curekelafine 25mg/500mg tablet
What is curekelafine 25mg/500mg tablet used for?
Curekelafine (Pyrimethamine + Sulphadoxine) is used to treat ANTI MALARIALS. It contains Pyrimethamine (25mg) + Sulphadoxine (500mg), which Pyrimethamine inhibits dihydrofolate reductase; Sulphadoxine inhibits dihydropte. Always consult your doctor before use. Take as prescribed.
- Generic Name: Pyrimethamine + Sulphadoxine
- Manufacturer: Unicure India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ curekelafine 25mg/500mg tablet Uses & Benefits
Treatment of uncomplicated falciparum malaria; prophylaxis in chloroquine-resistant areas
Off-label uses: Toxoplasmosis (pyrimethamine alone)
๐ Drug Information
| Generic Name(s) | Pyrimethamine + Sulphadoxine |
| Brand Name | Curekelafine |
| Manufacturer | Unicure India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI MALARIALS |
| Action Class | Antimalarial |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Pyrimethamine inhibits dihydrofolate reductase; Sulphadoxine inhibits dihydropteroate synthetase, synergistically blocking folate synthesis in Plasmodium
Mechanism Steps
๐ก How to Take curekelafine 25mg/500mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of curekelafine 25mg/500mg tablet
โ Common Side Effects
- Nausea
- Vomiting
- Headache
- Dizziness
- Rash
๐จ Serious Side Effects
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Agranulocytosis
- Aplastic anemia
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Megaloblastic anemia
- Pulmonary infiltrates
- Peripheral neuropathy
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Phenytoin | Major | Increased phenytoin levels |
| Sulfonylureas | Major | Increased hypoglycemic effect |
| Chloramphenicol | Moderate | Increased bone marrow suppression |
| Oral contraceptives | Moderate | Reduced contraceptive efficacy |
| Thiazide diuretics | Moderate | Increased risk of thrombocytopenia |
| Vitamin C | Minor | Possible decreased absorption |
| Folic acid | Minor | Antagonizes effect |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Phenytoin
- Sulfonylureas
โก Moderate Interactions
- Chloramphenicol
- Oral contraceptives
- Thiazide diuretics
โน๏ธ Minor Interactions
- Vitamin C
- Folic acid
๐ฝ๏ธ Food Interactions
No significant food interactions
๐ท Alcohol Interaction
Avoid alcohol due to increased hepatotoxicity risk
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to sulfonamides or pyrimethamine; severe hepatic or renal impairment; megaloblastic anemia; pregnancy (first trimester)
๐ Monitoring Parameters
Complete blood count, liver function tests, renal function tests, folate levels
๐คฑ Lactation Safety
Caution; excreted in breast milk
๐ Overdose Management
Gastric lavage, activated charcoal, supportive care; folinic acid for pyrimethamine toxicity
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
This medicine was effective for me. I followed the doctor's advice.
Found this to be a helpful product. Good results.
Found this to be a helpful product. Good results.
Good quality medicine. Satisfied with the outcome.
Effective and reliable. Worked as expected.