Crifate O Syrup: Complete Medicine Guide for Patients
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Vomiting blood or material that looks like coffee grounds
- Black, tarry stools or blood in stool
- Severe, persistent abdominal pain
- Difficulty breathing or swelling of the face, lips, or throat
- Yellowing of the skin or eyes
- Decreased urine output or swelling in the legs
- Confusion, weakness, or bone pain in people with kidney disease
- No bowel movement for several days with abdominal swelling
If experiencing severe symptoms, call emergency services immediately.
What is cotul o syrup used for?
This medicine is a prescription oral suspension containing sucralfate and oxetacaine. It is used to treat gastritis, peptic ulcers, and acid-related stomach irritation. Sucralfate forms a protective barrier over damaged stomach lining, while oxetacaine numbs the area to relieve pain. It is usually taken before meals and at bedtime, and should be taken exactly as prescribed by a doctor.
- Generic Name: Sucralfate + Oxetacaine
- Manufacturer: GRAF Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cotul o syrup के बारे में (Hindi Summary)
उपयोग: यह दवा सुक्राल्फेट और ऑक्सेटाकेन का संयोजन है, जिसका उपयोग पेट की गैस्ट्राइटिस, पेप्टिक अल्सर, एसिड रिफ्लक्स और पेट की परत में जलन के इलाज के लिए किया जाता है। सुक्राल्फेट पेट की क्षतिग्रस्त परत पर एक सुरक्षात्मक परत बनाता है, जबकि ऑक्सेटाकेन दर्द और जलन को कम करने के लिए उस क्षेत्र को सुन्न करता है। यह दवा आमतौर पर खाने से पहले और रात को सोने से पहले ली जाती है। यह दवा डॉक्टर के निर्देशानुसार ही लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में कब्ज, मुँह सूखना, हल्की मतली और मुँह या गले में अस्थायी सुन्नपन शामिल हैं। कभी-कभी चक्कर आना, सिरदर्द या पेट में हल्की असुविधा हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर त्वचा पर चकत्ते, सूजन, साँस लेने में कठिनाई या गंभीर पेट दर्द हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें और हर बार लेने से पहले बोतल को अच्छी तरह हिलाएँ। अन्य दवाओं के साथ इस दवा को लेने में कम से कम 2 घंटे का अंतर रखें। शराब और धूम्रपान से बचें क्योंकि ये पेट की जलन को बढ़ाते हैं। अगर आपको किडनी की बीमारी है, गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर को पहले बताएं। दवा को ठंडी और सूखी जगह पर रखें और बच्चों की पहुँच से दूर रखें।
💊 cotul o syrup Uses & Benefits
[{"condition":"Peptic ulcer disease","description":"Helps heal gastric and duodenal ulcers by forming a protective barrier over the ulcerated mucosa and reducing pain.","evidence":"Well-established"},{"condition":"Gastritis and dyspepsia","description":"Relieves burning, discomfort, and irritation of the stomach lining associated with acute or chronic gastritis.","evidence":"Well-established"},{"condition":"Gastroesophageal reflux disease (GERD)","description":"Provides symptomatic relief from heartburn and acid irritation of the oesophagus as an add-on therapy.","evidence":"Moderate"},{"condition":"Medication-induced gastric irritation","description":"Used to protect the stomach lining in people taking pain relievers or other medicines that irritate the gut.","evidence":"Moderate"},{"condition":"Stress ulcer prophylaxis","description":"Sometimes used in hospital settings to prevent stress-related mucosal bleeding in critically ill patients.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Radiation-induced oesophagitis","description":"Occasionally used to soothe oesophageal irritation caused by radiation therapy.","evidence":"Limited"},{"condition":"Mouth ulcers and oral mucositis","description":"Sometimes used as a rinse or oral suspension to relieve pain from mouth sores.","evidence":"Limited"},{"condition":"Bile reflux gastropathy","description":"May be used to protect the stomach lining from bile-induced irritation after stomach surgery.","evidence":"Limited"}]
Primary treatment for: Peptic ulcer disease and gastritis
Also treats: Gastroesophageal reflux disease, Dyspepsia, Medication-induced gastric irritation, Stress ulcer prophylaxis
📋 Drug Information
| Generic Name(s) | Sucralfate + Oxetacaine |
| Brand Name | Axid O Suspension |
| Manufacturer | GRAF Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Gastrointestinal protective agent |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place, away from direct sunlight. Do not freeze. Keep the bottle tightly closed and out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the pack. Use within the recommended period after opening, as advised by the manufacturer. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works through two complementary mechanisms. Sucralfate is a complex of aluminium hydroxide and sucrose sulphate that polymerises in the acidic environment of the stomach to form a viscous, sticky paste. This paste selectively binds to damaged, ulcerated mucosa and creates a physical barrier that protects the tissue from acid, pepsin, and bile. It also mildly inhibits pepsin activity and stimulates local production of protective prostaglandins and mucus. Oxetacaine is a local anaesthetic that diffuses into the irritated mucosa and reversibly blocks sodium channels in nerve endings, reducing pain and burning sensations. Together, they provide both protection and rapid symptomatic relief.
Mechanism Steps
💡 How to Take cotul o syrup
Strength: Each 5 ml of oral suspension contains sucralfate 500 mg and oxetacaine 10 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 ml of the suspension taken orally three to four times a day, preferably before meals and at bedtime, or as directed by your doctor. The exact dose and duration depend on the condition being treated, such as gastritis, GERD, or peptic ulcer, and on your overall health. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Older adults may use this medicine at the same dose as younger adults, but caution is advised in those with reduced kidney function. Kidney function should be assessed before starting treatment, and the dose may need to be adjusted or the medicine avoided in severe kidney impairment. Dose must be individualized by a qualified clinician. |
| Renal Impairment | This medicine should be used with caution in people with kidney disease because sucralfate contains aluminium, which can accumulate and cause toxicity. In severe kidney impairment or dialysis, the medicine is generally avoided. If used, the dose and duration should be minimized and monitored by a doctor. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | No specific dose adjustment is established for people with liver disease. Sucralfate is minimally absorbed, but oxetacaine is metabolised in the liver. Use with caution in severe liver disease and follow your doctor's advice. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose is not established from the available information. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cotul o syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ciprofloxacin | Major | |
| Tetracycline | Major | |
| Levothyroxine | Major | |
| Digoxin | Major | |
| Antacids | Moderate | |
| Iron supplements | Moderate | |
| Ketoconazole | Moderate | |
| Phenytoin | Moderate | |
| Paracetamol | Minor | |
| Metformin | Minor |
🚨 Major Interactions
- Fluoroquinolone antibiotics (e.g., ciprofloxacin, levofloxacin)
- Tetracycline antibiotics
- Levothyroxine
- Digoxin
⚡ Moderate Interactions
- Antacids containing aluminium or magnesium
- Iron supplements
- Ketoconazole
- Phenytoin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol increases stomach acid production, irritates the gastric mucosa, and can worsen ulcers or gastritis, reducing the benefit of treatment. It may also increase the risk of dizziness or drowsiness in some people.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to sucralfate, oxetacaine, or any component of the formulation","Severe kidney impairment or dialysis-dependent kidney failure","Suspected or confirmed gastrointestinal obstruction or perforation","Severe dehydration or electrolyte imbalance","Children below the age recommended by the prescribing doctor"]
⚠️ Warnings & Precautions
["Shake the bottle well before each use to ensure uniform mixing of the suspension.","Maintain a gap of at least 2 hours between this medicine and other oral medicines.","Use with caution in people with kidney disease because of the risk of aluminium accumulation.","Avoid alcohol and smoking, as they delay healing and worsen symptoms.","Do not use for longer than prescribed without medical review.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Keep out of reach of children and do not share with others.","If symptoms persist or worsen after 7 days, consult your doctor."]
🤱 Lactation Safety
Sucralfate is poorly absorbed systemically, so the amount passing into breast milk is expected to be negligible. Data on oxetacaine in breast milk are limited. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose with this medicine is unlikely to cause serious systemic toxicity because sucralfate and oxetacaine are poorly absorbed. However, large amounts may cause constipation, abdominal bloating, or, in rare cases, aluminium toxicity in people with kidney disease. If you suspect an overdose, contact your doctor or a poison control centre immediately. Treatment is supportive and symptomatic, with attention to hydration and bowel function.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, provided there is enough time before your next scheduled dose. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually before meals and at bedtime, and shake the bottle well each time. Do not exceed the recommended dose or duration without medical advice. Maintain a gap of at least two hours between this medicine and other oral medicines, because sucralfate can reduce their absorption. Avoid alcohol and smoking, as they worsen stomach irritation and delay healing. If you have kidney disease, are pregnant, planning pregnancy, or breastfeeding, inform your doctor before using this medicine. Keep the bottle tightly closed, store it at room temperature, and keep it out of reach of children. Do not use this medicine for more than the prescribed period without review, and do not share it with others.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more prone to constipation and aluminium accumulation, especially if kidney function is reduced. Kidney function should be checked before and during treatment. The dose may need to be adjusted or the medicine avoided in severe kidney impairment.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, inform your doctor before using this medicine. Sucralfate is generally considered acceptable in pregnancy when prescribed, but oxetacaine has limited safety data. Your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
After stomach or intestinal surgery, this medicine may be used to protect the healing mucosa, but only under medical supervision. It should be avoided if there is any suspicion of obstruction or perforation.
🦷 Dental Procedures
The local anaesthetic component may cause temporary mouth numbness, which usually resolves quickly. Inform your dentist if you are taking this medicine before any dental procedure. Maintain good oral hygiene, as the sweetener in the suspension may affect teeth with prolonged use.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Mild to moderate exercise is generally safe while taking this medicine. Avoid strenuous exercise immediately after meals, as it may worsen reflux or abdominal discomfort. If you feel dizzy or weak, stop and rest. Consult your doctor before starting a new exercise routine if you have an ulcer or severe gastritis.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to work or drive. However, if you experience dizziness, drowsiness, or blurred vision, avoid driving or operating heavy machinery until you feel normal. The suspension may cause temporary mouth numbness, which usually resolves quickly.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If your symptoms have completely resolved and your doctor advises stopping, you may do so. If you experience severe side effects such as allergic reactions, persistent vomiting, or signs of aluminium toxicity, stop the medicine and seek medical help immediately.
📅 Long-Term Use Effects
Long-term use of this medicine should be supervised by a doctor. Prolonged use, especially in people with kidney disease, can lead to aluminium accumulation, which may cause bone pain, weakness, or confusion. Constipation may become persistent. Regular review is needed to assess whether continued treatment is necessary and to monitor kidney function.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Avoiding trigger foods and eating small frequent meals can reduce acid irritation.
Evidence: Well-establishedYoga, meditation, and relaxation techniques can help reduce stress-related acid production.
Evidence: ModerateThese medicines reduce acid production and may be prescribed for severe ulcers or GERD.
Evidence: Well-establishedThese reduce acid secretion and may be an alternative for some patients.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive routine vaccinations while taking this medicine unless your doctor advises otherwise.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not freeze or refrigerate unless specified
✅ DO
Keep the bottle tightly closed in its original carton
❌ DON'T
Do not transfer to another unmarked container
✅ DO
Keep away from direct sunlight and heat
❌ DON'T
Do not store in the bathroom or near the stove
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription copy when travelling. Keep it in your hand luggage if flying, as checked baggage may expose it to extreme temperatures. Store it at room temperature and avoid leaving it in a hot car. If you are crossing time zones, continue your doses at regular intervals as advised by your doctor. Check customs rules for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The local anaesthetic effect starts within a few minutes, while the protective barrier forms within 30 to 60 minutes. Symptom relief may take a few days of regular use.
A: It is best taken on an empty stomach, at least 1 hour before meals or 2 hours after meals, so that it can coat the stomach lining effectively.
A: It should be used with caution in kidney disease because sucralfate contains aluminium. Your doctor may avoid it or monitor you closely.
A: Sucralfate is generally considered acceptable in pregnancy when prescribed, but oxetacaine has limited data. Consult your doctor before use.
A: Take it as soon as you remember if there is enough time before the next dose. Otherwise, skip it and continue your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for cotul o syrup
View AllAlternative brands with exact same active ingredient:
-
crifate o syrupArion Healthcare ₹89.06 1% CHEAPER
-
sucracon-o syrupCatholicon Pharmaceuticals Pvt Ltd ₹95.00 5.6% COSTLIER
-
s cool suspensionOstrich Pharmaceuticals Pvt Ltd ₹96.00 6.7% COSTLIER
-
sucrafil o gel sugar freeFourrts India Laboratories Pvt Ltd ₹113.44 26% COSTLIER
-
sucralcoat o 1gm syrupOrdain Health Care Global Pvt Ltd ₹222.19 146.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine reduces stomach acid like antacids.
Fact: This medicine does not reduce acid production. It protects the stomach lining and numbs pain. - Myth: It can be taken with any other medicine at the same time.
Fact: Sucralfate can reduce the absorption of many medicines, so a gap of at least 2 hours is needed. - Myth: It is safe to use for months without review.
Fact: Prolonged use should be reviewed by a doctor, especially in people with kidney disease. - Myth: It works instantly for all types of stomach pain.
Fact: It helps acid-related pain but is not effective for all causes of abdominal pain.
🔄 Alternative Options
Generic Alternatives
- Sucralfate + Oxetacaine oral suspension
- Sucralfate oral suspension
- Oxetacaine oral gel
Brand Alternatives
- Crifate O Syrup