cosmegen 0.5mg injection - Uses, Price, Side Effects & Substitutes
What is cosmegen 0.5mg injection used for?
Actinocin 0.5mg Injection (Dactinomycin) is used to treat ANTI NEOPLASTICS. It contains Dactinomycin (0.5mg), which Intercalates between DNA base pairs, inhibiting RNA synthesis and DNA replicatio. Always consult your doctor before use. Take as prescribed.
- Generic Name: Dactinomycin
- Manufacturer: Wockhardt Ltd
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ cosmegen 0.5mg injection Uses & Benefits
Wilms tumor, rhabdomyosarcoma, Ewing sarcoma, gestational trophoblastic neoplasia, testicular cancer.
Off-label uses: Kaposi sarcoma, neuroblastoma, soft tissue sarcoma.
๐ Drug Information
| Generic Name(s) | Dactinomycin |
| Brand Name | Actinocin 0.5mg Injection |
| Manufacturer | Wockhardt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkaloids-cytotoxic agents |
| Route of Administration | Intravenous |
| Storage | Store at 2-8ยฐC, protect from light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Intercalates between DNA base pairs, inhibiting RNA synthesis and DNA replication.
Mechanism Steps
๐ก How to Take cosmegen 0.5mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cosmegen 0.5mg injection
โ Common Side Effects
- Nausea
- vomiting
- alopecia
- myelosuppression
- mucositis
๐จ Serious Side Effects
- Hepatotoxicity
- veno-occlusive disease
- severe myelosuppression
- infection
โ ๏ธ Rare Side Effects
- Anaphylaxis
- secondary malignancies
- pulmonary fibrosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Live vaccines | Major | Risk of disseminated infection |
| Phenytoin | Major | Decreased phenytoin levels |
| Corticosteroids | Moderate | Increased immunosuppression |
| Immunosuppressants | Moderate | Additive immunosuppression |
| Hepatotoxic drugs | Moderate | Increased hepatotoxicity |
| Allopurinol | Minor | Possible increased toxicity |
| Probenecid | Minor | Decreased renal excretion |
๐จ Major Interactions
- Warfarin
- Live vaccines
- Phenytoin
โก Moderate Interactions
- Corticosteroids
- Immunosuppressants
- Hepatotoxic drugs
โน๏ธ Minor Interactions
- Allopurinol
- Probenecid
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
Avoid alcohol due to hepatotoxicity risk.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, pregnancy, breastfeeding, severe hepatic impairment.
๐ Monitoring Parameters
CBC, liver function tests, renal function, uric acid levels.
๐คฑ Lactation Safety
Contraindicated; excreted in breast milk.
๐ Overdose Management
Supportive care; no specific antidote; monitor for myelosuppression and hepatic toxicity.
โฐ Missed Dose
Do not double dose; consult physician.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for cosmegen 0.5mg injection
View AllAlternative brands with exact same active ingredient (Dactinomycin (0.5mg)):
-
Tinowel 0.5mg InjectionGetwell Oncology Pvt Ltd โน345.00 280.9% COSTLIER
-
actinocin 0.5mg injectionNeon Laboratories Ltd โน495.00 446.5% COSTLIER
-
dactinoget 0.5mg injectionGLS Pharma Ltd. โน525.00 479.6% COSTLIER
-
dacmozen 0.5mg injectionVhb Life Sciences Inc โน699.00 671.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.