cosmodex n eye drop - Neomycin (0.5% w/v) + Dexamethasone (0.1% w/v) medicine

Cosmodex N Eye Drop

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🏭 Cosmopack Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 31, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Oct 31, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

What is cosmodex n eye drop used for?

This medicine contains Neomycin (0.5% w/v) + Dexamethasone (0.1% w/v) and is used to treat OPHTHAL OTOLOGICALS. Neomycin inhibits bacterial protein synthesis by binding to 30S ribosomal subunit; Dexamethasone sup. Always consult your doctor before use.

  • Generic Name: Neomycin + Dexamethasone
  • Manufacturer: Cosmopack Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 cosmodex n eye drop Uses & Benefits

Treatment of bacterial infections with inflammation in eye (conjunctivitis, blepharitis) and ear (otitis externa)

Off-label uses: None commonly reported

📋 Drug Information

Generic Name(s)Neomycin + Dexamethasone
Brand NameBentodex Eye/Ear Drops
ManufacturerCosmopack Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL OTOLOGICALS
Action ClassAntibiotic + Corticosteroid
Route of AdministrationTopical (ophthalmic/otic drops)
StorageStore at 15-30°C; protect from light; keep tightly closed
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMinimal systemic absorption after topical ophthalmic/otic administration
DistributionLocal distribution in eye/ear tissues; negligible systemic distribution
Protein BindingNeomycin: low; Dexamethasone: ~77%
MetabolismNeomycin: not metabolized; Dexamethasone: hepatic via CYP3A4
Half-LifeNeomycin: 2-3 hours (systemic); Dexamethasone: 36-54 hours
ExcretionNeomycin: renal; Dexamethasone: renal
BioavailabilityLow due to topical administration
Onset of ActionWithin 24-48 hours
Peak Plasma TimeNot applicable (topical)
Duration of ActionSeveral hours to days depending on dosing

How It Works

Neomycin inhibits bacterial protein synthesis by binding to 30S ribosomal subunit; Dexamethasone suppresses inflammation by inhibiting phospholipase A2 and reducing prostaglandin synthesis

Mechanism Steps

1Neomycin binds to 30S ribosomal subunit of bacteria, inhibiting protein synthesis
2Dexamethasone binds to glucocorticoid receptors, inhibiting phospholipase A2
3Reduced arachidonic acid release decreases prostaglandin and leukotriene synthesis
4Decreased inflammation and immune response

💡 How to Take cosmodex n eye drop

Follow your doctor's prescription exactly.

⚠️ Side Effects of cosmodex n eye drop

✅ Common Side Effects

Burning
Stinging
Blurred vision
Ear discomfort

🚨 Serious Side Effects

Superinfection
Increased intraocular pressure
Cataract formation
Ototoxicity (with prolonged otic use)

⚠️ Rare Side Effects

Allergic reaction
Perforation of eardrum
Systemic effects from prolonged use

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Aminoglycosides (systemic) Major Increased risk of ototoxicity and nephrotoxicity
Ototoxic drugs Major Additive ototoxicity
Nephrotoxic drugs Major Additive nephrotoxicity
Neuromuscular blocking agents Moderate Enhanced neuromuscular blockade
Loop diuretics Moderate Increased ototoxicity risk
Anticholinesterases Minor Possible antagonism of neuromuscular effects

🚨 Major Interactions

  • Aminoglycosides (systemic)
  • Ototoxic drugs
  • Nephrotoxic drugs

⚡ Moderate Interactions

  • Neuromuscular blocking agents
  • Loop diuretics

🍷 Alcohol Interaction

No known interaction

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to neomycin, dexamethasone, or any component; viral or fungal infections; untreated bacterial infections; perforated eardrum (for otic use)

🤱 Lactation Safety

Caution; limited data, but systemic absorption minimal

💊 Overdose Management

Rinse with water; symptomatic treatment; unlikely to cause systemic toxicity

⏰ Missed Dose

Apply as soon as remembered; skip if almost time for next dose; do not double dose

🔄 Substitutes for cosmodex n eye drop

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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