cufrio br syrup - Bromhexine (4mg/5ml) + Guaifenesin (50mg/5ml) medicine

cufrio br syrup - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Riomedica Healthcare Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 26, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
Dr. SaathiMed Expert Panel | Jun 26, 2026

What is cufrio br syrup used for?

Ascoril Plus Expectorant (Bromhexine + Guaifenesin) is used to treat RESPIRATORY. It contains Bromhexine (4mg/5ml) + Guaifenesin (50mg/5ml), which Bromhexine increases secretion of respiratory tract fluid and reduces mucus visc. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Bromhexine + Guaifenesin
  • Manufacturer: Riomedica Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š cufrio br syrup Uses & Benefits

Productive cough, acute bronchitis, chronic bronchitis, COPD

Off-label uses: Sinusitis, Cystic fibrosis (adjunct)

๐Ÿ“‹ Drug Information

Generic Name(s)Bromhexine + Guaifenesin
Brand NameAscoril Plus Expectorant
ManufacturerRiomedica Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassMucolytic and Expectorant
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally
DistributionDistributes widely in body tissues
Protein BindingBromhexine: ~99%; Guaifenesin: low
MetabolismHepatic
Half-LifeBromhexine: ~12 hours; Guaifenesin: ~1 hour
ExcretionRenal (as metabolites)
BioavailabilityBromhexine: ~75-80%; Guaifenesin: well absorbed
Onset of ActionBromhexine: 30-60 min; Guaifenesin: 15-30 min
Peak Plasma TimeBromhexine: 1-2 hours; Guaifenesin: 0.5-1 hour
Duration of ActionBromhexine: 6-8 hours; Guaifenesin: 4-6 hours

How It Works

Bromhexine increases secretion of respiratory tract fluid and reduces mucus viscosity; Guaifenesin increases respiratory tract fluid output and reduces mucus viscosity.

Mechanism Steps

1Bromhexine stimulates secretion of respiratory tract fluid
2Bromhexine depolymerizes mucopolysaccharides, reducing mucus viscosity
3Guaifenesin increases respiratory tract fluid output

๐Ÿ’ก How to Take cufrio br syrup

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of cufrio br syrup

โœ… Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Headache

๐Ÿšจ Serious Side Effects

  • Bronchospasm
  • Severe allergic reaction
  • GI bleeding

โš ๏ธ Rare Side Effects

  • Stevens-Johnson syndrome
  • Anaphylaxis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Codeine Major Reduced cough clearance
Atropine Major Increased mucus viscosity
MAOIs Moderate Increased CNS effects
Alcohol Minor Increased sedation

๐Ÿšจ Major Interactions

  • Cough suppressants
  • Anticholinergics

โšก Moderate Interactions

  • MAOIs
  • Tricyclic antidepressants

โ„น๏ธ Minor Interactions

  • Other CNS depressants

๐Ÿฝ๏ธ Food Interactions

No significant food interactions

๐Ÿท Alcohol Interaction

May increase CNS depression

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity, peptic ulcer, persistent cough with high fever

๐Ÿ“Š Monitoring Parameters

Cough frequency, sputum characteristics, respiratory status

๐Ÿคฑ Lactation Safety

Excreted in breast milk; use with caution

๐Ÿ’Š Overdose Management

Gastric lavage, supportive care

โฐ Missed Dose

Take as soon as remembered; skip if near next dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

Dr. SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 26, 2026

๐Ÿ”— View Profile

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