Cyclophosphamide 500mg Injection: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever, chills, or sore throat (signs of infection)
- Unusual bleeding or bruising
- Blood in urine or painful urination
- Chest pain or shortness of breath
- New or worsening cough
- Severe abdominal pain
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is cyphos 500mg injection used for?
Cyclophosphamide injection is a chemotherapy medicine used to treat certain cancers and severe autoimmune diseases. It works by slowing or stopping the growth of abnormal cells. It is given by a healthcare professional and requires close monitoring.
- Generic Name: Cyclophosphamide
- Manufacturer: Getwell Oncology Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cyphos 500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा कैंसर और कुछ गंभीर ऑटोइम्यून बीमारियों के इलाज के लिए दी जाती है। यह शरीर में असामान्य कोशिकाओं की वृद्धि को रोकती है। यह केवल डॉक्टर की देखरेख में अस्पताल या क्लिनिक में इंजेक्शन के रूप में दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, बालों का झड़ना, थकान और भूख में कमी शामिल हैं। गंभीर दुष्प्रभावों में रक्त कोशिकाओं की कमी, मूत्र में खून आना, हृदय और फेफड़ों की समस्याएं हो सकती हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल प्रशिक्षित स्वास्थ्यकर्मियों द्वारा दी जानी चाहिए। इलाज के दौरान खूब पानी पिएं। नियमित रक्त जांच करवाएं। गर्भवती महिलाओं और स्तनपान कराने वाली महिलाओं को यह दवा नहीं लेनी चाहिए। डॉक्टर की सलाह के बिना कोई भी टीका न लगवाएं।
💊 cyphos 500mg injection Uses & Benefits
[{"condition":"Lymphoma","description":"Used as part of combination chemotherapy regimens to treat Hodgkin and non-Hodgkin lymphoma.","evidence":"Well-established"},{"condition":"Leukemia","description":"Included in treatment protocols for acute and chronic leukemias.","evidence":"Well-established"},{"condition":"Multiple myeloma","description":"Often combined with other agents to manage multiple myeloma.","evidence":"Well-established"},{"condition":"Breast cancer","description":"Used in some chemotherapy regimens for breast cancer.","evidence":"Well-established"},{"condition":"Ovarian cancer","description":"Part of chemotherapy for ovarian cancer.","evidence":"Well-established"},{"condition":"Lupus nephritis","description":"Used to suppress severe kidney inflammation in lupus.","evidence":"Well-established"},{"condition":"Vasculitis","description":"Helps control severe vasculitis by suppressing the immune system.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Multiple sclerosis","description":"Sometimes used off-label for aggressive multiple sclerosis.","evidence":"Limited"},{"condition":"Scleroderma","description":"May be used off-label for severe scleroderma lung disease.","evidence":"Limited"}]
Primary treatment for: Cancer
Also treats: Lymphoma, Leukemia, Multiple myeloma, Breast cancer, Ovarian cancer, Lupus nephritis, Vasculitis
📋 Drug Information
| Generic Name(s) | Cyclophosphamide |
| Brand Name | Adcyclo Tablet |
| Manufacturer | Getwell Oncology Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkylating agent |
| Route of Administration | Parenteral |
| Storage | Store at controlled room temperature (20-25°C). Protect from light. Keep in original container. |
| Shelf Life | Not established from the available information. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Cyclophosphamide is a prodrug that requires activation by liver enzymes. Its active metabolites, including phosphoramide mustard, cross-link DNA strands at guanine N-7 positions. This cross-linking prevents DNA replication and transcription, leading to cell cycle arrest and apoptosis. The medicine is cell-cycle non-specific but is most effective against rapidly dividing cells.
Mechanism Steps
💡 How to Take cyphos 500mg injection
Strength: Injection: 500 mg
Dosage Information
| Adult Dosage | The dose of this medicine is highly individualized and depends on the specific condition being treated, the patient's body weight, kidney and liver function, and other factors. It is given as an injection by a healthcare professional. Common regimens may involve doses ranging from 500 mg to 1000 mg per square meter of body surface area, but the exact dose must be determined by a qualified clinician. Never attempt to self-administer this medicine. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially bone marrow suppression and cardiotoxicity. Doses may need to be adjusted based on kidney and liver function. Close monitoring is required. |
| Renal Impairment | Dose adjustment may be necessary in patients with kidney impairment. Consult a clinician for individualized dosing. |
| Hepatic Impairment | Dose adjustment may be necessary in patients with liver impairment. Consult a clinician for individualized dosing. |
| Maximum Daily Dose | Not established from the available information. The maximum dose is determined by the treating clinician based on the specific protocol. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cyphos 500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Allopurinol | Major | |
| Live vaccines | Major | |
| Cimetidine | Moderate | |
| Corticosteroids | Moderate |
🚨 Major Interactions
- Warfarin
- Allopurinol
- Live vaccines
⚡ Moderate Interactions
- Cimetidine
- Corticosteroids
🍷 Alcohol Interaction
Alcohol may increase the risk of stomach irritation and liver toxicity. It is best to avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to cyclophosphamide","Severe bone marrow suppression","Active infection","Urinary outflow obstruction","Pregnancy (unless benefit outweighs risk)"]
⚠️ Warnings & Precautions
["This medicine can cause severe bone marrow suppression; regular blood tests are required.","It can cause hemorrhagic cystitis; drink plenty of fluids.","It may cause heart damage; report chest pain or shortness of breath.","It can cause lung toxicity; report new cough or breathing difficulty.","It may increase the risk of infections; avoid contact with sick people.","It can harm a developing baby; use effective contraception.","It may cause secondary cancers; long-term follow-up is important."]
🤱 Lactation Safety
Not established from the available information. Breastfeeding is not recommended during treatment.
💊 Overdose Management
Overdose can cause severe bone marrow suppression, cardiotoxicity, and other serious effects. Treatment is supportive and symptomatic. There is no specific antidote. In case of overdose, seek immediate medical attention.
⏰ Missed Dose
This medicine is given by a healthcare professional. If you miss an appointment for your dose, contact your doctor as soon as possible to reschedule. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be handled and administered by trained healthcare professionals. Patients should avoid contact with the injection site and wash hands thoroughly if any spillage occurs. It is important to drink plenty of fluids to help flush the bladder and reduce the risk of bladder irritation. Regular blood tests are necessary to monitor blood counts, kidney function, and liver function. Both men and women should use effective contraception during treatment and for a period after, as this medicine can harm a developing baby. Breastfeeding is not recommended while receiving this medicine. Do not receive any live vaccines without consulting your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the toxic effects of cyclophosphamide, especially bone marrow suppression and cardiotoxicity. Close monitoring and dose adjustments may be necessary.
🤰 Pregnancy Planning (TTC)
This medicine can cause harm to a developing baby. Both men and women should use effective contraception during treatment and for a period after. Discuss pregnancy planning with your doctor before starting treatment.
🏥 Post-Surgery Considerations
Cyclophosphamide can impair wound healing and increase the risk of infection. Inform your surgeon if you are receiving this medicine. Your doctor may recommend delaying surgery or adjusting your treatment plan.
🦷 Dental Procedures
Cyclophosphamide can increase the risk of bleeding and infection during dental procedures. Inform your dentist that you are receiving this medicine. Your dentist may recommend postponing non-urgent procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Fatigue is common during treatment. Listen to your body and rest when needed. Avoid strenuous exercise if you feel unwell. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may experience fatigue, nausea, or other side effects that can affect your ability to work. Discuss your treatment schedule with your employer and plan for rest periods. Avoid driving if you feel dizzy or fatigued.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping suddenly may worsen your condition. Your doctor will determine when it is safe to stop based on your response to treatment and overall health.
📅 Long-Term Use Effects
Long-term use of cyclophosphamide may increase the risk of secondary cancers, infertility, and organ damage. Regular monitoring of blood counts, kidney function, liver function, and heart function is necessary. Discuss any long-term concerns with your healthcare provider.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the condition, other chemotherapy medicines may be used.
Evidence: Well-establishedFor autoimmune diseases, other immunosuppressants may be considered.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with cyclophosphamide. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at controlled room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is given in a healthcare setting, so travel is not applicable for self-administration. If you need to travel for treatment, carry your prescription and medical records. Inform your doctor about your travel plans to coordinate care. Store the medicine as directed by your healthcare provider.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The effects of cyclophosphamide are not immediate. It may take several weeks to months to see the full benefit, depending on the condition being treated.
A: Hair loss is a common side effect, but it is usually temporary. Hair typically regrows after treatment is completed.
A: No, this medicine can harm a developing baby. Use effective contraception during treatment and for a period after.
🤔 Common Patient Concerns
🔄 Substitutes for cyphos 500mg injection
View AllAlternative brands with exact same active ingredient:
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phosmid 500mg injectionNeon Laboratories Ltd ₹43.00 47.6% CHEAPER
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endoxan 500 mg tabletZydus Cadila ₹43.47 47% CHEAPER
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oncomide 500mg injectionKhandelwal Laboratories Pvt Ltd ₹57.14 30.3% CHEAPER
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oncoxan 500mg injectionChandra Bhagat Pharma Pvt Ltd ₹57.14 30.3% CHEAPER
-
cycram 500mg injectionVhb Life Sciences Inc ₹59.52 27.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Cyclophosphamide is safe for everyone.
Fact: It is a powerful medicine with serious side effects and is only used under strict medical supervision. - Myth: You can take cyclophosphamide at home.
Fact: It must be given by a healthcare professional in a clinic or hospital setting.
🔄 Alternative Options
Generic Alternatives
- Cyclophosphamide injection
Brand Alternatives
- Cycloxan 500mg injection