costrim v tablet
What is costrim v tablet used for?
Costrim V (Tinidazole + Clotrimazole) is used to treat GASTRO INTESTINAL. It contains Tinidazole (NA) + Clotrimazole (NA), which Tinidazole inhibits DNA synthesis in protozoa; Clotrimazole inhibits ergosterol . Always consult your doctor before use. Take as prescribed.
- Generic Name: Tinidazole + Clotrimazole
- Manufacturer: Espee Formulation Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ costrim v tablet Uses & Benefits
Trichomoniasis, Bacterial vaginosis, Giardiasis, Amebiasis, Candidal infections
Off-label uses: Helicobacter pylori eradication, Periodontitis
๐ Drug Information
| Generic Name(s) | Tinidazole + Clotrimazole |
| Brand Name | Costrim V |
| Manufacturer | Espee Formulation Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antiprotozoal + Antifungal |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Tinidazole inhibits DNA synthesis in protozoa; Clotrimazole inhibits ergosterol synthesis in fungi.
Mechanism Steps
๐ก How to Take costrim v tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of costrim v tablet
โ Common Side Effects
- Nausea
- Metallic taste
- Headache
- Vaginal discharge
- Abdominal pain
๐จ Serious Side Effects
- Seizures
- Peripheral neuropathy
- Stevens-Johnson syndrome
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Pancreatitis
- Leukopenia
- Anaphylaxis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk |
| Disulfiram | Major | Psychotic reactions |
| Alcohol | Major | Disulfiram-like reaction |
| CYP3A4 inducers | Moderate | Reduced tinidazole efficacy |
| CYP3A4 inhibitors | Moderate | Increased tinidazole toxicity |
๐จ Major Interactions
- Warfarin
- Disulfiram
- Alcohol
- CYP3A4 inducers/inhibitors
โก Moderate Interactions
- Lithium
- Phenytoin
- Cyclosporine
โน๏ธ Minor Interactions
- Oral contraceptives
- Antacids
๐ฝ๏ธ Food Interactions
Avoid alcohol-containing foods; food may delay absorption but not extent.
๐ท Alcohol Interaction
Disulfiram-like reaction (nausea, vomiting, flushing) with tinidazole.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to nitroimidazoles or azoles, Pregnancy (first trimester), Lactation, Blood dyscrasias, CNS disorders
๐ Monitoring Parameters
LFTs, CBC, Neurological symptoms, Signs of superinfection
๐คฑ Lactation Safety
Tinidazole excreted in milk; avoid breastfeeding during therapy and for 3 days after last dose.
๐ Overdose Management
Symptomatic and supportive; no specific antidote; hemodialysis may remove tinidazole.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double.
๐จโโ๏ธ Reviewed by Expert
โญ User Reviews
Effective and reliable. Worked as expected.
This medicine was effective for me. I followed the doctor's advice.
This medicine was effective for me. I followed the doctor's advice.
Found this to be a helpful product. Good results.
Effective and reliable. Worked as expected.