cyphos 1000mg injection - Uses, Price, Side Effects & Substitutes
What is cyphos 1000mg injection used for?
Adcyclo Tablet (Cyclophosphamide) is used to treat ANTI NEOPLASTICS. It contains Cyclophosphamide (1000mg), which Alkylating agent; cross-links DNA, inhibiting DNA replication and transcription. Always consult your doctor before use. Take as prescribed.
- Generic Name: Cyclophosphamide
- Manufacturer: Getwell Oncology Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cyphos 1000mg injection Uses & Benefits
Malignant lymphomas, leukemias, breast cancer, ovarian cancer, neuroblastoma, retinoblastoma, multiple myeloma, autoimmune diseases (off-label)
Off-label uses: Systemic lupus erythematosus, Wegener's granulomatosis, Multiple sclerosis, Organ transplant rejection
๐ Drug Information
| Generic Name(s) | Cyclophosphamide |
| Brand Name | Adcyclo Tablet |
| Manufacturer | Getwell Oncology Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkylating agent |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Alkylating agent; cross-links DNA, inhibiting DNA replication and transcription
Mechanism Steps
๐ก How to Take cyphos 1000mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cyphos 1000mg injection
โ Common Side Effects
- Nausea
- vomiting
- alopecia
- myelosuppression
- hemorrhagic cystitis
- amenorrhea
- oligospermia
๐จ Serious Side Effects
- Cardiotoxicity
- secondary malignancies
- hepatic veno-occlusive disease
- interstitial pneumonitis
- SIADH
โ ๏ธ Rare Side Effects
- Anaphylaxis
- typhlitis
- acute pancreatitis
- pulmonary fibrosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased anticoagulant effect and bleeding risk |
| Rifampin | Major | Reduced cyclophosphamide efficacy due to increased metabolism |
| Ketoconazole | Major | Increased cyclophosphamide toxicity due to decreased metabolism |
| Live vaccines | Major | Risk of disseminated infection |
| Digoxin | Moderate | Reduced digoxin absorption |
| Thiazide diuretics | Moderate | Increased myelosuppression |
| Allopurinol | Moderate | Increased bone marrow suppression |
| Tamoxifen | Moderate | Increased thromboembolic risk |
| Cimetidine | Minor | Possible increased cyclophosphamide toxicity |
| Chloramphenicol | Minor | Possible increased myelosuppression |
๐จ Major Interactions
- Warfarin
- CYP2B6 inducers (e.g., rifampin)
- CYP3A4 inhibitors (e.g., ketoconazole)
- Live vaccines
โก Moderate Interactions
- Digoxin
- Thiazide diuretics
- Allopurinol
- Tamoxifen
โน๏ธ Minor Interactions
- Cimetidine
- Chloramphenicol
๐ฝ๏ธ Food Interactions
Grapefruit juice (may increase toxicity)
๐ท Alcohol Interaction
Avoid; may increase hepatotoxicity and dehydration
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, severe bone marrow suppression, active infections, pregnancy
๐ Monitoring Parameters
CBC with differential, renal function, liver function, urinalysis (for hematuria), cardiac function (if high dose)
๐คฑ Lactation Safety
Contraindicated; excreted in breast milk
๐ Overdose Management
Supportive care; monitor for myelosuppression, cardiotoxicity, hemorrhagic cystitis; consider hemodialysis
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for cyphos 1000mg injection
View AllAlternative brands with exact same active ingredient (Cyclophosphamide (1000mg)):
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oncomide 1000mg injectionKhandelwal Laboratories Pvt Ltd โน99.77 25.5% CHEAPER
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cycram 1000mg injectionVhb Life Sciences Inc โน104.76 21.8% CHEAPER
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oncoxan 1000mg injectionChandra Bhagat Pharma Pvt Ltd โน106.00 20.9% CHEAPER
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oncophos 1000mg infusionCadila Pharmaceuticals Ltd โน106.00 20.9% CHEAPER
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uniphos 1000mg injectionUnited Biotech Pvt Ltd โน107.30 19.9% CHEAPER
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cycrame 1000mg injectionMiracalus Pharma Pvt Ltd โน110.00 17.9% CHEAPER
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oncophos 1000mg injectionCadila Pharmaceuticals Ltd โน112.64 15.9% CHEAPER
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cysmide 1000mg injectionSamarth Life Sciences Pvt Ltd โน118.00 11.9% CHEAPER
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phoxelon 1000mg injectionCelon Laboratories Ltd โน125.00 6.7% CHEAPER
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cytero 1000mg injectionHetero Drugs Ltd โน130.00 3% CHEAPER
Medical Note: Always consult your doctor before switching medications.