Adgest 100 Capsule (Progesterone 100 mg) – Intramuscular Uses, Side Effects, and Safety Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Chest pain, breathlessness, or coughing up blood
- Pain, swelling, or redness in one leg
- Severe headache with vision changes
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Heavy vaginal bleeding or passage of tissue
- High fever with chills and worsening injection site pain
- Swelling of face, lips, or throat or difficulty breathing
If experiencing severe symptoms, call emergency services immediately.
What is curenin 100mg injection used for?
This medicine contains progesterone 100 mg and is given by intramuscular injection. It is used to support the uterine lining in fertility treatment, help maintain early pregnancy in selected cases, and protect the uterus during hormone replacement therapy. It must be administered by a healthcare professional.
- Generic Name: Progesterone (Natural Micronized)
- Manufacturer: Mancare Labs Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 curenin 100mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा प्रोजेस्टेरोन 100 मिलीग्राम कैप्सूल के रूप में उपलब्ध है और इसे इंट्रामस्क्युलर इंजेक्शन द्वारा दिया जाता है। इसका उपयोग मुख्य रूप से प्रजनन उपचार में गर्भाशय की परत को सहारा देने, कुछ मामलों में शुरुआती गर्भावस्था को बनाए रखने, और हार्मोन रिप्लेसमेंट थेरेपी में गर्भाशय की सुरक्षा के लिए किया जाता है। यह दवा केवल प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही लगाई जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन की जगह पर दर्द, लालिमा या सूजन, सिरदर्द, चक्कर आना, नींद आना, स्तनों में कोमलता, मूड में बदलाव और अनियमित योनि रक्तस्राव शामिल हैं। गंभीर दुष्प्रभाव कम होते हैं, लेकिन खून के थक्के, गंभीर एलर्जी, यकृत की समस्या या इंजेक्शन स्थल पर संक्रमण हो सकता है। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल इंट्रामस्क्युलर इंजेक्शन के रूप में दी जानी चाहिए, इसे नस में या त्वचा के नीचे न लगाएं। इंजेक्शन के बाद चक्कर या नींद आने पर वाहन न चलाएं। पैर में दर्द, सूजन, सीने में दर्द या सांस लेने में कठिनाई हो तो तुरंत आपातकालीन सहायता लें। अपने डॉक्टर को सभी दवाओं के बारे में बताएं और बिना सलाह दवा बंद न करें।
💊 curenin 100mg injection Uses & Benefits
[{"condition":"Luteal phase support in assisted reproduction","description":"This medicine is used to support the uterine lining after ovulation induction or embryo transfer in IVF and similar fertility treatments.","evidence":"Well-established"},{"condition":"Threatened or recurrent miscarriage","description":"Progesterone support may be prescribed to help maintain early pregnancy in women with a history of miscarriage or bleeding.","evidence":"Well-established"},{"condition":"Hormone replacement therapy","description":"Used in combination with estrogen to protect the uterine lining in women with a uterus who need hormone replacement.","evidence":"Well-established"},{"condition":"Menstrual irregularities","description":"May be used to regulate cycles in conditions such as secondary amenorrhea or oligomenorrhea due to progesterone deficiency.","evidence":"Established"},{"condition":"Endometrial preparation","description":"Helps prepare the endometrium for implantation in frozen embryo transfer cycles.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Preterm birth prevention","description":"Progesterone has been studied for preventing preterm birth in selected high-risk women, but use varies by guideline and patient profile.","evidence":"Limited"},{"condition":"Catamenial epilepsy","description":"Sometimes considered in seizure disorders linked to the menstrual cycle, but evidence is limited and specialist supervision is required.","evidence":"Limited"}]
Primary treatment for: Progesterone deficiency states including luteal phase support and threatened miscarriage
Also treats: Menstrual irregularities, Hormone replacement therapy in women with a uterus, Endometrial preparation for fertility treatment
📋 Drug Information
| Generic Name(s) | Progesterone (Natural Micronized) |
| Brand Name | Aqsusten 25 Solution for Injection |
| Manufacturer | Mancare Labs Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Natural Progesterone |
| Route of Administration | Intramuscular |
| Storage | Store in a cool, dry place away from direct sunlight, as directed on the label. Do not freeze unless specified. Keep the container tightly closed and out of reach of children. |
| Shelf Life | Not established from the available information for this specific product. Refer to the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information for this specific product. Progesterone use should follow national and institutional guidelines for the specific indication. |
| ICMR Guideline | Not established from the available information for this specific product. Follow your treating doctor's advice based on Indian clinical practice. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine delivers progesterone, which binds to intracellular progesterone receptors in target tissues such as the endometrium, myometrium, breast, and brain. The progesterone-receptor complex moves into the nucleus and modulates gene transcription, leading to changes in protein synthesis that prepare and maintain the endometrium for implantation, reduce uterine contractility, and support early pregnancy. It also influences the hypothalamic-pituitary-gonadal axis, helping to regulate ovulation and menstrual bleeding.
Mechanism Steps
💡 How to Take curenin 100mg injection
Strength: Progesterone 100 mg capsule for intramuscular use
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the indication, such as luteal phase support, miscarriage prevention, or hormone replacement. It is given by intramuscular injection, usually in a clinic or hospital setting. Do not self-administer unless specifically trained. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the sedative and fluid-retaining effects of this medicine. Use with caution and monitor for dizziness, falls, and cardiovascular events. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is established from the available information for renal impairment. Use with caution and follow your doctor's advice. |
| Hepatic Impairment | Use with caution in liver disease because progesterone is metabolized in the liver. Dose adjustment may be needed and must be determined by a qualified clinician. |
| Maximum Daily Dose | Not established from the available information for this specific product. Follow the dose prescribed by your clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of curenin 100mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Benzodiazepines | Moderate | |
| Antihypertensives | Moderate | |
| Thyroid hormone | Moderate | |
| Paracetamol | Minor | |
| Common antibiotics | Minor |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Strong CYP3A4 inhibitors such as ketoconazole
- Strong CYP3A4 inducers such as rifampicin
⚡ Moderate Interactions
- Benzodiazepines and sedatives
- Antihypertensives
- Thyroid hormone replacement
🍷 Alcohol Interaction
Alcohol may increase drowsiness, dizziness, and mood changes when used with this medicine. It is best to avoid alcohol or limit it strictly while you are receiving this treatment, especially if you feel sleepy or unsteady.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to progesterone or any ingredient of this product","Current or past blood clots in veins or lungs","Severe liver disease","Unexplained vaginal bleeding","Known or suspected hormone-sensitive cancers such as breast or endometrial cancer","Missed abortion or ectopic pregnancy where progesterone is not appropriate"]
⚠️ Warnings & Precautions
["This medicine must be given by intramuscular injection only, by a trained healthcare professional.","Do not inject into a vein or under the skin.","Use with caution if you have a history of blood clots, liver disease, kidney disease, or heart disease.","May cause drowsiness or dizziness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor about all medicines you take, especially blood thinners and enzyme-altering drugs.","Report any unusual vaginal bleeding, severe headache, vision changes, or leg pain immediately.","Do not use if the solution is discolored or contains particles."]
🤱 Lactation Safety
Progesterone passes into breast milk. Intramuscular progesterone is generally not used during breastfeeding unless specifically prescribed by a specialist. Discuss the risks and benefits with your doctor before use.
💊 Overdose Management
Overdose with intramuscular progesterone is unlikely to cause severe immediate harm, but it may worsen side effects such as drowsiness, dizziness, nausea, or vaginal bleeding. If you suspect an overdose, contact your doctor or a poison control center immediately. Treatment is supportive and based on symptoms.
⏰ Missed Dose
If you miss a scheduled dose of this medicine, contact your doctor or clinic for advice. Do not take an extra dose or double the next dose to make up for the missed one. Your doctor will advise whether to take the missed dose late or skip it based on your treatment plan.
Additional Safety Advice
This medicine must be given by intramuscular injection only, usually by a healthcare professional. Never inject it into a vein or under the skin. Tell your doctor about all your medicines, especially blood thinners, before starting this product. Do not drive or operate heavy machinery if you feel drowsy or dizzy after the injection. Report any calf pain, leg swelling, chest pain, or breathlessness immediately, as these may signal a blood clot. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Keep all follow-up appointments for monitoring. Do not stop or change the dose on your own. Store the product as directed on the label and never use a damaged or expired vial or ampoule.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to drowsiness, dizziness, and fluid retention. Use with caution and monitor for falls, blood pressure changes, and cardiovascular events.
🤰 Pregnancy Planning (TTC)
If you are trying to conceive, discuss this medicine with your fertility specialist. It may be prescribed to support the luteal phase or early pregnancy. Do not start or stop it without medical advice.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are receiving this medicine. It may affect fluid balance and clotting risk, so monitoring may be needed around surgery.
🦷 Dental Procedures
Tell your dentist about this medicine before any dental procedure. It is not known to cause specific dental interactions, but your overall medical condition and other medicines should be considered.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You may continue light to moderate exercise if you feel well, but avoid strenuous activity or heavy lifting if you feel dizzy, drowsy, or have injection site pain. Follow your doctor's advice, especially during fertility treatment or pregnancy.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their usual work activities, but discuss any specific job requirements with your doctor.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor will decide when to stop based on your condition, treatment response, and monitoring results. If you experience serious side effects, contact your doctor immediately for advice.
📅 Long-Term Use Effects
Long-term use of this medicine may require monitoring of liver function, blood pressure, and signs of blood clots. Prolonged progesterone therapy can affect mood, fluid balance, and menstrual bleeding patterns. Regular follow-up with your doctor is important to adjust treatment and detect any complications early.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be an alternative for some indications, but absorption and side effects differ.
Evidence: Well-establishedAnother route for luteal support and pregnancy support in selected cases.
Evidence: Well-establishedOptions such as dydrogesterone may be used for specific hormonal conditions.
Evidence: Established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions established for this medicine. You can receive routine vaccines as advised by your doctor, but inform the vaccination team about this medicine and your medical condition.
📦 Storage Guide
✅ DO
Store in a cool, dry place away from direct sunlight
❌ DON'T
Do not store in a hot or humid place
✅ DO
Keep in the original container with the label intact
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep out of reach of children
❌ DON'T
Do not use if the solution is discolored or contains particles
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription copy. Keep it in a cool, dry place away from direct sunlight during travel. If you need an injection while traveling, arrange for a trained healthcare professional to administer it. Check airline and customs rules for carrying injectable medicines and carry a doctor's letter if required. Do not freeze the product unless the label says it is safe to do so.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of action depends on the indication and your individual response. Your doctor will monitor your progress with appropriate tests.
A: No. This product is intended for intramuscular injection as specified by the route. Do not take it orally unless your doctor specifically instructs otherwise.
A: Avoid driving or operating machinery until you feel normal. Inform your doctor if drowsiness is severe or persistent.
A: It is used in pregnancy for specific medical indications under specialist supervision. Do not use it without your doctor's advice.
🤔 Common Patient Concerns
🔄 Substitutes for curenin 100mg injection
View AllAlternative brands with exact same active ingredient:
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oraprog 100mg injectionIva Healthcare Pvt. Ltd. ₹55.31 14.5% CHEAPER
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Forgest 100mg InjectionForgo Pharmaceuticals Pvt Ltd ₹63.75 1.5% CHEAPER
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crogest 100mg injectionCronus Biotech Ltd ₹69.00 6.7% COSTLIER
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N-Sanigest 100mg CapsuleSanify Healthcare Pvt Ltd ₹70.31 8.7% COSTLIER
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arigest 100mg injectionArika Healthcare ₹73.00 12.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be swallowed like a normal capsule.
Fact: This product is intended for intramuscular injection as specified by the route. Do not take it orally unless your doctor specifically instructs otherwise. - Myth: Progesterone injections are safe for everyone.
Fact: This medicine is not safe for people with blood clots, severe liver disease, unexplained vaginal bleeding, or hormone-sensitive cancers. - Myth: You can stop this medicine on your own once you feel better.
Fact: Stopping suddenly can disrupt your treatment plan. Always consult your doctor before stopping.
🔄 Alternative Options
Generic Alternatives
- Progesterone injection
Brand Alternatives
- Adgest 100 capsule