Alporate D 250mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the skin or eyes (jaundice)
- Severe abdominal pain that may radiate to the back
- Unusual bruising or bleeding
- Confusion, lethargy, or vomiting (possible hyperammonemia)
- Rash with blisters or peeling skin
- Thoughts of harming yourself or others
- Seizures that worsen or new types of seizures
- Decreased urine output or swelling in the legs
If experiencing severe symptoms, call emergency services immediately.
What is cylenc ds 250mg tablet used for?
This medicine is an anticonvulsant and mood stabiliser containing divalproex sodium 250 mg. It is used to treat epilepsy, bipolar mania, and to prevent migraines. It works by increasing GABA levels in the brain. It requires a prescription and regular monitoring.
- Generic Name: Divalproex
- Manufacturer: D.S. Lab
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cylenc ds 250mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डाइवलप्रोएक्स सोडियम 250 मिलीग्राम युक्त एक मौखिक गोली है। इसका उपयोग मिर्गी के दौरे, बाइपोलर डिसऑर्डर में मैनिया, और माइग्रेन के सिरदर्द को रोकने के लिए किया जाता है। यह मस्तिष्क में GABA नामक रसायन को बढ़ाकर काम करती है, जिससे दौरे और मूड स्विंग्स कम होते हैं। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, भूख न लगना, सिरदर्द, चक्कर आना, नींद आना और कंपन शामिल हैं। गंभीर दुष्प्रभावों में लिवर की क्षति, अग्न्याशय की सूजन, कम प्लेटलेट काउंट, और त्वचा पर गंभीर दाने हो सकते हैं। अगर आपको पीलिया, गंभीर पेट दर्द, या असामान्य खून बहना दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। शराब न पिएं क्योंकि इससे लिवर को नुकसान और नींद बढ़ सकती है। गाड़ी चलाने या मशीन चलाने से बचें जब तक आपको पता न चले कि यह दवा आप पर कैसे असर करती है। दवा अचानक बंद न करें। नियमित रूप से खून की जांच कराएं। गर्भवती महिलाओं को यह दवा नहीं लेनी चाहिए।
💊 cylenc ds 250mg tablet Uses & Benefits
[{"condition":"Complex partial seizures","description":"This medicine is used as monotherapy or add-on therapy to reduce the frequency and severity of complex partial seizures in adults and children.","evidence":"Well-established"},{"condition":"Simple and complex absence seizures","description":"It helps control absence seizures, which are brief episodes of impaired consciousness, often in children.","evidence":"Well-established"},{"condition":"Manic episodes of bipolar disorder","description":"This medicine is used to treat acute manic or mixed episodes and can also be used for maintenance therapy to prevent mood swings.","evidence":"Well-established"},{"condition":"Migraine prophylaxis","description":"It is prescribed to reduce the frequency of migraine headaches in adults who have not responded to other preventive treatments.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Neuropathic pain","description":"Sometimes prescribed off-label to relieve nerve pain, although evidence is limited.","evidence":"Limited"},{"condition":"Post-traumatic stress disorder (PTSD)","description":"Occasionally used off-label to help manage symptoms of PTSD, but evidence is not strong.","evidence":"Limited"}]
Primary treatment for: Epilepsy
Also treats: Bipolar disorder, Migraine
📋 Drug Information
| Generic Name(s) | Divalproex |
| Brand Name | Alporate D 500mg Tablet ER |
| Manufacturer | D.S. Lab |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Sodium channel modulators (AED) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep the container tightly closed and protect from moisture and light. Do not store in the bathroom. |
| Shelf Life | 24 months from the date of manufacture, or as indicated on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. GABA is an inhibitory neurotransmitter that reduces excessive nerve cell firing. Divalproex sodium is a stable coordination compound of sodium valproate and valproic acid. After oral administration, it dissociates into valproate ions in the gastrointestinal tract. Valproate is believed to act by inhibiting the enzymes responsible for GABA breakdown, thereby enhancing GABAergic transmission. It may also block voltage-gated sodium channels and affect other neurotransmitter systems, which contributes to its anticonvulsant and mood-stabilising effects.
Mechanism Steps
💡 How to Take cylenc ds 250mg tablet
Strength: Immediate-release oral tablet containing 250 mg of divalproex sodium.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and clinical response. For epilepsy, the usual starting dose is 10 to 15 mg/kg/day, which may be increased gradually. For bipolar mania, a typical starting dose is 750 mg/day in divided doses, with adjustments based on response and tolerability. For migraine prophylaxis, the recommended dose is 250 mg twice daily, which may be increased up to 1000 mg/day. Always follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and dizziness. Doses should be started low and increased slowly. Close monitoring for liver function, blood counts, and neurological effects is recommended. |
| Renal Impairment | Patients with renal impairment may require dose adjustment. Valproate is primarily metabolized in the liver, but renal impairment can affect the elimination of metabolites. Monitor closely and adjust dose as needed. |
| Hepatic Impairment | This medicine is contraindicated in patients with significant hepatic impairment. In patients with mild hepatic impairment, dose reduction and close monitoring of liver function are necessary. |
| Maximum Daily Dose | The maximum recommended dose is 60 mg/kg/day. Doses above this are not recommended due to increased risk of toxicity. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cylenc ds 250mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Lamotrigine | Major | |
| Carbamazepine | Major | |
| Aspirin | Major | |
| Phenytoin | Moderate | |
| Rifampicin | Moderate | |
| Erythromycin | Moderate | |
| Cimetidine | Moderate | |
| Paracetamol | Minor | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Lamotrigine
- Carbamazepine
- Aspirin
⚡ Moderate Interactions
- Phenytoin
- Rifampicin
- Erythromycin
- Cimetidine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Both alcohol and valproate can cause central nervous system depression, leading to increased drowsiness and dizziness. Alcohol also increases the risk of liver toxicity and may lower the seizure threshold, reducing the effectiveness of the medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to divalproex sodium, valproic acid, or any component of the formulation.","Active liver disease or significant hepatic impairment.","Urea cycle disorders.","Known mitochondrial disorders caused by mutations in the POLG gene.","Pregnancy for migraine prophylaxis.","Women of childbearing potential unless effective contraception is used and other treatments are ineffective."]
⚠️ Warnings & Precautions
["Hepatotoxicity: Liver failure can occur, especially in children under 2 years and those with mitochondrial disease. Monitor liver function closely.","Pancreatitis: Cases have been reported, sometimes fatal. Discontinue if suspected.","Suicidal thoughts: Monitor patients for depression or suicidal ideation.","Thrombocytopenia: Low platelet counts can occur; monitor blood counts.","Hyperammonemia: Can occur even with normal liver function; monitor if symptoms arise.","Fetal risk: Causes birth defects and neurodevelopmental disorders. Avoid in pregnancy unless essential.","Drug interactions: Many interactions can alter efficacy or toxicity; review all concomitant medications.","Withdrawal: Do not stop abruptly as it can precipitate seizures."]
🤱 Lactation Safety
Valproate is excreted in breast milk at low levels. The amount ingested by the infant is generally small, but there is a risk of side effects. Breastfeeding may be considered if the benefits outweigh the risks, but monitor the infant for jaundice, drowsiness, or poor feeding. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause serious toxicity, including deep coma, respiratory depression, and cerebral edema. There is no specific antidote. Treatment is supportive and may include gastric lavage if ingestion is recent, activated charcoal, and hemodialysis in severe cases. Naloxone has been used in some cases but is not routinely recommended. Immediate medical attention is essential.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Before starting this medicine, tell your doctor if you have any liver or kidney problems, a urea cycle disorder, or a history of depression or suicidal thoughts. Do not drink alcohol while taking this medicine because it can increase the risk of liver damage and excessive drowsiness. This medicine can cause dizziness and blurred vision, so avoid driving or operating heavy machinery until you know how it affects you. Always take this medicine exactly as prescribed, and do not stop it suddenly because doing so can trigger seizures. If you miss a dose, follow your doctor's instructions and never double the dose. Keep all follow-up appointments and blood tests, as they are important for monitoring your liver function, blood counts, and drug levels. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, because this medicine can harm the baby. Store this medicine at room temperature, away from moisture and heat, and keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and tremors. They may also have reduced liver and kidney function, requiring lower doses. Regular monitoring of liver function, blood counts, and drug levels is essential. Falls risk may be increased due to dizziness.
🤰 Pregnancy Planning (TTC)
This medicine is associated with a high risk of birth defects and neurodevelopmental disorders. Women planning pregnancy should discuss alternative treatments with their doctor. If this medicine is essential, effective contraception should be used, and the lowest effective dose should be taken. Folic acid supplementation is recommended before conception and during early pregnancy.
🏥 Post-Surgery Considerations
Inform your surgeon and anaesthesiologist that you are taking this medicine. It can interact with anaesthetic agents and increase the risk of bleeding. Your doctor may advise adjusting the dose before surgery. Do not stop the medicine without medical advice.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It can cause bleeding tendencies due to low platelet count, so dental procedures may need precautions. Good oral hygiene is important as the medicine can cause gum problems.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause dizziness and drowsiness, so avoid activities that require alertness until you know how it affects you. Moderate exercise is generally safe, but avoid extreme sports or activities where a sudden seizure could be dangerous. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. It is important to assess your individual response before performing such tasks. Mood stabilisation may improve work performance, but regular breaks and stress management are advised. Inform your employer about your condition if necessary for safety.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Abrupt discontinuation can cause seizures or mood relapse. Your doctor may gradually reduce the dose over time. If you experience serious side effects such as liver problems or pancreatitis, your doctor may advise stopping the medicine immediately.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to weight gain, hair loss, tremors, and bone density loss. It can also cause hormonal changes and polycystic ovary syndrome in women. Regular monitoring of liver function, blood counts, and drug levels is essential. Patients should have periodic eye examinations due to the risk of visual disturbances. Long-term use should be reviewed regularly to ensure the benefits outweigh the risks.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help manage mood symptoms in bipolar disorder alongside medication.
Evidence: Well-establishedSometimes used in children with epilepsy who do not respond to medication.
Evidence: Well-established for certain types of epilepsyMay help reduce stress and migraine frequency.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with most vaccines. However, it can affect immune function, so consult your doctor before receiving live vaccines. Annual flu vaccination is recommended for patients with chronic conditions.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. If crossing time zones, adjust dosing times gradually in consultation with your doctor. Store at room temperature and avoid leaving it in a hot car. Check customs regulations for controlled substances before travelling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: For seizures and mood stabilisation, it may take several days to weeks. For migraine prevention, it may take 2 to 4 weeks to see a reduction in headache frequency.
A: No, do not stop suddenly as it can cause withdrawal seizures or mood relapse. Always consult your doctor before stopping.
A: This medicine can cause serious birth defects and should be avoided during pregnancy, especially for migraine prophylaxis. Consult your doctor if you are pregnant or planning pregnancy.
🤔 Common Patient Concerns
🔄 Substitutes for cylenc ds 250mg tablet
View AllAlternative brands with exact same active ingredient:
-
esdival 250mg tablet erEsteem Pharmaceuticals ₹22.50 31.4% CHEAPER
-
diavox 250mg tabletPsycogen Captab ₹23.44 28.6% CHEAPER
-
davaindia divalproex 250mg tablet erDavaindia Generic Pharmacy ₹24.00 26.9% CHEAPER
-
kayval 250mg tabletSolitaire Pharmacia Pvt Ltd ₹24.00 26.9% CHEAPER
-
diproex 250mg tabletTorrent Pharmaceuticals Ltd ₹32.91 0.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is only for epilepsy.
Fact: It is also used for bipolar disorder and migraine prevention. - Myth: You can stop this medicine once you feel better.
Fact: Stopping suddenly can cause seizures or mood relapse; always consult your doctor. - Myth: This medicine is safe during pregnancy.
Fact: It can cause serious birth defects and should be avoided in pregnancy unless absolutely necessary.
🔄 Alternative Options
Generic Alternatives
- Divalproex sodium 250 mg tablet
- Valproic acid 250 mg tablet
Brand Alternatives
- Alporate D 250mg Tablet