccine, especially those that may cause bleeding.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing times gradually in consultation with your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1-2 hours after taking a dose, but its full anticoagulant effect may take a few days to stabilize.
A: No, you should not stop taking this medicine without consulting your doctor, as it may increase the risk of blood clots.
A: If you miss a dose, take it as soon as you remember if it is more than 6 hours until your next dose. If less than 6 hours, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for dabitra 110 capsule
View AllAlternative brands with exact same active ingredient:
-
dabigo 110mg capsuleSun Pharmaceutical Industries Ltd ₹154.51 31.3% CHEAPER
-
dabimend 110 capsuleMendcure Life Sciences Pvt Ltd ₹210.94 6.2% CHEAPER
-
dabxiga 110mg capsuleLupin Ltd ₹225.00 SAME PRICE
-
dabanex 110mg capsuleAjanta Pharma Ltd ₹234.38 4.2% COSTLIER
-
macdaxa 110mg capsuleMacleods Pharmaceuticals Pvt Ltd ₹253.13 12.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken without regular blood tests.
Fact: While routine coagulation monitoring is not required, kidney function should be monitored regularly. - Myth: This medicine is safe during pregnancy.
Fact: This medicine is not recommended during pregnancy due to risk of bleeding.
🔄 Alternative Options
Generic Alternatives
- Dabigatran Etexilate 110 mg capsule
Brand Alternatives
- Pradaxa
- Dabigatran