cypremal injection

4.3 (12 reviews)

Tramadol (NA)

🏭 Staunch Health Care Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is cypremal injection used for?

Asic 50mg Tablet (Tramadol) is used to treat PAIN ANALGESICS. It contains Tramadol (NA), which Binds to mu-opioid receptors and inhibits serotonin and norepinephrine reuptake.. Always consult your doctor before use. Take as prescribed.

Generic Name: Tramadol
Manufacturer: Staunch Health Care Pvt Ltd
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 cypremal injection Uses & Benefits

Moderate to moderately severe pain.

Off-label uses: Restless legs syndrome, premature ejaculation, neuropathic pain.

📋 Drug Information

Generic Name(s)	Tramadol
Brand Name	Asic 50mg Tablet
Manufacturer	Staunch Health Care Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	PAIN ANALGESICS
Action Class	Opioids
Route of Administration	Oral.
Storage	Store at room temperature (20-25°C), protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly and almost completely absorbed after oral administration.

DistributionWidely distributed throughout the body; crosses the blood-brain barrier and placenta.

Protein BindingApproximately 20% bound to plasma proteins.

MetabolismExtensively metabolized in the liver via CYP2D6 and CYP3A4 to active metabolite O-desmethyltramadol (M1).

Half-LifeApproximately 5-6 hours for tramadol; 7-9 hours for M1.

ExcretionPrimarily renal (90%), with about 30% excreted as unchanged drug.

BioavailabilityApproximately 70-75% after oral administration.

Onset of ActionWithin 1 hour.

Peak Plasma Time2 hours.

Duration of Action4-6 hours.

How It Works

Binds to mu-opioid receptors and inhibits serotonin and norepinephrine reuptake.

Mechanism Steps

1Binds to mu-opioid receptors in the CNS, activating G-protein coupled receptors.

2Inhibits adenylate cyclase, reducing cAMP levels.

3Opens potassium channels and closes calcium channels, reducing neurotransmitter release.

💡 How to Take cypremal injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of cypremal injection

✅ Common Side Effects

Nausea
Dizziness
Drowsiness
Constipation
Headache
Vomiting
Sweating
Dry mouth

🚨 Serious Side Effects

Seizures
Serotonin syndrome
Respiratory depression
Hypotension
Bradycardia
QT prolongation
Anaphylaxis

⚠️ Rare Side Effects

Adrenal insufficiency
SIADH
Hepatotoxicity
Pancreatitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
MAOIs	Major	Risk of serotonin syndrome
SSRIs	Major	Increased risk of serotonin syndrome
SNRIs	Major	Increased risk of serotonin syndrome
TCAs	Major	Increased risk of seizures and serotonin syndrome
Linezolid	Major	Risk of serotonin syndrome
Methylene Blue	Major	Risk of serotonin syndrome
Other CNS depressants	Major	Additive CNS depression
Alcohol	Major	Increased CNS depression and seizure risk
Carbamazepine	Moderate	Reduced tramadol efficacy
Rifampin	Moderate	Reduced tramadol efficacy
Quinidine	Moderate	Increased tramadol levels
CYP2D6 inhibitors	Moderate	Altered tramadol metabolism
CYP3A4 inhibitors	Moderate	Increased tramadol levels
Digoxin	Minor	Possible increased digoxin levels
Warfarin	Minor	Possible increased INR

🚨 Major Interactions

MAOIs
SSRIs
SNRIs
TCAs
Linezolid
Methylene Blue
Other CNS depressants
Alcohol

⚡ Moderate Interactions

Carbamazepine
Rifampin
Quinidine
CYP2D6 inhibitors
CYP3A4 inhibitors

ℹ️ Minor Interactions

Digoxin
Warfarin

🍽️ Food Interactions

Grapefruit juice may increase levels

🍷 Alcohol Interaction

Increased CNS depression and risk of seizures.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, acute intoxication with alcohol or CNS depressants, severe respiratory depression, MAOI use within 14 days, uncontrolled seizures.

📊 Monitoring Parameters

Pain relief, respiratory rate, blood pressure, heart rate, signs of serotonin syndrome, seizure activity.

🤱 Lactation Safety

Not recommended; excreted in breast milk.

💊 Overdose Management

Supportive care; naloxone may reverse respiratory depression but not all effects; monitor for seizures.

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for cypremal injection

View All

Alternative brands with exact same active ingredient (Tramadol (NA)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Verified User Jul 10, 2026

Effective and reliable. Worked as expected.