crolim power ointment - Uses, Price, Side Effects & Substitutes
What is crolim power ointment used for?
Advagraf (Tacrolimus) is used to treat ANTI NEOPLASTICS. It contains Tacrolimus (0.1% w/w), which Inhibits calcineurin, thereby preventing dephosphorylation and nuclear transloca. Always consult your doctor before use. Take as prescribed.
- Generic Name: Tacrolimus
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ crolim power ointment Uses & Benefits
Prophylaxis of organ rejection in kidney, liver, and heart transplant recipients.
Off-label uses: Autoimmune hepatitis, Ulcerative colitis, Atopic dermatitis, Nephrotic syndrome
๐ Drug Information
| Generic Name(s) | Tacrolimus |
| Brand Name | Advagraf |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Immunosuppressant- Calcineurin inhibitors |
| Route of Administration | Oral |
| Storage | Store at 25ยฐC (77ยฐF); excursions permitted to 15-30ยฐC (59-86ยฐF). Protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits calcineurin, thereby preventing dephosphorylation and nuclear translocation of nuclear factor of activated T-cells (NF-AT), leading to reduced transcription of interleukin-2 and other cytokines.
Mechanism Steps
๐ก How to Take crolim power ointment
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of crolim power ointment
โ Common Side Effects
- Tremor
- Headache
- Diarrhea
- Hypertension
- Nausea
- Renal impairment
- Hyperglycemia
- Hyperkalemia
- Insomnia
- Paresthesia
๐จ Serious Side Effects
- Nephrotoxicity
- Neurotoxicity (e.g., seizures, encephalopathy)
- Posterior reversible encephalopathy syndrome (PRES)
- Thrombotic microangiopathy
- Anaphylaxis
- Lymphoma
- Skin malignancies
โ ๏ธ Rare Side Effects
- Hemolytic uremic syndrome
- Cardiomyopathy
- Leukoencephalopathy
- Pure red cell aplasia
- Interstitial lung disease
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Ciclosporin | Major | Increased nephrotoxicity risk |
| Sirolimus | Major | Increased risk of thrombotic microangiopathy |
| Potassium-sparing diuretics | Major | Hyperkalemia |
| ACE inhibitors | Major | Hyperkalemia |
| NSAIDs | Major | Increased nephrotoxicity |
| Ketoconazole | Moderate | Increased tacrolimus levels |
| Rifampin | Moderate | Decreased tacrolimus levels |
| Grapefruit juice | Minor | Increased tacrolimus levels |
๐จ Major Interactions
- Ciclosporin
- Sirolimus
- Potassium-sparing diuretics
- ACE inhibitors
- NSAIDs
โก Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
- CYP3A4 inducers (e.g., rifampin, phenytoin)
- Antacids
โน๏ธ Minor Interactions
- Grapefruit juice
- Magnesium-containing antacids
๐ฝ๏ธ Food Interactions
Grapefruit juice increases tacrolimus levels, High-fat meals decrease absorption
๐ท Alcohol Interaction
Alcohol may increase hepatotoxicity risk; avoid excessive consumption.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to tacrolimus or any excipients; concomitant use with cyclosporine.
๐ Monitoring Parameters
Tacrolimus trough levels, renal function, liver function, blood pressure, blood glucose, electrolytes (especially potassium), and signs of infection.
๐คฑ Lactation Safety
Not recommended; excreted in breast milk.
๐ Overdose Management
Supportive care; no specific antidote. Hemodialysis not effective.
โฐ Missed Dose
Take as soon as remembered unless close to next dose; skip missed dose if near next dose. Do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for crolim power ointment
View AllAlternative brands with exact same active ingredient (Tacrolimus (0.1% w/w)):
-
taclix 0.1% ointmentBiochemix Health Care Pvt. Ltd. โน80.63 82.1% CHEAPER
-
tacrosze 0.1% ointmentZeelab Pharmacy Pvt Ltd โน100.00 77.8% CHEAPER
-
tacronid creamNidus Pharma Pvt Ltd โน101.25 77.5% CHEAPER
-
tacsus 0.1% ointmentBiovalence Skin Care โน196.88 56.2% CHEAPER
-
Tactis 0.1% OintmentJabs Biotech Pvt Ltd โน225.00 49.9% CHEAPER
-
acroli forte ointmentPsycormedies โน233.44 48.1% CHEAPER
-
cossrim forte 0.1% ointmentCosmoderm India โน234.38 47.9% CHEAPER
-
tic tac 0.1% ointmentCutis Biologicals โน234.38 47.9% CHEAPER
-
Tacrostar 0.1% OintmentUnimarck Healthcare Ltd โน234.38 47.9% CHEAPER
-
Tarmus OintmentParidhi Remedies โน234.38 47.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.