Curekelafine 25mg/500mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Skin rash, blisters, or peeling skin
- Mouth sores or ulcers
- Fever with sore throat
- Unusual bleeding or bruising
- Yellowing of skin or eyes
- Severe abdominal pain
- Difficulty breathing or swelling of face, lips, or throat
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is curekelafine 25mg/500mg tablet used for?
This medicine is a combination of pyrimethamine and sulphadoxine used to treat malaria and certain other infections. It works by blocking the parasite's ability to make folic acid. It is taken orally, usually as a single dose for malaria. It can cause serious skin reactions and blood problems, so it must be used under medical supervision.
- Generic Name: Pyrimethamine + Sulphadoxine
- Manufacturer: Unicure India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 curekelafine 25mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पाइरीमेथामिन और सल्फाडॉक्सिन का संयोजन है, जिसका उपयोग मलेरिया और कुछ अन्य संक्रमणों के इलाज के लिए किया जाता है। यह मुख्य रूप से प्लास्मोडियम फाल्सीपेरम मलेरिया के इलाज में प्रयोग की जाती है, खासकर उन क्षेत्रों में जहां क्लोरोक्वीन के प्रति परजीवी प्रतिरोधी हो गया है। यह टोक्सोप्लाज्मोसिस और निमोनिया के कुछ रूपों में भी उपयोग की जा सकती है। यह दवा परजीवी के फोलिक एसिड संश्लेषण को रोककर काम करती है, जिससे परजीवी मर जाता है। यह दवा केवल डॉक्टर के पर्चे पर ही मिलती है और इसे निर्देशानुसार ही लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, भूख न लगना, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में त्वचा पर गंभीर प्रतिक्रियाएं जैसे स्टीवंस-जॉनसन सिंड्रोम, रक्त विकार जैसे एग्रानुलोसाइटोसिस, यकृत विषाक्तता और गंभीर एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। दुर्लभ दुष्प्रभावों में दौरे, मानसिक अवसाद और अग्नाशयशोथ शामिल हैं।
सुरक्षा सलाह: इस दवा को पानी के साथ और भोजन के साथ लें ताकि पेट की परेशानी कम हो। निर्धारित खुराक से अधिक न लें। डॉक्टर के बताए अनुसार पूरा कोर्स करें। इस दवा के साथ शराब न लें। उपचार के दौरान और कम से कम 3 महीने बाद तक गर्भनिरोधक का उपयोग करें, क्योंकि यह दवा अजन्मे बच्चे को नुकसान पहुंचा सकती है। यदि आपको त्वचा पर दाने, मुंह में छाले, बुखार, या असामान्य रक्तस्राव या चोट लगने पर तुरंत डॉक्टर से मिलें।
💊 curekelafine 25mg/500mg tablet Uses & Benefits
[{"condition":"Uncomplicated Plasmodium falciparum malaria","description":"Used as a first-line or second-line treatment in regions where the parasite is resistant to other antimalarials.","evidence":"Well-established"},{"condition":"Toxoplasmosis","description":"Used in combination with other medicines for the treatment of toxoplasmosis, especially in immunocompromised patients.","evidence":"Well-established"},{"condition":"Pneumocystis jirovecii pneumonia (PCP) prophylaxis","description":"Used as an alternative for prevention of PCP in patients who cannot tolerate standard therapy.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Isosporiasis","description":"Sometimes used to treat diarrhea caused by Isospora belli in immunocompromised individuals.","evidence":"Limited"},{"condition":"Cyclosporiasis","description":"Occasionally used for treating Cyclospora infection, though not FDA-approved for this indication.","evidence":"Limited"}]
Primary treatment for: Malaria
Also treats: Toxoplasmosis, Pneumocystis jirovecii pneumonia
📋 Drug Information
| Generic Name(s) | Pyrimethamine + Sulphadoxine |
| Brand Name | Curekelafine |
| Manufacturer | Unicure India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI MALARIALS |
| Action Class | Antimalarial |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends sulfadoxine-pyrimethamine in combination with amodiaquine as an option for intermittent preventive treatment of malaria in pregnancy (IPTp) in areas of moderate to high transmission. It is also recommended for seasonal malaria chemoprevention in some regions. However, due to resistance, its use as monotherapy for treatment is limited. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) guidelines for malaria treatment recommend artemisinin-based combination therapy (ACT) as first-line treatment for uncomplicated P. falciparum malaria. Sulfadoxine-pyrimethamine is not recommended as first-line therapy in India due to widespread resistance, but may be used in specific situations as per national guidelines. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting two consecutive steps in the folic acid pathway of susceptible parasites. Pyrimethamine inhibits dihydrofolate reductase (DHFR), preventing the conversion of dihydrofolate to tetrahydrofolate. Sulphadoxine inhibits dihydropteroate synthase, blocking the formation of dihydropteroic acid. The combination produces a synergistic effect, effectively stopping the parasite's ability to synthesize nucleic acids and proteins, leading to its death.
Mechanism Steps
💡 How to Take curekelafine 25mg/500mg tablet
Strength: Each tablet contains pyrimethamine 25 mg and sulphadoxine 500 mg.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and the severity of the infection. For uncomplicated malaria, a common regimen is a single dose of 3 tablets (each containing 25 mg pyrimethamine and 500 mg sulphadoxine) taken orally. However, this may vary. For toxoplasmosis, the dose and duration are different and must be determined by a specialist. Do not self-medicate. Always follow your doctor's prescription. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing. |
| Elderly Dosage | Elderly patients may have reduced renal and hepatic function, which can affect drug elimination. Dose adjustment may be necessary. Use with caution and monitor closely. |
| Renal Impairment | In patients with renal impairment, dose reduction may be required. Monitor renal function closely. Use with caution in severe renal impairment. |
| Hepatic Impairment | In patients with hepatic impairment, dose reduction may be required. Monitor liver function closely. Use with caution in severe hepatic impairment. |
| Maximum Daily Dose | The maximum daily dose is not well established and depends on the indication. For malaria treatment, a single dose is usually given. For other indications, the dose is determined by the clinician. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of curekelafine 25mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Phenytoin | Major | |
| Trimethoprim | Major | |
| ACE inhibitors | Moderate | |
| Oral hypoglycemics | Moderate | |
| Thiazide diuretics | Moderate | |
| Antacids | Minor | |
| Kaolin-pectin | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Phenytoin
- Trimethoprim
⚡ Moderate Interactions
- ACE inhibitors
- Oral hypoglycemics
- Thiazide diuretics
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine as it may increase the risk of liver toxicity and gastrointestinal side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to pyrimethamine, sulphadoxine, or any sulphonamide","Severe renal impairment","Severe hepatic impairment","Blood dyscrasias","Pregnancy (especially first trimester)","Infants less than 2 months of age","G6PD deficiency (may cause hemolysis)"]
⚠️ Warnings & Precautions
["Serious skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported. Discontinue at the first sign of rash.","Fatalities associated with the administration of sulphonamides have occurred due to severe reactions including agranulocytosis, aplastic anemia, and other blood dyscrasias.","Use with caution in patients with impaired liver or kidney function.","May cause folate deficiency; consider folate supplementation if used for prolonged periods.","Avoid in patients with G6PD deficiency due to risk of hemolytic anemia.","Not recommended for malaria prophylaxis in pregnant women unless the benefit outweighs the risk."]
🤱 Lactation Safety
Pyrimethamine and sulphadoxine are excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
Overdose may cause nausea, vomiting, abdominal pain, dizziness, and headache. In severe cases, blood dyscrasias and liver toxicity may occur. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor blood counts and liver function. Consider folinic acid rescue in cases of significant overdose.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine with plenty of water and preferably with food to reduce stomach upset. Do not exceed the prescribed dose. Complete the full course as prescribed by your doctor. Avoid alcohol while taking this medicine. Use effective contraception during treatment and for at least 3 months after, as this medicine may harm an unborn baby. Inform your doctor if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency, liver or kidney problems, or blood disorders. Do not take this medicine if you are allergic to sulphonamides or pyrimethamine. Seek immediate medical attention if you experience skin rash, mouth sores, fever, or unusual bleeding or bruising.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney and liver function, which can affect how this medicine is cleared from the body. Dose adjustment may be necessary. Monitor for side effects closely.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before taking this medicine. It is not recommended during the first trimester and should be avoided unless absolutely necessary. Use effective contraception during treatment and for at least 3 months after.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with other medications used during surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may increase the risk of bleeding or interact with other medications.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel dizzy or weak. Rest until you recover from the infection. Gradually resume activities as you feel better.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue. Avoid driving or operating heavy machinery until you know how it affects you. Take rest and stay home if you have fever. Resume work only when you feel fully recovered.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full prescribed course. If you experience severe side effects such as skin rash, mouth sores, or unusual bleeding, stop the medicine and seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to folate deficiency, blood disorders, and liver toxicity. Regular monitoring of blood counts and liver function is recommended if used for prolonged periods. It is not intended for long-term use except in specific conditions like toxoplasmosis prophylaxis, where the benefits are carefully weighed against the risks.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
First-line treatment for uncomplicated P. falciparum malaria in many countries.
Evidence: Well-establishedUsed in areas where malaria is susceptible, but resistance is widespread.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are due for a vaccine, inform your doctor that you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust your dosing schedule as advised by your doctor. Check the customs regulations of your destination country regarding prescription medicines. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 24-48 hours, but you may feel better after a few days. Complete the full course as prescribed.
A: Yes, take it with food to reduce stomach upset.
A: Avoid alcohol and do not take more than the prescribed dose. Also, avoid driving if you feel dizzy.
A: It is not recommended during the first trimester and should be used during pregnancy only if the benefit outweighs the risk. Consult your doctor.
A: This medicine passes into breast milk. Consult your doctor before breastfeeding.
🤔 Common Patient Concerns
🔄 Substitutes for curekelafine 25mg/500mg tablet
View AllAlternative brands with exact same active ingredient:
-
reziz 25 mg/500 mg tabletShreya Life Sciences Pvt Ltd ₹4.00 33.3% CHEAPER
-
only 2 tabletKopran Ltd ₹4.31 28.2% CHEAPER
-
malasulf 25 mg/500 mg tabletBombay Tablet Mfg Co Pvt Ltd ₹4.39 26.8% CHEAPER
-
laridox tabletIpca Laboratories Ltd ₹4.67 22.2% CHEAPER
-
Rimodar Kid 25 mg/500 mg TabletAnglo-French Drugs & Industries Ltd ₹5.55 7.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of fever.
Fact: This medicine is specifically for malaria and certain other infections. It is not a general fever reducer and should not be used without a confirmed diagnosis. - Myth: It is safe to take this medicine without a prescription.
Fact: This is a prescription medicine. Self-medication can lead to serious side effects and contribute to drug resistance. - Myth: Once you feel better, you can stop taking this medicine.
Fact: You must complete the full course as prescribed by your doctor to ensure the infection is fully treated and to prevent resistance.
🔄 Alternative Options
Generic Alternatives
- Pyrimethamine + Sulphadoxine (generic)
Brand Alternatives
- Fansidar
- Metakelfin
- Laridox