curepime 500mg injection

4.7 (13 reviews)

Cefepime (500mg)

🏭 Mancure Drugs Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is curepime 500mg injection used for?

Appime 250mg Injection (Cefepime) is used to treat ANTI INFECTIVES. It contains Cefepime (500mg), which Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins. Always consult your doctor before use. Take as prescribed.

Generic Name: Cefepime
Manufacturer: Mancure Drugs Pvt Ltd
Form: Allopathy
Pregnancy Category: B
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 curepime 500mg injection Uses & Benefits

Treatment of pneumonia, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, febrile neutropenia.

Off-label uses: Meningitis, Osteomyelitis

📋 Drug Information

Generic Name(s)	Cefepime
Brand Name	Appime 250mg Injection
Manufacturer	Mancure Drugs Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI INFECTIVES
Action Class	Cephalosporins: 4th generation
Route of Administration	Intravenous (IV) or intramuscular (IM)
Storage	Store at 20-25°C (68-77°F); protect from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntravenous administration results in complete bioavailability.

DistributionWidely distributed into tissues and body fluids including cerebrospinal fluid.

Protein BindingApproximately 20%

MetabolismPartially metabolized to N-methylpyrrolidine (NMP) which is rapidly converted to N-methylpyrrolidine oxide.

Half-LifeApproximately 2 hours

ExcretionPrimarily excreted unchanged in urine via glomerular filtration and tubular secretion.

Bioavailability100% (intravenous)

Onset of ActionRapid

Peak Plasma TimeEnd of infusion

Duration of ActionApproximately 12 hours

How It Works

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis.

Mechanism Steps

1Cefepime binds to penicillin-binding proteins (PBPs) located on the bacterial cell wall.

2Inhibition of transpeptidase enzymes prevents cross-linking of peptidoglycan chains.

3Autolytic enzymes are activated, leading to cell wall degradation and bacterial lysis.

💡 How to Take curepime 500mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of curepime 500mg injection

✅ Common Side Effects

Diarrhea
Nausea
Vomiting
Rash
Injection site reactions

🚨 Serious Side Effects

Anaphylaxis
Clostridioides difficile colitis
Seizures
Acute renal failure

⚠️ Rare Side Effects

Hemolytic anemia
Agranulocytosis
Stevens-Johnson syndrome

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Aminoglycosides	Major	Increased risk of nephrotoxicity and ototoxicity
Loop diuretics	Major	Increased risk of nephrotoxicity
Probenecid	Major	Decreased renal excretion of cefepime, increased plasma levels
Warfarin	Moderate	Possible increased INR
Oral contraceptives	Moderate	Reduced efficacy of contraceptives
Antacids	Minor	No significant interaction

🚨 Major Interactions

Aminoglycosides
Loop diuretics
Probenecid

⚡ Moderate Interactions

Warfarin
Oral contraceptives

ℹ️ Minor Interactions

Antacids

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to cefepime or other cephalosporins, penicillins, or beta-lactam antibiotics.

📊 Monitoring Parameters

Renal function, complete blood count, signs of hypersensitivity, superinfection.

🤱 Lactation Safety

Excreted in breast milk in low concentrations; use with caution.

💊 Overdose Management

Supportive care; hemodialysis may enhance elimination.

⏰ Missed Dose

Administer as soon as remembered; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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🔄 Substitutes for curepime 500mg injection

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Alternative brands with exact same active ingredient (Cefepime (500mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.